{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:03:19Z","timestamp":1790823799441,"version":"4.1.0"},"reference-count":74,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002386","name":"Cairo University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract\n<\/jats:title><jats:sec>\n                <jats:title>Rationale<\/jats:title>\n                <jats:p>Alteration of the NAD<jats:sup>+<\/jats:sup> metabolic pathway is proposed to be implicated in lipopolysaccharide (LPS)-induced neurotoxicity and mitochondrial dysfunction in neurodegenerative diseases. Apigenin, a naturally-occurring flavonoid, has been reported to maintain NAD<jats:sup>+<\/jats:sup> levels and to preserve various metabolic functions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>This study aimed to explore the effect of apigenin on mitochondrial SIRT3 activity as a mediator through which it could modulate mitochondrial quality control and to protect against intracerebrovascular ICV\/LPS-induced neurotoxicity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Mice received apigenin (40\u00a0mg\/kg; p.o) for 7 consecutive days. One hour after the last dose, LPS (12\u00a0\u00b5g\/kg, icv) was administered.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Apigenin robustly guarded against neuronal degenerative changes and maintained a normal count of intact neurons in mice hippocampi. Consequently, it inhibited the deleterious effect of LPS on cognitive functions. Apigenin was effective in preserving the NAD<jats:sup>+<\/jats:sup>\/NADH ratio to boost mitochondrial sirtuin-3 (SIRT3), activity, and ATP production. It conserved normal mitochondrial features via induction of the master regulator of mitochondrial biogenesis, peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3) coactivator-1\u03b1 (PGC-1\u03b1), along with mitochondrial transcription factor A (TFAM) and the fusion proteins, mitofusin 2 (MFN2), and optic atrophy-1 (OPA1). Furthermore, it increased phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and parkin expression as well as the microtubule-associated protein 1 light chain 3 II\/I ratio (LC3II\/I) to induce degradation of unhealthy mitochondria via mitophagy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>These observations reveal the marked neuroprotective potential of apigenin against LPS-induced neurotoxicity through inhibition of NAD<jats:sup>+<\/jats:sup> depletion and activation of SIRT3 to maintain adequate mitochondrial homeostasis and function.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00213-022-06262-x","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T09:34:55Z","timestamp":1666776895000},"page":"3903-3917","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Apigenin attenuates LPS-induced neurotoxicity and cognitive impairment in mice via promoting mitochondrial fusion\/mitophagy: role of SIRT3\/PINK1\/Parkin pathway"],"prefix":"10.1007","volume":"239","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8894-9696","authenticated-orcid":false,"given":"Omaima A.","family":"Ahmedy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek M.","family":"Abdelghany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa E. A.","family":"El-Shamarka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Khattab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia M.","family":"El-Tanbouly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"6262_CR1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.pnpbp.2021.110366","volume":"110366","author":"NH Ashour","year":"2021","unstructured":"Ashour NH, El-Tanbouly DM, El Sayed NS, Khattab MM (2021) Roflumilast ameliorates cognitive deficits in a mouse model of amyloidogenesis and tauopathy: involvement of nitric oxide status, A\u03b2 extrusion transporter ABCB1, and reversal by PKA inhibitor H89. Prog Neuropsychopharmacol Biol Psychiatry 110366:111. https:\/\/doi.org\/10.1016\/j.pnpbp.2021.110366","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"6262_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.nbd.2015.10.011","volume":"90","author":"AM Bertholet","year":"2016","unstructured":"Bertholet AM, Delerue T, Millet AM et al (2016) Mitochondrial fusion\/fission dynamics in neurodegeneration and