{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:12:23Z","timestamp":1790835143860,"version":"4.1.0"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2016\/21\/B\/NZ7\/01131"],"award-info":[{"award-number":["2016\/21\/B\/NZ7\/01131"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008725","name":"Maj Institute of Pharmacology Polish Academy of Sciences","doi-asserted-by":"crossref","award":["statutory fund"],"award-info":[{"award-number":["statutory fund"]}],"id":[{"id":"10.13039\/501100008725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"InterDokMed","award":["POWR.03.02.00-00-I013\/16"],"award-info":[{"award-number":["POWR.03.02.00-00-I013\/16"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Rationale<\/jats:title>\n                <jats:p>4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (25I-NBOMe) is a potent serotonin 5-HT<jats:sub>2A\/2C<\/jats:sub> receptor agonist with hallucinogenic activity. There is no data on the 25I-NBOMe effect on brain neurotransmission and animal performance after chronic administration.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>We examined the effect of a 7-day treatment with 25I-NBOMe (0.3\u00a0mg\/kg\/day) on neurotransmitters\u2019 release and rats\u2019 behavior in comparison to acute dose.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Changes in dopamine (DA), serotonin (5-HT), acetylcholine (ACh), and glutamate release were studied using microdialysis in freely moving rats. The hallucinogenic activity was measured in the wet dog shake (WDS) test. The animal locomotion was examined in the open field (OF) test, short-term memory in the novel object recognition (NOR) test. The anxiogenic\/anxiolytic properties of the drug were tested using the light\/dark box (LDB) test.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Repeated administration of 25I-NBOMe decreased the response to a challenge dose of DA, 5-HT, and glutamatergic neurons in the frontal cortex as well as weakened the hallucinogenic activity in comparison to acute dose. In contrast, striatal and accumbal DA and 5-HT release and accumbal but not striatal glutamate release in response to the challenge dose of 25I-NBOMe was increased in comparison to acute treatment. The ACh release was increased in all brain regions. Behavioral tests showed a motor activity reduction and memory deficiency in comparison to a single dose and induction of anxiety after the drug\u2019s chronic and acute administration.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our findings suggest that multiple injections of 25I-NBOMe induce tolerance to hallucinogenic activity and produce alterations in neurotransmission. 25I-NBOMe effect on short-term memory, locomotor function, and anxiety seems to be the result of complex interactions between neurotransmitter pathways.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00213-021-05860-5","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T10:02:48Z","timestamp":1621936968000},"page":"2349-2364","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Tolerance to neurochemical and behavioral effects of the hallucinogen 25I-NBOMe"],"prefix":"10.1007","volume":"238","author":[{"given":"Monika","family":"Herian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Skawski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Wojtas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata K.","family":"Soboci\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Noworyta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5018-1394","authenticated-orcid":false,"given":"Krystyna","family":"Go\u0142embiowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"5860_CR1","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/S0028-3908(97)00051-8","volume":"36","author":"GK Aghajanian","year":"1997","unstructured":"Aghajanian GK, Marek GJ (1997) Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells. Neuropharmacology 36:589\u2013599. https:\/\/doi.org\/10.1016\/S0028-3908(97)00051-8","journal-title":"Neuropharmacology"},{"key":"5860_CR2","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/jpharmthera200608004","volume":"113","author":"KD Alex","year":"2007","unstructured":"Alex KD, Pehek EA (2007) Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacol Ther 113:296\u2013320. https:\/\/doi.org\/10.1016\/jpharmthera200608004","journal-title":"Pharmacol Ther"},{"key":"5860_CR3","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3389\/fnsys201100048","volume":"5","author":"TA Ansah","year":"2011","unstructured":"Ansah TA, Ferguson MC, Nayyar T (2011) The 5-HT(2A) receptor antagonist M100907 produces antiparkinsonian effects and decreases striatal glutamate. Front Syst Neurosci 