{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:03:01Z","timestamp":1740106981139,"version":"3.37.3"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["GM136467"],"award-info":[{"award-number":["GM136467"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s00213-021-06012-5","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T03:02:46Z","timestamp":1637722966000},"page":"413-427","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of repeated treatment with the 5-HT1A and 5-HT1B agonists (R)-(\u2009+)-8-hydroxy-DPAT and CP-94253 on the locomotor activity and axillary temperatures of preweanling rats: evidence of tolerance and behavioral sensitization"],"prefix":"10.1007","volume":"239","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4194-9744","authenticated-orcid":false,"given":"Sanders A.","family":"McDougall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan A.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Roe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance J.","family":"Greenwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"6012_CR1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1097\/FBP.0b013e32835d5b7a","volume":"24","author":"AH Alkhatib","year":"2013","unstructured":"Alkhatib AH, Dvorkin-Gheva A, Szechtman H (2013) Quinpirole and 8-OH-DPAT induce compulsive checking behavior in male rats by acting on different functional parts of an OCD neurocircuit. Behav Pharmacol 24:65\u201373. https:\/\/doi.org\/10.1097\/FBP.0b013e32835d5b7a","journal-title":"Behav Pharmacol"},{"key":"6012_CR2","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1177\/0269881117715598","volume":"31","author":"D Alter","year":"2017","unstructured":"Alter D, Beverley JA, Patel R, Bola\u00f1os-Guzm\u00e1n CA, Steiner H (2017) The 5-HT1B serotonin receptor regulates methylphenidate-induced gene expression in the striatum: differential effects on immediate-early genes. J Psychopharmacol 31:1078\u20131087. https:\/\/doi.org\/10.1177\/0269881117715598","journal-title":"J Psychopharmacol"},{"key":"6012_CR3","first-page":"787","volume":"282","author":"A Badiani","year":"1997","unstructured":"Badiani A, Camp DM, Robinson TE (1997) Enduring enhancement of amphetamine sensitization by drug-associated environmental stimuli. J Pharmacol Exp Ther 282:787\u2013794","journal-title":"J Pharmacol Exp Ther"},{"key":"6012_CR4","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1460-9568.2006.04885.x","volume":"24","author":"KT Ball","year":"2006","unstructured":"Ball KT, Budreau D, Rebec GV (2006) Context-dependent behavioural and neuronal sensitization in striatum to MDMA (ecstasy) administration in rats. Eur J Neurosci 24:217\u2013228. https:\/\/doi.org\/10.1111\/j.1460-9568.2006.04885.x","journal-title":"Eur J Neurosci"},{"key":"6012_CR5","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1111\/j.1476-5381.1990.tb14138","volume":"101","author":"HH Berendsen","year":"1990","unstructured":"Berendsen HH, Broekkamp CL (1990) Behavioural evidence for functional interactions between 5-HT-receptor subtypes in rats and mice. Br J Pharmacol 101:667\u2013673. https:\/\/doi.org\/10.1111\/j.1476-5381.1990.tb14138","journal-title":"Br J Pharmacol"},{"issue":"2020","key":"6012_CR6","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s00213-019-05380-3","volume":"237","author":"MD Berquist","year":"2020","unstructured":"Berquist MD, Leth-Petersen S, Kristensen JL, Fantegrossi WE (2020) Locomotor effects of 3,4-methylenedioxymethamphetamine (MDMA) and its deuterated form in mice: psychostimulant effects, stereotypy, and sensitization. Psychopharmacology 237(2020):431\u2013442. https:\/\/doi.org\/10.1007\/s00213-019-05380-3","journal-title":"Psychopharmacology"},{"key":"6012_CR7","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.bbr.2005.09.020","volume":"167","author":"B Bert","year":"2006","unstructured":"Bert B, Fink H, H\u00f6rtnagl H, Veh RW, Davies B, Theuring F, Kusserow H (2006) Mice over-expressing the 5-HT1A receptor in cortex and dentate gyrus display exaggerated locomotor and hypothermic response to 8-OH-DPAT. Behav Brain Res 167:328\u2013341. https:\/\/doi.org\/10.1016\/j.bbr.2005.09.020","journal-title":"Behav Brain Res"},{"issue":"2016","key":"6012_CR8","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.tips.2016.01.008","volume":"37","author":"A Bespalov","year":"2016","unstructured":"Bespalov A, M\u00fcller R, Relo AL, Hudzik T (2016) Drug tolerance: a known unknown in translational neuroscience. Trends Pharmacol Sci 37(2016):364\u2013378. https:\/\/doi.org\/10.1016\/j.tips.2016.01.008","journal-title":"Trends