{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:00:28Z","timestamp":1789502428424,"version":"build-2803163510"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA033358"],"award-info":[{"award-number":["DA033358"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["Intramural"],"award-info":[{"award-number":["Intramural"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["Intramural"],"award-info":[{"award-number":["Intramural"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1007\/s00213-023-06392-w","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T17:01:46Z","timestamp":1686157306000},"page":"1587-1600","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Toll-like receptor 4 antagonists reduce cocaine-primed reinstatement of drug seeking"],"prefix":"10.1007","volume":"240","author":[{"given":"Kyle T.","family":"Brown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia C.","family":"Levis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey E.","family":"O\u2019Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenner C.","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda R.","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5268-5927","authenticated-orcid":false,"given":"Ryan K.","family":"Bachtell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"6392_CR1","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1111\/adb.12156","volume":"20","author":"P Araos","year":"2015","unstructured":"Araos P, Pedraz M, Serrano A et al (2015) Plasma profile of pro-inflammatory cytokines and chemokines in cocaine users under outpatient treatment: influence of cocaine symptom severity and psychiatric co-morbidity. Addict Biol 20:756\u2013772. https:\/\/doi.org\/10.1111\/adb.12156","journal-title":"Addict Biol"},{"key":"6392_CR2","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1139\/cjpp-2015-0209","volume":"94","author":"R Arezoomandan","year":"2016","unstructured":"Arezoomandan R, Haghparast A (2016) Administration of the glial cell modulator, minocycline, in the nucleus accumbens attenuated the maintenance and reinstatement of morphine-seeking behavior. Can J Physiol Pharmacol 94:257\u2013264. https:\/\/doi.org\/10.1139\/cjpp-2015-0209","journal-title":"Can J Physiol Pharmacol"},{"key":"6392_CR3","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1111\/adb.12557","volume":"23","author":"R Arezoomandan","year":"2018","unstructured":"Arezoomandan R, Riahi E, Haghparast A (2018) Minocycline increases firing rates of accumbal neurons and modifies the effects of morphine on neuronal activity. Addict Biol 23:1055\u20131066. https:\/\/doi.org\/10.1111\/adb.12557","journal-title":"Addict Biol"},{"key":"6392_CR4","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.pnpbp.2014.04.008","volume":"53","author":"G Attarzadeh-Yazdi","year":"2014","unstructured":"Attarzadeh-Yazdi G, Arezoomandan R, Haghparast A (2014) Minocycline, an antibiotic with inhibitory effect on microglial activation, attenuates the maintenance and reinstatement of methamphetamine-seeking behavior in rat. Prog Neuropsychopharmacol Biol Psychiatry 53:142\u2013148. https:\/\/doi.org\/10.1016\/j.pnpbp.2014.04.008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"6392_CR5","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.drugalcdep.2017.08.003","volume":"180","author":"RK Bachtell","year":"2017","unstructured":"Bachtell RK, Jones JD, Heinzerling KG et al (2017) Glial and neuroinflammatory targets for treating substance use disorders. Drug Alcohol Depend 180:156\u2013170. https:\/\/doi.org\/10.1016\/j.drugalcdep.2017.08.003","journal-title":"Drug Alcohol Depend"},{"key":"6392_CR6","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.ejphar.2010.04.010","volume":"637","author":"PM Beardsley","year":"2010","unstructured":"Beardsley PM, Shelton KL, Hendrick E, Johnson KW (2010) The glial cell modulator and phosphodiesterase inhibitor, AV411 (ibudilast), attenuates prime- and stress-induced methamphetamine relapse. Eur J Pharmacol 637:102\u2013108. https:\/\/doi.org\/10.1016\/j.ejphar.2010.04.010","journal-title":"Eur