{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T20:43:35Z","timestamp":1786308215493,"version":"build-2736575974"},"reference-count":137,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Sciences and Engineering Research Council","award":["DGECR-2019-00207"],"award-info":[{"award-number":["DGECR-2019-00207"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Rationale<\/jats:title>\n                <jats:p>The female menstrual or estrous cycle and its associated fluctuations in circulating estradiol (E2), progesterone, and other gonadal hormones alter orexin or hypocretin peptide production and receptor activity. Depending on the estrous cycle phase, the transcription of prepro-orexin mRNA, post-translational modification of orexin peptide, and abundance of orexin receptors change in a brain region-specific manner. The most dramatic changes occur in the hypothalamus, which is considered the starting point of the hypothalamic-pituitary\u2013gonadal axis as well as the hub of orexin-producing neurons. Thus, hypothalamus-regulated behaviors, including arousal, feeding, reward processing, and the stress response depend on coordinated efforts between E2, progesterone, and the orexin system. Given the rise of orexin therapeutics for various neuropsychiatric conditions including insomnia and affective disorders, it is important to delineate the behavioral outcomes of this drug class in both sexes, as well as within different time points of the female reproductive cycle.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>Summarize how the menstrual or estrous cycle affects orexin system functionality in animal models in order to predict how orexin pharmacotherapies exert varying degrees of behavioral effects across the dynamic hormonal milieu.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00213-022-06296-1","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T09:10:36Z","timestamp":1672045836000},"page":"15-25","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Estradiol-dependent hypocretinergic\/orexinergic behaviors throughout the estrous cycle"],"prefix":"10.1007","volume":"240","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3941-9151","authenticated-orcid":false,"given":"Hye Ji J.","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel A.","family":"Dickie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Laprairie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"issue":"1","key":"6296_CR1","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.yhbeh.2014.04.016","volume":"66","author":"A Abdulhay","year":"2014","unstructured":"Abdulhay A, Benton NA, Klingerman CM, Krishnamoorthy K, Brozek JM, Schneider JE (2014) Estrous cycle fluctuations in sex and ingestive behavior are accentuated by exercise or cold ambient temperatures. Horm Behav 66(1):135\u2013147","journal-title":"Horm Behav"},{"issue":"5","key":"6296_CR2","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1523\/JNEUROSCI.2988-17.2017","volume":"38","author":"C Adams","year":"2018","unstructured":"Adams C, Stroberg W, DeFazio RA, Schnell S, Moenter SM (2018) Gonadotropin-releasing hormone (GnRH) neuron excitability is regulated by estradiol feedback and kisspeptin. J Neurosci 38(5):1249\u20131263","journal-title":"J Neurosci"},{"key":"6296_CR3","doi-asserted-by":"crossref","unstructured":"Ajayi AF, Akhigbe RE (2020) Staging of the estrous cycle and induction of estrus in experimental rodents: an update. Fert Res Pract 6:5","DOI":"10.1186\/s40738-020-00074-3"},{"key":"6296_CR4","doi-asserted-by":"crossref","unstructured":"Alexandre C, Andermann ML, Scammell TE (2013) Control of arousal by the orexin neurons. Curr Opin Neurobiol 23(5):752\u2013759","DOI":"10.1016\/j.conb.2013.04.008"},{"key":"6296_CR5","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.alcohol.2018.04.003","volume":"73","author":"LR Amodeo","year":"2018","unstructured":"Amodeo LR, Wills DN, Sanchez-Alavez M, Nguyen W, Conti B, Ehlers CL (2018) Intermittent voluntary ethanol consumption combined with ethanol vapor exposure during adolescence increases drinking and alters other behaviors in adulthood in female and male rats. Alcohol 73:57\u201366","journal-title":"Alcohol"},{"issue":"5","key":"6296_CR6","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1037\/1064-1297.15.5.472","volume":"15","author":"JJ Anker","year":"2007","unstructured":"Anker JJ, Larson EB, Gliddon LA, Carroll ME (2007) Effects of progesterone on the reinstatement of cocaine-seeking behavior in female rats. Exp Clin Psychopharmacol 15(5):472\u2013480","journal-title":"Exp Clin Psychopharmacol"},{"issue":"10","key":"6296_CR7","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1007\/s00125-014-3335-4","volume":"57","author":"AM Arafat","year":"2014","unstructured":"Arafat AM, Kacsmarek P, Skrzypski M, Pruszy\u0144ska-Ozmalek E, Koloziejski P, Adamidou A, Ruhla S, Szczepankieqicz D, Sassek M, Billert M et al (2014) Glucagon regulates orexin A secretion in humans and rodents. Diabetologia 57(10):2108\u20132116","journal-title":"Diabetologia"},{"key":"6296_CR8","doi-asserted-by":"crossref","unstructured":"Arthaud S, Villalba M, Blondet C, Morel AL, Peyron C (2022) Effects of sex and estrous cycle on sleep and cataplexy in narcoleptic mice. Sleep 45(7):zsac089","DOI":"10.1093\/sleep\/zsac089"},{"key":"6296_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/hbeh.2002.1799","volume":"42","author":"L Asarian","year":"2002","unstructured":"Asarian L, Geary N (2002) Cyclic estradiol treatment normalizes body weight and restores physiological patterns of spontaneous feeding and sexual receptivity in ovar- iectomized rats. Horm Behav 42:1\u201312","journal-title":"Horm Behav"},{"issue":"1471","key":"6296_CR10","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1098\/rstb.2006.1860","volume":"361","author":"L Asarian","year":"2006","unstructured":"Asarian L, Geary N (2006) Modulation of appetite by gonadal steroid hormones. Proc R Soc Lond B Biol Sci 361(1471):1251\u20131263","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"6296_CR11","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.physbeh.2017.09.025","volume":"187","author":"DA Bangasser","year":"2018","unstructured":"Bangasser DA, Eck SR, Telenson AM, Salvatore M (2018) Sex differences in stress regulation of arousal and cognition. Physiol Behav 187:42\u201350","journal-title":"Physiol Behav"},{"key":"6296_CR12","doi-asserted-by":"crossref","unstructured":"Baram T, Koch Y (1977) Evidence for the dependence of serum luteinizing hormone surge on a transient, enhanced secretion of gonadotropin-releasing hormone from the hypothalamus. Neuroendocrinology 23(3):151\u2013156","DOI":"10.1159\/000122663"},{"key":"6296_CR13","doi-asserted-by":"crossref","unstructured":"Becker JB (2016) Sex differences in addiction. Dialogues