Pharmacol Sci"},{"key":"6012_CR9","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/0014-2999(90)94194-3","volume":"190","author":"HN Bhargava","year":"1990","unstructured":"Bhargava HN, Gulati A (1990) Down-regulation of brain and spinal cord mu-opiate receptors in morphine tolerant-dependent rats. Eur J Pharmacol 190:305\u2013311. https:\/\/doi.org\/10.1016\/0014-2999(90)94194-3","journal-title":"Eur J Pharmacol"},{"key":"6012_CR10","first-page":"462","volume":"7","author":"B Bjorvatn","year":"1996","unstructured":"Bjorvatn B, Neckelmann D, Bj\u00f8rkum AA, Ursin R (1996) Hypothermia and the 5-HT syndrome induced by CGS 12066B independently of 5-HT1B receptor activation. Behav Pharmacol 7:462\u2013469","journal-title":"Behav Pharmacol"},{"key":"6012_CR11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/BF02247363","volume":"112","author":"RJ Blanchard","year":"1993","unstructured":"Blanchard RJ, Shepherd JK, Armstrong J, Tsuda SF, Blanchard DC (1993) An ethopharmacological analysis of the behavioral effects of 8-OH-DPAT. Psychopharmacology 112:55\u201363. https:\/\/doi.org\/10.1007\/BF02247363","journal-title":"Psychopharmacology"},{"key":"6012_CR12","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/sj.npp.1301445","volume":"33","author":"J Borycz","year":"2008","unstructured":"Borycz J, Zapata A, Quiroz C, Volkow ND, Ferr\u00e9 S (2008) 5-HT1B receptor-mediated serotoninergic modulation of methylphenidate-induced locomotor activation in rats. Neuropsychopharmacology 33:619\u2013626. https:\/\/doi.org\/10.1038\/sj.npp.1301445","journal-title":"Neuropsychopharmacology"},{"key":"6012_CR13","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.pbb.2009.08.008","volume":"94","author":"BR Brookshire","year":"2009","unstructured":"Brookshire BR, Jones SR (2009) Direct and indirect 5-HT receptor agonists produce gender-specific effects on locomotor and vertical activities in C57 BL\/6J mice. Pharmacol Biochem Behav 94:194\u2013203. https:\/\/doi.org\/10.1016\/j.pbb.2009.08.008","journal-title":"Pharmacol Biochem Behav"},{"key":"6012_CR14","first-page":"104","volume":"252","author":"CK Burton","year":"1990","unstructured":"Burton CK, Ho IK, Hoskins B (1990) Evidence for involvement of cyclic GMP phosphodiesterase in morphine tolerance. J Pharmacol Exp Ther 252:104\u2013111","journal-title":"J Pharmacol Exp Ther"},{"key":"6012_CR15","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/0278-5846(88)90005-x","volume":"12","author":"DL Cameron","year":"1988","unstructured":"Cameron DL, Crosbie J, Crocker AD (1988) A fixed interval momentary sampling method for assessing on-going behaviours induced by dopamine receptor agonists. Prog Neuro-Psychopharmacol Biol Psychi 12:595\u2013606. https:\/\/doi.org\/10.1016\/0278-5846(88)90005-x","journal-title":"Prog Neuro-Psychopharmacol Biol Psychi"},{"key":"6012_CR16","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/s0166-4328(97)00126-5","volume":"92","author":"RJ Carey","year":"1998","unstructured":"Carey RJ, Gui J (1998) Cocaine conditioning and cocaine sensitization: what is the relationship? Behav Brain Res 92:67\u201376. https:\/\/doi.org\/10.1016\/s0166-4328(97)00126-5","journal-title":"Behav Brain Res"},{"key":"6012_CR17","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1037\/\/1064-1297.6.3.248","volume":"6","author":"A Cepeda-Benito","year":"1998","unstructured":"Cepeda-Benito A, Reynoso J, McDaniel EH (1998) Associative tolerance to nicotine analgesia in the rat: tail-flick and hot-plate tests. Exp Clin Psychopharmacol 6:248\u2013254. https:\/\/doi.org\/10.1037\/\/1064-1297.6.3.248","journal-title":"Exp Clin Psychopharmacol"},{"key":"6012_CR18","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1111\/j.1476-5381.1993.tb14010.x","volume":"110","author":"SC Cheetham","year":"1993","unstructured":"Cheetham SC, Heal DJ (1993) Evidence that RU 24969-induced locomotor activity in C57\/B1\/6 mice is specifically mediated by the 5-HT1B receptor. Br J Pharmacol 110:1621\u20131629. https:\/\/doi.org\/10.1111\/j.1476-5381.1993.tb14010.x","journal-title":"Br J Pharmacol"},{"key":"6012_CR19","first-page":"610","volume":"292","author":"RII De La Garza","year":"2000","unstructured":"De La Garza RII, Cunningham KA (2000) The effects of the 5-hydroxytryptamine1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin on spontaneous activity, cocaine-induced hyperactivity and behavioral sensitization: a microanalysis of locomotor activity. J Pharmacol Exp Ther 292:610\u2013617","journal-title":"J Pharmacol Exp