{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:09:25Z","timestamp":1790687365191,"version":"4.1.0"},"reference-count":104,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2021-125977OB-I00"],"award-info":[{"award-number":["PID2021-125977OB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016386","name":"Conselleria de Innovaci\u00f3n, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana","doi-asserted-by":"publisher","award":["PROMETEO\/2020\/032"],"award-info":[{"award-number":["PROMETEO\/2020\/032"]}],"id":[{"id":"10.13039\/501100016386","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004834","name":"Universitat Jaume I","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004834","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Depression is a disorder twice as common in women than in men. There are sex differences in the symptomatology and treatment response to this disorder. Impairments in behavioral activation (i.e. anergia, fatigue) are often seen in people with depression and are highly resistant to treatment. The role of mesolimbic dopamine (DA) in regulating behavioral activation has been extensively studied in male rodents, but little is known in female rodents.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>The present studies assessed potential sex differences in rodent paradigms used to study different components of depressive-like behavior, and in the treatment response to antidepressants with different mechanisms of action.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Male and female CD1 mice received Tetrabenazine (TBZ), a VMAT-2 blocker that depletes DA and induces depressive symptoms in humans. Mice were tested on the Forced Swim Test, (FST), the Dark\u2013Light box (DL), the elevated plus maze (EPM), Social Interaction (SI) test, and sucrose preference and consumption using the two bottles test. In addition, bupropion (a DA reuptake inhibitor) or fluoxetine (a serotonin reuptake inhibitor) were used to reverse TBZ-induced anergia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the FST, bupropion reversed TBZ effects in both sexes but fluoxetine was only effective in female mice. DA depletion did not affect other aspects of depression such as anxiety, sociability or sucrose consumption, and there was no interaction with bupropion on these parameters. In TBZ treated-females SERT-blockers may be effective at reversing anergia in aversive contexts (FST), and potentiating avoidance of anxiogenic stimuli.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Pro-dopaminergic antidepressants seem more efficacious at improving anergia in both sexes than SERT-blockers.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00213-023-06412-9","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T19:01:32Z","timestamp":1688583692000},"page":"1615-1628","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effects of the dopamine depleting agent tetrabenazine in tests evaluating different components of depressive-like behavior in mice: sex-dependent response to antidepressant drugs with SERT and DAT blocker profiles"],"prefix":"10.1007","volume":"240","author":[{"given":"Carla","family":"Carratal\u00e1-Ros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mart\u00ednez-Verd\u00fa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regulo","family":"Olivares-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Salamone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9868-3131","authenticated-orcid":false,"given":"Merc\u00e8","family":"Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,5]]},"reference":[{"key":"6412_CR1","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/J.PHARMTHERA.2006.08.004","volume":"113","author":"KD Alex","year":"2007","unstructured":"Alex KD, Pehek EA (2007) Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacol Ther 113:296\u2013320. https:\/\/doi.org\/10.1016\/J.PHARMTHERA.2006.08.004","journal-title":"Pharmacol Ther"},{"key":"6412_CR2","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/0014-2999(88)90068-4","volume":"158","author":"A Armario","year":"1988","unstructured":"Armario A, Gavald\u00e0 A, Mart\u00ed O (1988) Forced swimming test in rats: effect of desipramine administration and the period of exposure to the test on struggling behavior, swimming, immobility and defecation rate. Eur J Pharmacol 158:207\u2013212. https:\/\/doi.org\/10.1016\/0014-2999(88)90068-4","journal-title":"Eur J Pharmacol"},{"key":"6412_CR3","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1126\/SCIENCE.1120972","volume":"311","author":"O Berton","year":"2006","unstructured":"Berton O, McClung CA, DiLeone RJ et al (2006) Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311:864\u2013868. https:\/\/doi.org\/10.1126\/SCIENCE.1120972","journal-title":"Science"},{"key":"6412_CR4","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/S00127-010-0197-Z","volume":"46","author":"S Bjornelv","year":"2011","unstructured":"Bjornelv S, Nordahl HM, Holmen TL (2011) Psychological factors and weight problems in adolescents. The role of eating problems, emotional problems, and personality traits: the Young-HUNT study. Soc Psychiatry Psychiatr Epidemiol 46:353\u2013362. https:\/\/doi.org\/10.1007\/S00127-010-0197-Z","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"key":"6412_CR5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0091-3057(83)90247-2","volume":"18","author":"LK Blumstein","year":"1983","unstructured":"Blumstein LK, Crawley JN (1983) Further characterization of a simple, automated exploratory model for the anxiolytic effects of benzodiazepines. Pharmacol Biochem Behav 18:37\u201340. https:\/\/doi.org\/10.1016\/0091-3057(83)90247-2","journal-title":"Pharmacol Biochem