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Antidepressant drugs acutely affect how emotional information is processed, pushing the brain to prioritise positive relative to negative input. Whether BLT could have a similar effect is not known to date.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To test whether BLT acutely influences emotional information processing similar to antidepressant drugs, using an established healthy volunteer assay.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Following a double-blind, parallel-group design, 49 healthy volunteers (18\u201365 years, 26 females) were randomly allocated to 60-min BLT (\u2265 10,000 lux) or sham-placebo treatment early in the morning in autumn\/winter. Immediately after treatment, emotional information processing was assessed using the Oxford Emotional Test Battery, a validated set of behavioural tasks tapping into emotional information processing in different cognitive domains. Participants also completed questionnaires before and after treatment to assess changes in subjective state.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The BLT group did not show significantly more positively biased emotional information processing compared to the placebo group (<jats:italic>p<\/jats:italic> &gt; 0.05 for all measures). After adjustment for pre-treatment scores, there were also no significant post-treatment differences between groups in subjective state (<jats:italic>p<\/jats:italic> &gt; 0.05 for all measures).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>BLT did not show immediate effects on emotional information processing in an established healthy volunteer assay. Thus, BLT might exert its clinical effects through a different (cognitive) mechanism than other antidepressant interventions. Future studies should corroborate this finding including clinical populations and more intensive treatment regimes, and control for potential chronobiological effects.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00213-021-06003-6","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T19:02:42Z","timestamp":1636225362000},"page":"277-286","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["No antidepressant-like acute effects of bright light on emotional information processing in healthy volunteers"],"prefix":"10.1007","volume":"239","author":[{"given":"Alexander","family":"Kaltenboeck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tereza","family":"Ruzickova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Breunh\u00f6lder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek","family":"Zghoul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip J.","family":"Cowen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine J.","family":"Harmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,6]]},"reference":[{"key":"6003_CR1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jad.2016.03.016","volume":"198","author":"D Al-Karawi","year":"2016","unstructured":"Al-Karawi D, Jubair L (2016) Bright light therapy for nonseasonal depression: meta-analysis of clinical trials. 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