Ther"},{"key":"6012_CR20","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3389\/fnsys.2017.00073","volume":"11","author":"TS Der-Ghazarian","year":"2017","unstructured":"Der-Ghazarian TS, Call T, Scott SN, Dai K, Brunwasser SJ, Noudali SN, Pentkowski NS, Neisewander JL (2017) Effects of a 5-HT1B receptor agonist on locomotion and reinstatement of cocaine-conditioned place preference after abstinence from repeated injections in mice. Front Syst Neurosci 11:73. https:\/\/doi.org\/10.3389\/fnsys.2017.00073","journal-title":"Front Syst Neurosci"},{"key":"6012_CR21","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/j.1476-5381.1986.tb10270.x","volume":"89","author":"RJ De Souza","year":"1986","unstructured":"De Souza RJ, Goodwin GM, Green AR, Heal DJ (1986) Effect of chronic treatment with 5-HT1 agonist (8-OH-DPAT and RU 24969) and antagonist (isapirone) drugs on the behavioural responses of mice to 5-HT1 and 5-HT2 agonists. Br J Pharmacol 89:377\u2013384. https:\/\/doi.org\/10.1111\/j.1476-5381.1986.tb10270.x","journal-title":"Br J Pharmacol"},{"key":"6012_CR22","first-page":"18","volume":"18","author":"PB Dews","year":"1978","unstructured":"Dews PB (1978) Behavioral tolerance. NIDA Res Monogr 18:18\u201326","journal-title":"NIDA Res Monogr"},{"key":"6012_CR23","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/BF02247129","volume":"102","author":"JL Evenden","year":"1990","unstructured":"Evenden JL, \u00c4ngeby-M\u00f6ller K (1990) Effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on locomotor activity and rearing of mice and rats. Psychopharmacology 102:485\u2013491. https:\/\/doi.org\/10.1007\/BF02247129","journal-title":"Psychopharmacology"},{"key":"6012_CR24","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/pl00005484","volume":"146","author":"EW Fish","year":"1999","unstructured":"Fish EW, Faccidomo S, Miczek KA (1999) Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT1B receptor agonist CP-94,253. Psychopharmacology 146:391\u2013399. https:\/\/doi.org\/10.1007\/pl00005484","journal-title":"Psychopharmacology"},{"key":"6012_CR25","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s002130000370","volume":"149","author":"EW Fish","year":"2000","unstructured":"Fish EW, Sekinda M, Ferrari PF, Dirks A, Miczek KA (2000) Distress vocalizations in maternally separated mouse pups: modulation via 5-HT1A, 5-HT1B and GABAA receptors. Psychopharmacology 149:277\u2013285. https:\/\/doi.org\/10.1007\/s002130000370","journal-title":"Psychopharmacology"},{"key":"6012_CR26","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41398-020-00956-6","volume":"10","author":"R Garcia","year":"2020","unstructured":"Garcia R, Le T, Scott SN, Charmchi D, Sprout JML, Pentkowski NS, Neisewander JL (2020) Preclinical support for the therapeutic potential of zolmitriptan as a treatment for cocaine use disorders. Transl Psychiatry 10:266. https:\/\/doi.org\/10.1038\/s41398-020-00956-6","journal-title":"Transl Psychiatry"},{"key":"6012_CR27","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1214\/aoms\/1177706545","volume":"29","author":"S Geisser","year":"1958","unstructured":"Geisser S, Greenhouse SW (1958) An extension of Box\u2019s results on the use of the F distribution in multivariate analysis. Ann Math Statist 29:885\u2013891. https:\/\/doi.org\/10.1214\/aoms\/1177706545","journal-title":"Ann Math Statist"},{"issue":"1986","key":"6012_CR28","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1007\/bf00174379","volume":"89","author":"GM Goodwin","year":"1986","unstructured":"Goodwin GM, De Souza RJ, Green AR (1986) The effects of a 5-HT1 receptor ligand isapirone (TVX Q 7821) on 5-HT synthesis and the behavioural effects of 5-HT agonists in mice and rats. Psychopharmacology 89(1986):382\u2013387. https:\/\/doi.org\/10.1007\/bf00174379","journal-title":"Psychopharmacology"},{"key":"6012_CR29","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ejphar.2004.01.031","volume":"487","author":"PB Hedlund","year":"2004","unstructured":"Hedlund PB, Kelly L, Mazur C, Lovenberg T, Sutcliffe JG, Bonaventure P (2004) 8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents. Eur J Pharmacol 487:125\u2013132. https:\/\/doi.org\/10.1016\/j.ejphar.2004.01.031","journal-title":"Eur J Pharmacol"},{"key":"6012_CR30","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/sj.bjp.0703855","volume":"132","author":"J Hensler","year":"2001","unstructured":"Hensler J, Durgam H (2001) Regulation of 5-HT1A receptor-stimulated [35S]-GTP\u03b3S binding as measured by quantitative autoradiography following chronic agonist administration. Br J Pharmacol 