neuronal plasticity. Neurobiol Dis 90:3\u201319. https:\/\/doi.org\/10.1016\/j.nbd.2015.10.011","journal-title":"Neurobiol Dis"},{"key":"6262_CR3","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1155\/2013\/271359","volume":"2013","author":"S Biesmans","year":"2013","unstructured":"Biesmans S, Meert TF, Bouwknecht JA et al (2013) Systemic immune activation leads to neuroinflammation and sickness behavior in mice. Mediat Inflamm 2013 2013:14. https:\/\/doi.org\/10.1155\/2013\/271359","journal-title":"Mediat Inflamm 2013"},{"key":"6262_CR4","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.bbr.2004.01.022","volume":"154","author":"A Blokland","year":"2004","unstructured":"Blokland A, Geraerts E, Been M (2004) A detailed analysis of rats\u2019 spatial memory in a probe trial of a Morris task. Behav Brain Res 154:71\u201375. https:\/\/doi.org\/10.1016\/j.bbr.2004.01.022","journal-title":"Behav Brain Res"},{"issue":"6","key":"6262_CR5","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.cmet.2016.05.006","volume":"23","author":"J Camacho-Pereira","year":"2016","unstructured":"Camacho-Pereira J, Tarrag\u00f3 MG, Chini CCS et al (2016) CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism. Cell Metab 23(6):1127\u20131139. https:\/\/doi.org\/10.1016\/j.cmet.2016.05.006","journal-title":"Cell Metab"},{"key":"6262_CR6","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.tips.2018.02.001","volume":"39","author":"EN Chini","year":"2018","unstructured":"Chini EN, Chini CCS, Netto JME et al (2018) The pharmacology of CD38\/NADase: an emerging target in cancer and diseases of aging. Trends Pharmacol Sci 39:424\u2013436. https:\/\/doi.org\/10.1016\/j.tips.2018.02.001","journal-title":"Trends Pharmacol Sci"},{"key":"6262_CR7","doi-asserted-by":"crossref","unstructured":"Chirumbolo S (2019) Letter to editor: is mitochondria biogenesis and neuronal loss prevention in rat hippocampus promoted by apigenin. Basic Clin Neurosci 10(6):541\u2013543. 10.325982Fbcn.10.6.541","DOI":"10.32598\/bcn.10.6.541"},{"key":"6262_CR8","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/S0165-0173(01)00067-4","volume":"36","author":"R D\u2019Hooge","year":"2001","unstructured":"D\u2019Hooge R, De Deyn PP (2001) Applications of the Morris water maze in the study of learning and memory. Brain Res Rev 36:60\u201390. https:\/\/doi.org\/10.1016\/S0165-0173(01)00067-4","journal-title":"Brain Res Rev"},{"key":"6262_CR9","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/345105","author":"S Das","year":"2014","unstructured":"Das S, Mitrovsky G, Vasanthi HR, Das DK (2014) Antiaging properties of a grape-derived antioxidant are regulated by mitochondrial balance of fusion and fission leading to mitophagy triggered by a signaling network of sirt1-sirt3-foxo3-pink1-parkin. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2014\/345105","journal-title":"Oxid Med Cell Longev"},{"key":"6262_CR10","doi-asserted-by":"publisher","first-page":"17664","DOI":"10.3390\/ijms140917664","volume":"14","author":"S Duarte","year":"2013","unstructured":"Duarte S, Arango D, Parihar A et al (2013) Apigenin protects endothelial cells from lipopolysaccharide (LPS)-induced inflammation by decreasing caspase-3 activation and modulating mitochondrial function. Int J Mol Sci 14:17664\u201317679. https:\/\/doi.org\/10.3390\/ijms140917664","journal-title":"Int J Mol Sci"},{"key":"6262_CR11","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.2337\/db12-1139","volume":"62","author":"C Escande","year":"2013","unstructured":"Escande C, Nin V, Price NL et al (2013) Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes 62:1084\u20131093. https:\/\/doi.org\/10.2337\/db12-1139","journal-title":"Diabetes"},{"issue":"45","key":"6262_CR12","doi-asserted-by":"publisher","first-page":"12413","DOI":"10.1523\/JNEUROSCI.0719-07.2007","volume":"27","author":"N Exner","year":"2007","unstructured":"Exner N, Treske B, Paquet D et al (2007) Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci 27(45):12413\u201312418. https:\/\/doi.org\/10.1523\/JNEUROSCI.0719-07.2007","journal-title":"J Neurosci"},{"key":"6262_CR13","doi-asserted-by":"publisher","first-page":"e23295","DOI":"10.1371\/journal.pone.0023295","volume":"6","author":"LWS Finley","year":"2011","unstructured":"Finley