Clin Neurosci 18(4):395\u2013402","DOI":"10.31887\/DCNS.2016.18.4\/jbecker"},{"issue":"1","key":"6296_CR14","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/2042-6410-3-14","volume":"3","author":"JB Becker","year":"2012","unstructured":"Becker JB, Perry AN, Westenbroek C (2012) Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis. Biol Sex Differ 3(1):14","journal-title":"Biol Sex Differ"},{"key":"6296_CR15","doi-asserted-by":"crossref","unstructured":"Benmansour S, Piotrowski JP, Altamirano AV, Frazer A (2009) Impact of ovarian hormones on the modulation of the serotonin transporter by fluvoxamine. Neuropsychopharmacology 34(3):555\u2013564","DOI":"10.1038\/npp.2008.23"},{"key":"6296_CR16","doi-asserted-by":"crossref","unstructured":"Bielert C, Busse C (1983) Influences of ovarian hormones on the food intake and feeding of captive and wild female chacma baboons (Papio ursinus). Physiol Behav 30(1):103\u2013111","DOI":"10.1016\/0031-9384(83)90045-8"},{"issue":"2","key":"6296_CR17","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0031-9384(76)90064-0","volume":"17","author":"JD Blaustein","year":"1976","unstructured":"Blaustein JD, Wade GN (1976) Ovarian impacts on the meal patterns of the female rats. Physiol Behav 17(2):201\u2013208","journal-title":"Physiol Behav"},{"issue":"4","key":"6296_CR18","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.neuron.2006.01.016","volume":"29","author":"SL Borgland","year":"2006","unstructured":"Borgland SL, Taha SA, Sarti F, Fields HL, Bonci A (2006) Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine. Neuron 29(4):589\u2013601","journal-title":"Neuron"},{"key":"6296_CR19","doi-asserted-by":"crossref","unstructured":"Brann DW, Lu Y, Wang J, Zhang Q, Thakkar R, Sareddy GR, Pratap UP, Tekmal RR, Vadlamudi RK (2021) Brain-derived estrogen and neural function. Neurosci Biobehav Rev 132:793\u2013817","DOI":"10.1016\/j.neubiorev.2021.11.014"},{"key":"6296_CR20","doi-asserted-by":"crossref","unstructured":"Brot MD, Koob GF, Britton KT (1995) Anxiolytic effects of steroid hormones during the estrous cycle. Interactions with ethanol. Recent Dev Alcohol\n12:243\u201325","DOI":"10.1007\/0-306-47138-8_16"},{"issue":"3","key":"6296_CR21","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1095\/biolreprod17.3.309","volume":"17","author":"JF Bruni","year":"1977","unstructured":"Bruni JF, Huang HH, Marshall S, Meites J (1977) Effects of single and multiple injections of synthetic GnRH on serum LH, FSH and testosterone in young and old male rats. Biol Reprod 17(3):309\u2013312","journal-title":"Biol Reprod"},{"key":"6296_CR22","doi-asserted-by":"crossref","unstructured":"Burdakov D (2004) Electrical signaling in central orexin\/hypocretin circuits: tuning arousal and appetite to fit the environment. Neuroscientist 10(4):286\u2013291","DOI":"10.1177\/1073858404263597"},{"key":"6296_CR23","doi-asserted-by":"crossref","unstructured":"Butera PC (2010) Estradiol and the control of food intake. Physiol Behav 99(2):175\u2013180","DOI":"10.1016\/j.physbeh.2009.06.010"},{"issue":"4","key":"6296_CR24","doi-asserted-by":"publisher","first-page":"e35538","DOI":"10.1371\/journal.pone.0035538","volume":"7","author":"SL Byers","year":"2012","unstructured":"Byers SL, Wiles MV, Dunn SL, Taft RA (2012) Mouse estrous cycle identification tool and images. PLoS One 7(4):e35538","journal-title":"PLoS One"},{"issue":"1","key":"6296_CR25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0304-3940(99)00403-6","volume":"269","author":"I Camacho-Arroyo","year":"1999","unstructured":"Camacho-Arroyo I, Hern\u00e1ndez-Gollas R, Manjarrez J, Alvarado R (1999) Progesterone microinjections into the pontine reticular formation modify sleep in male and female rats. Neurosci Lett 269(1):9\u201312","journal-title":"Neurosci Lett"},{"issue":"3","key":"6296_CR26","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s00213-002-1030-5","volume":"161","author":"ME Carroll","year":"2002","unstructured":"Carroll ME, Morgan AD, Lynch WJ, Campbell UC, Dess NK (2002) Intravenous cocaine and heroin self-administration in rats selectively bred for differential saccharin intake: phenotype and sex differences. Psychopharmacology 161(3):304\u2013313","journal-title":"Psychopharmacology"},{"key":"6296_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jchemneu.2015.03.002","volume":"66\u201367","author":"SS Ch'ng","year":"2015","unstructured":"Ch\u2019ng SS, Lawrence AJ (2015) Distribution of the orexin-1 receptor (OX1R) in the mouse forebrain and rostral brainstem: a characterization of OX1R-eGFP mice. J Chem Neuroanat 66\u201367:1\u20139","journal-title":"J Chem Neuroanat"},{"issue":"1","key":"6296_CR28","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.brainres.2006.05.054","volume":"1103","author":"J Chen","year":"2006","unstructured":"Chen J, Karteris E, Collins D, Randeva HS (2006) Differential expression of mouse orexin receptor type-2 (OX2R) variants in the mouse brain. Brain Res 1103(1):20\u201324","journal-title":"Brain Res"},{"issue":"5","key":"6296_CR29","first-page":"511","volume":"40","author":"M Coryn","year":"1979","unstructured":"Coryn M, Spincemaille J, Vandeplassche M (1979) Estrous cycle, pregnancy and parturition in the mare, cow and sow: progesterone and estrogens. Ann Endocrinol (paris) 40(5):511\u2013512","journal-title":"Ann Endocrinol (paris)"},{"issue":"2","key":"6296_CR30","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1073\/pnas.96.2.748","volume":"96","author":"Y Date","year":"1999","unstructured":"Date Y, Ueta Y, Yamashita H, Yamaguchi H, Matsukura S, Kangawa K, Sakurai T, Yanagisawa M, Nakazato M (1999) Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. PNAS 96(2):748\u2013753","journal-title":"PNAS"},{"issue":"1","key":"6296_CR31","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1073\/pnas.95.1.322","volume":"95","author":"L de Lecea","year":"1998","unstructured":"de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS 2nd, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG (1998) The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. PNAS 95(1):322\u2013327","journal-title":"PNAS"},{"issue":"1","key":"6296_CR32","doi-asserted-by":"publisher","first-page":"4163","DOI":"10.1038\/s41467-022-31591-y","volume":"13","author":"R De Luca","year":"2022","unstructured":"De Luca R, Nardone S, Grace KP, Venner A, Cristofolini M, Bandaru SS, Sohn LT, Kong D, Mochizuki T, Viberti B, Zhu L, Zito A, Scammell TE, Saper CB, Lowell BB, Fuller PM, Arrigoni E (2022) Orexin neurons inhibit sleep to promote arousal. Nat Commun 13(1):4163","journal-title":"Nat Commun"},{"issue":"4","key":"6296_CR33","doi-asserted-by":"publisher","first-page":"R1328","DOI":"10.1152\/ajpregu.90576.2008","volume":"295","author":"S Deurveilher","year":"2008","unstructured":"Deurveilher