132:605\u2013611. https:\/\/doi.org\/10.1038\/sj.bjp.0703855","journal-title":"Br J Pharmacol"},{"key":"6012_CR31","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/s0014-2999(02)01344-4","volume":"441","author":"GP Hern\u00e1ndez-Delgadillo","year":"2002","unstructured":"Hern\u00e1ndez-Delgadillo GP, Ventura Mart\u00ednez R, D\u00edaz Reval MI, Dom\u00ednguez Ram\u00edrez AM, L\u00f3pez-Mu\u00f1oz FJ (2002) Metamizol potentiates morphine antinociception but not constipation after chronic treatment. Eur J Pharmacol 441:177\u2013183. https:\/\/doi.org\/10.1016\/s0014-2999(02)01344-4","journal-title":"Eur J Pharmacol"},{"key":"6012_CR32","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/0091-3057(89)90036-1","volume":"32","author":"V Hillegaart","year":"1989","unstructured":"Hillegaart V, Wadenberg ML, Ahlenius S (1989) Effects of 8-OH-DPAT on motor activity in the rat. Pharmacol Biochem Behav 32:797\u2013800. https:\/\/doi.org\/10.1016\/0091-3057(89)90036-1","journal-title":"Pharmacol Biochem Behav"},{"key":"6012_CR33","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/0892-0362(92)90020-B","volume":"14","author":"RR Holson","year":"1992","unstructured":"Holson RR, Pearce B (1992) Principles and pitfalls in the analysis of prenatal treatment effects in multiparous species. Neurotoxicol Teratol 14:221\u2013228. https:\/\/doi.org\/10.1016\/0892-0362(92)90020-B","journal-title":"Neurotoxicol Teratol"},{"key":"6012_CR34","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/0028-3908(89)90143-3","volume":"28","author":"HC Jackson","year":"1989","unstructured":"Jackson HC, Kitchen I (1989) Behavioural profiles of putative 5-hydroxytryptamine receptor agonists and antagonists in developing rats. Neuropharmacology 28:635\u2013642. https:\/\/doi.org\/10.1016\/0028-3908(89)90143-3","journal-title":"Neuropharmacology"},{"key":"6012_CR35","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1177\/026988118900300106","volume":"3","author":"C Johansson","year":"1989","unstructured":"Johansson C, Ahlenius S (1989) Evidence for the involvement of 5-HT1A receptors in the mediation of exploratory locomotor activity in the rat. J Psychopharmacol 3:32\u201335. https:\/\/doi.org\/10.1177\/026988118900300106","journal-title":"J Psychopharmacol"},{"key":"6012_CR36","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0014-2999(91)90420-u","volume":"196","author":"CE Johansson","year":"1991","unstructured":"Johansson CE, Meyerson BJ (1991) The effects of long-term treatment with 8-OH-DPAT on the lordosis response and hypothermia in female rats. Eur J Pharmacol 196:143\u2013147. https:\/\/doi.org\/10.1016\/0014-2999(91)90420-u","journal-title":"Eur J Pharmacol"},{"key":"6012_CR37","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/0028-3908(94)90061-2","volume":"33","author":"CE Johansson-Wallsten","year":"1994","unstructured":"Johansson-Wallsten CE, Meyerson BJ (1994) The ontogeny of tolerance to the 5-HT1A agonist 8-OH-DPAT: a study in the rat. Neuropharmacology 33:325\u2013330. https:\/\/doi.org\/10.1016\/0028-3908(94)90061-2","journal-title":"Neuropharmacology"},{"key":"6012_CR38","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1097\/FBP.0000000000000219","volume":"27","author":"EF Johnson","year":"2016","unstructured":"Johnson EF, Szechtman H (2016) A dose-response study of separate and combined effects of the serotonin agonist 8-OH-DPAT and the dopamine agonist quinpirole on locomotor sensitization, cross-sensitization, and conditioned activity. Behav Pharmacol 27:439\u2013450. https:\/\/doi.org\/10.1097\/FBP.0000000000000219","journal-title":"Behav Pharmacol"},{"key":"6012_CR39","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0893-133X(97)00195-4","volume":"18","author":"PW Kalivas","year":"1998","unstructured":"Kalivas PW, Duffy P, White SR (1998) MDMA elicits behavioral and neurochemical sensitization in rats. Neuropsychopharmacology 18:469\u2013479. https:\/\/doi.org\/10.1016\/S0893-133X(97)00195-4","journal-title":"Neuropsychopharmacology"},{"key":"6012_CR40","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1007\/s007020070041","volume":"107","author":"P Kaur","year":"2000","unstructured":"Kaur P, Ahlenius S (2000) Non-serotonergic potentiation by (-)-pindolol of DOI-induced forward locomotion in rats: possible involvement of beta-adrenoceptors? J Neural Transm 107:903\u2013917. https:\/\/doi.org\/10.1007\/s007020070041","journal-title":"J Neural Transm"},{"key":"6012_CR41","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1034\/j.1600-0773.2001.d01-163.x","volume":"89","author":"D Kelder","year":"2001","unstructured":"Kelder D, Ross SB (2001) Differential sensitivity to 8-hydroxy-2-(di-n-propylamino)tetralin-induced corticosterone secretion and hypothermia between Sprague-Dawley rats from different breeding colonies. Pharmacol Toxicol 89:295\u2013300. https:\/\/doi.org\/10.1034\/j.1600-0773.2001.d01-163.x","journal-title":"Pharmacol Toxicol"},{"key":"6012_CR42","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1034\/j.1600-0773.2002.900104.x","volume":"90","author":"D Kelder","year":"2002","unstructured":"Kelder D, Ross SB (2002) Counteraction of the rapid tolerance to 8-hydroxy-2-(di-n-propylamino)tetralin-induced hypothermia in rats by activation of the GABAA receptor-chloride channel complex. Pharmacol Toxicol 90:14\u201319. https:\/\/doi.org\/10.1034\/j.1600-0773.2002.900104.x","journal-title":"Pharmacol Toxicol"},{"key":"6012_CR43","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/s0014-2999(98)00795-x","volume":"364","author":"GR King","year":"1999","unstructured":"King GR, Xiong Z, Ellinwood EH (1999) Blockade of accumbens 5-HT3 receptor down-regulation by ondansetron administered during continuous cocaine administration. Eur J Pharmacol 364:79\u201387. https:\/\/doi.org\/10.1016\/s0014-2999(98)00795-x","journal-title":"Eur J Pharmacol"},{"key":"6012_CR44","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/ddr.430260305","volume":"26","author":"BK Koe","year":"1992","unstructured":"Koe BK, Nielsen JA, Macor JE, Heym J (1992) Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP94,253. Drug Dev Res 26:241\u2013250. https:\/\/doi.org\/10.1002\/ddr.430260305","journal-title":"Drug Dev Res"},{"key":"6012_CR45","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/0028-3908(90)90047-u","volume":"29","author":"LG Larsson","year":"1990","unstructured":"Larsson LG, R\u00e9nyi L, Ross SB, Svensson B, \u00c4ngeby-M\u00f6ller K (1990) Different effects on the responses of functional pre- and postsynaptic 5-HT1A receptors by repeated treatment of rats with the 5-HT1A receptor agonist 8-OH-DPAT. Neuropharmacology 29:85\u201391. https:\/\/doi.org\/10.1016\/0028-3908(90)90047-u","journal-title":"Neuropharmacology"},{"key":"6012_CR46","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/s0091-3057(01)00712-2","volume":"71","author":"D Lin","year":"2002","unstructured":"Lin D, Parsons LH (2002) Anxiogenic-like effect of serotonin1B receptor stimulation in the rat elevated plus-maze. Pharmacol Biochem Behav 71:581\u2013587. https:\/\/doi.org\/10.1016\/s0091-3057(01)00712-2","journal-title":"Pharmacol Biochem Behav"},{"key":"6012_CR47","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/0024-3205(89)90272-5","volume":"45","author":"GSF Ling","year":"1989","unstructured":"Ling GSF, Paul D, Simantov R, Pasternak GW (1989) Differential development of acute tolerance to analgesia, respiratory depression, gastrointestinal transit and hormone release in a morphine infusion model. Life Sci 45:1627\u20131636. https:\/\/doi.org\/10.1016\/0024-3205(89)90272-5","journal-title":"Life Sci"},{"key":"6012_CR48","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.neuropharm.2018.01.023","volume":"133","author":"J Lucchetti","year":"2018","unstructured":"Lucchetti J, Marzo CM, Passoni A, Moro F, di Clemente A, Bagnati R, Cervo L, Gobbi M (2018) Brain disposition, metabolism and behavioral effects of the synthetic opioid AH-7921 in rats. Neuropharmacology 133:51\u201362. https:\/\/doi.org\/10.1016\/j.neuropharm.2018.01.023","journal-title":"Neuropharmacology"},{"key":"6012_CR49","first-page":"965","volume":"290","author":"AC McCreary","year":"1999","unstructured":"McCreary AC, Bankson MG, Cunningham KA (1999) Pharmacological studies of the acute and chronic effects of (+)-3,4-methylenedioxymethamphetamine on locomotor activity: role of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B\/1D receptors. J Pharmacol Exp Ther 290:965\u2013973","journal-title":"J Pharmacol Exp Ther"},{"key":"6012_CR50","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1007\/s00213-008-1407-1","volume":"203","author":"SA McDougall","year":"2009","unstructured":"McDougall SA, Charntikov S, Cortez AM, Amodeo DA, Martinez CE, Crawford CA (2009) Persistence of one-trial cocaine-induced behavioral sensitization in young rats: regional differences in Fos immunoreactivity. Psychopharmacology 203:617\u2013628. https:\/\/doi.org\/10.1007\/s00213-008-1407-1","journal-title":"Psychopharmacology"},{"key":"6012_CR51","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1007\/s00210-020-02011-z","volume":"394","author":"SA McDougall","year":"2021","unstructured":"McDougall SA, Montejano NR, Park GI, Robinson JAM (2021a) Importance of dopaminergic neurotransmission for the RU 24969-induced locomotor activity of male and female rats during the preweanling period. Naunyn Schmiedebergs Arch Pharmacol 394:903\u2013913. https:\/\/doi.org\/10.1007\/s00210-020-02011-z","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"6012_CR52","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.euroneuro.2019.03.013","volume":"29","author":"SA McDougall","year":"2019","unstructured":"McDougall SA, Park GI, Ramirez GI, Gomez V, Adame BC, Crawford CA (2019) Sex-dependent changes in ketamine-induced locomotor activity and ketamine pharmacokinetics in preweanling, adolescent, and adult rats. Eur Neuropsychopharmacol 29:740\u2013755. https:\/\/doi.org\/10.1016\/j.euroneuro.2019.03.013","journal-title":"Eur Neuropsychopharmacol"},{"key":"6012_CR53","doi-asserted-by":"publisher","first-page":"112982","DOI":"10.1016\/j.bbr.2020.112982","volume":"398","author":"SA McDougall","year":"2021","unstructured":"McDougall SA, Razo JL, Rios JW, Taylor JA (2021b) Effects of repeated RU 24969 treatment on the locomotor activity, motoric capacity, and axillary temperatures of male and female preweanling rats. Behav Brain Res 398:112982. https:\/\/doi.org\/10.1016\/j.bbr.2020.112982","journal-title":"Behav Brain Res"},{"key":"6012_CR54","doi-asserted-by":"publisher","first-page":"172857","DOI":"10.1016\/j.pbb.2020.172857","volume":"189","author":"SA McDougall","year":"2020","unstructured":"McDougall SA, Robinson JAM, Ramirez EL, Diaz HA (2020) Serotonin 5-HT1A and 5-HT1B receptors co-mediate the RU 24969-induced locomotor activity of male and female preweanling rats. Pharmacol Biochem Behav 189:172857. https:\/\/doi.org\/10.1016\/j.pbb.2020.172857","journal-title":"Pharmacol Biochem Behav"},{"key":"6012_CR55","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/0091-3057(92)90169-g","volume":"43","author":"E Meller","year":"1992","unstructured":"Meller E, Chalfin M, Bohmaker K (1992) Serotonin 5-HT1A receptor-mediated hypothermia in mice: absence of spare receptors and rapid induction of tolerance. Pharmacol Biochem Behav 43:405\u2013411. https:\/\/doi.org\/10.1016\/0091-3057(92)90169-g","journal-title":"Pharmacol Biochem Behav"},{"key":"6012_CR56","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0014-2999(83)90230-3","volume":"90","author":"DN Middlemiss","year":"1983","unstructured":"Middlemiss DN, Fozard JR (1983) 8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site. Eur J Pharmacol 90:151\u2013153. https:\/\/doi.org\/10.1016\/0014-2999(83)90230-3","journal-title":"Eur J Pharmacol"},{"key":"6012_CR57","volume-title":"Guide for the care and use of laboratory animals","author":"National Research Council","year":"2010","unstructured":"National Research Council (2010) Guide for the care and use of laboratory animals, 8th edn. National Academies Press, Washington","edition":"8"},{"key":"6012_CR58","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/0014-2999(87)90253-6","volume":"139","author":"C Oberlander","year":"1987","unstructured":"Oberlander C, Demassey Y, Verdu A, Van de Velde D, Bardelay C (1987) Tolerance to the serotonin 5-HT1 agonist RU24969 and effects on dopaminergic behavior. Eur J Pharmacol 139:205\u2013214. https:\/\/doi.org\/10.1016\/0014-2999(87)90253-6","journal-title":"Eur J Pharmacol"},{"key":"6012_CR59","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0014-2999(96)00496-7","volume":"312","author":"MT O\u2019Connell","year":"1996","unstructured":"O\u2019Connell MT, Curzon G (1996) A comparison of the effects of 8-OH-DPAT pretreatment of different behavioural responses to 8-OH-DPAT. Eur J Pharmacol 312:137\u2013143. https:\/\/doi.org\/10.1016\/0014-2999(96)00496-7","journal-title":"Eur J Pharmacol"},{"key":"6012_CR60","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s002130000659","volume":"154","author":"S Oerther","year":"2001","unstructured":"Oerther S, Ahlenius S (2001) Involvement of 5-HT1A and 5-HT1B receptors for citalopram-induced hypothermia in the rat. Psychopharmacology 154:429\u2013434. https:\/\/doi.org\/10.1007\/s002130000659","journal-title":"Psychopharmacology"},{"key":"6012_CR61","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s002130050343","volume":"132","author":"MF O\u2019Neill","year":"1997","unstructured":"O\u2019Neill MF, Parameswaran T (1997) RU24969-induced behavioural syndrome requires activation of both 5HT1A and 5HT1B receptors. Psychopharmacology 132:255\u2013260. https:\/\/doi.org\/10.1007\/s002130050343","journal-title":"Psychopharmacology"},{"key":"6012_CR62","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/s0014-2999(99)00090-4","volume":"370","author":"MF