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Eighteen studies met inclusion\/exclusion criteria. Samples comprised 918 participants (340 female) aged 16\u201338\u00a0years. Of these, 603 were regular cannabis users, and 315 were controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The literature consistently reported greater brain activity in cannabis users while exposed to cannabis vs neutral stimuli in three key brain areas: the striatum, the prefrontal (anterior cingulate, middle frontal) and the parietal cortex (posterior cingulate\/precuneus) and additional brain regions (hippocampus, amygdala, thalamus, occipital cortex). Preliminary correlations emerged between cannabis craving\u00a0and\u00a0the function of partially overlapping regions (amygdala,\u00a0striatum, orbitofrontal cortex ).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Exposure to cannabis-cues may elicit\u00a0greater brain function and thus trigger\u00a0cravings\u00a0in regular cannabis users and thus trigger\u00a0cannabis craving. Standardised and longitudinal\u00a0assessments of cannabis use\u00a0and\u00a0related\u00a0problems\u00a0are required\u00a0to profile with greater precision the neurobiology\u00a0of\u00a0cannabis\u00a0cue-reactivity, and its role in predicting \u00a0cravings\u00a0and relapse.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00213-021-05973-x","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T03:02:57Z","timestamp":1631242977000},"page":"2709-2728","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Patterns of brain function associated with cannabis cue-reactivity in regular cannabis users: a systematic review of fMRI studies"],"prefix":"10.1007","volume":"238","author":[{"given":"Hannah","family":"Sehl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gill","family":"Terrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa-Marie","family":"Greenwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Kowalczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govinda","family":"Poudel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Manning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5917-7068","authenticated-orcid":false,"given":"Valentina","family":"Lorenzetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,10]]},"reference":[{"key":"5973_CR3","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders (Fifth ed.). 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