S, Cumyn EM, Peers T, Rusak B, Semba K (2008) Estradiol replacement enhances sleep deprivation-induces c-Fos immunoreactivity in forebrain arousal regions of ovariectomized rats. Am J Physiol Regul Integr Comp Physiol 295(4):R1328\u2013R1340","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"6296_CR34","unstructured":"Deurveilher S, Rusak B, Semba K (2009) Estradiol and progesterone modulate spontaneous sleep patterns and recovery from sleep deprivation in ovariectomized rats. Sleep 32(7):865\u2013877"},{"issue":"4","key":"6296_CR35","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/S0091-3057(00)00283-5","volume":"66","author":"G D\u00edaz-V\u00e9liz","year":"2000","unstructured":"D\u00edaz-V\u00e9liz G, Butr\u00f3n S, Benavides MS, Dussaubat N, Mora S (2000) Gender, estrous cycle, ovariectomy, and ovarian hormones influence the effects of diazepam on avoidance conditioning in rats. Pharmacol Biochem Behav 66(4):887\u2013892","journal-title":"Pharmacol Biochem Behav"},{"key":"6296_CR36","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3389\/fnins.2018.00084","volume":"12","author":"N Diotel","year":"2018","unstructured":"Diotel N, Charlier TD, Lefebvre d\u2019Hellencourt C, Couret D, Trudeau VL, Nicolau JC, Meilhac O, Kah O, Pellegrini E (2018) Steroid transport, local synthesis, and signaling within the brain: roles in neurogenesis, neuroprotection, and sexual behaviors. Front Neurosci 12:84","journal-title":"Front Neurosci"},{"issue":"1","key":"6296_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1037\/0735-7044.120.1.1","volume":"120","author":"A Easton","year":"2006","unstructured":"Easton A, Dwyer E, Pfaff DW (2006) Estradiol and orexin-2 saporin actions on multiple forms of behavioral arousal in female mice. Behav Neurosci 120(1):1\u20139","journal-title":"Behav Neurosci"},{"issue":"4","key":"6296_CR38","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1111\/j.1471-0528.2009.02474.x","volume":"117","author":"MSh El-Sedeek","year":"2010","unstructured":"El-Sedeek MSh, Korish AA, Deef MM (2010) Plasma orexin-A levels in postmenopausal women: possible interaction with estrogen and correlation with cardiovascular risk status. BJOG 117(4):488\u2013492","journal-title":"BJOG"},{"issue":"2","key":"6296_CR39","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s00213-010-2048-8","volume":"214","author":"RA Espa\u00f1a","year":"2011","unstructured":"Espa\u00f1a RA, Melchior JR, Roberts DC, Jones SR (2011) Hypocretin 1\/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration. Psychopharmacology 214(2):415\u2013426","journal-title":"Psychopharmacology"},{"issue":"2","key":"6296_CR40","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/S0006-8993(02)02653-7","volume":"943","author":"RA Espa\u00f1a","year":"2002","unstructured":"Espa\u00f1a RA, Plahn S, Berridge CW (2002) Circadian-dependent and circadian-independent behavioral actions of hypocretin\/orexin. Brain Res 943(2):224\u2013236","journal-title":"Brain Res"},{"issue":"4","key":"6296_CR41","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s00213-001-0944-7","volume":"159","author":"SM Evans","year":"2002","unstructured":"Evans SM, Haney M, Foltin RW (2002) The effects of smoked cocaine during the follicular and luteal phases of the menstrual cycle in women. Psychopharmacology 159(4):397\u2013406","journal-title":"Psychopharmacology"},{"issue":"6","key":"6296_CR42","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/0031-9384(86)90469-5","volume":"36","author":"M Fantino","year":"1986","unstructured":"Fantino M, Brinnel H (1986) Body weight set-point changes during the ovarian cycle: experimental study of rats using hoarding behavior. Physiol Behav 36(6):991\u2013996","journal-title":"Physiol Behav"},{"key":"6296_CR43","doi-asserted-by":"publisher","first-page":"104694","DOI":"10.1016\/j.psyneuen.2020.104694","volume":"119","author":"RJ Flores","year":"2020","unstructured":"Flores RJ, Cruz B, Uribe KP, Correa VL, Arreguin MC, Carcoba LM, Mendez IA, O\u2019Dell LE (2020) Estradiol promotes and progesterone reduces anxiety-like behavior produced by nicotine withdrawal in female rats. Psychoneuroendocrinology 119:104694","journal-title":"Psychoneuroendocrinology"},{"issue":"2","key":"6296_CR44","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1037\/0735-7044.118.2.306","volume":"118","author":"CA Frye","year":"2004","unstructured":"Frye CA, Walf AA (2004) Estrogen and\/or progesterone administered systemically or to the amygdala can have anxiety-, fear-, and pain-reducing effects in ovariectomized rats. Behav Neurosci 118(2):306\u2013313","journal-title":"Behav Neurosci"},{"key":"6296_CR45","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3389\/fnins.2015.00088","volume":"9","author":"A Fukushima","year":"2015","unstructured":"Fukushima A, Hagiwara H, Fujioka H, Kimura F, Akema T, Hunabashi T (2015) Sex differences in feeding behaviour in rats: the relationship with neuronal activation in the hypothalamus. Front Neurosci 9:88","journal-title":"Front Neurosci"},{"issue":"1","key":"6296_CR46","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.neulet.2009.07.035","volume":"463","author":"T Funabashi","year":"2009","unstructured":"Funabashi T, Hagiqara H, Mogi K, Mitsushima D, Shinohara K, Kimura F (2009) Sex differences in the response of orexin neurons in the lateral hypothalamic area and feeding behavior to fasting. Neurosci Lett 463(1):31\u201334","journal-title":"Neurosci Lett"},{"issue":"6","key":"6296_CR47","doi-asserted-by":"publisher","first-page":"R1634","DOI":"10.1152\/ajpregu.00219.2010","volume":"299","author":"ED Giles","year":"2010","unstructured":"Giles ED, Jackman MR, Johnson GC, Schedin PJ, Houser JL, MacLean PS (2010) Effect of the estrous cycle and surgical ovariectomy on energy balance, fuel utilization, and physical activity in lean and obese female rats. Am J Physiol Regul Integr Comp Physiol 299(6):R1634\u2013R1642","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"12","key":"6296_CR48","first-page":"1072","volume":"5","author":"EM Glover","year":"2020","unstructured":"Glover EM (2020) Unlocking the potential of estradiol in posttraumatic stress disorder symptom reduction: is habituation the key? Biol Psychiatry Cogn Neurosci Neuroimaging 5(12):1072\u20131074","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"key":"6296_CR49","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.yfrne.2018.06.003","volume":"51","author":"LA Grafe","year":"2018","unstructured":"Grafe LA, Bhatnagar S (2018) Orexins and Stress Front Neuroendocrin 51:132\u2013145","journal-title":"Orexins and Stress Front Neuroendocrin"},{"key":"6296_CR50","doi-asserted-by":"crossref","unstructured":"Grafe LA, Eacret D, Dobkin J, Bhatnagar S (2018) Reduced orexin system function contributes to resilience