O\u2019Neill","year":"1999","unstructured":"O\u2019Neill MF, Sanger GJ (1999) GR46611 potentiates 5-HT1A receptor-mediated locomotor activity in the guinea pig. Eur J Pharmacol 370:85\u201392. https:\/\/doi.org\/10.1016\/s0014-2999(99)00090-4","journal-title":"Eur J Pharmacol"},{"key":"6012_CR63","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/s0960-894x(98)00090-0","volume":"8","author":"M Perez","year":"1998","unstructured":"Perez M, Pauwels PJ, Fourrier C, Chopin P, Valentin JP, John GW, Marien M, Halazy S (1998) Dimerization of sumatriptan as an efficient way to design a potent, centrally and orally active 5-HT1B agonist. Bioorg Med Chem Lett 8:675\u2013680. https:\/\/doi.org\/10.1016\/s0960-894x(98)00090-0","journal-title":"Bioorg Med Chem Lett"},{"key":"6012_CR64","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/s0165-0173(97)00021-0","volume":"25","author":"RC Pierce","year":"1997","unstructured":"Pierce RC, Kalivas PW (1997) A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. Brain Res Rev 25:192\u2013216. https:\/\/doi.org\/10.1016\/s0165-0173(97)00021-0","journal-title":"Brain Res Rev"},{"key":"6012_CR65","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/npp.1993.22","volume":"8","author":"N Rempel","year":"1993","unstructured":"Rempel N, Callaway CW, Geyer MA (1993) Serotonin1B receptor activation mimics behavioral effects of presynaptic serotonin release. Neuropsychopharmacology 8:201\u2013212. https:\/\/doi.org\/10.1038\/npp.1993.22","journal-title":"Neuropsychopharmacology"},{"key":"6012_CR66","first-page":"1335","volume":"255","author":"LE Schechter","year":"1990","unstructured":"Schechter LE, Bola\u00f1os FJ, Gozlan H, Lanfumey L, Haj-Dahmane S, Laporte AM, Fattaccini CM, Hamon M (1990) Alterations of central serotoninergic and dopaminergic neurotransmission in rats chronically treated with ipsapirone: biochemical and electrophysiological studies. J Pharmacol Exp Ther 255:1335\u20131347","journal-title":"J Pharmacol Exp Ther"},{"key":"6012_CR67","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1111\/j.1476-5381.1992.tb09047.x","volume":"105","author":"E Schlicker","year":"1992","unstructured":"Schlicker E, Werner U, Hamon M, Gozlan H, Nickel B, Szelenyi I, G\u00f6thert M (1992) Anpirtoline, a novel, highly potent 5-HT1B receptor agonist with antinociceptive\/antidepressant-like actions in rodents. Br J Pharmacol 105:732\u2013738. https:\/\/doi.org\/10.1111\/j.1476-5381.1992.tb09047.x","journal-title":"Br J Pharmacol"},{"key":"6012_CR68","first-page":"4","volume":"18","author":"CR Schuster","year":"1978","unstructured":"Schuster CR (1978) Theoretical basis of behavioral tolerance: implications of the phenomenon for problems of drug abuse. NIDA Res Monogr 18:4\u201317","journal-title":"NIDA Res Monogr"},{"key":"6012_CR69","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/0091-3057(95)02098-5","volume":"53","author":"H Sershen","year":"1996","unstructured":"Sershen H, Hashim A, Lajtha A (1996) Effect of ibogaine on cocaine-induced efflux of [3H] dopamine and [3H] serotonin from mouse striatum. Pharmacol Biochem Behav 53:863\u2013869. https:\/\/doi.org\/10.1016\/0091-3057(95)02098-5","journal-title":"Pharmacol Biochem Behav"},{"key":"6012_CR70","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.biopsych.2008.09.026","volume":"65","author":"NA Shanahan","year":"2009","unstructured":"Shanahan NA, Holick Pierz KA, Masten VL, Waeber C, Ansorge M, Gingrich JA, Geyer MA, Hen R, Dulawa SC (2009) Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice. Biol Psychiatry 65:401\u2013408. https:\/\/doi.org\/10.1016\/j.biopsych.2008.09.026","journal-title":"Biol Psychiatry"},{"key":"6012_CR71","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/s0006-8993(03)02944-5","volume":"980","author":"M Shayit","year":"2003","unstructured":"Shayit M, Yadid G, Overstreet DH, Weller A (2003) 5-HT1A receptor subsensitivity in infancy and supersensitivity in adulthood in an animal model of depression. Brain Res 980:100\u2013108. https:\/\/doi.org\/10.1016\/s0006-8993(03)02944-5","journal-title":"Brain Res"},{"key":"6012_CR72","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1037\/\/1064-1297.8.3.276","volume":"8","author":"S Siegel","year":"2000","unstructured":"Siegel S, Baptista MA, Kim JA, McDonald RV, Weise-Kelly L (2000) Pavlovian psychopharmacology: the associative basis of tolerance. Exp Clin Psychopharmacol 8:276\u2013293. https:\/\/doi.org\/10.1037\/\/1064-1297.8.3.276","journal-title":"Exp Clin