J Pharmacol"},{"key":"6392_CR7","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/adb.12106","volume":"20","author":"RL Bell","year":"2015","unstructured":"Bell RL, Lopez MF, Cui C et al (2015) Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence. Addict Biol 20:38\u201342. https:\/\/doi.org\/10.1111\/adb.12106","journal-title":"Addict Biol"},{"key":"6392_CR8","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.drugalcdep.2017.05.016","volume":"178","author":"JB Birath","year":"2017","unstructured":"Birath JB, Briones M, Amaya S et al (2017) Ibudilast may improve attention during early abstinence from methamphetamine. Drug Alcohol Depend 178:386\u2013390. https:\/\/doi.org\/10.1016\/j.drugalcdep.2017.05.016","journal-title":"Drug Alcohol Depend"},{"key":"6392_CR9","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.bbi.2017.08.012","volume":"67","author":"KT Brown","year":"2018","unstructured":"Brown KT, Levis SC, O\u2019Neill CE et al (2018) Innate immune signaling in the ventral tegmental area contributes to drug-primed reinstatement of cocaine seeking. Brain Behav Immun 67:130\u2013138. https:\/\/doi.org\/10.1016\/j.bbi.2017.08.012","journal-title":"Brain Behav Immun"},{"key":"6392_CR10","doi-asserted-by":"publisher","first-page":"134951","DOI":"10.1016\/j.neulet.2020.134951","volume":"728","author":"ME Burkovetskaya","year":"2020","unstructured":"Burkovetskaya ME, Small R, Guo L et al (2020) Cocaine self-administration differentially activates microglia in the mouse brain. Neurosci Lett 728:134951. https:\/\/doi.org\/10.1016\/j.neulet.2020.134951","journal-title":"Neurosci Lett"},{"key":"6392_CR11","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41467-017-01881-x","volume":"9","author":"ES Calipari","year":"2018","unstructured":"Calipari ES, Godino A, Peck EG et al (2018) Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine. Nat Commun 9:9. https:\/\/doi.org\/10.1038\/s41467-017-01881-x","journal-title":"Nat Commun"},{"key":"6392_CR12","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.neulet.2009.01.078","volume":"452","author":"H Chen","year":"2009","unstructured":"Chen H, Uz T, Manev H (2009) Minocycline affects cocaine sensitization in mice. Neurosci Lett 452:258\u2013261. https:\/\/doi.org\/10.1016\/j.neulet.2009.01.078","journal-title":"Neurosci Lett"},{"key":"6392_CR13","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1111\/adb.12261","volume":"21","author":"ZD Cooper","year":"2016","unstructured":"Cooper ZD, Johnson KW, Pavlicova M et al (2016) The effects of ibudilast, a glial activation inhibitor, on opioid withdrawal symptoms in opioid-dependent volunteers. Addict Biol 21:895\u2013903. https:\/\/doi.org\/10.1111\/adb.12261","journal-title":"Addict Biol"},{"key":"6392_CR14","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.drugalcdep.2017.04.029","volume":"178","author":"ZD Cooper","year":"2017","unstructured":"Cooper ZD, Johnson KW, Vosburg SK et al (2017) Effects of ibudilast on oxycodone-induced analgesia and subjective effects in opioid-dependent volunteers. Drug Alcohol Depend 178:340\u2013347. https:\/\/doi.org\/10.1016\/j.drugalcdep.2017.04.029","journal-title":"Drug Alcohol Depend"},{"key":"6392_CR15","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1007\/s00213-017-4560-6","volume":"234","author":"FT Crews","year":"2017","unstructured":"Crews FT, Walter TJ, Coleman LG, Vetreno RP (2017) Toll-like receptor signaling and stages of addiction. Psychopharmacology (Berl) 234:1483\u20131498. https:\/\/doi.org\/10.1007\/s00213-017-4560-6","journal-title":"Psychopharmacology (Berl)"},{"key":"6392_CR16","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1002\/hup.1251","volume":"27","author":"HC Fox","year":"2012","unstructured":"Fox HC, D\u2019Sa C, Kimmerling A et al (2012) Immune system inflammation in cocaine dependent individuals: implications for medications development. Hum Psychopharmacol 27:156\u2013166. https:\/\/doi.org\/10.1002\/hup.1251","journal-title":"Hum