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Therefore, it is possible that obesity-prone rats may also be more sensitive to the motivational properties of cocaine and cocaine-paired cues, and to plasticity induced by cocaine.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To examine baseline differences in motivation for cocaine and effects of intermittent access (IntA) cocaine self-administration on cocaine motivation, neurobehavioral responsivity to cocaine-paired cues, and locomotor sensitization in male obesity-prone vs obesity-resistant rats.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Intravenous cocaine self-administration was used to examine drug-taking and drug-seeking in males. Motivation for cocaine was measured using a within session threshold procedure. Cue-induced c-Fos expression in mesocorticolimbic regions was measured.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Drug-taking and drug-seeking, cue-induced c-Fos, locomotor sensitization, and preferred level of cocaine consumption (<jats:italic>Q<\/jats:italic><jats:sub>0<\/jats:sub>) were similar between obesity-prone and obesity-resistant groups. Maximal responding during demand testing (<jats:italic>R<\/jats:italic><jats:sub>max<\/jats:sub>) was lower in obesity-prone rats. IntA experience enhanced motivation for cocaine (<jats:italic>P<\/jats:italic><jats:sub>max<\/jats:sub>) in obesity-prone rats.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The results do not support robust inherent differences in motivation for cocaine, cue-induced cocaine seeking, or neurobehavioral plasticity induced by IntA in obesity-prone vs obesity-resistant rats. This contrasts with previously established differences seen for food and food cues in these populations and shows that inherent enhancements in motivation for food and food-paired cues do not necessarily transfer to drugs and drug-paired cues.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00213-023-06327-5","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T22:40:06Z","timestamp":1676760006000},"page":"853-870","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cocaine-induced plasticity, motivation, and cue responsivity do not differ in obesity-prone vs obesity-resistant rats; implications for food addiction"],"prefix":"10.1007","volume":"240","author":[{"given":"Anish A.","family":"Saraswat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren G.","family":"Longyear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex B.","family":"Kawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9673-7028","authenticated-orcid":false,"given":"Carrie R.","family":"Ferrario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,18]]},"reference":[{"issue":"4","key":"6327_CR1","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1007\/s00438-015-1015-9","volume":"290","author":"D Albuquerque","year":"2015","unstructured":"Albuquerque D, Stice E, Rodr\u00edguez-L\u00f3pez R, Manco L, N\u00f3brega C (2015) Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective. 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