to repeated social stress. Eneuro 5(2):ENEURO.0273-17.2018","DOI":"10.1523\/ENEURO.0273-17.2018"},{"issue":"1\u20133","key":"6296_CR51","first-page":"1531","volume":"104","author":"AC Haynes","year":"2002","unstructured":"Haynes AC, Chapman H, Taylor C, Moore GB, Cawthorne MA, Tadayyon M, Clapham JC, Arch JR (2002) Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob\/ob mice. Regul Pept 104(1\u20133):1531\u20131559","journal-title":"Regul Pept"},{"issue":"3","key":"6296_CR52","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.maturitas.2011.12.016","volume":"71","author":"AL Hirschberg","year":"2012","unstructured":"Hirschberg AL (2012) Sex hormones, appetite and eating behaviour in women. Maturitas 71(3):248\u2013256","journal-title":"Maturitas"},{"key":"6296_CR53","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1523\/JNEUROSCI.19-03-01072.1999","volume":"19","author":"TL Horvath","year":"1999","unstructured":"Horvath TL, Diano S, van den Pol AN (1999) Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. J Neurosci 19:1072\u20131087","journal-title":"J Neurosci"},{"issue":"1","key":"6296_CR54","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/sj.npp.1300301","volume":"29","author":"M Hu","year":"2004","unstructured":"Hu M, Crombag HS, Robinson TE, Becker JB (2004) Biological basis of sex differences in the propensity to self-administer cocaine. Neuropsychopharmacology 29(1):81\u201385","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"6296_CR55","doi-asserted-by":"publisher","first-page":"E1520","DOI":"10.1152\/ajpendo.00497.2006","volume":"292","author":"NA Hunnell","year":"2007","unstructured":"Hunnell NA, Rockcastle NJ, McCormick KN, Sinko LK, Sullivan EL, Cameron JL (2007) Physical activity of adult female rhesus monkeys (Macaca mulatta) across the menstrual cycle. Am J Physiol Endocrinol Metab 292(6):E1520\u2013E1525","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"6296_CR56","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1006\/bbrc.2000.2412","volume":"270","author":"T Ida","year":"2000","unstructured":"Ida T, Nakahara K, Murakami T, Hanada R, Nakazato M, Murakami N (2000) Possible involvement of orexin in the stress reaction in rats. Biochem Biophys Res Commun 270(1):318\u2013323","journal-title":"Biochem Biophys Res Commun"},{"key":"6296_CR57","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.brainres.2018.04.002","volume":"1690","author":"T Ikeno","year":"2018","unstructured":"Ikeno T, Yan L (2018) A comparison of the orexin receptor distribution in the brain between diurnal Nile grass rats (Arvicanthis niloticus) and nocturnal mice (Mus musculus). Brain Res 1690:89\u201395","journal-title":"Brain Res"},{"issue":"4","key":"6296_CR58","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s00737-020-01094-0","volume":"24","author":"KM Joyce","year":"2021","unstructured":"Joyce KM, Good KP, Tibbo P, Brown J, Stewart SH (2021) Addictive behaviors across the menstrual cycle: a systematic review. Arch Womens Ment Health 24(4):529\u2013542","journal-title":"Arch Womens Ment Health"},{"key":"6296_CR59","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/B978-0-12-394623-2.00004-4","volume":"89","author":"T Kaminski","year":"2012","unstructured":"Kaminski T, Smolinska N (2012) Expression of orexin receptors in the pituitary. Vitam Horm 89:61\u201373","journal-title":"Vitam Horm"},{"issue":"3","key":"6296_CR60","first-page":"363","volume":"61","author":"T Kaminski","year":"2010","unstructured":"Kaminski T, Smolinska N, Nitkiewicz A, Przala J (2010a) Expression of orexin receptors 1 (OX1R) and 2 (OX2R) in the porcine hypothalamus during the oestrous cycle. J Physiol Pharmacol 61(3):363\u2013371","journal-title":"J Physiol Pharmacol"},{"issue":"1\u20132","key":"6296_CR61","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.anireprosci.2009.03.007","volume":"117","author":"T Kaminski","year":"2010","unstructured":"Kaminski T, Smolinska N, Nitkiewicz A, Przala J (2010b) Expression of orexin receptors 1 (OX1R) and 2 (OX2R) in the porcine pituitary during the oestrous cycle. Anim Reprod Sci 117(1\u20132):111\u2013118","journal-title":"Anim Reprod Sci"},{"key":"6296_CR62","doi-asserted-by":"publisher","first-page":"790546","DOI":"10.3389\/fnins.2021.790546","volume":"15","author":"HJ Kim","year":"2021","unstructured":"Kim HJ, Zagzoog A, Smolyakova AM, Ezeaka UC, Benko MJ, Holt T, Laprairie RB (2021) In vivo evidence for brain region-specific molecular interactions between cannabinoid and orexin receptors. Front Neurosci 15:790546","journal-title":"Front Neurosci"},{"issue":"3","key":"6296_CR63","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1210\/jc.2017-02299","volume":"103","author":"SH Kim","year":"2018","unstructured":"Kim SH, Lundgren JA, Bhabhra R, Collins JS, Patrie JT, Burt Solorzano CM, Marshall JC, McCartney CR (2018) Progesterone-mediated inhibition of the GnRH pulse generator: differential sensitivity as a function of sleep status. J Clin Endocrinol Metab 103(3):1112\u20131121","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"6296_CR64","first-page":"205","volume":"295","author":"B Kinkead","year":"2000","unstructured":"Kinkead B, Lorch SM, Owens MJ, Nemerof CB (2000) Sex- and estrous cycle-related differences in the effects of acute antipsychotic drug administration on neurotensin-containing neurons in the rat brain. JPET 295(1):205\u2013211","journal-title":"JPET"},{"key":"6296_CR65","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/B978-0-12-820107-7.00015-X","volume":"180","author":"HW Korf","year":"2021","unstructured":"Korf HW, M\u00f8ller M (2021) Arcuate nucleus, median eminence, and hypophysial pars tuberalis. Handb Clin Neurol 180:227\u2013251","journal-title":"Handb Clin Neurol"},{"key":"6296_CR66","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1002\/(SICI)1097-4695(19980905)36:3<357::AID-NEU5>3.0.CO;2-V","volume":"36","author":"N Laflamme","year":"1998","unstructured":"Laflamme N, Nappi RE, Drolet G, Labrie C, Rivest S (1998) Expression and neuropeptidergic characterization of estrogen receptors (ER\u03b1 and ER\u03b2) throughout the rat brain: anatomical evidence of distinct roles of each subtype. J Neurobiol 36:357\u2013378","journal-title":"J Neurobiol"},{"issue":"4 Pt 1","key":"6296_CR67","first-page":"E763","volume":"271","author":"M Lancel","year":"1996","unstructured":"Lancel M, Faulhaber J, Holsboer F, Rupprecht R (1996) Progesterone induces changes in sleep comparable to those of agonistic GABAA receptor modulators. Am J Physiol 271(4 Pt 1):E763\u2013E772","journal-title":"Am J Physiol"},{"key":"6296_CR68","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1152\/jn.00873.2006","volume":"97","author":"ZW Liu","year":"2007","unstructured":"Liu ZW, Gao XB (2007) Adenosine inhibits activity of hypocretin\/orexin