5:48. https:\/\/doi.org\/10.3389\/fnsys201100048","journal-title":"Front Syst Neurosci"},{"key":"5860_CR4","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","volume":"13","author":"M Antunes","year":"2012","unstructured":"Antunes M, Biala G (2012) The novel object recognition memory: neurobiology test, procedure, and its modifications. Cogn Process 13:93\u2013110. https:\/\/doi.org\/10.1007\/s10339-011-0430-z","journal-title":"Cogn Process"},{"key":"5860_CR5","doi-asserted-by":"publisher","first-page":"10721","DOI":"10.1523\/jneurosci.6413-10.2011","volume":"31","author":"GRI Barker","year":"2011","unstructured":"Barker GRI, Warburton EC (2011) When is the hippocampus involved in recognition memory? J Neurosci 31:10721\u201310731. https:\/\/doi.org\/10.1523\/jneurosci.6413-10.2011","journal-title":"J Neurosci"},{"key":"5860_CR6","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1097\/pra0000000000000409","volume":"25","author":"MJ Begola","year":"2019","unstructured":"Begola MJ, Schillerstrom JE (2019) Hallucinogens and their therapeutic use. J Psychiatr Pract 25:334\u2013346. https:\/\/doi.org\/10.1097\/pra0000000000000409","journal-title":"J Psychiatr Pract"},{"key":"5860_CR7","doi-asserted-by":"publisher","first-page":"15716","DOI":"10.1523\/JNEUROSCI2087-132013","volume":"33","author":"P Bekinschtein","year":"2013","unstructured":"Bekinschtein P, Renner MC, Gonzalez MC, Weisstaub N (2013) Role of medial prefrontal cortex serotonin 2A receptors in the control of retrieval of recognition memory in rats. J Neurosci 33:15716\u201315725. https:\/\/doi.org\/10.1523\/JNEUROSCI2087-132013","journal-title":"J Neurosci"},{"key":"5860_CR8","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1113\/jphysiol2005098269","volume":"569","author":"C Blomeley","year":"2005","unstructured":"Blomeley C, Bracci E (2005) Excitatory effects of serotonin on rat striatal cholinergic interneurons. J Physiol 569:715\u2013721. https:\/\/doi.org\/10.1113\/jphysiol2005098269","journal-title":"J Physiol"},{"key":"5860_CR9","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/7854_2016_464","volume-title":"Curr Top Behav Neurosci 36: Behavioral neurobiology of psychedelic drugs","author":"MP Bogenschutz","year":"2018","unstructured":"Bogenschutz MP, Ross S (2018) Therapeutic applications of classic hallucinogens. In: Halberstadt AL, Vollenweider FX, Nichols DE (eds) Curr Top Behav Neurosci 36: Behavioral neurobiology of psychedelic drugs. Springer-Verlag GmbH, Berlin, pp 361\u2013391. https:\/\/doi.org\/10.1007\/7854_2016_464"},{"key":"5860_CR10","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1038\/sjnpp1301294","volume":"32","author":"P Bonsi","year":"2007","unstructured":"Bonsi P, Cuomo D, Ding J, Sciamanna G, Ulrich S, Tscherter A, Bernardi G, Surmeier DJ, Pisani A (2007) Endogenous serotonin excites striatal cholinergic interneurons via the activation of 5-HT2C, 5-HT6, and 5-HT7 serotonin receptors: implications for extrapyramidal side effects of serotonin reuptake inhibitors. Neuropsychopharmacology 32:1840\u20131854. https:\/\/doi.org\/10.1038\/sjnpp1301294","journal-title":"Neuropsychopharmacology"},{"key":"5860_CR11","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1002\/1098-2396(20010315)39:4<297::AID-SYN1012>30CO;2-Q","volume":"39","author":"M Bubser","year":"2001","unstructured":"Bubser M, Backstrom JR, Sanders-Bush E, Roth BL, Deutch AY (2001) Distribution of serotonin 5-HT(2A) receptors in afferents of the rat striatum. Synapse 39:297\u2013304. https:\/\/doi.org\/10.1002\/1098-2396(20010315)39:4%3c297::AID-SYN1012%3e30CO;2-Q","journal-title":"Synapse"},{"key":"5860_CR12","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3389\/fphar201800017","volume":"9","author":"T Buchborn","year":"2018","unstructured":"Buchborn T, Lyons T, Kn\u00f6pfel T (2018) Tolerance and tachyphylaxis to head twitches induced by the 5-HT2A agonist 25CN-NBOH in mice. Front Pharmacol 9:17. https:\/\/doi.org\/10.3389\/fphar201800017","journal-title":"Front Pharmacol"},{"key":"5860_CR13","first-page":"137","volume":"3","author":"NS Buckholtz","year":"1990","unstructured":"Buckholtz NS, Zhou DF, Freedman DX, Potter WZ (1990) Lysergic acid diethylamide (LSD) administration selectively downregulates serotonin2 receptors in rat brain. Neuropsychopharmacology 3:137\u2013148","journal-title":"Neuropsychopharmacology"},{"key":"5860_CR14","doi-asserted-by":"publisher","first-page":"13187","DOI":"10.1038\/s41598-017-13282-7","volume":"7","author":"RL Carhart-Harris","year":"2017","unstructured":"Carhart-Harris RL, Roseman L, Bolstridge M, Demetriou L, Pannekoek JN, Wall MB, Tanner M, Kaelen M, McGonigle J, Murphy K, Leech R, Curran HV, Nutt DJ (2017) Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. Sci Rep 7:13187. https:\/\/doi.org\/10.1038\/s41598-017-13282-7","journal-title":"Sci Rep"},{"key":"5860_CR15","doi-asserted-by":"publisher","first-page":"9576","DOI":"10.1073\/pnas90209576","volume":"90","author":"C Cepeda","year":"1993","unstructured":"Cepeda C, Buchwald NA, Levine MS (1993) Neuromodulatory actions of dopamine in the neostriatum are dependent upon the excitatory amino acid receptor subtypes activated. Proc Natl Acad Sci USA 90:9576\u20139580. https:\/\/doi.org\/10.1073\/pnas90209576","journal-title":"Proc Natl Acad Sci USA"},{"key":"5860_CR16","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1152\/jn2001852659","volume":"85","author":"C Cepeda","year":"2001","unstructured":"Cepeda C, Hurst R, Altemus K, Flores-Hernandez J, Calvert C, Jokel E, Grandy D, Low M, Rubinstein M, Ariano MA, Levine M (2001) Facilitated glutamatergic transmission in the striatum of D2 dopamine receptor mice. J Neurophysiol 85:659\u2013670. https:\/\/doi.org\/10.1152\/jn2001852659","journal-title":"J Neurophysiol"},{"key":"5860_CR17","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1017\/S1092852900010427","volume":"10","author":"BM Cortese","year":"2005","unstructured":"Cortese BM, Phan KL (2005) The role of glutamate in anxiety and related disorders CNS. Spectr 10:820\u2013830. https:\/\/doi.org\/10.1017\/S1092852900010427","journal-title":"Spectr"},{"key":"5860_CR18","doi-asserted-by":"publisher","first-page":"e12850","DOI":"10.1111\/adb12850","volume":"25","author":"RJP Custodio","year":"2019","unstructured":"Custodio RJP, Sayson LV, Botanas CJ, Abiero A, You KY, Kim M, Lee HJ, Yoo SY, Lee KW, Lee YS, Seo JW, Ryu IS, Kim HJ, Cheong JH (2019) 25B-NBOMe, a novel N-2-methoxybenzyl-phenethylamine (NBOMe) derivative, may induce rewarding and reinforcing effects via a dopaminergic mechanism: evidence of abuse potential. Addict Biol 25:e12850. https:\/\/doi.org\/10.1111\/adb12850","journal-title":"Addict Biol"},{"key":"5860_CR19","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1124\/jpet.103.062067","volume":"309","author":"KJ Damjanoska","year":"2004","unstructured":"Damjanoska KJ, Heidenreich BA, Kindel GH, D\u2019Souza DN, Zhang Y, Garcia F, Battaglia G, Wolf WA, Van de Kar LD, Muma NA (2004) Agonist-induced serotonin 2A receptor desensitization in the rat frontal cortex and hypothalamus. J Pharmacol Exp Ther 309:1043\u20131050. https:\/\/doi.org\/10.1124\/jpet.103.062067","journal-title":"J Pharmacol Exp Ther"},{"key":"5860_CR20","first-page":"60","volume":"3","author":"M Deepak","year":"2012","unstructured":"Deepak M, Tripathi AS, Wadhwani PJ, Shriao AV, Chandewar AV (2012) Neurobiological modulators of anxiety. IRJP 3:60\u201364","journal-title":"IRJP"},{"key":"5860_CR21","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/jpbb200804011","volume":"90","author":"A Del Arco","year":"2008","unstructured":"Del Arco A, Mora F (2008) Prefrontal cortex-nucleus accumbens interaction: in vivo modulation by dopamine and glutamate in the prefrontal cortex. Pharmacol Biochem Behav 90:226\u2013235. https:\/\/doi.org\/10.1016\/jpbb200804011","journal-title":"Pharmacol Biochem Behav"},{"key":"5860_CR22","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s00702-006-0533-3","volume":"114","author":"A Del Arco","year":"2007","unstructured":"Del Arco A, Mora F, Mohammed AH, Fuxe K (2007) Stimulation of D2 receptors in the prefrontal cortex reduces PCP-induced hyperactivity, acetylcholine release and dopamine metabolism in the nucleus accumbens. J Neural Transm (Vienna) 114:185\u2013193. https:\/\/doi.org\/10.1007\/s00702-006-0533-3","journal-title":"J Neural Transm (Vienna)"},{"key":"5860_CR23","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S0079-6123(08)00902-3","volume":"172","author":"V Di Matteo","year":"2008","unstructured":"Di Matteo V, Di Giovanni G, Pierucci M, Esposito E (2008) Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies. Prog Brain Res 172:7\u201344. https:\/\/doi.org\/10.1016\/S0079-6123(08)00902-3","journal-title":"Prog Brain Res"},{"key":"5860_CR24","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/jneuropharm201802033","volume":"142","author":"JS Elmore","year":"2018","unstructured":"Elmore JS, Decker AM, Sulima A, Rice KC, Partilla JS, Blough BE, Baumann MH (2018) Comparative neuropharmacology of N-(2-methoxybenzyl)-25-dimethoxyphenethylamine (NBOMe) hallucinogens and their 2C counterparts in male rats. Neuropharmacology 142:240\u2013250. https:\/\/doi.org\/10.1016\/jneuropharm201802033","journal-title":"Neuropharmacology"},{"key":"5860_CR25","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/jbcp200707018","volume":"75","author":"WE