LWS, Haas W, Desquiret-Dumas V et al (2011) Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. PLoS ONE 6:e23295\u2013e23295. https:\/\/doi.org\/10.1371\/journal.pone.0023295","journal-title":"PLoS ONE"},{"key":"6262_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-43532-9","volume":"9","author":"MG Fronza","year":"2019","unstructured":"Fronza MG, Baldinotti R, Martins MC et al (2019) Rational design, cognition and neuropathology evaluation of QTC-4-MeOBnE in a streptozotocin-induced mouse model of sporadic Alzheimer\u2019s disease. Sci Rep 9:1\u201314. https:\/\/doi.org\/10.1038\/s41598-019-43532-9","journal-title":"Sci Rep"},{"key":"6262_CR15","doi-asserted-by":"publisher","unstructured":"Fu J, Jin J, Cichewicz RH, Hageman SA, Ellis TK, Xiang L, Peng Q, Jiang M, Arbez N, Hotaling K, Ross CA, Duan Wenzhen (2012) trans-(\u2212)-\u03b5-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated Protein Kinase (AMPK), and protects cells in models of huntington disease. J Biol Chem 287(29):24460\u201324472. https:\/\/doi.org\/10.1074\/jbc.m112.382226","DOI":"10.1074\/jbc.m112.382226"},{"key":"6262_CR16","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s13024-020-00367-7","volume":"15","author":"P Ge","year":"2020","unstructured":"Ge P, Dawson VL, Dawson TM (2020) PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson\u2019s disease. Mol Neurodegeneration 15:20. https:\/\/doi.org\/10.1186\/s13024-020-00367-7","journal-title":"Mol Neurodegeneration"},{"key":"6262_CR17","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/s41580-018-0052-8","volume":"19","author":"C Giorgi","year":"2018","unstructured":"Giorgi C, Marchi S, Pinton P (2018) The machineries, regulation and cellular functions of mitochondrial calcium. Nat Rev Mol Cell Biol 19:713\u2013730. https:\/\/doi.org\/10.1038\/s41580-018-0052-8","journal-title":"Nat Rev Mol Cell Biol"},{"key":"6262_CR18","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.pbb.2012.03.028","volume":"102","author":"R Gupta","year":"2012","unstructured":"Gupta R, Gupta LK (2012) Improvement in long term and visuo-spatial memory following chronic pioglitazone in mouse model of Alzheimer\u2019s disease. Pharmacol Biochem Behav 102:184\u2013190. https:\/\/doi.org\/10.1016\/j.pbb.2012.03.028","journal-title":"Pharmacol Biochem Behav"},{"key":"6262_CR19","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1146\/annurev.pathol.4.110807.092250","volume":"5","author":"MC Haigis","year":"2010","unstructured":"Haigis MC, Sinclair DA (2010) Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 5:253\u2013295. https:\/\/doi.org\/10.1146\/annurev.pathol.4.110807.092250","journal-title":"Annu Rev Pathol"},{"issue":"8","key":"6262_CR20","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1523\/JNEUROSCI.2324-19.2020","volume":"40","author":"M Harland","year":"2020","unstructured":"Harland M, Torres S, Liu J, Wang X (2020) Neuronal mitochondria modulation of LPS-induced neuroinflammation. J Neurosci 40(8):1756\u20131765. https:\/\/doi.org\/10.1523\/JNEUROSCI.2324-19.2020","journal-title":"J Neurosci"},{"issue":"14","key":"6262_CR21","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1016\/j.jacc.2015.02.032","volume":"65","author":"B Ib\u00e1\u00f1ez","year":"2015","unstructured":"Ib\u00e1\u00f1ez B, Heusch G, Ovize M, Van De Werf F (2015) Evolving therapies for myocardial ischemia\/reperfusion injury. J Am Coll Cardiol 65(14):1454\u20131471","journal-title":"J Am Coll Cardiol"},{"key":"6262_CR22","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/BF03033974","volume":"8","author":"S Johansson","year":"2005","unstructured":"Johansson S, Bohman S, Rades\u00e4ter A-C et al (2005) Salmonella lipopolysaccharide (LPS) mediated neurodegeneration in hippocampal slice cultures. Neurotox Res 8:207\u2013220. https:\/\/doi.org\/10.1007\/BF03033974","journal-title":"Neurotox Res"},{"issue":"3","key":"6262_CR23","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1124\/jpet.112.192138","volume":"342","author":"A Johri","year":"2012","unstructured":"Johri A, Beal MF (2012) Mitochondrial dysfunction in neurodegenerative diseases. J Pharmacol Exp Ther 342(3):619\u2013630. https:\/\/doi.org\/10.1124\/jpet.112.192138","journal-title":"J Pharmacol Exp