neurons by the A1 receptor in the lateral hypothalamus: a possible sleep-promoting effect. J Neurophysiol 97:837\u2013848","journal-title":"J Neurophysiol"},{"key":"6296_CR69","doi-asserted-by":"publisher","first-page":"711065","DOI":"10.3389\/fpsyt.2021.711065","volume":"12","author":"TA Lovick","year":"2021","unstructured":"Lovick TA, Zangrossi H Jr (2021) Effect of estrous cycle on behavior of females in rodent tests of anxiety. Front Psychiatry 12:711065","journal-title":"Front Psychiatry"},{"key":"6296_CR70","doi-asserted-by":"crossref","unstructured":"Maleszka A, Smolinska N, Nitkiewicz A, Kiezun M, Chojnowska K, Dobrzyn K, Jazowska J, Kaminski T (2013) Expression of orexin A and B in the porcine hypothalamus during the oestrous cycle. J Physiol Pharmacol 64(1):55\u201363","DOI":"10.1155\/2014\/957076"},{"issue":"1","key":"6296_CR71","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1002\/cne.1190","volume":"435","author":"JN Marcus","year":"2001","unstructured":"Marcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, Yanagisawa M, Elmquist JK (2001) Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 435(1):6\u201325","journal-title":"J Comp Neurol"},{"key":"6296_CR72","doi-asserted-by":"publisher","first-page":"620868","DOI":"10.3389\/fnbeh.2021.620868","volume":"15","author":"A Matzeu","year":"2021","unstructured":"Matzeu A, Martin-Fardon R (2021) Cocaine-seeking behavior induces by orexin A administration in the posterior paraventricular nucleus of the thalamus is not long-lasting: neuroadaptation of the orexin system during cocaine abstinence. Front Behav Neurosci 15:620868","journal-title":"Front Behav Neurosci"},{"key":"6296_CR73","doi-asserted-by":"crossref","unstructured":"Messina G, Viggiano A, De Luca V, Messina A, Chieffi S, Monda M (2013) Hormonal changes in menopause and orexin-a action. Obstet Gynecol Int 209812","DOI":"10.1155\/2013\/209812"},{"key":"6296_CR74","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.cpr.2017.10.012","volume":"66","author":"RK McHugh","year":"2018","unstructured":"McHugh RK, Votaw VR, Sugarman DE, Greenfield SF (2018) Sex and gender differences in substance use disorders. Clin Psychol Rev 66:12\u201323","journal-title":"Clin Psychol Rev"},{"issue":"11","key":"6296_CR75","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1080\/17425255.2020.1817380","volume":"16","author":"C Muehlan","year":"2020","unstructured":"Muehlan C, Vaillant C, Zenklusen I, Kraehenbuehl S, Dingemanse J (2020) Clinical pharmacology, efficacy, and safety of orexin receptor antagonists for the treatment of insomnia disorders. Expert Opin Drug Metab Toxicol 16(11):1063\u20131078","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"6296_CR76","doi-asserted-by":"publisher","first-page":"7159","DOI":"10.1523\/JNEUROSCI.1027-04.2004","volume":"24","author":"Y Muraki","year":"2004","unstructured":"Muraki Y, Yamanaka A, Tsujino N, Kilduff TS, Goto K, Sakurai T (2004) Serotonergic regulation of the orexin\/hypocretin neurons through the 5-HT1A receptor. J Neurosci 24:7159\u20137166","journal-title":"J Neurosci"},{"issue":"5","key":"6296_CR77","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1111\/jnc.15328","volume":"157","author":"M Muthmainah","year":"2021","unstructured":"Muthmainah M, Gogos A, Sumithran P, Brown RM (2021) Orexins (hypocretins): the intersection between homeostatic and hedonic feeding. J Neurochem 157(5):1473\u20131494","journal-title":"J Neurochem"},{"key":"6296_CR78","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1016\/j.peptides.2010.04.029","volume":"31","author":"Y Nakamura","year":"2010","unstructured":"Nakamura Y, Miura S, Yoshida T, Kim J, Sasaki K (2010) Cytosolic calcium elevation induced by orexin\/hypocretin in granule cell domain cells of the rat cochlear nucleus in vitro. Peptides 31:1579\u20131588","journal-title":"Peptides"},{"key":"6296_CR79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0074-7696(08)62105-1","volume":"159","author":"VR Panti\u0107","year":"1995","unstructured":"Panti\u0107 VR (1995) Biology of hypothalamic neurons and pituitary cells. Int Rev Cytol 159:1\u2013112","journal-title":"Int Rev Cytol"},{"issue":"3","key":"6296_CR80","doi-asserted-by":"publisher","first-page":"376","DOI":"10.3390\/ani12030376","volume":"12","author":"Y Park","year":"2022","unstructured":"Park Y, Park YB, Lim SW, Lim B, Kim JM (2022) Time series ovarian transcriptome analyses of the porcine estrous cycle reveals gene expression changes during steroid metabolism and corpus luteum development. Animals 12(3):376","journal-title":"Animals"},{"key":"6296_CR81","doi-asserted-by":"publisher","first-page":"104584","DOI":"10.1016\/j.neubiorev.2022.104584","volume":"135","author":"DR Peart","year":"2022","unstructured":"Peart DR, Andrade AK, Logan CN, Knackstedt LA, Murray JE (2022) Regulation of cocaine-related behaviours by estrogen and progesterone. Neurosci Biobehav Rev 135:104584","journal-title":"Neurosci Biobehav Rev"},{"issue":"5","key":"6296_CR82","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s40263-018-0525-5","volume":"32","author":"MR Peltier","year":"2018","unstructured":"Peltier MR, Sofuoglu M (2018) Role of exogenous progesterone in the treatment of men and women with substance use disorders: a narrative review. CNS Drugs 32(5):421\u2013435","journal-title":"CNS Drugs"},{"key":"6296_CR83","doi-asserted-by":"publisher","first-page":"145922","DOI":"10.1016\/j.brainres.2018.08.025","volume":"1731","author":"DA Perrey","year":"2020","unstructured":"Perrey DA, Zhang Y (2020) Therapeutics development for addiction: orexin-1 receptor antagonists. Brain Res 1731:145922","journal-title":"Brain Res"},{"issue":"4","key":"6296_CR84","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S0003-3472(76)80023-1","volume":"24","author":"S Peterson","year":"1976","unstructured":"Peterson S (1976) The temporal pattern of feeding over the oestrous cycle of the mouse. Anim Behav 24(4):939\u2013955","journal-title":"Anim Behav"},{"issue":"9","key":"6296_CR85","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1523\/JNEUROSCI.1708-16.2016","volume":"37","author":"C Peyron","year":"2017","unstructured":"Peyron C, Kilduff TS (2017) Mapping the hypocretin\/orexin neuronal system: an unexpectedly productive journey. J Neurosci 37(9):2268\u20132272","journal-title":"J Neurosci"},{"issue":"23","key":"6296_CR86","doi-asserted-by":"publisher","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","volume":"18","author":"C Peyron","year":"1998","unstructured":"Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18(23):9996\u201310015","journal-title":"J Neurosci"},{"issue":"9","key":"6296_CR87","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1038\/npp.2012.48","volume":"37","author":"L Piccoli","year":"2012","unstructured":"Piccoli