Fantegrossi","year":"2008","unstructured":"Fantegrossi WE, Murnane KS, Reissig CJ (2008) The behavioral pharmacology of hallucinogens. Biochem Pharmacol 75:17\u201333. https:\/\/doi.org\/10.1016\/jbcp200707018","journal-title":"Biochem Pharmacol"},{"key":"5860_CR26","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/0306-4522(84)90294-x","volume":"13","author":"TF Freund","year":"1984","unstructured":"Freund TF, Powell JF, Smith AD (1984) Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines. Neuroscience 13:1189\u20131215. https:\/\/doi.org\/10.1016\/0306-4522(84)90294-x","journal-title":"Neuroscience"},{"key":"5860_CR27","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1097\/FBP0000000000000309","volume":"28","author":"MB Gatch","year":"2017","unstructured":"Gatch MB, Dolan SB, Forster MJ (2017) Locomotor and discriminative stimulus effects of four novel hallucinogens in rodents. Behav Pharmacol 28:375\u2013385. https:\/\/doi.org\/10.1097\/FBP0000000000000309","journal-title":"Behav Pharmacol"},{"key":"5860_CR28","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1126\/science2147780","volume":"250","author":"CR Gerfen","year":"1990","unstructured":"Gerfen CR, Engber TM, Mahan LC, Susel Z, Chase TN, Monsma FJ Jr, Sibley DR (1990) D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science 250:1429\u20131432. https:\/\/doi.org\/10.1126\/science2147780","journal-title":"Science"},{"key":"5860_CR29","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1016\/0024-3205(84)90436-3","volume":"35","author":"RA Glennon","year":"1984","unstructured":"Glennon RA, Titeler M, McKenney JD (1984) Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents. Life Sci 35:2505\u20132511. https:\/\/doi.org\/10.1016\/0024-3205(84)90436-3","journal-title":"Life Sci"},{"key":"5860_CR30","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1038\/sjnpp1300711","volume":"30","author":"PJ Gresch","year":"2005","unstructured":"Gresch PJ, Smith RL, Barrett RJ, Sanders-Bush E (2005) Behavioral tolerance to lysergic acid diethylamide is associated with reduced serotonin-2A receptor signaling in rat cortex. Neuropsychopharmacology 30:1693\u20131702. https:\/\/doi.org\/10.1038\/sjnpp1300711","journal-title":"Neuropsychopharmacology"},{"key":"5860_CR31","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1001\/archgenpsychiatry2010116","volume":"68","author":"CS Grob","year":"2011","unstructured":"Grob CS, Danforth AL, Chopra GS, Hagerty M, McKay CR, Halberstadt AL, Greer GR (2011) Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer. Arch Gen Psychiatry 68:71\u201380. https:\/\/doi.org\/10.1001\/archgenpsychiatry2010116","journal-title":"Arch Gen Psychiatry"},{"key":"5860_CR32","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/jbbr201407016","volume":"277","author":"AL Halberstadt","year":"2015","unstructured":"Halberstadt AL (2015) Recent advances in the neuropsychopharmacology of serotonergic hallucinogens. Behav Brain Res 277:99\u2013120. https:\/\/doi.org\/10.1016\/jbbr201407016","journal-title":"Behav Brain Res"},{"key":"5860_CR33","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/7854_2016_64","volume-title":"Curr Top Behav Neurosci 32: Neuropharmacology of new psychoactive substances","author":"AL Halberstadt","year":"2017","unstructured":"Halberstadt AL (2017) Pharmacology and toxicology of N-benzylphenethylamine (\u201cNBOMe\u201d) hallucinogens. In: Baumann MH, Glennon RA, Wiley JL (eds) Curr Top Behav Neurosci 32: Neuropharmacology of new psychoactive substances. Springer Nature, Cham, pp 283\u2013311. https:\/\/doi.org\/10.1007\/7854_2016_64"},{"key":"5860_CR34","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/7854_2016_466","volume-title":"Curr Top Behav Neurosci 36: Behavioral neurobiology of psychedelic drugs","author":"AL Halberstadt","year":"2018","unstructured":"Halberstadt AL, Geyer MA (2018) Effect of hallucinogens on unconditioned behavior. In: Halberstadt AL, Vollenweider FX, Nichols DE (eds) Curr Top Behav Neurosci 36: Behavioral neurobiology of psychedelic drugs. Springer-Verlag GmbH, Berlin, pp 159\u2013199. https:\/\/doi.org\/10.1007\/7854_2016_466"},{"key":"5860_CR35","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/jbbr201011047","volume":"221","author":"R Havekes","year":"2011","unstructured":"Havekes R, Abel T, Van der Zee EA (2011) The cholinergic system and neostriatal memory functions. Behav Brain Res 221:412\u2013423. https:\/\/doi.org\/10.1016\/jbbr201011047","journal-title":"Behav Brain Res"},{"key":"5860_CR36","doi-asserted-by":"publisher","unstructured":"Herian M, Kaminska K, Wojtas A, Swit P, Golembiowska K (2018) Comparison between LSD and 25-I-NBOMe effects on brain neurotransmitters and WDS response in rats. In: 