Ther"},{"issue":"34","key":"6262_CR24","doi-asserted-by":"publisher","first-page":"22938","DOI":"10.1074\/jbc.M109.035774","volume":"284","author":"A Kathrin Lutz","year":"2009","unstructured":"Kathrin Lutz A, Exner N, Fett ME et al (2009) Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem 284(34):22938\u201322951. https:\/\/doi.org\/10.1074\/jbc.M109.035774","journal-title":"J Biol Chem"},{"key":"6262_CR25","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.3389\/fphar.2018.01","volume":"9","author":"A Khan","year":"2018","unstructured":"Khan A, Ali T, Rehman SU et al (2018) Neuroprotective effect of quercetin against the detrimental effects of LPS in the adult mouse brain. Front Pharmacol 9:1383. https:\/\/doi.org\/10.3389\/fphar.2018.01","journal-title":"Front Pharmacol"},{"key":"6262_CR26","doi-asserted-by":"publisher","unstructured":"Kimura S, Fujita N, Noda T, Yoshimori T (2009) Chapter 1 Monitoring Autophagy in Mammalian Cultured Cells through the Dynamics of LC3. 452, 1\u201312. https:\/\/doi.org\/10.1016\/S0076-6879(08)03601-X","DOI":"10.1016\/S0076-6879(08)03601-X"},{"key":"6262_CR27","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3389\/fnagi.2013.00048","volume":"5","author":"B Kincaid","year":"2013","unstructured":"Kincaid B, Bossy-Wetzel E (2013) Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. Front Aging Neurosci 5:48. https:\/\/doi.org\/10.3389\/fnagi.2013.00048","journal-title":"Front Aging Neurosci"},{"issue":"4","key":"6262_CR28","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.cmet.2019.09.001","volume":"30","author":"S Lautrup","year":"2019","unstructured":"Lautrup S, Sinclair DA, Mattson MP, Fang EF (2019) NAD+ in brain aging and neurodegenerative disorders. Cell Metab 30(4):630\u2013655. https:\/\/doi.org\/10.1016\/j.cmet.2019.09.001","journal-title":"Cell Metab"},{"key":"6262_CR29","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nature14893","volume":"524","author":"M Lazarou","year":"2015","unstructured":"Lazarou M, Sliter DA, Kane LA et al (2015) The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature 524:309\u2013314. https:\/\/doi.org\/10.1038\/nature14893","journal-title":"Nature"},{"key":"6262_CR30","doi-asserted-by":"publisher","first-page":"e12679","DOI":"10.1111\/acel.12679","volume":"17","author":"J Lee","year":"2018","unstructured":"Lee J, Kim Y, Liu T et al (2018) SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer\u2019s disease. Aging Cell 17:e12679. https:\/\/doi.org\/10.1111\/acel.12679","journal-title":"Aging Cell"},{"key":"6262_CR31","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1038\/s41598-019-39419-4","volume":"9","author":"CF Lee","year":"2019","unstructured":"Lee CF, Caudal A, Abell L et al (2019) (2019) Targeting NAD + metabolism as interventions for mitochondrial disease. Sci Rep 9:3073. https:\/\/doi.org\/10.1038\/s41598-019-39419-4","journal-title":"Sci Rep"},{"issue":"5","key":"6262_CR32","doi-asserted-by":"publisher","first-page":"341","DOI":"10.5607\/en21021","volume":"30","author":"S Lee","year":"2021","unstructured":"Lee S, Jeon YM, Jo M, Kim HJ (2021) Overexpression of SIRT3 suppresses oxidative stress-induced neurotoxicity and mitochondrial dysfunction in dopaminergic neuronal cells. Exp Neurobiol 30(5):341\u2013355. https:\/\/doi.org\/10.5607\/en21021","journal-title":"Exp Neurobiol"},{"key":"6262_CR33","doi-asserted-by":"publisher","first-page":"598078","DOI":"10.3389\/fcell.2020.598078","volume":"8","author":"M Liu","year":"2020","unstructured":"Liu M, Li X, Huang D (2020) Mfn2 overexpression attenuates cardio-cerebrovascular ischemia-reperfusion injury through mitochondrial fusion and activation of the AMPK\/Sirt3 signaling. Frontiers Cell Dev Biol 8:598078. https:\/\/doi.org\/10.3389\/fcell.2020.598078","journal-title":"Frontiers Cell Dev Biol"},{"key":"6262_CR34","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/sj.npp.1300602","volume":"30","author":"JJ Luszczki","year":"2005","unstructured":"Luszczki JJ, Wojcik-Cwikla J, Andres MM, Czuczwar SJ (2005) Pharmacological and behavioral characteristics of interactions between vigabatrin and conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis. Neuropsychopharmacology 30:958\u2013973. https:\/\/doi.org\/10.1038\/sj.npp.1300602","journal-title":"Neuropsychopharmacology"},{"key":"6262_CR35","doi-asserted-by":"publisher","unstructured":"Lyu Z, Luo S, Li Y, et al (2021) SIRT3 protects against cognitive dysfunction induced by sepsis-associated encephalopathy via JNK\/p66Shc-regulated mitochondrial apoptosis in mice.