Behav"},{"key":"6412_CR6","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1007\/s00127-006-0079-6","volume":"41","author":"F Breslin","year":"2006","unstructured":"Breslin F, William G, Ren\u00e9e-Louise F, Mustard C, Elizabeth L (2006) Depression and activity limitations: examining gender differences in the general population. Social Psychiatry Epidemiology 41:648\u2013655. https:\/\/doi.org\/10.1007\/s00127-006-0079-6","journal-title":"Social Psychiatry Epidemiology"},{"key":"6412_CR7","doi-asserted-by":"publisher","unstructured":"Carratal\u00e1-Ros C, L\u00f3pez-Cruz L, SanMiguel N, et al (2020) Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia. Front Behav Neurosci 13:. https:\/\/doi.org\/10.3389\/fnbeh.2019.00289","DOI":"10.3389\/fnbeh.2019.00289"},{"key":"6412_CR8","doi-asserted-by":"publisher","unstructured":"Carratal\u00e1-Ros C, L\u00f3pez-Cruz L, Mart\u00ednez-Verd\u00fa A, et al (2021a) Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion. Front Behav Neurosci 15:. https:\/\/doi.org\/10.3389\/FNBEH.2021.700182","DOI":"10.3389\/FNBEH.2021.700182"},{"key":"6412_CR9","doi-asserted-by":"publisher","first-page":"3357","DOI":"10.1007\/S00213-021-05950-4","volume":"238","author":"C Carratal\u00e1-Ros","year":"2021","unstructured":"Carratal\u00e1-Ros C, Olivares-Garc\u00eda R, Mart\u00ednez-Verd\u00fa A et al (2021b) Energizing effects of bupropion on effortful behaviors in mice under positive and negative test conditions: modulation of DARPP-32 phosphorylation patterns. Psychopharmacology 238:3357\u20133373. https:\/\/doi.org\/10.1007\/S00213-021-05950-4","journal-title":"Psychopharmacology"},{"key":"6412_CR10","doi-asserted-by":"publisher","unstructured":"Castagn\u00e9 V, Moser P, Roux S, Porsolt RD (2010) Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice. Curr Protoc Pharmacol Chapter 5: https:\/\/doi.org\/10.1002\/0471141755.PH0508S49","DOI":"10.1002\/0471141755.PH0508S49"},{"key":"6412_CR11","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1016\/j.clinthera.2012.06.010","volume":"34","author":"JJ Chen","year":"2012","unstructured":"Chen JJ, Ondo WG, Dashtipour K, Swope DM (2012) Tetrabenazine for the Treatment of Hyperkinetic Movement Disorders: A Review of the Literature. Clin Ther 34:1487\u20131504","journal-title":"Clin Ther"},{"key":"6412_CR12","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1177\/0269881113514878","volume":"28","author":"JA Cooper","year":"2014","unstructured":"Cooper JA, Tucker VL, Papakostas GI (2014) Resolution of sleepiness and fatigue: A comparison of bupropion and selective serotonin reuptake inhibitors in subjects with major depressive disorder achieving remission at doses approved in the European Union. J Psychopharmacol 28:118\u2013124. https:\/\/doi.org\/10.1177\/0269881113514878","journal-title":"J Psychopharmacol"},{"key":"6412_CR13","doi-asserted-by":"publisher","unstructured":"Correa M, SanMiguel N, L\u00f3pez-Cruz L, et al (2018) Caffeine modulates food intake depending on the context that gives access to food: Comparison with dopamine depletion. Front Psychiatry 9:. https:\/\/doi.org\/10.3389\/fpsyt.2018.00411","DOI":"10.3389\/fpsyt.2018.00411"},{"key":"6412_CR14","doi-asserted-by":"publisher","unstructured":"Correa M, Pardo M, Carratal\u00e1-Ros C, et al (2020) Preference for vigorous exercise versus sedentary sucrose drinking: an animal model of anergia induced by dopamine receptor antagonismhttps:\/\/doi.org\/10.1097\/FBP.0000000000000556","DOI":"10.1097\/FBP.0000000000000556"},{"key":"6412_CR15","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.pnpbp.2013.05.002","volume":"45","author":"APR Costa","year":"2013","unstructured":"Costa APR, Vieira C, Bohner LOL et al (2013) A proposal for refining the forced swim test in Swiss mice. Prog Neuropsychopharmacol Biol Psychiatry 45:150\u2013155. https:\/\/doi.org\/10.1016\/j.pnpbp.2013.05.002","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"6412_CR16","doi-asserted-by":"publisher","unstructured":"Cuthbert BN, Insel TR (2013) Toward the future of psychiatric diagnosis: The seven pillars of RDoC. BMC Med 11:. https:\/\/doi.org\/10.1186\/1741-7015-11-126","DOI":"10.1186\/1741-7015-11-126"},{"key":"6412_CR17","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.physbeh.2007.10.020","volume":"93","author":"C Dalla","year":"2008","unstructured":"Dalla C, Antoniou K, Kokras N et al (2008) Sex differences in the effects of two stress paradigms on dopaminergic neurotransmission. Physiol Behav 93:595\u2013605. https:\/\/doi.org\/10.1016\/j.physbeh.2007.10.020","journal-title":"Physiol Behav"},{"key":"6412_CR18","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1111\/j.1742-7843.2009.00516.x","volume":"106","author":"C Dalla","year":"2010","unstructured":"Dalla C, Pitychoutis PM, Kokras N, Papadopoulou-Daifoti Z (2010) Sex Differences in Animal Models of Depression and Antidepressant Response. Basic Clin Pharmacol Toxicol 106:226\u2013233. https:\/\/doi.org\/10.1111\/j.1742-7843.2009.00516.x","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"6412_CR19","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1300\/J013V46N04_02","volume":"46","author":"J Dekker","year":"2007","unstructured":"Dekker J, Koelen JA, Peen J et al (2007) Gender differences in clinical features of depressed outpatients: preliminary evidence for subtyping of depression? Women Health 46:19\u201338. https:\/\/doi.org\/10.1300\/J013V46N04_02","journal-title":"Women Health"},{"key":"6412_CR20","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1002\/da.22199","volume":"31","author":"M Fava","year":"2014","unstructured":"Fava M, Ball S, Nelson JC et al (2014) Clinical relevance of fatigue as a residual symptom in major depressive disorder. Depress Anxiety 31:250\u2013257","journal-title":"Depress