14th International Symposium Molecular basis of pathology and therapy in neurological disorders, Folia Neuropathologica 56\/3 264. https:\/\/doi.org\/10.5114\/fn201878705","DOI":"10.5114\/fn201878705"},{"key":"5860_CR37","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s12640-019-00033-x","volume":"36","author":"M Herian","year":"2019","unstructured":"Herian M, Wojtas A, Kaminska K, Swit P, Wach A, Golembiowska K (2019) Hallucinogen-like action of the novel designer drug 25I-NBOMe and its effect on cortical neurotransmitters in rats. Neurotox Res 36:91\u2013100. https:\/\/doi.org\/10.1007\/s12640-019-00033-x","journal-title":"Neurotox Res"},{"key":"5860_CR38","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1007\/s43440-020-00181-4","volume":"72","author":"M Herian","year":"2020","unstructured":"Herian M, Wojtas A, Sobocinska MK, Skawski M, Gonzalez-Marin A, Golembiowska K (2020) Contribution of serotonin receptor subtypes to hallucinogenic activity of 25I-NBOMe and to its effect on neurotransmission. Pharmacol Rep 72:1593\u20131603. https:\/\/doi.org\/10.1007\/s43440-020-00181-4","journal-title":"Pharmacol Rep"},{"key":"5860_CR39","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1097\/FBP0000000000000394","volume":"29","author":"RR Horsley","year":"2018","unstructured":"Horsley RR, Palenicek T, Kolin J, Vales K (2018) Psilocin and ketamine microdosing: effects of subchronic intermittent microdoses in the elevated plus-maze in male Wistar rats. Behav Pharmacol 29:530\u2013536. https:\/\/doi.org\/10.1097\/FBP0000000000000394","journal-title":"Behav Pharmacol"},{"key":"5860_CR40","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/jneuint201902007","volume":"125","author":"SY Jeon","year":"2019","unstructured":"Jeon SY, Kim YH, Kim SJ, Suh SK, Cha HJ (2019) Abuse potential of 2-(4-iodo-25-dimethoxyphenyl)-N-(2-methoxybenzzyl)ethanamine (25I-NBOMe); in vivo and ex vivo approaches. Neurochem Int 125:74\u201381. https:\/\/doi.org\/10.1016\/jneuint201902007","journal-title":"Neurochem Int"},{"key":"5860_CR41","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/jneuropharm201802028","volume":"142","author":"LM Klein","year":"2018","unstructured":"Klein LM, Cozzi NV, Daley PF, Brandt SD, Halberstadt AL (2018) Receptor binding profiles and behavioral pharmacology of ring substituted N, N-diallyltryptamine analogs. Neuropharmacology 142:231\u2013239. https:\/\/doi.org\/10.1016\/jneuropharm201802028","journal-title":"Neuropharmacology"},{"key":"5860_CR42","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/0306-4522(93)90325-a","volume":"55","author":"Y Koyama","year":"1993","unstructured":"Koyama Y, Kayama Y (1993) Mutual interactions among cholinergic, noradrenergic and serotonergic neurons studied by ionophoresis of these transmitters in rat brainstem nuclei. Neuroscience 55:1117\u20131126. https:\/\/doi.org\/10.1016\/0306-4522(93)90325-a","journal-title":"Neuroscience"},{"key":"5860_CR43","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1177\/0269881114523866","volume":"28","author":"W Lawn","year":"2014","unstructured":"Lawn W, Barrat M, Williams M, Horne A, Winstock A (2014) The NBOMe hallucinogenic drug series: pattern of use, characteristics of users and self-reported effects in a large international sample. J Psychopharmacol 28:780\u2013788. https:\/\/doi.org\/10.1177\/0269881114523866","journal-title":"J Psychopharmacol"},{"key":"5860_CR44","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/jneuropharm201711018","volume":"136","author":"EP Lebois","year":"2018","unstructured":"Lebois EP, Thorn C, Edgerton JR, Popiolek M, Xi S (2018) Muscarinic receptor subtype distribution in the central nervous system and relevance to aging and Alzheimer disease. Neuropharmacology 136:362\u2013373. https:\/\/doi.org\/10.1016\/jneuropharm201711018","journal-title":"Neuropharmacology"},{"key":"5860_CR45","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/jpsc200905004","volume":"32","author":"EI Martin","year":"2009","unstructured":"Martin EI, Ressler K, Binder E, Nemeroff CB (2009) The neurobiology of anxiety disorders: brain imaging, genetics, and psychoneuroendocrinology. Psychiatr Clin N Am 32:549\u2013575. https:\/\/doi.org\/10.1016\/jpsc200905004","journal-title":"Psychiatr Clin N Am"},{"key":"5860_CR46","doi-asserted-by":"publisher","first-page":"9856","DOI":"10.1523\/JNEUROSCI21-24-098562001","volume":"21","author":"R Martin-Ruiz","year":"2001","unstructured":"Martin-Ruiz R, Puig MV, Celada P, Shapiro DA, Roth BL, Mengod G, Artigas F (2001) Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism. J Neurosci 21:9856\u20139866. https:\/\/doi.org\/10.1523\/JNEUROSCI21-24-098562001","journal-title":"J