Psychopharmacol"},{"key":"6392_CR17","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.pbb.2012.01.005","volume":"101","author":"Y Fujita","year":"2012","unstructured":"Fujita Y, Kunitachi S, Iyo M, Hashimoto K (2012) The antibiotic minocycline prevents methamphetamine-induced rewarding effects in mice. Pharmacol Biochem Behav 101:303\u2013306. https:\/\/doi.org\/10.1016\/j.pbb.2012.01.005","journal-title":"Pharmacol Biochem Behav"},{"key":"6392_CR18","doi-asserted-by":"publisher","first-page":"e12739","DOI":"10.1111\/adb.12739","volume":"25","author":"S-Q Gao","year":"2020","unstructured":"Gao S-Q, Zhang H, He J-G et al (2020) Neuronal HMGB1 in nucleus accumbens regulates cocaine reward memory. Addict Biol 25:e12739. https:\/\/doi.org\/10.1111\/adb.12739","journal-title":"Addict Biol"},{"key":"6392_CR19","doi-asserted-by":"publisher","first-page":"e0213791","DOI":"10.1371\/journal.pone.0213791","volume":"14","author":"N Garc\u00eda-Marchena","year":"2019","unstructured":"Garc\u00eda-Marchena N, Barrera M, Mestre-Pint\u00f3 JI et al (2019) Inflammatory mediators and dual depression: potential biomarkers in plasma of primary and substance-induced major depression in cocaine and alcohol use disorders. PLoS One 14:e0213791. https:\/\/doi.org\/10.1371\/journal.pone.0213791","journal-title":"PLoS One"},{"key":"6392_CR20","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1080\/15548627.2015.1052205","volume":"11","author":"M-L Guo","year":"2015","unstructured":"Guo M-L, Liao K, Periyasamy P et al (2015) Cocaine-mediated microglial activation involves the ER stress-autophagy axis. Autophagy 11:995\u20131009. https:\/\/doi.org\/10.1080\/15548627.2015.1052205","journal-title":"Autophagy"},{"key":"6392_CR21","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/j.1530-0277.2009.01090.x","volume":"34","author":"KG Hill","year":"2010","unstructured":"Hill KG, Sable HJK, Ferraro Iii FM, Kiefer SW (2010) Chronic naltrexone treatment and ethanol responsivity in outbred rats. Alcohol Clin Exp Res 34:272\u2013279. https:\/\/doi.org\/10.1111\/j.1530-0277.2009.01090.x","journal-title":"Alcohol Clin Exp Res"},{"key":"6392_CR22","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1111\/ejn.14143","volume":"50","author":"RS Hofford","year":"2019","unstructured":"Hofford RS, Russo SJ, Kiraly DD (2019) Neuroimmune mechanisms of psychostimulant and opioid use disorders. Eur J Neurosci 50:2562\u20132573. https:\/\/doi.org\/10.1111\/ejn.14143","journal-title":"Eur J Neurosci"},{"key":"6392_CR23","doi-asserted-by":"publisher","first-page":"11187","DOI":"10.1523\/JNEUROSCI.0684-12.2012","volume":"32","author":"MR Hutchinson","year":"2012","unstructured":"Hutchinson MR, Northcutt AL, Hiranita T et al (2012) Opioid activation of Toll-like receptor 4 contributes to drug reinforcement. J Neurosci 32:11187\u201311200. https:\/\/doi.org\/10.1523\/JNEUROSCI.0684-12.2012","journal-title":"J Neurosci"},{"issue":"Pt B","key":"6392_CR24","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.neuropharm.2013.05.039","volume":"76","author":"MR Hutchinson","year":"2014","unstructured":"Hutchinson MR, Watkins LR (2014) Why is neuroimmunopharmacology crucial for the future of addiction research? Neuropharmacology 76(Pt B):218\u2013227. https:\/\/doi.org\/10.1016\/j.neuropharm.2013.05.039","journal-title":"Neuropharmacology"},{"key":"6392_CR25","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/j.1460-9568.2008.06321.x","volume":"28","author":"MR Hutchinson","year":"2008","unstructured":"Hutchinson MR, Zhang Y, Brown K et al (2008) Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of Toll-like receptor 4 (TLR4). Eur J Neurosci 28:20\u201329. https:\/\/doi.org\/10.1111\/j.1460-9568.2008.06321.x","journal-title":"Eur J Neurosci"},{"key":"6392_CR26","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/B978-0-12-801284-0.00006-3","volume":"118","author":"JHW Jacobsen","year":"2014","unstructured":"Jacobsen JHW, Watkins LR, Hutchinson MR (2014) Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction. Int Rev Neurobiol 