L, Micioni Di Bonaventura MV, Cifani C, Costantini VJ, Massagrand M, Montanari D, Martinelli P, Antolini M, Ciccocioppo R, Mass M, Merlo-Pich E, Di Fabio R, Corsi M (2012) Role of orexin-1 receptor mechanisms on compulsive food consumption in a model of binge eating in female rats. Neuropsychopharmacology 37(9):1999\u20132011","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"6296_CR88","doi-asserted-by":"publisher","first-page":"T41","DOI":"10.1530\/JOE-15-0113","volume":"226","author":"TM Plant","year":"2015","unstructured":"Plant TM (2015) 60 years of neuroendocrinology: the hypothamalo-pituitary-gonadal axis. J Endocrinol 226(2):T41\u2013T54","journal-title":"J Endocrinol"},{"issue":"3","key":"6296_CR89","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/s12035-012-8255-z","volume":"45","author":"A Plaza-Zabala","year":"2012","unstructured":"Plaza-Zabala A, Maldonado R, Berrendero F (2012) The hypocretin\/orexin system: implications for drug reward and relapse. Mol Neurobiol 45(3):424\u2013439","journal-title":"Mol Neurobiol"},{"issue":"5","key":"6296_CR90","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1530\/eje.0.1500737","volume":"150","author":"T Porkka-Heiskanen","year":"2004","unstructured":"Porkka-Heiskanen T, Kalinchuk A, Alanko L, Huhtaniemi I, Stenberg D (2004) Orexin A and B levels in the hypothalamus of female rats: the effects of the estrous cycle and age. Eur J Endocrinol 150(5):737\u2013742","journal-title":"Eur J Endocrinol"},{"key":"6296_CR91","doi-asserted-by":"publisher","first-page":"113015","DOI":"10.1016\/j.bbr.2020.113015","volume":"399","author":"SK Prajapati","year":"2021","unstructured":"Prajapati SK, Krishnamurthy S (2021) Non-selective orexin-receptor antagonist attenuates stress-re-stress-induced core PTSD-like symptoms in rats: behavioural and neurochemical analyses. Behav Brain Res 399:113015","journal-title":"Behav Brain Res"},{"issue":"1","key":"6296_CR92","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.yhbeh.2009.10.002","volume":"58","author":"V Quinones-Jenab","year":"2010","unstructured":"Quinones-Jenab V, Jenab S (2010) Progesterone attenuates cocaine-induced responses. Horm Behav 58(1):22\u201332","journal-title":"Horm Behav"},{"issue":"4","key":"6296_CR93","doi-asserted-by":"publisher","first-page":"e119","DOI":"10.1002\/cpz1.119","volume":"1","author":"AK Radke","year":"2021","unstructured":"Radke AK, Sneddon EA, Monroe SC (2021) Studying sex differences in rodent models of addictive behavior. Curr Protoc 1(4):e119","journal-title":"Curr Protoc"},{"issue":"12","key":"6296_CR94","doi-asserted-by":"publisher","first-page":"6049","DOI":"10.1210\/jc.2019-00803","volume":"104","author":"SA Rahman","year":"2019","unstructured":"Rahman SA, Grant LK, Gooley JJ, Rajaratnam S, Czeisler CA, Lockley SW (2019) Endogenous circadian regulation of female reproductive hormones. J Clin Endocrinol Metab 104(12):6049\u20136059","journal-title":"J Clin Endocrinol Metab"},{"key":"6296_CR95","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.psyneuen.2017.01.014","volume":"78","author":"JE Richard","year":"2017","unstructured":"Richard JE, L\u00f3pez-Ferreras L, Anderberg RH, Olandersson K, Skibicka KP (2017) Estradiol is a critical regulator of food-reward behavior. Psychoneuroendocrinology 78:193\u2013202","journal-title":"Psychoneuroendocrinology"},{"issue":"6","key":"6296_CR96","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1210\/endo-99-6-1562","volume":"99","author":"JS Richards","year":"1976","unstructured":"Richards JS, Ireland JJ, Rao MC, Bernath GA, Midgley A Jr, Reichert LE Jr (1976) Ovarian follicular development in the rat: hormone receptor regulation by estradiol, follicle stimulating hormone and luteinizing hormone. Endocrinology 99(6):1562\u20131570","journal-title":"Endocrinology"},{"issue":"3","key":"6296_CR97","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1007\/BF00451696","volume":"98","author":"DC Roberts","year":"1989","unstructured":"Roberts DC, Bennet SA, Vickers GJ (1989) The estrous cycle affects cocaine self-administration on a progressive ratio schedule in rates. Psychopharmacology 98(3):408\u2013411","journal-title":"Psychopharmacology"},{"issue":"1\u20132","key":"6296_CR98","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0167-0115(00)00203-2","volume":"96","author":"RJ Rodgers","year":"2000","unstructured":"Rodgers RJ, Halford JC, Nunes de Souza RL, Canto de Souza AL, Piper D, Arch JR, Blundell JE (2000) Dose-response effects of orexin-A on food intake and the behavioural satiety sequence in rats. Regul Pept 96(1\u20132):71\u201384","journal-title":"Regul Pept"},{"issue":"4","key":"6296_CR99","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.pbb.2005.11.016","volume":"82","author":"ME Roth","year":"2005","unstructured":"Roth ME, Negus SS, Knudson IM, Burgess MP, Mello NK (2005) Effects of gender and menstrual cycle phase on food-maintained responding under a progressive-ratio schedule in cynomolgus monkeys. Pharmacol Biochem Behav 82(4):735\u2013743","journal-title":"Pharmacol Biochem Behav"},{"key":"6296_CR100","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.664781","volume":"15","author":"R Rothhaas","year":"2021","unstructured":"Rothhaas R, Chung S (2021) Role of the preoptic area in sleep and thermoregulation. Front Neurosci 15:664781","journal-title":"Front Neurosci"},{"issue":"12","key":"6296_CR101","doi-asserted-by":"publisher","first-page":"5294","DOI":"10.1210\/endo.142.12.8558","volume":"142","author":"SH Russel","year":"2001","unstructured":"Russel SH, Small CJ, Kennedy AR, Stanley SA, Seth A, Murphy KG, Taheri S, Ghatei MA, Bloom SR (2001) Orexin A interactions in the hypothalamo-pituitary gonadal axis. Endocrinology 142(12):5294\u20135302","journal-title":"Endocrinology"},{"key":"6296_CR102","doi-asserted-by":"crossref","unstructured":"Sakurai T (1999) Orexins and orexin receptors: implication in feeding behavior. Regul Pept 85(1):25\u201330","DOI":"10.1016\/S0167-0115(99)00076-2"},{"issue":"4","key":"6296_CR103","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S0092-8674(00)80949-6","volume":"92","author":"T Sakurai","year":"1998","unstructured":"Sakurai T, Ameniya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92(4):573\u2013585","journal-title":"Cell"},{"issue":"1","key":"6296_CR104","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/s41398-020-00937-9","volume":"10","author":"G Salvadore","year":"2020","unstructured":"Salvadore G, Bonaventure P, Shekhar A, Johnson PL, Lord B, Shireman BT, Lebold TP, Nepomuceno D, Dugovic C, Brooks S, Zuiker R, Bleys C, Tatikola K, Remmerie B, Jacobs GE, Schruers K, Moyer J, Nash A, Van Nueten L, Drevet WC (2020) Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans. Transl Psych 10(1):308","journal-title":"Transl