Neurosci"},{"key":"5860_CR47","first-page":"680","volume":"247","author":"G Maura","year":"1988","unstructured":"Maura G, Giardi A, Raiteri M (1988) Release-regulating D-2 dopamine receptors are located on striatal glutamatergic nerve terminals. J Pharmacol Exp Ther 247:680\u2013684","journal-title":"J Pharmacol Exp Ther"},{"key":"5860_CR48","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1002\/cne902960203","volume":"296","author":"GE Meredith","year":"1990","unstructured":"Meredith GE, Wouterlood FG (1990) Hippocampal and midline thalamic fibers and terminals in relation to the choline acetyltransferase-immunoreactive neurons in nucleus accumbens of the rat: a light and electron microscopic study. J Comp Neurol 296:204\u2013221. https:\/\/doi.org\/10.1002\/cne902960203","journal-title":"J Comp Neurol"},{"key":"5860_CR49","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.3389\/fphar201901406","volume":"10","author":"C Miliano","year":"2019","unstructured":"Miliano C, Marti M, Pintori N, Castelli MP, Tirri M, Arfe R, De Luca MA (2019) Neurochemical and behavioral profiling in male and female rats of the psychedelic agent 25I-NBOMe. Front Pharmacol 10:1406. https:\/\/doi.org\/10.3389\/fphar201901406","journal-title":"Front Pharmacol"},{"key":"5860_CR50","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/s0306-4522(02)00580-8","volume":"116","author":"LA Miner","year":"2003","unstructured":"Miner LA, Backstrom JR, Sanders-Bush E, Sesack SR (2003) Ultrastructural localization of serotonin2A receptors in the middle layers of the rat prelimbic prefrontal cortex. Neuroscience 116:107\u2013117. https:\/\/doi.org\/10.1016\/s0306-4522(02)00580-8","journal-title":"Neuroscience"},{"key":"5860_CR51","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1038\/sjnpp1300479","volume":"29","author":"C Mirjana","year":"2004","unstructured":"Mirjana C, Baviera M, Invernizzi RW, Balducci C (2004) The serotonin 5-HT2A receptors antagonist M100907 prevents impairment in attentional performance by NMDA receptor blockade in the rat prefrontal cortex. Neuropsychopharmacology 29:1637\u20131647. https:\/\/doi.org\/10.1038\/sjnpp1300479","journal-title":"Neuropsychopharmacology"},{"key":"5860_CR52","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/jbrainres200407044","volume":"1023","author":"JW Muschamp","year":"2004","unstructured":"Muschamp JW, Regina MJ, Hull EM, Winter JC, Rabin RA (2004) Lysergic acid diethylamide and [-]-2,5-dimethoxy-4-methylamphetamine increase extracellular glutamate in rat prefrontal cortex. Brain Res 1023:134\u2013140. https:\/\/doi.org\/10.1016\/jbrainres200407044","journal-title":"Brain Res"},{"key":"5860_CR53","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/BF02805983","volume":"127","author":"H Nagayama","year":"1996","unstructured":"Nagayama H, Lu JQ (1996) Circadian rhythm in the responsiveness of central 5-HT(2A) receptor to DOI in rats. Psychopharmacology 127:113\u2013116. https:\/\/doi.org\/10.1007\/BF02805983","journal-title":"Psychopharmacology"},{"key":"5860_CR54","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1002\/syn20054","volume":"53","author":"SG Nair","year":"2004","unstructured":"Nair SG, Gudelsky GA (2004) Activation of 5-HT2 receptors enhances the release of acetylcholine in the prefrontal cortex and hippocampus of the rat. Synapse 53:202\u2013207. https:\/\/doi.org\/10.1002\/syn20054","journal-title":"Synapse"},{"key":"5860_CR55","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1124\/pr.115.011478","volume":"68","author":"DE Nichols","year":"2016","unstructured":"Nichols DE (2016) Psychedelics. Pharmacol Rev 68:264\u2013355. https:\/\/doi.org\/10.1124\/pr.115.011478","journal-title":"Pharmacol Rev"},{"key":"5860_CR56","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1007\/s12640-016-9654-0","volume":"30","author":"K Noworyta-Sokolowska","year":"2016","unstructured":"Noworyta-Sokolowska K, Kaminska K, Kreiner G, Rogoz Z, Go\u0142embiowska K (2016) Neurotoxic effects of 5-MeO-DIPT: a psychoactive tryptamine derivative in rats. Neurotox Res 30:606\u2013619. https:\/\/doi.org\/10.1007\/s12640-016-9654-0","journal-title":"Neurotox Res"},{"key":"5860_CR57","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1007\/s00213-019-05333-w","volume":"236","author":"K Noworyta-Sokolowska","year":"2019","unstructured":"Noworyta-Sokolowska K, Kozub A, Jablonska J, Parkitna JR, Drozd R, Rygula R (2019) Sensitivity to negative and positive feedback as a stable and enduring behavioural trait in rats. Psychopharmacology 236:2389\u20132403. https:\/\/doi.org\/10.1007\/s00213-019-05333-w","journal-title":"Psychopharmacology"},{"key":"5860_CR58","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/jpharep201603012","volume":"68","author":"J