118:129\u2013163. https:\/\/doi.org\/10.1016\/B978-0-12-801284-0.00006-3","journal-title":"Int Rev Neurobiol"},{"key":"6392_CR27","doi-asserted-by":"publisher","first-page":"8865","DOI":"10.1073\/pnas.1705974114","volume":"114","author":"DT Kashima","year":"2017","unstructured":"Kashima DT, Grueter BA (2017) Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior. Proc Natl Acad Sci USA 114:8865\u20138870. https:\/\/doi.org\/10.1073\/pnas.1705974114","journal-title":"Proc Natl Acad Sci USA"},{"key":"6392_CR28","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","volume":"13","author":"T Kawai","year":"2007","unstructured":"Kawai T, Akira S (2007) Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med 13:460\u2013469. https:\/\/doi.org\/10.1016\/j.molmed.2007.09.002","journal-title":"Trends Mol Med"},{"key":"6392_CR29","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1111\/adb.12393","volume":"22","author":"ER Korpi","year":"2017","unstructured":"Korpi ER, Linden A-M, Hyt\u00f6nen HR et al (2017) Continuous delivery of naltrexone and nalmefene leads to tolerance in reducing alcohol drinking and to supersensitivity of brain opioid receptors. Addict Biol 22:1022\u20131035. https:\/\/doi.org\/10.1111\/adb.12393","journal-title":"Addict Biol"},{"key":"6392_CR30","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/npp.2016.121","volume":"42","author":"MJ Lacagnina","year":"2017","unstructured":"Lacagnina MJ, Rivera PD, Bilbo SD (2017) Glial and neuroimmune mechanisms as critical modulators of drug use and abuse. Neuropsychopharmacology 42:156\u2013177. https:\/\/doi.org\/10.1038\/npp.2016.121","journal-title":"Neuropsychopharmacology"},{"key":"6392_CR31","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.drugalcdep.2016.08.010","volume":"167","author":"ML Levandowski","year":"2016","unstructured":"Levandowski ML, Viola TW, Prado CH et al (2016) Distinct behavioral and immunoendocrine parameters during crack cocaine abstinence in women reporting childhood abuse and neglect. Drug Alcohol Depend 167:140\u2013148. https:\/\/doi.org\/10.1016\/j.drugalcdep.2016.08.010","journal-title":"Drug Alcohol Depend"},{"key":"6392_CR32","doi-asserted-by":"publisher","first-page":"107776","DOI":"10.1016\/j.drugalcdep.2019.107776","volume":"206","author":"MJ Li","year":"2020","unstructured":"Li MJ, Briones MS, Heinzerling KG et al (2020) Ibudilast attenuates peripheral inflammatory effects of methamphetamine in patients with methamphetamine use disorder. Drug Alcohol Depend 206:107776. https:\/\/doi.org\/10.1016\/j.drugalcdep.2019.107776","journal-title":"Drug Alcohol Depend"},{"key":"6392_CR33","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12974-016-0501-2","volume":"13","author":"K Liao","year":"2016","unstructured":"Liao K, Guo M, Niu F et al (2016) Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis. J Neuroinflammation 13:33. https:\/\/doi.org\/10.1186\/s12974-016-0501-2","journal-title":"J Neuroinflammation"},{"key":"6392_CR34","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41467-019-14173-3","volume":"11","author":"KE Linker","year":"2020","unstructured":"Linker KE, Gad M, Tawadrous P et al (2020) Microglial activation increases cocaine self-administration following adolescent nicotine exposure. Nat Commun 11:306. https:\/\/doi.org\/10.1038\/s41467-019-14173-3","journal-title":"Nat Commun"},{"key":"6392_CR35","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/sj.bjp.0706732","volume":"148","author":"HQ Liu","year":"2006","unstructured":"Liu HQ, Zhang WY, Luo XT et al (2006) Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson\u2019s disease by activation of adenosine A1 receptor. Br J Pharmacol 148:314\u2013325. https:\/\/doi.org\/10.1038\/sj.bjp.0706732","journal-title":"Br J Pharmacol"},{"key":"6392_CR36","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.biopsych.2018.05.022","volume":"84","author":"L Lo Iacono","year":"2018","unstructured":"Lo Iacono L, Catale C, Martini A et al (2018) From traumatic childhood to cocaine abuse: the critical function