\u00a0https:\/\/doi.org\/10.21203\/rs.3.rs-895666\/v2","DOI":"10.21203\/rs.3.rs-895666\/v2"},{"issue":"11","key":"6262_CR36","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1111\/jcmm.13330","volume":"21","author":"C Maneechote","year":"2017","unstructured":"Maneechote C, Palee S, Chattipakorn SC, Chattipakorn N (2017) Roles of mitochondrial dynamics modulators in cardiac ischaemia\/reperfusion injury. J Cellular Mole Med 21(11):2643\u20132653. https:\/\/doi.org\/10.1111\/jcmm.13330","journal-title":"J Cellular Mole Med"},{"key":"6262_CR37","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.peptides.2019.170157","volume":"292","author":"BR McConn","year":"2015","unstructured":"McConn BR, Park J, Gilbert ER, Cline MA (2015) A novel role for xenopsin: stimulation of food intake. Behav Brain Res 292:500\u2013507. https:\/\/doi.org\/10.1016\/j.peptides.2019.170157","journal-title":"Behav Brain Res"},{"key":"6262_CR38","doi-asserted-by":"publisher","first-page":"170157","DOI":"10.1016\/j.peptides.2019.170157","volume":"122","author":"BR McConn","year":"2019","unstructured":"McConn BR, Newmyer BA, John NS et al (2019) The anorexigenic effect of neuropeptide K in chicks involves the paraventricular nucleus and arcuate nucleus of the hypothalamus. Peptides 122:170157","journal-title":"Peptides"},{"key":"6262_CR39","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3389\/fnagi.2019.00313","volume":"11","author":"H Meng","year":"2019","unstructured":"Meng H, Yan W-Y, Lei Y-H et al (2019) SIRT3 regulation of mitochondrial quality control in neurodegenerative diseases. Frontiers Aging Neurosci 11:313. https:\/\/doi.org\/10.3389\/fnagi.2019.00313","journal-title":"Frontiers Aging Neurosci"},{"issue":"6","key":"6262_CR40","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1002\/glia.23587","volume":"67","author":"S Nair","year":"2019","unstructured":"Nair S, Sobotka KS, Joshi P et al (2019) Lipopolysaccharide-induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo. Glia 67(6):1047\u20131061. https:\/\/doi.org\/10.1002\/glia.23587","journal-title":"Glia"},{"issue":"5","key":"6262_CR41","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1083\/jcb.200809125","volume":"183","author":"D Narendra","year":"2008","unstructured":"Narendra D, Tanaka A, Suen DF, Youle RJ (2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183(5):795\u2013803. https:\/\/doi.org\/10.1083\/jcb.200809125","journal-title":"J Cell Biol"},{"key":"6262_CR42","doi-asserted-by":"publisher","first-page":"11325","DOI":"10.18632\/aging.103410","volume":"12","author":"Y Ogura","year":"2020","unstructured":"Ogura Y, Kitada M, Xu J et al (2020) CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD(+)\/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats. Aging 12:11325\u201311336. https:\/\/doi.org\/10.18632\/aging.103410","journal-title":"Aging"},{"key":"6262_CR43","doi-asserted-by":"publisher","unstructured":"Park J-H, Burgess JD, Faroqi AH, DeMeo NN, Fiesel FC, Springer W, Delenclos M, McLean PJ (2020) Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway. Mol Neurodegener 15:1\u201319. https:\/\/doi.org\/10.1186\/s13024-019-0349-x","DOI":"10.1186\/s13024-019-0349-x"},{"key":"6262_CR44","first-page":"799","volume":"293","author":"MA Pelleymounter","year":"2000","unstructured":"Pelleymounter MA, Joppa M, Carmouche M et al (2000) Role of corticotropin-releasing factor (CRF) receptors in the anorexic syndrome induced by CRF. J Pharmacol Exp Ther 293:799\u2013806","journal-title":"J Pharmacol Exp Ther"},{"key":"6262_CR45","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1124\/jpet.302.1.145","volume":"302","author":"MA Pelleymounter","year":"2002","unstructured":"Pelleymounter MA, Joppa M, Ling N, Foster AC (2002) Pharmacological evidence supporting a role for central corticotropin-releasing factor2 receptors in behavioral, but not endocrine, response to environmental stress. J Pharmacol Exp Ther 