Orzelska-Gorka","year":"2016","unstructured":"Orzelska-Gorka J, Talarek S, Listos J, Kedzierska E, Fidecka S (2016) l-NAME differential effects on diazepam and flunitrazepam responses of rats in the object recognition test. Pharmacol Rep 68:728\u2013732. https:\/\/doi.org\/10.1016\/jpharep201603012","journal-title":"Pharmacol Rep"},{"key":"5860_CR59","volume-title":"The rat brain in stereotaxic coordinates","author":"G Paxinos","year":"1998","unstructured":"Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates, 7th edn. Academic Press, Cambridge","edition":"7"},{"key":"5860_CR60","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/jneuron201208036","volume":"76","author":"MR Picciotto","year":"2012","unstructured":"Picciotto MR, Higley MJ, Mineur YS (2012) Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior. Neuron 76:116\u2013129. https:\/\/doi.org\/10.1016\/jneuron201208036","journal-title":"Neuron"},{"key":"5860_CR61","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1007\/bf00443425","volume":"97","author":"PA Pierce","year":"1989","unstructured":"Pierce PA, Peroutka SJ (1989) Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex. Psychopharmacology 97:118\u2013122. https:\/\/doi.org\/10.1007\/bf00443425","journal-title":"Psychopharmacology"},{"key":"5860_CR62","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/jtins200707008","volume":"30","author":"A Pisani","year":"2007","unstructured":"Pisani A, Bernardi G, Ding J, Surmeier DJ (2007) Re-emergence of striatal cholinergic interneurons in movement disorders. Trends Neurosci 30:545\u2013553. https:\/\/doi.org\/10.1016\/jtins200707008","journal-title":"Trends Neurosci"},{"key":"5860_CR63","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/jneuropharm201508034","volume":"99","author":"A Rickli","year":"2015","unstructured":"Rickli A, Luethi D, Reinisch J, Buchy D, Hoener MC, Liechti ME (2015) Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs). Neuropharmacology 99:546\u2013553. https:\/\/doi.org\/10.1016\/jneuropharm201508034","journal-title":"Neuropharmacology"},{"key":"5860_CR64","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1016\/s1734-1140(11)70719-8","volume":"63","author":"Z Rogoz","year":"2011","unstructured":"Rogoz Z, Skuza G (2011) Anxiolytic-like effects of olanzapine risperidone and fluoxetine in the elevated plus-maze test in rats. Pharmacol Rep 63:1547\u20131552. https:\/\/doi.org\/10.1016\/s1734-1140(11)70719-8","journal-title":"Pharmacol Rep"},{"key":"5860_CR65","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/0165-0270(94)00132-z","volume":"57","author":"HL Rowley","year":"1995","unstructured":"Rowley HL, Martin KF, Marsden CA (1995) Determination of in vivo amino acid neurotransmitters by high-performance liquid chromatography with o-phthalaldehydesulphite derivatization. J Neurosci Methods 57:93\u201399. https:\/\/doi.org\/10.1016\/0165-0270(94)00132-z","journal-title":"J Neurosci Methods"},{"key":"5860_CR66","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1254\/jjp70203","volume":"70","author":"H Saito","year":"1996","unstructured":"Saito H, Matsumoto M, Togashi H, Yoshioka M (1996) Functional interaction between serotonin and other neuronal systems: focus on in vivo microdialysis studies. Jpn J Pharmacol 70:203\u2013205. https:\/\/doi.org\/10.1254\/jjp70203","journal-title":"Jpn J Pharmacol"},{"key":"5860_CR67","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/s0304-3940(03)00547-0","volume":"346","author":"JL Scruggs","year":"2003","unstructured":"Scruggs JL, Schmidt D, Deutch AY (2003) The hallucinogen 1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane (DOI) increases cortical extracellular glutamate levels in rats. Neurosci Lett 346:137\u2013140. https:\/\/doi.org\/10.1016\/s0304-3940(03)00547-0","journal-title":"Neurosci Lett"},{"key":"5860_CR68","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/jbrainresbull201907002","volume":"152","author":"J-Y Seo","year":"2019","unstructured":"Seo J-Y, Hur K-H, Ko Y-H, Kim K, Lee B-R, Kim Y-J, Kim S-K, Kim S-E, Lee Y-S, Kim H-C, Lee S-Y, Jang C-G (2019) A novel designer drug, 25N-NBOMe, exhibits abuse potential via the dopaminergic systems in rodents. Brain Res Bull 152:19\u201326. https:\/\/doi.org\/10.1016\/jbrainresbull201907002","journal-title":"Brain Res Bull"},{"key":"5860_CR69","doi-asserted-by":"publisher","first-page":"S70","DOI":"10.1016\/s0387-7604(03)90012-x","volume":"25","author":"HS Singer","year":"2003","unstructured":"Singer HS, Minzer K (2003) Neurobiology of Tourette\u2019s syndrome: concepts of neuroanatomic localization and neurochemical abnormalities. Brain Dev 