{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:25:17Z","timestamp":1793157917182,"version":"4.5.0"},"reference-count":103,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Rationale<\/jats:title>\n                <jats:p>Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interaction and restricted\/stereotyped behavior. Prenatal exposure to valproic acid (VPA) is associated with an increased risk of developing ASD in humans and autistic-like behaviors in rodents. Increasing evidence indicates that dysfunctions of glutamate receptors at synapses are associated with ASD. In the VPA rat model, an involvement of glutamate receptors in autism-like phenotypes has been suggested; however, few studies were carried out on metabotropic glutamate (mGlu) receptors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>We examined the protein expression levels of group I (mGlu1 and mGlu5) and group II (mGlu2\/3) mGlu receptors in rats prenatally exposed to VPA and evaluated the effect of mGlu receptor modulation on an early autism-like phenotype in these animals.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We used western blotting analysis on synaptosomes obtained from forebrain of control and VPA rats at different ages (postnatal day P13, 35, 90) and carried out ultrasonic vocalization (USV) emission test in infant control and VPA rats.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The expression levels of all these receptors were significantly increased in infant VPA rats. No changes were detected in adolescent and adult rats. An acute treatment with the preferential mGlu2\/3 antagonist, LY341495, attenuated the impairment in the USV emission in VPA rats. No effect was observed after a treatment with the mGlu5 selective antagonist, MTEP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our findings demonstrate that the expression of group I and group II mGlu receptors is upregulated at synapses of infant VPA rats and suggest that mGlu2\/3 receptor modulation may have a therapeutic potential in ASD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00213-023-06457-w","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T04:02:23Z","timestamp":1694664143000},"page":"2617-2629","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid"],"prefix":"10.1007","volume":"240","author":[{"given":"Simona","family":"D\u2019Antoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Schiavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Buzzelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuele","family":"Giuffrida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Feo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Ascone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Letizia","family":"Busceti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Trezza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9329-8517","authenticated-orcid":false,"given":"Maria Vincenza","family":"Catania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"issue":"5","key":"6457_CR1","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/nrg2346","volume":"9","author":"BS Abrahams","year":"2008","unstructured":"Abrahams BS, Geschwind DH (2008) Advances in autism genetics: on the threshold of a new neurobiology. Nat Rev Genet 9(5):341\u2013355. https:\/\/doi.org\/10.1038\/nrg2346","journal-title":"Nat Rev Genet"},{"issue":"31","key":"6457_CR2","doi-asserted-by":"publisher","first-page":"11125","DOI":"10.1523\/JNEUROSCI.4615-14.2015","volume":"35","author":"A Aguilar-Valles","year":"2015","unstructured":"Aguilar-Valles A, Matta-Camacho E, Khoutorsky A, Gkogkas C, Nader K, Lacaille JC, Sonenberg N (2015) Inhibition of group I metabotropic glutamate receptors reverses autistic-like phenotypes caused by deficiency of the translation repressor eIF4E binding protein 2. J Neurosci 35(31):11125\u201311132. https:\/\/doi.org\/10.1523\/JNEUROSCI.4615-14.2015","journal-title":"J