Anxiety"},{"key":"6412_CR21","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1097\/00004714-198602000-00006","volume":"6","author":"J Feighner","year":"1986","unstructured":"Feighner J, Hendrickson G, Miller L, Stern W (1986) Double-Blind comparison of doxepin versus bupropion in outpatients with a major depressive disorder. J Clin Psychopharmacol 6:27\u201332. https:\/\/doi.org\/10.1097\/00004714-198602000-00006","journal-title":"J Clin Psychopharmacol"},{"key":"6412_CR22","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/S0091-3057(99)00139-2","volume":"64","author":"C Fernandes","year":"1999","unstructured":"Fernandes C, Gonz\u00e1lez MI, Wilson CA, File SE (1999) Factor analysis shows that female rat behaviour is characterized primarily by activity, male rats are driven by sex and anxiety. Pharmacol Biochem Behav 64:731\u2013736. https:\/\/doi.org\/10.1016\/S0091-3057(99)00139-2","journal-title":"Pharmacol Biochem Behav"},{"key":"6412_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/J.PBB.2016.12.003","volume":"152","author":"A Fern\u00e1ndez-Guasti","year":"2017","unstructured":"Fern\u00e1ndez-Guasti A (2017) Sex differences on drugs affecting behavior. Pharmacol Biochem Behav 152:1\u20133. https:\/\/doi.org\/10.1016\/J.PBB.2016.12.003","journal-title":"Pharmacol Biochem Behav"},{"key":"6412_CR24","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/J.1476-5381.1978.TB07001.X","volume":"62","author":"SE File","year":"1978","unstructured":"File SE, Hyde JRG (1978) Can social interaction be used to measure anxiety? Br J Pharmacol 62:19\u201324. https:\/\/doi.org\/10.1111\/J.1476-5381.1978.TB07001.X","journal-title":"Br J Pharmacol"},{"key":"6412_CR25","doi-asserted-by":"publisher","unstructured":"Fonseca-Rodrigues D, Gon\u00e7alves J, Laranjeira I, et al (2022) Sucrose intake and preference by Wistar Han rats are not influenced by sex or food\/water deprivation. Pharmacol Biochem Behav 216:. https:\/\/doi.org\/10.1016\/J.PBB.2022.173387","DOI":"10.1016\/J.PBB.2022.173387"},{"key":"6412_CR26","doi-asserted-by":"publisher","unstructured":"Frank S (2009) Tetrabenazine as anti-chorea therapy in Huntington Disease: An open-label continuation study. Huntington Study Group\/TETRA-HD Investigators. BMC Neurol 9:. https:\/\/doi.org\/10.1186\/1471-2377-9-62","DOI":"10.1186\/1471-2377-9-62"},{"key":"6412_CR27","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0166-4328(97)00109-5","volume":"91","author":"M Gil","year":"1998","unstructured":"Gil M, Armario A (1998) Chronic immobilization stress appears to increase the role of dopamine in the control of active behaviour in the forced swimming test. Behav Brain Res 91:91\u201397. https:\/\/doi.org\/10.1016\/S0166-4328(97)00109-5","journal-title":"Behav Brain Res"},{"key":"6412_CR28","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S1550-8579(06)80199-3","volume":"3","author":"JM Gorman","year":"2006","unstructured":"Gorman JM (2006) Gender differences in depression and response to psychotropic medication. Gender Medicine 3:93\u2013109","journal-title":"Gender Medicine"},{"key":"6412_CR29","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.amjopharm.2010.08.006","volume":"8","author":"DRP Guay","year":"2010","unstructured":"Guay DRP (2010) Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders. Am J Geriatr Pharmacother 8:331\u2013373","journal-title":"Am J Geriatr Pharmacother"},{"key":"6412_CR30","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1159\/000118187","volume":"13","author":"AP Guy","year":"1985","unstructured":"Guy AP, Gardner CR (1985) Pharmacological characterisation of a modified social interaction model of anxiety in the rat. Neuropsychobiology 13:194\u2013200. https:\/\/doi.org\/10.1159\/000118187","journal-title":"Neuropsychobiology"},{"key":"6412_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/J.PHYSBEH.2017.01.025","volume":"173","author":"YO Henderson","year":"2017","unstructured":"Henderson YO, Nalloor R, Vazdarjanova A et al (2017) Sex-dependent effects of early life inflammatory pain on sucrose intake and sucrose-associated hippocampal Arc expression in adult rats. Physiol Behav 173:1\u20138. https:\/\/doi.org\/10.1016\/J.PHYSBEH.2017.01.025","journal-title":"Physiol Behav"},{"key":"6412_CR32","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/mp.2015.53","volume":"21","author":"F Hieronymus","year":"2016","unstructured":"Hieronymus F, Emilsson JF, Nilsson S, Eriksson E (2016) Consistent superiority of selective serotonin reuptake inhibitors over placebo in reducing depressed mood in patients with major depression. Mol Psychiatry 21:523\u2013530. https:\/\/doi.org\/10.1038\/mp.2015.53","journal-title":"Mol Psychiatry"},{"key":"6412_CR33","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.neulet.2008.12.024","volume":"451","author":"DP Jang","year":"2009","unstructured":"Jang DP, Lee SH, Park CW et al (2009) Effects of fluoxetine on the rat brain in the forced swimming test: A [F-18]FDG micro-PET imaging study. Neurosci Lett 451:60\u201364. https:\/\/doi.org\/10.1016\/j.neulet.2008.12.024","journal-title":"Neurosci Lett"},{"key":"6412_CR34","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1038\/SJ.NPP.1300664","volume":"30","author":"MD Jones","year":"2005","unstructured":"Jones MD, Lucki I (2005) Sex differences in the regulation of serotonergic transmission and behavior in 5-HT receptor knockout mice. Neuropsychopharmacology 30:1039\u20131047. https:\/\/doi.org\/10.1038\/SJ.NPP.1300664","journal-title":"Neuropsychopharmacology"},{"key":"6412_CR35","unstructured":"Keppel G (1991) Design and Analysis A Researcher\u2019s Handbook. 