of the immune system. Biol Psychiatry 84:905\u2013916. https:\/\/doi.org\/10.1016\/j.biopsych.2018.05.022","journal-title":"Biol Psychiatry"},{"key":"6392_CR37","doi-asserted-by":"publisher","unstructured":"Metz VE, Jones JD, Manubay J et al (2017) Effects of ibudilast on the subjective, reinforcing, and analgesic effects of oxycodone in recently detoxified adults with opioid dependence. Neuropsychopharmacology. https:\/\/doi.org\/10.1038\/npp.2017.70","DOI":"10.1038\/npp.2017.70"},{"key":"6392_CR38","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.drugalcdep.2015.11.024","volume":"158","author":"FP Moreira","year":"2016","unstructured":"Moreira FP, Medeiros JRC, Lhullier AC et al (2016) Cocaine abuse and effects in the serum levels of cytokines IL-6 and IL-10. Drug Alcohol Depend 158:181\u2013185. https:\/\/doi.org\/10.1016\/j.drugalcdep.2015.11.024","journal-title":"Drug Alcohol Depend"},{"key":"6392_CR39","doi-asserted-by":"publisher","unstructured":"Northcutt AL, Hutchinson MR, Wang X et al (2015) DAT isn\u2019t all that: cocaine reward and reinforcement requires toll like receptor 4 signaling. Mol Psychiatry. https:\/\/doi.org\/10.1038\/mp.2014.177","DOI":"10.1038\/mp.2014.177"},{"key":"6392_CR40","unstructured":"Paxinos G,\u00a0Watson,\u00a0C (2013) The Rat Brain in Stereotaxic Coordinates.\u00a0Netherlands:\u00a0Elsevier Science."},{"key":"6392_CR41","doi-asserted-by":"publisher","first-page":"e0118610","DOI":"10.1371\/journal.pone.0118610","volume":"10","author":"M Pedraz","year":"2015","unstructured":"Pedraz M, Mart\u00edn-Velasco AI, Garc\u00eda-Marchena N et al (2015) Plasma concentrations of BDNF and IGF-1 in abstinent cocaine users with high prevalence of substance use disorders: relationship to psychiatric comorbidity. PLoS One 10:e0118610. https:\/\/doi.org\/10.1371\/journal.pone.0118610","journal-title":"PLoS One"},{"key":"6392_CR42","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","volume":"282","author":"A Poltorak","year":"1998","unstructured":"Poltorak A, He X, Smirnova I et al (1998) Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene. Science 282:2085\u20132088. https:\/\/doi.org\/10.1126\/science.282.5396.2085","journal-title":"Science"},{"key":"6392_CR43","doi-asserted-by":"publisher","first-page":"32","DOI":"10.9758\/cpn.2020.18.1.32","volume":"18","author":"HE Soder","year":"2020","unstructured":"Soder HE, Berumen AM, Gomez KE et al (2020) Elevated neutrophil to lymphocyte ratio in older adults with cocaine use disorder as a marker of chronic inflammation. Clin Psychopharmacol Neurosci 18:32\u201340. https:\/\/doi.org\/10.9758\/cpn.2020.18.1.32","journal-title":"Clin Psychopharmacol Neurosci"},{"key":"6392_CR44","doi-asserted-by":"publisher","unstructured":"Stamatovich S, Lopez-Gamundi P, Suchting R et al (2021) Plasma pro- and anti-inflammatory cytokines may relate to cocaine use, cognitive functioning, and depressive symptoms in cocaine use disorder. Am J Drug Alcohol Abuse 47. https:\/\/doi.org\/10.1080\/00952990.2020.1828439","DOI":"10.1080\/00952990.2020.1828439"},{"key":"6392_CR45","doi-asserted-by":"publisher","first-page":"2772","DOI":"10.1038\/npp.2016.91","volume":"41","author":"G Tanda","year":"2016","unstructured":"Tanda G, Mereu M, Hiranita T et al (2016) Lack of specific involvement of (+)-naloxone and (+)-naltrexone on the reinforcing and neurochemical effects of cocaine and opioids. Neuropsychopharmacology 41:2772\u20132781. https:\/\/doi.org\/10.1038\/npp.2016.91","journal-title":"Neuropsychopharmacology"},{"key":"6392_CR46","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.biopsych.2012.12.019","volume":"73","author":"FR Theberge","year":"2013","unstructured":"Theberge FR, Li X, Kambhampati S et al (2013) Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving. Biological psychiatry 73:729\u2013737. https:\/\/doi.org\/10.1016\/j.biopsych.2012.12.019","journal-title":"Biological psychiatry"},{"key":"6392_CR47","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.bbr.2015.03.054","volume":"287","author":"LS