302:145\u2013152. https:\/\/doi.org\/10.1124\/jpet.302.1.145","journal-title":"J Pharmacol Exp Ther"},{"key":"6262_CR46","doi-asserted-by":"publisher","first-page":"3783","DOI":"10.1007\/s12035-016-9944-9","volume":"54","author":"K Peng","year":"2017","unstructured":"Peng K, Yang L, Wang J et al (2017) The interaction of mitochondrial biogenesis and fission\/fusion mediated by PGC-1\u03b1 regulates rotenone-induced dopaminergic neurotoxicity. Mol Neurobiol 54:3783\u20133797. https:\/\/doi.org\/10.1007\/s12035-016-9944-9","journal-title":"Mol Neurobiol"},{"key":"6262_CR47","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.bbi.2020.09.005","volume":"90","author":"Y Peng","year":"2020","unstructured":"Peng Y, Shi Z, Kumaran Satyanarayanan S et al (2020) Fish oil alleviates LPS-induced inflammation and depressive-like behavior in mice via restoration of metabolic impairments. Brain Behav Immun 90:393\u2013402. https:\/\/doi.org\/10.1016\/j.bbi.2020.09.005","journal-title":"Brain Behav Immun"},{"key":"6262_CR48","doi-asserted-by":"publisher","unstructured":"Quinn, P.M., Moreira, P.I., Ambr\u00f3sio, A.F. and Alves, C.H., (2020). PINK1\/PARKIN signalling in neurodegeneration and neuroinflammation. https:\/\/doi.org\/10.1186\/s40478-020-01062-w","DOI":"10.1186\/s40478-020-01062-w"},{"key":"6262_CR49","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.pnpbp.2018.05.010","volume":"86","author":"NOA Rasheed","year":"2018","unstructured":"Rasheed NOA, El Sayed NS, El-Khatib AS (2018) Targeting central \u03b22 receptors ameliorates streptozotocin-induced neuroinflammation via inhibition of glycogen synthase kinase3 pathway in mice. Progress Neuropsychopharmacol Biol Psychiatry 86:65\u201375. https:\/\/doi.org\/10.1016\/j.pnpbp.2018.05.010","journal-title":"Progress Neuropsychopharmacol Biol Psychiatry"},{"issue":"6","key":"6262_CR50","doi-asserted-by":"publisher","first-page":"3922","DOI":"10.1007\/s12035-018-1342-z","volume":"56","author":"MF Ribeiro","year":"2019","unstructured":"Ribeiro MF, Genebra T, Rego AC, Rodrigues CMP, Sol\u00e1 S (2019) Amyloid \u03b2 peptide compromises neural stem cell fate by irreversibly disturbing mitochondrial oxidative state and blocking mitochondrial biogenesis and dynamics. Mol Neurobiol 56(6):3922\u20133936. https:\/\/doi.org\/10.1007\/s12035-018-1342-z","journal-title":"Mol Neurobiol"},{"key":"6262_CR51","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.3390\/ijms20061305","volume":"20","author":"B Salehi","year":"2019","unstructured":"Salehi B, Venditti A, Sharifi-Rad M et al (2019) The therapeutic potential of apigenin. Int J Mol Sci 20:1305. https:\/\/doi.org\/10.3390\/ijms20061305","journal-title":"Int J Mol Sci"},{"key":"6262_CR52","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/nrn.2017.42","volume":"18","author":"A Satoh","year":"2017","unstructured":"Satoh A, Imai S, Guarente L (2017) The brain, sirtuins, and ageing. Nat Rev Neurosci 18:362. https:\/\/doi.org\/10.1038\/nrn.2017.42","journal-title":"Nat Rev Neurosci"},{"key":"6262_CR53","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1111\/j.1471-4159.2011.07581.x","volume":"120","author":"B Sheng","year":"2012","unstructured":"Sheng B, Wang X, Su B et al (2012) Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer\u2019s disease. J Neurochem 120:419\u2013429. https:\/\/doi.org\/10.1111\/j.1471-4159.2011.07581.x","journal-title":"J Neurochem"},{"key":"6262_CR54","doi-asserted-by":"publisher","unstructured":"Shin J-H, Ko HS, Kang H, Lee Y, Lee Y-I, Pletinkova O, Troconso JC, Dawson VL, Dawson TM (2011) Paris (ZNF746) repression of PGC-1\u03b1 contributes to neurodegeneration in Parkinson\u2019s disease. Cell 144(5):689\u2013702. https:\/\/doi.org\/10.1016\/j.cell.2011.02.010","DOI":"10.1016\/j.cell.2011.02.010"},{"key":"6262_CR55","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3389\/fncel.2018.00196","volume":"12","author":"E Sidorova-Darmos","year":"2018","unstructured":"Sidorova-Darmos E, Sommer R, Eubanks JH (2018) The role of SIRT3 in the brain under physiological and pathological conditions. Front Cell Neurosci 12:196. https:\/\/doi.org\/10.3389\/fncel.2018.00196","journal-title":"Front Cell Neurosci"},{"issue":"37","key":"6262_CR56","doi-asserted-by":"publisher","first-page":"11696","DOI":"10.1073\/pnas.1500624112","volume":"112","author":"DA