3rd Edition. In: Prentice Hall, Englewood Clifts, New York. https:\/\/www.scirp.org\/(S(351jmbntvnsjt1aadkozje))\/reference\/ReferencesPapers.aspx?ReferenceID=1606519. Accessed 18 Jul 2020"},{"key":"6412_CR36","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/S0165-0327(02)00426-3","volume":"74","author":"RC Kessler","year":"2003","unstructured":"Kessler RC (2003) Epidemiology of women and depression. J Affect Disord 74:5\u201313. https:\/\/doi.org\/10.1016\/S0165-0327(02)00426-3","journal-title":"J Affect Disord"},{"key":"6412_CR37","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1097\/01.JCP.0000168879.03169.CE","volume":"25","author":"A Khan","year":"2005","unstructured":"Khan A, Brodhead AE, Schwartz KA et al (2005) Sex differences in antidepressant response in recent antidepressant clinical trials. J Clin Psychopharmacol 25:318\u2013324. https:\/\/doi.org\/10.1097\/01.JCP.0000168879.03169.CE","journal-title":"J Clin Psychopharmacol"},{"key":"6412_CR38","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3109\/10401239409148989","volume":"6","author":"A Kiev","year":"1994","unstructured":"Kiev A, Masco HL, Wenger TL et al (1994) The cardiovascular effects of bupropion and nortriptyline in depressed outpatients. Ann Clin Psychiatry 6:107\u2013115. https:\/\/doi.org\/10.3109\/10401239409148989","journal-title":"Ann Clin Psychiatry"},{"key":"6412_CR39","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00210-010-0521-x","volume":"382","author":"Y Kitamura","year":"2010","unstructured":"Kitamura Y, Yagi T, Kitagawa K et al (2010) Effects of bupropion on the forced swim test and release of dopamine in the nucleus accumbens in ACTH-treated rats. Naunyn Schmiedebergs Arch Pharmacol 382:151\u2013158. https:\/\/doi.org\/10.1007\/s00210-010-0521-x","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"6412_CR40","doi-asserted-by":"publisher","unstructured":"Knight P, Chellian R, Wilson R, et al (2021) Sex differences in the elevated plus-maze test and large open field test in adult Wistar rats. Pharmacol Biochem Behav 204:. https:\/\/doi.org\/10.1016\/J.PBB.2021.173168","DOI":"10.1016\/J.PBB.2021.173168"},{"key":"6412_CR41","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/J.NEUROPHARM.2011.08.025","volume":"62","author":"N Kokras","year":"2012","unstructured":"Kokras N, Dalla C, Sideris AC et al (2012) Behavioral sexual dimorphism in models of anxiety and depression due to changes in HPA axis activity. Neuropharmacology 62:436\u2013445. https:\/\/doi.org\/10.1016\/J.NEUROPHARM.2011.08.025","journal-title":"Neuropharmacology"},{"key":"6412_CR42","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.neuropharm.2015.03.016","volume":"99","author":"N Kokras","year":"2015","unstructured":"Kokras N, Antoniou K, Mikail HG et al (2015) Forced swim test: What about females? Neuropharmacology 99:408\u2013421. https:\/\/doi.org\/10.1016\/j.neuropharm.2015.03.016","journal-title":"Neuropharmacology"},{"key":"6412_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0165-0327(99)00158-5","volume":"60","author":"SG Kornstein","year":"2000","unstructured":"Kornstein SG, Schatzberg AF, Thase ME et al (2000) Gender differences in chronic major and double depression. J Affect Disord 60:1\u201311. https:\/\/doi.org\/10.1016\/S0165-0327(99)00158-5","journal-title":"J Affect Disord"},{"key":"6412_CR44","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.physbeh.2014.05.006","volume":"133","author":"N Kulesskaya","year":"2014","unstructured":"Kulesskaya N, Voikar V (2014) Assessment of mouse anxiety-like behavior in the light-dark box and open-field arena: Role of equipment and procedure. Physiol Behav 133:30\u201338. https:\/\/doi.org\/10.1016\/j.physbeh.2014.05.006","journal-title":"Physiol Behav"},{"key":"6412_CR45","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/0091-3057(82)90117-4","volume":"17","author":"MR Landauer","year":"1982","unstructured":"Landauer MR, Balster RL (1982) Opiate effects on social investigatory behavior of male mice. Pharmacol Biochem Behav 17:1181\u20131186. https:\/\/doi.org\/10.1016\/0091-3057(82)90117-4","journal-title":"Pharmacol Biochem Behav"},{"key":"6412_CR46","doi-asserted-by":"publisher","unstructured":"Levine AS, Kotz CM, Gosnell BA (2003) Sugars: hedonic aspects, neuroregulation, and energy balance. Am J Clin Nutr 78:. https:\/\/doi.org\/10.1093\/AJCN\/78.4.834S","DOI":"10.1093\/AJCN\/78.4.834S"},{"key":"6412_CR47","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/BF00177912","volume":"92","author":"RG Lister","year":"1987","unstructured":"Lister RG (1987) The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology 92:180\u2013185. https:\/\/doi.org\/10.1007\/BF00177912","journal-title":"Psychopharmacology"},{"key":"6412_CR48","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.bbr.2014.05.020","volume":"270","author":"L L\u00f3pez-Cruz","year":"2014","unstructured":"L\u00f3pez-Cruz L, Pardo M, Salamone JD, Correa M (2014) Differences between the nonselective adenosine receptor antagonists caffeine and theophylline in motor and mood effects: Studies using medium to high doses in animal models. Behav Brain Res 270:213\u2013222. https:\/\/doi.org\/10.1016\/j.bbr.2014.05.020","journal-title":"Behav Brain Res"},{"key":"6412_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnbeh.2016.00206","volume":"10","author":"L L\u00f3pez-Cruz","year":"2016","unstructured":"L\u00f3pez-Cruz L, San-Miguel N, Bayarri P et al (2016) Ethanol and Caffeine Effects on Social Interaction and Recognition in Mice: Involvement of Adenosine A2A and A1 Receptors. Front Behav Neurosci 10:1\u201315. https:\/\/doi.org\/10.3389\/fnbeh.2016.00206","journal-title":"Front Behav Neurosci"},{"key":"6412_CR50","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.neuropharm.2018.01.034","volume":"138","author":"L L\u00f3pez-Cruz","year":"2018","unstructured":"L\u00f3pez-Cruz L, San Miguel N, Carratal\u00e1-Ros C et al (2018) Dopamine depletion shifts behavior from activity