Psych"},{"issue":"1","key":"6296_CR105","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.bbr.2012.04.010","volume":"232","author":"J Santollo","year":"2012","unstructured":"Santollo J, Yao D, Neal-Perry G, Etgen AM (2012) Middle-aged female rats sensitivity to the anorexigenic effect of exogenous estradiol. Behav Brain Res 232(1):159\u2013164","journal-title":"Behav Brain Res"},{"issue":"4","key":"6296_CR106","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.neuron.2017.01.014","volume":"93","author":"TE Scammell","year":"2017","unstructured":"Scammell TE, Arrigoni E, Lipton JO (2017) Neural circuitry of wakefulness and sleep. Neuron 93(4):747\u2013765","journal-title":"Neuron"},{"issue":"1\u20132","key":"6296_CR107","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/S0006-8993(98)00991-3","volume":"811","author":"B Schwierin","year":"1998","unstructured":"Schwierin B, Borbely AA, Tobler I (1998) Sleep homeostasis in the female rat during the estrous cycle. Brain Res 811(1\u20132):96\u2013104","journal-title":"Brain Res"},{"issue":"3","key":"6296_CR108","doi-asserted-by":"publisher","first-page":"E820","DOI":"10.1152\/ajpendo.00467.2006","volume":"292","author":"P Silveyra","year":"2007","unstructured":"Silveyra P, Catalano PN, Lux-Lantos V, Libertun C (2007a) Impact of proestrous milieu on expression of orexin receptors and prepro-orexin in rat hypothalamus and hypophysis: actions of cetrorelix and nembutal. Am J Physiol Endocrinol Metab 292(3):E820\u2013E828","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"6296_CR109","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1111\/j.1748-1716.2009.02049.x","volume":"198","author":"P Silveyra","year":"2010","unstructured":"Silveyra P, Cataldi NI, Lux-Lantos VA, Libertun C (2010) Role of orexins in the hypothalamic-pituitary-ovarian relationships. Acta Physiol Scand 198(3):355\u2013360","journal-title":"Acta Physiol Scand"},{"key":"6296_CR110","doi-asserted-by":"publisher","first-page":"e977","DOI":"10.1152\/ajpendo.00179.2007","volume":"293","author":"P Silveyra","year":"2007","unstructured":"Silveyra P, Lux-Lantos V, Libertun C (2007b) Both orexin receptors are expresses in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on go-nadotropins and ovulation. Am J Phisiol Endocrinol Metab 293:e977\u2013e985","journal-title":"Am J Phisiol Endocrinol Metab"},{"issue":"15\u201316","key":"6296_CR111","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1007\/s00213-016-4345-3","volume":"233","author":"JR Smethells","year":"2016","unstructured":"Smethells JR, Swalve NL, Eberly LE, Carroll ME (2016) Sex differences in the reduction of impulsive choice (delay discounting) for cocaine in rats with atomoxetine and progesterone. Psychopharmacology 233(15\u201316):2999\u20133008","journal-title":"Psychopharmacology"},{"issue":"2","key":"6296_CR112","first-page":"300","volume":"8","author":"N Smolinska","year":"2014","unstructured":"Smolinska N, Nitkiewicz A, Maleszka A, Kiezun M, Dobrzyn K, Czerwinska J, Chojnowska K, Kaminski T (2014) The effect of the estrous cycle on the expression of prepro-orexin gene and protein and the levels of orexin A and B in the porcine pituitary. Anim Biosci 8(2):300\u2013307","journal-title":"Anim Biosci"},{"issue":"2","key":"6296_CR113","first-page":"129","volume":"68","author":"M So","year":"2018","unstructured":"So M, Hashimoto H, Saito R, Yamamoto Y, Motojima Y, Ueno H, Sonoda S, Yoshimura M, Maruyama T, Kusuhara K, Ueta Y (2018) Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist. JPS 68(2):129\u2013136","journal-title":"JPS"},{"issue":"4","key":"6296_CR114","first-page":"331","volume":"33","author":"CN Soares","year":"2008","unstructured":"Soares CN, Zitek B (2008) Reproductive hormone sensitivity and risk for depression across the female life cycle: a continuum of vulnerability? JPN 33(4):331\u2013343","journal-title":"JPN"},{"key":"6296_CR115","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.neures.2019.04.005","volume":"168","author":"WN Sovijit","year":"2021","unstructured":"Sovijit WN, Sovijit WE, Pu S, Usuda K, Inoue R, Watanabe G, Yamaguchi H, Nagaoka K (2021) Ovarian progesterone suppresses depression and anxiety-like behaviors by increasing the Lactobacillus population of gut microbiota in ovariectomized mice. Neurosci Res 168:76\u201382","journal-title":"Neurosci Res"},{"key":"6296_CR116","doi-asserted-by":"publisher","first-page":"691","DOI":"10.3389\/fnins.2020.00691","volume":"14","author":"S Soya","year":"2020","unstructured":"Soya S, Sakurai T (2020) Evolution of orexin neuropeptide system: structure and function. Front Neurosci 14:691","journal-title":"Front Neurosci"},{"key":"6296_CR117","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3389\/fendo.2019.00329","volume":"10","author":"DJ Spergel","year":"2019","unstructured":"Spergel DJ (2019) Modulation of gonadotropin-releasing hormone neuron activity and secretion in mice by non-peptide neurotransmitters, gasotransmitters, and gliotransmitters. Front Endocrinol 10:329","journal-title":"Front Endocrinol"},{"key":"6296_CR118","doi-asserted-by":"crossref","unstructured":"Sun BZ, Kangarloo T, Adams JM, Sluss P, Chandler DW, Zava DT, McGrath JA, Umbach DM, Shaw ND (2019) The relationship between progesterone, sleep, and LH and FSH secretory dynamics in early postmenarchal girls. J Clin Endocrinol Metab 103 104(6):2184\u20132194","DOI":"10.1210\/jc.2018-02400"},{"key":"6296_CR119","doi-asserted-by":"crossref","unstructured":"Swift KM, Keus K, Echeverria CG, Cabrera Y, Jimenez J, Holloway J, Clawson BC, Poe GR (2020) Sex differences within sleep in gonadally intact rats. Sleep 43(5):zsz289","DOI":"10.1093\/sleep\/zsz289"},{"key":"6296_CR120","doi-asserted-by":"crossref","unstructured":"Tenorio-Lopes L, Fournier S, Henry MS, Bretzner F, Kinkead R (2020) Disruption of estradiol regulation of orexin neurons: a novel mechanism in excessive ventilatory response to CO2 inhalation in a female rat model of panic disorder. Transl Psychiatry 10(1):394","DOI":"10.1038\/s41398-020-01076-x"},{"issue":"1\u20132","key":"6296_CR121","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0014-5793(98)01266-6","volume":"438","author":"P Trivedi","year":"1998","unstructured":"Trivedi P, Yu H, MacNeil DJ, Van der Ploeg LH, Guan XM (1998) Distribution of orexin receptor mRNA in the rat brain. FEBS Lett 438(1\u20132):71\u201375","journal-title":"FEBS Lett"},{"issue":"5","key":"6296_CR122","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1507\/endocrj.EJ12-0030","volume":"59","author":"H Tsuneki","year":"2012","unstructured":"Tsuneki H, Wada T, Sasaoka T (2012) Role of orexin in the central regulation of glucose and energy homeostasis. Endocr J 59(5):365\u2013374","journal-title":"Endocr J"},{"key":"6296_CR123","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1097\/00001756-200107030-00024","volume":"12","author":"K