25:S70\u2013S84. https:\/\/doi.org\/10.1016\/s0387-7604(03)90012-x","journal-title":"Brain Dev"},{"key":"5860_CR70","doi-asserted-by":"publisher","first-page":"8557","DOI":"10.1523\/JNEUROSCI0589-142014","volume":"34","author":"C Straub","year":"2014","unstructured":"Straub C, Tritsch NX, Hagan NA, Gu C, Sabatini BL (2014) Multiphasic modulation of cholinergic interneurons by nigrostriatal afferents. J Neurosci 34:8557\u20138569. https:\/\/doi.org\/10.1523\/JNEUROSCI0589-142014","journal-title":"J Neurosci"},{"key":"5860_CR71","unstructured":"UNODC Report (2016) World drug report United Nations publication. Sales No E16XI7 https:\/\/www.unodc.org\/doc\/wdr2016\/ (accessed 5 Oct 2020)"},{"key":"5860_CR72","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1073\/pnas1524183113","volume":"113","author":"MS Virk","year":"2016","unstructured":"Virk MS, Sagi Y, Medrihan L, Leung J, Kaplitt MG, Greengard P (2016) Opposing roles for serotonin in cholinergic neurons of the ventral and dorsal striatum. PNAS 113:734\u2013739. https:\/\/doi.org\/10.1073\/pnas1524183113","journal-title":"PNAS"},{"key":"5860_CR73","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/(SICI)1096-9861(19960701)370:3<405::AID-CNE10>30CO;2-R","volume":"370","author":"RP Ward","year":"1996","unstructured":"Ward RP, Dorsa DM (1996) Colocalization of serotonin receptor subtypes 5-HT2A 5-HT2C and 5-HT6 with neuropeptides in rat striatum. J Comp Neurol 370:405\u2013414. https:\/\/doi.org\/10.1002\/(SICI)1096-9861(19960701)370:3%3c405::AID-CNE10%3e30CO;2-R","journal-title":"J Comp Neurol"},{"key":"5860_CR74","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3389\/fnins201000036","volume":"4","author":"ET Weber","year":"2010","unstructured":"Weber ET, Andrade R (2010) Htr2a gene and 5-HT2A receptor expression in the cerebral cortex studied using genetically modified mice. Front Neurosci 4:36. https:\/\/doi.org\/10.3389\/fnins201000036","journal-title":"Front Neurosci"},{"key":"5860_CR75","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1007\/BF00173396","volume":"338","author":"K Wedzony","year":"1988","unstructured":"Wedzony K, Limberger N, Spath L, Wichman T, Starke K (1988) Acetylcholine release in rat nucleus accumbens is regulated through dopamine D2-receptor. Naunyn- Schmiedeberg\u2019s Arch Pharmacol 338:250\u2013255. https:\/\/doi.org\/10.1007\/BF00173396","journal-title":"Naunyn- Schmiedeberg\u2019s Arch Pharmacol"},{"key":"5860_CR76","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/(SICI)1098-2396(199709)27:1<79::AID-SYN8>30CO;2-A","volume":"27","author":"DL Willins","year":"1997","unstructured":"Willins DL, Deutch AY, Roth BL (1997) Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex. Synapse 27:79\u201382. https:\/\/doi.org\/10.1002\/(SICI)1098-2396(199709)27:1%3c79::AID-SYN8%3e30CO;2-A","journal-title":"Synapse"},{"key":"5860_CR77","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3389\/fphar201500225","volume":"6","author":"G Zhang","year":"2015","unstructured":"Zhang G, Stackman RW Jr (2015) The role of serotonin 5-HT2A receptors in memory and cognition. Front Pharmacol 6:225. https:\/\/doi.org\/10.3389\/fphar201500225","journal-title":"Front Pharmacol"},{"key":"5860_CR78","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/jneuropharm201206007","volume":"64","author":"G Zhang","year":"2013","unstructured":"Zhang G, Asgeirsdottir HN, Cohen SJ, Munchow AH, Barrera MP, Stackman RW Jr (2013) Stimulation of serotonin 2A receptors facilitates consolidation and extinction of fear memory in C57BL\/6J mice. Neuropharmacology 64:403\u2013413. https:\/\/doi.org\/10.1016\/jneuropharm201206007","journal-title":"Neuropharmacology"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-021-05860-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-021-05860-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-021-05860-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T03:39:28Z","timestamp":1626838768000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-021-05860-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,25]]},"references-count":78,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["5860"],"URL":"https:\/\/doi.org\/10.1007\/s00213-021-05860-5","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,25]]},"assertion":[{"value":"2 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal use procedures were conducted in strict accordance with the European regulations for animal experimentation (EU Directive 2010\/63\/EU on the Protection of Animals Used for Scientific Purposes). The experimental protocols were approved by the Local Ethics Commission for Experimentation on Animals (permit numbers: 186\/2017 and 188\/2017).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}