based reinforcers to more sedentary ones and adenosine receptor antagonism reverses that shift: Relation to ventral striatum DARPP32 phosphorylation patterns. Neuropharmacology 138:349\u2013359. https:\/\/doi.org\/10.1016\/j.neuropharm.2018.01.034","journal-title":"Neuropharmacology"},{"key":"6412_CR51","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1097\/00008877-199711000-00010","volume":"8","author":"I Lucki","year":"1997","unstructured":"Lucki I (1997) The forced swimming test as a model for core and component behavioral effects of antidepressant drugs. Behav Pharmacol 8:523\u2013532","journal-title":"Behav Pharmacol"},{"key":"6412_CR52","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/J.JAD.2004.09.008","volume":"87","author":"SM Marcus","year":"2005","unstructured":"Marcus SM, Young EA, Kerber KB et al (2005) Gender differences in depression: findings from the STAR*D study. J Affect Disord 87:141\u2013150. https:\/\/doi.org\/10.1016\/J.JAD.2004.09.008","journal-title":"J Affect Disord"},{"key":"6412_CR53","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/J.PHYSBEH.2011.05.027","volume":"104","author":"L Mart\u00ednez-Mota","year":"2011","unstructured":"Mart\u00ednez-Mota L, Ulloa RE, Herrera-P\u00e9rez J et al (2011) Sex and age differences in the impact of the forced swimming test on the levels of steroid hormones. Physiol Behav 104:900\u2013905. https:\/\/doi.org\/10.1016\/J.PHYSBEH.2011.05.027","journal-title":"Physiol Behav"},{"key":"6412_CR54","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/BF02246218","volume":"117","author":"S Monleon","year":"1995","unstructured":"Monleon S, Parra A, Simon VM et al (1995) Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine. Psychopharmacology 117:453\u2013457. https:\/\/doi.org\/10.1007\/BF02246218","journal-title":"Psychopharmacology"},{"key":"6412_CR55","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/J.BBR.2010.05.017","volume":"213","author":"V Mourlon","year":"2010","unstructured":"Mourlon V, Baudin A, Blanc O et al (2010) Maternal deprivation induces depressive-like behaviours only in female rats. Behav Brain Res 213:278\u2013287. https:\/\/doi.org\/10.1016\/J.BBR.2010.05.017","journal-title":"Behav Brain Res"},{"key":"6412_CR56","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/BF00634461","volume":"99","author":"R Muscat","year":"1989","unstructured":"Muscat R, Willner P (1989) Effects of dopamine receptor antagonists on sucrose consumption and preference. Psychopharmacology 99:98\u2013102. https:\/\/doi.org\/10.1007\/BF00634461","journal-title":"Psychopharmacology"},{"key":"6412_CR57","doi-asserted-by":"publisher","first-page":"19120","DOI":"10.1523\/JNEUROSCI.2730-13.2013","volume":"33","author":"EJ Nunes","year":"2013","unstructured":"Nunes EJ, Randall PA, Hart EE et al (2013a) Effort-related motivational effects of the VMAT-2 inhibitor tetrabenazine: Implications for animal models of the motivational symptoms of depression. J Neurosci 33:19120\u201319130. https:\/\/doi.org\/10.1523\/JNEUROSCI.2730-13.2013","journal-title":"J Neurosci"},{"key":"6412_CR58","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1016\/j.neubiorev.2013.04.002","volume":"37","author":"EJ Nunes","year":"2013","unstructured":"Nunes EJ, Randall PA, Podurgiel S et al (2013b) Nucleus accumbens neurotransmission and effort-related choice behavior in food motivation: Effects of drugs acting on dopamine, adenosine, and muscarinic acetylcholine receptors. Neurosci Biobehav Rev 37:2015\u20132025. https:\/\/doi.org\/10.1016\/j.neubiorev.2013.04.002","journal-title":"Neurosci Biobehav Rev"},{"key":"6412_CR59","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1007\/s00213-013-3285-4","volume":"231","author":"EJ Nunes","year":"2014","unstructured":"Nunes EJ, Randall PA, Estrada A et al (2014) Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: Studies with the concurrent fixed ratio 5\/ chow feeding choice task. Psychopharmacology 231:727\u2013736. https:\/\/doi.org\/10.1007\/s00213-013-3285-4","journal-title":"Psychopharmacology"},{"issue":"Suppl 17","key":"6412_CR60","first-page":"23","volume":"60","author":"DJ Nutt","year":"1999","unstructured":"Nutt DJ (1999) Care of depressed patients with anxiety symptoms. J Clin Psychiatry 60(Suppl 17):23\u201327","journal-title":"J Clin Psychiatry"},{"key":"6412_CR61","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1177\/0269881106069938","volume":"21","author":"D Nutt","year":"2007","unstructured":"Nutt D, Demyttenaere K, Janka Z et al (2007) The other face of depression, reduced positive affect: the role of catecholamines in causation and cure. J Psychopharmacol 21:461\u2013471. https:\/\/doi.org\/10.1177\/0269881106069938","journal-title":"J Psychopharmacol"},{"key":"6412_CR62","doi-asserted-by":"publisher","unstructured":"Padala PR, Padala KP, Monga V, et al (2012) Reversal of SSRI-associated apathy syndrome by discontinuation of therapy. Annals of Pharmacotherapy 46:. https:\/\/doi.org\/10.1345\/aph.1Q656","DOI":"10.1345\/aph.1Q656"},{"key":"6412_CR63","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1586\/14737175.7.10.1251","volume":"7","author":"CU Pae","year":"2007","unstructured":"Pae CU, Lim HK, Han C et al (2007) Fatigue as a core symptom in major depressive disorder: Overview and the role of bupropion. Expert Rev Neurother 7:1251\u20131263","journal-title":"Expert Rev Neurother"},{"key":"6412_CR64","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1016\/j.biopsych.2006.06.015","volume":"60","author":"GI Papakostas","year":"2006","unstructured":"Papakostas GI, Nutt DJ, Hallett LA et al (2006) Resolution of Sleepiness and Fatigue in Major Depressive Disorder: A Comparison of Bupropion and the Selective Serotonin Reuptake Inhibitors. Biol Psychiatry 