Stevens","year":"2015","unstructured":"Stevens DA, Lee Y, Kang HC, Lee BD, Lee YI, Bower A, Jiang H, Kang S-U, Andrabi SA, Dawson VL, Shin J-H, Dawson TM (2015) Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration. Proceedings of the National Academy of Sciences 112(37):11696\u201311701. https:\/\/doi.org\/10.1073\/pnas.1500624112","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"6262_CR57","doi-asserted-by":"publisher","first-page":"5574","DOI":"10.2174\/1381612820666140305224906","volume":"20","author":"M Uittenbogaard","year":"2014","unstructured":"Uittenbogaard M, Chiaramello A (2014) Mitochondrial biogenesis: a therapeutic target for neurodevelopmental disorders and neurodegenerative diseases. Curr Pharm Des 20:5574\u20135593","journal-title":"Curr Pharm Des"},{"issue":"3","key":"6262_CR58","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1113\/JP271301","volume":"594","author":"C V\u00e1squez-Trincado","year":"2016","unstructured":"V\u00e1squez-Trincado C, Garc\u00eda-Carvajal I, Pennanen C et al (2016) Mitochondrial dynamics, mitophagy and cardiovascular disease. J Physiol 594(3):509\u2013525. https:\/\/doi.org\/10.1113\/JP271301","journal-title":"J Physiol"},{"key":"6262_CR59","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.ejphar.2017.08.027","volume":"814","author":"W Wadie","year":"2017","unstructured":"Wadie W, El-Tanbouly DM (2017) Vinpocetine mitigates proteinuria and podocytes injury in a rat model of diabetic nephropathy. Eur J Pharmacol 814:187\u2013195. https:\/\/doi.org\/10.1016\/j.ejphar.2017.08.027","journal-title":"Eur J Pharmacol"},{"issue":"13","key":"6262_CR60","doi-asserted-by":"publisher","first-page":"11649","DOI":"10.1074\/jbc.M110.144238","volume":"286","author":"H Wang","year":"2011","unstructured":"Wang H, Song P, Du L et al (2011) Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease. J Biol Chem 286(13):11649\u201311658. https:\/\/doi.org\/10.1074\/jbc.M110.144238","journal-title":"J Biol Chem"},{"issue":"6","key":"6262_CR61","doi-asserted-by":"publisher","first-page":"605","DOI":"10.5582\/bst.2018.01263","volume":"12","author":"C Wang","year":"2018","unstructured":"Wang C, Yang Y, Zhang Y et al (2018) Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1\/Parkin-dependent mitophagy in primary chondrocytes. Biosci Trends 12(6):605\u2013612. https:\/\/doi.org\/10.5582\/bst.2018.01263","journal-title":"Biosci Trends"},{"issue":"11","key":"6262_CR62","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1093\/gerona\/glaa214","volume":"75","author":"D Wang","year":"2020","unstructured":"Wang D, Yang Y, Zou X et al (2020) Antioxidant apigenin relieves age-related muscle atrophy by inhibiting oxidative stress and hyperactive mitophagy and apoptosis in skeletal muscle of mice. J Gerontol - Series A Biol Sci Med Sci 75(11):2081\u20132088. https:\/\/doi.org\/10.1093\/gerona\/glaa214","journal-title":"J Gerontol - Series A Biol Sci Med Sci"},{"key":"6262_CR63","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/sj.bjp.0702309","volume":"126","author":"K Yamada","year":"1999","unstructured":"Yamada K, Tanaka T, Mamiya T et al (1999) Improvement by nefiracetam of \u03b2-amyloid-(1\u201342)-induced learning and memory impairments in rats. Br J Pharmacol 126:235\u2013244. https:\/\/doi.org\/10.1038\/sj.bjp.0702309","journal-title":"Br J Pharmacol"},{"key":"6262_CR64","doi-asserted-by":"publisher","first-page":"2346","DOI":"10.3390\/cells9112346","volume":"9","author":"A Yammine","year":"2020","unstructured":"Yammine A, Zarrouk A, Nury T et al (2020) Prevention by dietary polyphenols (resveratrol, quercetin, apigenin) against 7-ketocholesterol-induced oxiapoptophagy in neuronal N2a cells: potential interest for the treatment of neurodegenerative and age-related diseases. Cells 9:2346. https:\/\/doi.org\/10.3390\/cells9112346","journal-title":"Cells"},{"issue":"19","key":"6262_CR65","doi-asserted-by":"publisher","first-page":"7070","DOI":"10.1073\/pnas.0711845105","volume":"105","author":"Y Yang","year":"2008","unstructured":"Yang Y, Ouyang Y, Yang L et al (2008) Pink1 regulates mitochondrial dynamics through interaction with the fission\/fusion machinery. Proc Natl Acad Sci USA 105(19):7070\u20137075. https:\/\/doi.org\/10.1073\/pnas.0711845105","journal-title":"Proc Natl Acad Sci USA"},{"key":"6262_CR66","doi-asserted-by":"publisher","unstructured":"Yu W, Gao B, Li N et al (2017) Sirt3 deficiency exacerbates diabetic cardiac dysfunction: role of Foxo3A-Parkin-mediated mitophagy. Biochimica Et Biophysica Acta - Molecular Basis of Disease 8:1973\u20131983. https:\/\/doi.org\/10.1016\/j.bbadis.2016.10.021","DOI":"10.1016\/j.bbadis.2016.10.021"},{"key":"6262_CR67","doi-asserted-by":"publisher","first-page":"9949","DOI":"10.3390\/molecules18089949","volume":"18","author":"L Zhao","year":"2013","unstructured":"Zhao L, Wang J-L, Liu R et al (2013) Neuroprotective, anti-amyloidogenic and neurotrophic effects of apigenin in an Alzheimer\u2019s disease mouse model. Molecules 18:9949\u20139965. https:\/\/doi.org\/10.3390\/molecules18089949","journal-title":"Molecules"},{"key":"6262_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-42286-8","volume":"9","author":"J Zhao","year":"2019","unstructured":"Zhao J, Bi W, Xiao S et al (2019) Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice. Sci Rep 9:1\u201312. https:\/\/doi.org\/10.1038\/s41598-019-42286-8","journal-title":"Sci Rep"},{"issue":"2","key":"6262_CR69","doi-asserted-by":"publisher","first-page":"601","DOI":"10.3390\/ijms22020601","volume":"22","author":"F Zhao","year":"2021","unstructured":"Zhao F, Austria Q, Wang W, Zhu X (2021) Mfn2 overexpression attenuates mptp neurotoxicity in vivo. Int J Mol Sci 22(2):601. https:\/\/doi.org\/10.3390\/ijms22020601","journal-title":"Int J Mol Sci"},{"issue":"11","key":"6262_CR70","doi-asserted-by":"publisher","first-page":"8103","DOI":"10.4049\/jimmunol.177.11.8103","volume":"177","author":"H Zhou","year":"2006","unstructured":"Zhou H, Lapointe BM, Clark SR et al (2006) A requirement for microglial TLR4 in leukocyte recruitment into brain in response to lipopolysaccharide. J Immunol 177(11):8103\u20138110. https:\/\/doi.org\/10.4049\/jimmunol.177.11.8103","journal-title":"J Immunol"},{"key":"6262_CR71","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1038\/s41418-018-0086-7","volume":"25","author":"H Zhou","year":"2018","unstructured":"Zhou H, Zhu P, Wang J et al (2018) Pathogenesis of cardiac ischemia reperfusion injury is associated with CK2\u03b1-disturbed mitochondrial homeostasis via suppression of FUNDC1-related mitophagy. Cell Death Differ 25:1080\u20131093. https:\/\/doi.org\/10.1038\/s41418-018-0086-7","journal-title":"Cell Death Differ"},{"key":"6262_CR72","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.4161\/auto.24135","volume":"9","author":"J Zhu","year":"2013","unstructured":"Zhu J, Wang KZQ, Chu CT (2013) After the banquet: mitochondrial biogenesis, mitophagy, and cell survival. Autophagy 9:1663\u20131676. https:\/\/doi.org\/10.4161\/auto.24135","journal-title":"Autophagy"},{"key":"6262_CR73","doi-asserted-by":"publisher","first-page":"660","DOI":"10.4161\/auto.6.5.12242","volume":"6","author":"E Ziviani","year":"2010","unstructured":"Ziviani E, Whitworth AJ (2010) How could Parkin-mediated ubiquitination of mitofusin promote mitophagy? Autophagy 6:660\u2013662. https:\/\/doi.org\/10.4161\/auto.6.5.12242","journal-title":"Autophagy"},{"issue":"11","key":"6262_CR74","doi-asserted-by":"publisher","first-page":"5018","DOI":"10.1073\/pnas.0913485107","volume":"107","author":"E Ziviani","year":"2010","unstructured":"Ziviani E, Tao RN, Whitworth AJ (2010) Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin. Proc Natl Acad Sci USA 107(11):5018\u20135023. https:\/\/doi.org\/10.1073\/pnas.0913485107","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-022-06262-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-022-06262-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-022-06262-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T05:07:03Z","timestamp":1668661623000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-022-06262-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,26]]},"references-count":74,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["6262"],"URL":"https:\/\/doi.org\/10.1007\/s00213-022-06262-x","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,26]]},"assertion":[{"value":"25 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}