Tortorelli","year":"2015","unstructured":"Tortorelli LS, Engelke DS, Lunardi P et al (2015) Cocaine counteracts LPS-induced hypolocomotion and triggers locomotor sensitization expression. Behav Brain Res 287:226\u2013229. https:\/\/doi.org\/10.1016\/j.bbr.2015.03.054","journal-title":"Behav Brain Res"},{"key":"6392_CR48","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.neuropharm.2011.08.029","volume":"62","author":"EM Valdiz\u00e1n","year":"2012","unstructured":"Valdiz\u00e1n EM, D\u00edaz A, Pilar-Cu\u00e9llar F et al (2012) Chronic treatment with the opioid antagonist naltrexone favours the coupling of spinal cord \u03bc-opioid receptors to G\u03b1z protein subunits. Neuropharmacology 62:757\u2013764. https:\/\/doi.org\/10.1016\/j.neuropharm.2011.08.029","journal-title":"Neuropharmacology"},{"key":"6392_CR49","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.drugalcdep.2017.01.030","volume":"175","author":"EJ Vallender","year":"2017","unstructured":"Vallender EJ, Goswami DB, Shinday NM et al (2017) Transcriptomic profiling of the ventral tegmental area and nucleus accumbens in rhesus macaques following long-term cocaine self-administration. Drug Alcohol Depend 175:9\u201323. https:\/\/doi.org\/10.1016\/j.drugalcdep.2017.01.030","journal-title":"Drug Alcohol Depend"},{"key":"6392_CR50","doi-asserted-by":"publisher","first-page":"3622","DOI":"10.1021\/acschemneuro.9b00225","volume":"10","author":"X Wang","year":"2019","unstructured":"Wang X, Northcutt AL, Cochran TA et al (2019) Methamphetamine activates Toll-like receptor 4 to induce central immune signaling within the ventral tegmental area and contributes to extracellular dopamine increase in the nucleus accumbens shell. ACS Chem Neurosci 10:3622\u20133634. https:\/\/doi.org\/10.1021\/acschemneuro.9b00225","journal-title":"ACS Chem Neurosci"},{"key":"6392_CR51","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.drugalcdep.2016.02.036","volume":"162","author":"MJ Worley","year":"2016","unstructured":"Worley MJ, Heinzerling KG, Roche DJO, Shoptaw S (2016) Ibudilast attenuates subjective effects of methamphetamine in a placebo-controlled inpatient study. Drug Alcohol Depend 162:245\u2013250. https:\/\/doi.org\/10.1016\/j.drugalcdep.2016.02.036","journal-title":"Drug Alcohol Depend"},{"key":"6392_CR52","doi-asserted-by":"publisher","first-page":"603445","DOI":"10.3389\/fphar.2020.603445","volume":"11","author":"R Wu","year":"2020","unstructured":"Wu R, Li J-X (2020) Toll-like receptor 4 signaling and drug addiction. Front Pharmacol 11:603445. https:\/\/doi.org\/10.3389\/fphar.2020.603445","journal-title":"Front Pharmacol"},{"key":"6392_CR53","doi-asserted-by":"publisher","unstructured":"Yue K, Tanda G, Katz JL, Zanettini C (2019) A further assessment of a role for Toll-like receptor 4 in the reinforcing and reinstating effects of opioids. Behav Pharmacol. https:\/\/doi.org\/10.1097\/FBP.0000000000000474","DOI":"10.1097\/FBP.0000000000000474"},{"key":"6392_CR54","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1021\/acs.jcim.7b00717","volume":"58","author":"X Zhang","year":"2018","unstructured":"Zhang X, Cui F, Chen H et al (2018) Dissecting the innate immune recognition of opioid inactive isomer (+)-naltrexone derived Toll-like receptor 4 (TLR4) antagonists. J Chem Inf Model 58:816\u2013825. https:\/\/doi.org\/10.1021\/acs.jcim.7b00717","journal-title":"J Chem Inf Model"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-023-06392-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-023-06392-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-023-06392-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T11:07:33Z","timestamp":1686827253000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-023-06392-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,7]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["6392"],"URL":"https:\/\/doi.org\/10.1007\/s00213-023-06392-w","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,7]]},"assertion":[{"value":"21 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}