Uramura","year":"2001","unstructured":"Uramura K, Funahashi H, Muroya S, Shioda S, Takigawa M, Yada T (2001) Orexin-a activates phospholipase C- and protein kinase C-mediated Ca2+ signaling in dopamine neurons of the ventral tegmental area. NeuroReport 12:1885\u20131889","journal-title":"NeuroReport"},{"key":"6296_CR124","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.bbr.2014.10.028","volume":"278","author":"MW Vanderhaven","year":"2015","unstructured":"Vanderhaven MW, Cornish JL, Staples LG (2015) The orexin-1 receptor antagonist SB-334867 decreases anxiety-like behavior and c-Fos expression in the hypothalamus of rats exposed to cat odor. Behav Brain Res 278:563\u2013568","journal-title":"Behav Brain Res"},{"issue":"1","key":"6296_CR125","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1037\/h0076186","volume":"88","author":"GN Wade","year":"1975","unstructured":"Wade GN (1975) Some effects of ovarian hormones on food intake and body weight in female rats. J Comp Psychol 88(1):183\u2013193","journal-title":"J Comp Psychol"},{"issue":"3","key":"6296_CR126","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/0031-9384(79)90028-3","volume":"22","author":"GN Wade","year":"1979","unstructured":"Wade GN, Gray JM (1979) Gonadal effects on food intake and adiposity: a metabolic hypothesis. Physiol Behav 22(3):583\u2013593","journal-title":"Physiol Behav"},{"issue":"2","key":"6296_CR127","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S0149-7634(05)80183-6","volume":"16","author":"GN Wade","year":"1992","unstructured":"Wade GN, Schneider JE (1992) Metabolic fuels and reproduction in female mammals. Neurosci Biobehav Rev 16(2):235\u2013272","journal-title":"Neurosci Biobehav Rev"},{"key":"6296_CR128","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3389\/fnmol.2018.00220","volume":"11","author":"C Wang","year":"2018","unstructured":"Wang C, Wang Q, Ji B, Pan Y, Xu C, Cheng B, Bai B, Chen J (2018) The orexin\/receptor system: molecular mechanism and therapeutic potential for neurological diseases. Front Mol Neurosci 11:220","journal-title":"Front Mol Neurosci"},{"issue":"2","key":"6296_CR129","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1385\/ENDO:22:2:127","volume":"22","author":"JB Wang","year":"2003","unstructured":"Wang JB, Murata T, Narita K, Honda K, Higuchi T (2003) Variation in the expression of orexin and orexin receptors in the rat hypothalamus during the estrous cycle, pregnancy, parturition, and lactation. Endocrine 22(2):127\u2013134","journal-title":"Endocrine"},{"issue":"4","key":"6296_CR130","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/S0091-3057(02)00818-3","volume":"73","author":"TL White","year":"2002","unstructured":"White TL, Justice AJ, de Wit H (2002) Differential subjective effects of D-amphetamine by gender, hormone levels and menstrual cycle phase. Pharmacol Biochem Behav 73(4):729\u2013741","journal-title":"Pharmacol Biochem Behav"},{"issue":"50","key":"6296_CR131","doi-asserted-by":"publisher","first-page":"11439","DOI":"10.1523\/JNEUROSCI.3459-04.2004","volume":"24","author":"R Winsky-Sommerer","year":"2004","unstructured":"Winsky-Sommerer R, Yamanaka A, Diano S, Borok E, Roberts AJ, Sakurai T, Kilduff TS, Horvath TL, de Lecea L (2004) Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. J Neurosci 24(50):11439\u201311448","journal-title":"J Neurosci"},{"issue":"1","key":"6296_CR132","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1159\/000122968","volume":"30","author":"PM Wise","year":"1980","unstructured":"Wise PM, Ratner A (1980) Effect of ovariectomy on plasma LH, FSH, estradiol, and progesterone and medial basal hypothalamic LHRH concentrations old and young rats. Neuroendocrinology 30(1):15\u201319","journal-title":"Neuroendocrinology"},{"issue":"3","key":"6296_CR133","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/S1734-1140(11)70583-7","volume":"63","author":"A Woldan-Tambor","year":"2011","unstructured":"Woldan-Tambor A, Bieganska K, Wiktorowska-Owczarek A, Zawilska JB (2011) Activation of orexin\/hypocretin type 1 receptors stimulates cAMP synthesis in primary cultures of rat astrocytes. Pharmacol Rep 63(3):717\u2013723","journal-title":"Pharmacol Rep"},{"key":"6296_CR134","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/BF03179063","volume":"65","author":"JX Xia","year":"2009","unstructured":"Xia JX, Fan SY, Yan J, Chen F, Li Y, Yu ZP, Hu ZA (2009) Orexin A-induced extracellular calcium influx in prefrontal cortex neurons involves L-type calcium channels. J Physiol Biochem 65:125\u2013136","journal-title":"J Physiol Biochem"},{"issue":"4","key":"6296_CR135","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nsmb.3183","volume":"23","author":"J Yin","year":"2016","unstructured":"Yin J, Babaoglu K, Brautigam CA, Clark L, Shao Z, Scheuermann TH, Harrell CM, Gotter AL, Roecker AJ, Winrow CJ, Renger JJ, Coleman PJ, Rosenbaum DM (2016) Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors. Nat Struct Mol Biol 23(4):293\u2013299","journal-title":"Nat Struct Mol Biol"},{"issue":"5","key":"6296_CR136","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1007\/s00213-020-05456-5","volume":"237","author":"CN Yohn","year":"2020","unstructured":"Yohn CN, Shifman S, Garino A, Diethorn E, Bokka L, Ashamalla SA, Samuels BA (2020) Fluoxetine effects on behavior and adult hippocampal neurogenesis in female C57BL\/6J mice across the estrous cycle. Psychopharmacology 237(5):1281\u20131290","journal-title":"Psychopharmacology"},{"issue":"3","key":"6296_CR137","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1124\/jpet.111.187567","volume":"340","author":"L Zhou","year":"2012","unstructured":"Zhou L, Ghee SM, Chan C, Lin L, Cameron MD, Kenny PJ, See RE (2012) Orexin-1 receptor mediation of cocaine seeking in male and female rats. J Pharmacol Exp Ther 340(3):801\u2013809","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-022-06296-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-022-06296-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-022-06296-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T11:04:46Z","timestamp":1672916686000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-022-06296-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,26]]},"references-count":137,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["6296"],"URL":"https:\/\/doi.org\/10.1007\/s00213-022-06296-1","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,26]]},"assertion":[{"value":"16 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"RBL has served as expert witnesses in various medicolegal cases involving cannabis. RBL is a consultant member of the scientific advisory board for Shackleford Pharma Inc.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}