Neurosci"},{"key":"6457_CR3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.mcn.2014.01.007","volume":"59","author":"LE Almeida","year":"2014","unstructured":"Almeida LE, Roby CD, Krueger BK (2014) Increased BDNF expression in fetal brain in the valproic acid model of autism. Mol Cell Neurosci 59:57\u201362. https:\/\/doi.org\/10.1016\/j.mcn.2014.01.007","journal-title":"Mol Cell Neurosci"},{"issue":"6840","key":"6457_CR4","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/35082096","volume":"411","author":"F Ango","year":"2001","unstructured":"Ango F, Pr\u00e9zeau L, Muller T, Tu JC, Xiao B, Worley PF, Pin JP, Bockaert J, Fagni L (2001) Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature 411(6840):962\u2013965. https:\/\/doi.org\/10.1038\/35082096","journal-title":"Nature"},{"issue":"7","key":"6457_CR5","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.tins.2004.04.009","volume":"27","author":"MF Bear","year":"2004","unstructured":"Bear MF, Huber KM, Warren ST (2004) The mGluR theory of fragile X mental retardation. Trends Neurosci 27(7):370\u2013377. https:\/\/doi.org\/10.1016\/j.tins.2004.04.009","journal-title":"Trends Neurosci"},{"issue":"321","key":"6457_CR6","doi-asserted-by":"publisher","first-page":"321ra5","DOI":"10.1126\/scitranslmed.aab4109","volume":"8","author":"E Berry-Kravis","year":"2016","unstructured":"Berry-Kravis E, Des Portes V, Hagerman R, Jacquemont S, Charles P, Visootsak J, Brinkman M, Rerat K, Koumaras B, Zhu L, Barth GM, Jaecklin T, Apostol G, von Raison F (2016) Mavoglurant in fragile X syndrome: results of two randomized, double-blind, placebo-controlled trials. Sci Transl Med 8(321):321ra5. https:\/\/doi.org\/10.1126\/scitranslmed.aab4109","journal-title":"Sci Transl Med"},{"issue":"4","key":"6457_CR7","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/nrd.2017.221","volume":"17","author":"EM Berry-Kravis","year":"2018","unstructured":"Berry-Kravis EM, Lindemann L, J\u00f8nch AE, Apostol G, Bear MF, Carpenter RL, Crawley JN, Curie A, Des Portes V, Hossain F, Gasparini F, Gomez-Mancilla B, Hessl D, Loth E, Scharf SH, Wang PP, Von Raison F, Hagerman R, Spooren W, Jacquemont S (2018) Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome. Nat Rev Drug Discov 17(4):280\u2013299. https:\/\/doi.org\/10.1038\/nrd.2017.221","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"6457_CR8","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.neuroscience.2008.06.073","volume":"156","author":"K Boer","year":"2008","unstructured":"Boer K, Troost D, Timmermans W, Gorter JA, Spliet WG, Nellist M, Jansen F, Aronica E (2008) Cellular localization of metabotropic glutamate receptors in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex. Neurosci 156(1):203\u2013215. https:\/\/doi.org\/10.1016\/j.neuroscience.2008.06.073","journal-title":"Neurosci"},{"issue":"6","key":"6457_CR9","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.3390\/ijms22062863","volume":"22","author":"JR Bra\u0161i\u0107","year":"2021","unstructured":"Bra\u0161i\u0107 JR, Nandi A, Russell DS, Jennings D, Barret O, Martin SD, Slifer K, Sedlak T, Seibyl JP, Wong DF, Budimirovic DB (2021) Cerebral expression of metabotropic glutamate receptor subtype 5 in idiopathic autism spectrum disorder and fragile X syndrome: A Pilot Study. Int J Mol Sci 22(6):2863. https:\/\/doi.org\/10.3390\/ijms22062863","journal-title":"Int J Mol Sci"},{"issue":"1","key":"6457_CR10","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/s41398-022-02143-1","volume":"12","author":"C Carey","year":"2022","unstructured":"Carey C, Singh N, Dunn JT, Sementa T, Mendez MA, Velthuis H, Pereira AC, Pretzsch CM, Horder J, Hader S, Lythgoe DJ, Rotaru DG, Gee A, Cash D, Veronese M, Murphy D, McAlonan G (2022) From bench to bedside: the mGluR5 system in people with and without autism spectrum disorder and animal