60:1350\u20131355. https:\/\/doi.org\/10.1016\/j.biopsych.2006.06.015","journal-title":"Biol Psychiatry"},{"key":"6412_CR65","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.4088\/JCP.V69N0812","volume":"69","author":"GI Papakostas","year":"2008","unstructured":"Papakostas GI, Stahl SM, Krishen A et al (2008) Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of major depressive disorder with high levels of anxiety (anxious depression): a pooled analysis of 10 studies. J Clin Psychiatry 69:1287\u20131292. https:\/\/doi.org\/10.4088\/JCP.V69N0812","journal-title":"J Clin Psychiatry"},{"key":"6412_CR66","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.1007\/s00213-015-3872-7","volume":"232","author":"M Pardo","year":"2015","unstructured":"Pardo M, L\u00f3pez-Cruz L, Miguel NS et al (2015) Selection of sucrose concentration depends on the effort required to obtain it: Studies using tetrabenazine, D1, D2, and D3 receptor antagonists. Psychopharmacology 232:2377\u20132391. https:\/\/doi.org\/10.1007\/s00213-015-3872-7","journal-title":"Psychopharmacology"},{"key":"6412_CR67","doi-asserted-by":"publisher","first-page":"429","DOI":"10.3109\/09540261.2010.492391","volume":"22","author":"G Parker","year":"2010","unstructured":"Parker G, Brotchie H (2010) Gender differences in depression. Int Rev Psychiatry 22:429\u2013436. https:\/\/doi.org\/10.3109\/09540261.2010.492391","journal-title":"Int Rev Psychiatry"},{"key":"6412_CR68","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/J.EXGER.2016.01.012","volume":"76","author":"AE Perkins","year":"2016","unstructured":"Perkins AE, Doremus-Fitzwater TL, Spencer RL et al (2016) A working model for the assessment of disruptions in social behavior among aged rats: The role of sex differences, social recognition, and sensorimotor processes. Exp Gerontol 76:46\u201357. https:\/\/doi.org\/10.1016\/J.EXGER.2016.01.012","journal-title":"Exp Gerontol"},{"key":"6412_CR69","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00213-004-2048-7","volume":"177","author":"B Petit-Demouliere","year":"2005","unstructured":"Petit-Demouliere B, Chenu F, Bourin M (2005) Forced swimming test in mice: A review of antidepressant activity. Psychopharmacology 177:245\u2013255","journal-title":"Psychopharmacology"},{"key":"6412_CR70","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/0014-2999(84)90562-4","volume":"102","author":"DJ Pettibone","year":"1984","unstructured":"Pettibone DJ, Totaro JA, Pflueger AB (1984) Tetrabenazine-induced depletion of brain monoamines: Characterization and interaction with selected antidepressants. Eur J Pharmacol 102:425\u2013430. https:\/\/doi.org\/10.1016\/0014-2999(84)90562-4","journal-title":"Eur J Pharmacol"},{"issue":"9","key":"6412_CR71","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1038\/npp.2015.69","volume":"40","author":"SJ Podurgiel","year":"2015","unstructured":"Podurgiel SJ, Milligan MN, Yohn SE, Purcell LJ, Contreras-Mora HM, Correa M, Salamone JD (2015) Fluoxetine administration exacerbates oral tremor and striatal dopamine depletion in a rodent pharmacological model of Parkinsonism. Neuropsychopharmacology 40(9):2240\u20132247. https:\/\/doi.org\/10.1038\/npp.2015.69","journal-title":"Neuropsychopharmacology"},{"key":"6412_CR72","first-page":"327","volume":"229","author":"RD Porsolt","year":"1977","unstructured":"Porsolt RD, Bertin A, Jalfre M (1977) Behavioral despair in mice: A primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229:327\u2013336","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"6412_CR73","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3109\/13814780903186423","volume":"15","author":"O Poutanen","year":"2009","unstructured":"Poutanen O, Koivisto A, Mattila A et al (2009) Gender differences in the symptoms of major depression and in the level of social functioning in public primary care patients. European Journal of General Practice 15:161\u2013167. https:\/\/doi.org\/10.3109\/13814780903186423","journal-title":"European Journal of General Practice"},{"key":"6412_CR74","doi-asserted-by":"publisher","unstructured":"Presby RE, Rotolo RA, Hurley EM, et al (2021) Sex differences in lever pressing and running wheel tasks of effort-based choice behavior in rats: Suppression of high effort activity by the serotonin transport inhibitor fluoxetine. Pharmacol Biochem Behav 202:. https:\/\/doi.org\/10.1016\/J.PBB.2021.173115","DOI":"10.1016\/J.PBB.2021.173115"},{"key":"6412_CR75","doi-asserted-by":"publisher","unstructured":"Randall PA, Pardo M, Nunes EJ, et al (2012) Dopaminergic Modulation of Effort-Related Choice Behavior as Assessed by a Progressive Ratio Chow Feeding Choice Task: Pharmacological Studies and the Role of Individual Differences. PLoS One 7:. https:\/\/doi.org\/10.1371\/journal.pone.0047934","DOI":"10.1371\/journal.pone.0047934"},{"key":"6412_CR76","doi-asserted-by":"publisher","unstructured":"Randall PA, Lee CA, Nunes EJ, et al (2014) The VMAT-2 inhibitor tetrabenazine affects effort-related decision making in a progressive ratio\/chow feeding choice task: Reversal with antidepressant drugs. PLoS One 9:. https:\/\/doi.org\/10.1371\/journal.pone.0099320","DOI":"10.1371\/journal.pone.0099320"},{"key":"6412_CR77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ijnp\/pyu017","volume":"18","author":"PA Randall","year":"2015","unstructured":"Randall PA, Lee CA, Podurgiel SJ et al (2015) Bupropion increases selection of high effort activity in rats tested on a progressive ratio\/chow feeding choice procedure: Implications for treatment of effort-related motivational symptoms. Int J Neuropsychopharmacol 18:1\u201311. https:\/\/doi.org\/10.1093\/ijnp\/pyu017","journal-title":"Int J Neuropsychopharmacol"},{"key":"6412_CR78","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.jad.2013.06.050","volume":"151","author":"SJ Rizvi","year":"2013","unstructured":"Rizvi SJ, Salomons TV, Konarski JZ et al (2013) Neural response to emotional stimuli associated with successful antidepressant treatment and behavioral activation. J Affect Disord 151:573\u2013581. https:\/\/doi.org\/10.1016\/j.jad.2013.06.050","journal-title":"J Affect Disord"},{"key":"6412_CR79","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1177\/0269881112450779","volume":"26","author":"G Rosenblau","year":"2012","unstructured":"Rosenblau G, Sterzer P, Stoy M et al (2012) Functional neuroanatomy of emotion processing in major depressive disorder is altered after successful antidepressant therapy. J Psychopharmacol 26:1424\u20131433. https:\/\/doi.org\/10.1177\/0269881112450779","journal-title":"J Psychopharmacol"},{"key":"6412_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.comppsych.2013.08.008","volume":"55","author":"AJ Rothschild","year":"2014","unstructured":"Rothschild AJ, Raskin J, Wang CN et al (2014) The relationship between change in apathy and changes in cognition and functional outcomes in currently non-depressed SSRI-treated patients with major depressive disorder. Compr Psychiatry 55:1\u201310. https:\/\/doi.org\/10.1016\/j.comppsych.2013.08.008","journal-title":"Compr Psychiatry"},{"key":"6412_CR81","doi-asserted-by":"publisher","unstructured":"Rotolo RA, Dragacevic V, Kalaba P, et al (2019) The novel atypical dopamine uptake inhibitor (S)-CE-123 partially reverses the effort-related effects of the dopamine depleting agent tetrabenazine and increases progressive ratio responding. Front Pharmacol 10:. https:\/\/doi.org\/10.3389\/fphar.2019.00682","DOI":"10.3389\/fphar.2019.00682"},{"key":"6412_CR82","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/J.NEURON.2012.10.021","volume":"76","author":"JD Salamone","year":"2012","unstructured":"Salamone JD, Correa M (2012) The mysterious motivational functions of mesolimbic dopamine. Neuron 76:470\u2013485. https:\/\/doi.org\/10.1016\/J.NEURON.2012.10.021","journal-title":"Neuron"},{"key":"6412_CR83","doi-asserted-by":"publisher","unstructured":"Salamone JD, Correa M (2022) Critical review of RDoC approaches to the study of motivation with animal models: effort valuation\/willingness to work. Emerg Top Life Sci https:\/\/doi.org\/10.1042\/ETLS20220008","DOI":"10.1042\/ETLS20220008"},{"key":"6412_CR84","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.brainresbull.2022.01.019","volume":"182","author":"JD Salamone","year":"2022","unstructured":"Salamone JD, Ecevitoglu A, Carratala-Ros C, Presby RE, Edelstein GA, Fleeher R, Rotolo RA, Meka N, Srinath S, Masthay JC, Correa M (2022) Complexities and paradoxes in understanding the role of dopamine in incentive motivation and instrumental action: Exertion of effort vs. anhedonia. Brain Res Bull 182:57\u201366. https:\/\/doi.org\/10.1016\/j.brainresbull.2022.01.019","journal-title":"Brain Res Bull"},{"key":"6412_CR85","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.pbb.2018.04.004","volume":"169","author":"N San Miguel","year":"2018","unstructured":"San Miguel N, Pardo M, Carratala-Ros C et al (2018) Individual differences in the energizing effects of caffeine on effort-based decision making tests in rats. Pharmacol Biochem Behav 169:27\u201334. https:\/\/doi.org\/10.1016\/j.pbb.2018.04.004","journal-title":"Pharmacol Biochem Behav"},{"key":"6412_CR86","doi-asserted-by":"publisher","unstructured":"Scholl JL, Afzal A, Fox LC, et al (2019) Sex differences in anxiety-like behaviors in rats. Physiol Behav 211:. https:\/\/doi.org\/10.1016\/J.PHYSBEH.2019.112670","DOI":"10.1016\/J.PHYSBEH.2019.112670"},{"key":"6412_CR87","doi-asserted-by":"publisher","unstructured":"Seedat S, Scott KM, Angermeyer MC, et al (2010) Cross-national associations between gender and mental disorders in the WHO World Mental Health Surveys. 66:785\u2013795https:\/\/doi.org\/10.1001\/archgenpsychiatry.2009.36.Cross-national","DOI":"10.1001\/archgenpsychiatry.2009.36.Cross-national"},{"key":"6412_CR88","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1176\/appi.ajp.159.6.1051","volume":"159","author":"B Silverstein","year":"2002","unstructured":"Silverstein B (2002) Gender Differences in the Prevalence of Somatic Versus Pure Depression\u202f: A Replication. Am J Psychiatry 159:1051\u20131052","journal-title":"Am J Psychiatry"},{"key":"6412_CR89","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.mehy.2012.10.007","volume":"80","author":"E Stenman","year":"2013","unstructured":"Stenman E, Lilja \u00c5 (2013) Increased monoaminergic neurotransmission improves compliance with physical activity recommendations in depressed patients with fatigue. Med Hypotheses 80:47\u201349. https:\/\/doi.org\/10.1016\/j.mehy.2012.10.007","journal-title":"Med Hypotheses"},{"key":"6412_CR90","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.phrs.2017.04.027","volume":"121","author":"C Tannenbaum","year":"2017","unstructured":"Tannenbaum C, Day D (2017) Age and sex in drug development and testing for adults. Pharmacol Res 121:83\u201393","journal-title":"Pharmacol Res"},{"key":"6412_CR91","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/s41586-019-1657-6","volume":"575","author":"C Tannenbaum","year":"2019","unstructured":"Tannenbaum C, Ellis RP, Eyssel F et al (2019) Sex and gender analysis improves science and engineering. Nature 575:137\u2013146. https:\/\/doi.org\/10.1038\/s41586-019-1657-6","journal-title":"Nature"},{"key":"6412_CR92","first-page":"40","volume":"8","author":"SD Targum","year":"2011","unstructured":"Targum SD, Fava M (2011) Fatigue as a residual symptom of depression. Innov Clin Neurosci 8:40\u201343","journal-title":"Innov Clin Neurosci"},{"key":"6412_CR93","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00004850-200501000-00001","volume":"20","author":"C