Psychopharmacol"},{"key":"6012_CR73","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/s0091-3057(00)00178-7","volume":"66","author":"ML Sipos","year":"2000","unstructured":"Sipos ML, Bauman RA, Widholm JJ, Kant GJ (2000) Behavioral effects of 8-OH-DPAT in chronically stressed male and female rats. Pharmacol Biochem Behav 66:403\u2013411. https:\/\/doi.org\/10.1016\/s0091-3057(00)00178-7","journal-title":"Pharmacol Biochem Behav"},{"key":"6012_CR74","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.ntt.2008.01.003","volume":"30","author":"KS Smith","year":"2008","unstructured":"Smith KS, Morrell JL (2008) Behavioral responses during the initial exposures to a low dose of cocaine in late preweanling and adult rats. Neurotoxicol Teratol 30:202\u2013212. https:\/\/doi.org\/10.1016\/j.ntt.2008.01.003","journal-title":"Neurotoxicol Teratol"},{"key":"6012_CR75","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/s0149-7634(03)00018-6","volume":"27","author":"E Tirelli","year":"2003","unstructured":"Tirelli E, Laviola G, Adriani W (2003) Ontogenesis of behavioral sensitization and conditioned place preference induced by psychostimulants in laboratory rodents. Neurosci Biobehav Rev 27:163\u2013178. https:\/\/doi.org\/10.1016\/s0149-7634(03)00018-6","journal-title":"Neurosci Biobehav Rev"},{"key":"6012_CR76","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/0091-3057(91)90104-a","volume":"40","author":"L Uphouse","year":"1991","unstructured":"Uphouse L, Salamanca S, Caldarola-Pastuszka M (1991) Gender and estrous cycle differences in the response to the 5-HT1A agonist 8-OH-DPAT. Pharmacol Biochem Behav 40:901\u2013906. https:\/\/doi.org\/10.1016\/0091-3057(91)90104-a","journal-title":"Pharmacol Biochem Behav"},{"key":"6012_CR77","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/0924-977x(93)90278-t","volume":"3","author":"JW van der Laan","year":"1993","unstructured":"van der Laan JW, Jansen van\u2019t Land C, de Groot G (1993) Tolerance and withdrawal after chronic lorazepam treatment in rats. Eur Neuropsychopharmacol 3:521\u2013531. https:\/\/doi.org\/10.1016\/0924-977x(93)90278-t","journal-title":"Eur Neuropsychopharmacol"},{"key":"6012_CR78","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s002130000493","volume":"151","author":"LJ Vanderschuren","year":"2000","unstructured":"Vanderschuren LJ, Kalivas PW (2000) Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies. Psychopharmacology 151:99\u2013120. https:\/\/doi.org\/10.1007\/s002130000493","journal-title":"Psychopharmacology"},{"key":"6012_CR79","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/0028-3908(93)90052-5","volume":"32","author":"S Wieland","year":"1993","unstructured":"Wieland S, Fischette CT, Lucki I (1993) Effect of chronic treatments with tandospirone and imipramine on serotonin-mediated behavioral responses and monoamine receptors. Neuropharmacology 32:561\u2013573. https:\/\/doi.org\/10.1016\/0028-3908(93)90052-5","journal-title":"Neuropharmacology"},{"key":"6012_CR80","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/s0301-0082(97)00090-7","volume":"54","author":"ME Wolf","year":"1998","unstructured":"Wolf ME (1998) The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants. Prog Neurobiol 54:679\u2013720. https:\/\/doi.org\/10.1016\/s0301-0082(97)00090-7","journal-title":"Prog Neurobiol"},{"key":"6012_CR81","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1002\/(SICI)1098-2302(199703)30:2<141::AID-DEV5>3.0.CO;2-Q","volume":"30","author":"EP Zorrilla","year":"1997","unstructured":"Zorrilla EP (1997) Multiparous species present problems (and possibilities) to developmentalists. Dev Psychobiol 30:141\u2013150. https:\/\/doi.org\/10.1002\/(SICI)1098-2302(199703)30:2%3c141::AID-DEV5%3e3.0.CO;2-Q","journal-title":"Dev Psychobiol"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-021-06012-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-021-06012-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-021-06012-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T03:11:00Z","timestamp":1643425860000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-021-06012-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,24]]},"references-count":81,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["6012"],"URL":"https:\/\/doi.org\/10.1007\/s00213-021-06012-5","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"type":"print","value":"0033-3158"},{"type":"electronic","value":"1432-2072"}],"subject":[],"published":{"date-parts":[[2021,11,24]]},"assertion":[{"value":"27 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}