Thiels","year":"2005","unstructured":"Thiels C, Linden M, Grieger F, Leonard J (2005) Gender differences in routine treatment of depressed outpatients with the selective serotonin reuptake inhibitor sertraline. Int Clin Psychopharmacol 20:1\u20137. https:\/\/doi.org\/10.1097\/00004850-200501000-00001","journal-title":"Int Clin Psychopharmacol"},{"issue":"Suppl","key":"6412_CR94","first-page":"7","volume":"60","author":"A Tylee","year":"1999","unstructured":"Tylee A (1999) Depression in the community: physician and patient perspective. J Clin Psychiatry 60(Suppl):7","journal-title":"J Clin Psychiatry"},{"key":"6412_CR95","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/J.PHYSBEH.2009.11.002","volume":"99","author":"P Verma","year":"2010","unstructured":"Verma P, Hellemans KGC, Choi FY et al (2010) Circadian phase and sex effects on depressive\/anxiety-like behaviors and HPA axis responses to acute stress. Physiol Behav 99:276\u2013285. https:\/\/doi.org\/10.1016\/J.PHYSBEH.2009.11.002","journal-title":"Physiol Behav"},{"key":"6412_CR96","doi-asserted-by":"publisher","first-page":"196","DOI":"10.4088\/JCP.v61n0309","volume":"61","author":"KL Weihs","year":"2000","unstructured":"Weihs KL, Settle EC, Batey SR et al (2000) Bupropion sustained release versus paroxetine for the treatment of depression in the elderly. J Clin Psychiatry 61:196\u2013202. https:\/\/doi.org\/10.4088\/JCP.v61n0309","journal-title":"J Clin Psychiatry"},{"key":"6412_CR97","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.ejphar.2004.09.057","volume":"504","author":"J Yamada","year":"2004","unstructured":"Yamada J, Sugimoto Y, Yamada S (2004) Involvement of dopamine receptors in the anti-immobility effects of dopamine re-uptake inhibitors in the forced swimming test. Eur J Pharmacol 504:207\u2013211. https:\/\/doi.org\/10.1016\/j.ejphar.2004.09.057","journal-title":"Eur J Pharmacol"},{"key":"6412_CR98","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1556\/APHYSIOL.95.2008.2.2","volume":"95","author":"T Yamamoto","year":"2008","unstructured":"Yamamoto T (2008) Central mechanisms of roles of taste in reward and eating. Acta Physiol Hung 95:165\u2013186. https:\/\/doi.org\/10.1556\/APHYSIOL.95.2008.2.2","journal-title":"Acta Physiol Hung"},{"key":"6412_CR99","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.1007\/s00213-020-05578-w","volume":"237","author":"JH Yang","year":"2020","unstructured":"Yang JH, Presby RE, Rotolo RA et al (2020) The dopamine depleting agent tetrabenazine alters effort-related decision making as assessed by mouse touchscreen procedures. Psychopharmacology 237:2845\u20132854. https:\/\/doi.org\/10.1007\/s00213-020-05578-w","journal-title":"Psychopharmacology"},{"key":"6412_CR100","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1007\/s00213-014-3766-0","volume":"232","author":"SE Yohn","year":"2015","unstructured":"Yohn SE, Thompson C, Randall PA et al (2015) The VMAT-2 inhibitor tetrabenazine alters effort-related decision making as measured by the T-maze barrier choice task: Reversal with the adenosine A2A antagonist MSX-3 and the catecholamine uptake blocker bupropion. Psychopharmacology 232:1313\u20131323. https:\/\/doi.org\/10.1007\/s00213-014-3766-0","journal-title":"Psychopharmacology"},{"key":"6412_CR101","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/npp.2015.188","volume":"41","author":"SE Yohn","year":"2016","unstructured":"Yohn SE, Collins SL, Contreras-Mora HM et al (2016) Not All Antidepressants Are Created Equal: Differential Effects of Monoamine Uptake Inhibitors on Effort-Related Choice Behavior. Neuropsychopharmacology 41:686\u2013694. https:\/\/doi.org\/10.1038\/npp.2015.188","journal-title":"Neuropsychopharmacology"},{"key":"6412_CR102","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/J.JPSYCHIRES.2008.07.002","volume":"43","author":"EA Young","year":"2009","unstructured":"Young EA, Kornstein SG, Marcus SM et al (2009) Sex differences in response to citalopram: a STAR*D report. J Psychiatr Res 43:503\u2013511. https:\/\/doi.org\/10.1016\/J.JPSYCHIRES.2008.07.002","journal-title":"J Psychiatr Res"},{"key":"6412_CR103","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.pbb.2017.09.002","volume":"161","author":"E Yuen","year":"2017","unstructured":"Yuen E, Swanson S, Witkin JM (2017) Prediction of human efficacious antidepressant doses using the mouse forced swim test. Pharmacol Biochem Behav 161:22\u201329. https:\/\/doi.org\/10.1016\/j.pbb.2017.09.002","journal-title":"Pharmacol Biochem Behav"},{"key":"6412_CR104","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1038\/465690A","volume":"465","author":"I Zucker","year":"2010","unstructured":"Zucker I, Beery AK (2010) Males still dominate animal studies. Nature 465:690. https:\/\/doi.org\/10.1038\/465690A","journal-title":"Nature"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-023-06412-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-023-06412-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-023-06412-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T09:06:07Z","timestamp":1689411967000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-023-06412-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,5]]},"references-count":104,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["6412"],"URL":"https:\/\/doi.org\/10.1007\/s00213-023-06412-9","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,5]]},"assertion":[{"value":"3 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"JS has received grants from, and done consulting work for, Shire, Prexa, Chronos, Blackthorn, Lundbeck, NOEMA, and Acadia. On behalf of all the other authors, the corresponding author states that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}