model systems. Transl Psychiatry 12(1):395. https:\/\/doi.org\/10.1038\/s41398-022-02143-1","journal-title":"Transl Psychiatry"},{"key":"6457_CR11","doi-asserted-by":"publisher","first-page":"113891","DOI":"10.1016\/j.bbr.2022.113891","volume":"428","author":"A Caruso","year":"2022","unstructured":"Caruso A, Ricceri L, Caruso A, Nicoletti F, Gaetano A, Scaccianoce S (2022) Postweaning social isolation and autism-like phenotype: a biochemical and behavioral comparative analysis. Behav Brain Res 428:113891. https:\/\/doi.org\/10.1016\/j.bbr.2022.113891","journal-title":"Behav Brain Res"},{"issue":"6","key":"6457_CR12","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.tips.2017.03.008","volume":"38","author":"S Chaki","year":"2017","unstructured":"Chaki S (2017) mGlu2\/3 receptor antagonists as novel antidepressants. Trends Pharmacol Sci 38(6):569\u2013580. https:\/\/doi.org\/10.1016\/j.tips.2017.03.008","journal-title":"Trends Pharmacol Sci"},{"key":"6457_CR13","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/bs.apha.2019.03.004","volume":"86","author":"S Chaki","year":"2019","unstructured":"Chaki S (2019) mGlu2\/3 receptor antagonists. Adv Pharmacol 86:97\u2013120. https:\/\/doi.org\/10.1016\/bs.apha.2019.03.004","journal-title":"Adv Pharmacol"},{"key":"6457_CR14","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.bbr.2016.09.003","volume":"316","author":"DK Chau","year":"2017","unstructured":"Chau DK, Choi AY, Yang W, Leung WN, Chan CW (2017) Downregulation of glutamatergic and GABAergic proteins in valproic acid associated social impairment during adolescence in mice. Behav Brain Res 316:255\u2013260. https:\/\/doi.org\/10.1016\/j.bbr.2016.09.003","journal-title":"Behav Brain Res"},{"key":"6457_CR15","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3389\/fnbeh.2014.00219","volume":"8","author":"YW Chen","year":"2014","unstructured":"Chen YW, Lin HC, Ng MC, Hsiao YH, Wang CC, Gean PW, Chen PS (2014) Activation of mGluR2\/3 underlies the effects of N-acetylcystein on amygdala-associated autism-like phenotypes in a valproate-induced rat model of autism. Front Behav Neurosci 8:219. https:\/\/doi.org\/10.3389\/fnbeh.2014.00219","journal-title":"Front Behav Neurosci"},{"key":"6457_CR16","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.brainres.2010.11.032","volume":"1380","author":"CH Choi","year":"2011","unstructured":"Choi CH, Schoenfeld BP, Bell AJ, Hinchey P, Kollaros M, Gertner MJ, Woo NH, Tranfaglia MR, Bear MF, Zukin RS, McDonald TV, Jongens TA, McBride SM (2011) Pharmacological reversal of synaptic plasticity deficits in the mouse model of fragile X syndrome by group II mGluR antagonist or lithium treatment. Brain Res 1380:106\u2013119. https:\/\/doi.org\/10.1016\/j.brainres.2010.11.032","journal-title":"Brain Res"},{"issue":"16","key":"6457_CR17","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1001\/jama.2013.2270","volume":"309","author":"J Christensen","year":"2013","unstructured":"Christensen J, Gr\u00f8nborg TK, S\u00f8rensen MJ, Schendel D, Parner ET, Pedersen LH, Vestergaard M (2013) Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA 309(16):1696\u20131703. https:\/\/doi.org\/10.1001\/jama.2013.2270","journal-title":"JAMA"},{"issue":"2","key":"6457_CR18","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1021\/jm025570j","volume":"46","author":"ND Cosford","year":"2003","unstructured":"Cosford ND, Tehrani L, Roppe J, Schweiger E, Smith ND, Anderson J, Bristow L, Brodkin J, Jiang X, McDonald I, Rao S, Washburn M, Varney MA (2003) 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity. J Med Chem 46(2):204\u2013206. https:\/\/doi.org\/10.1021\/jm025570j","journal-title":"J Med Chem"},{"issue":"12","key":"6457_CR19","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1007\/s11064-008-9694-9","volume":"33","author":"S D'Antoni","year":"2008","unstructured":"D\u2019Antoni S, Berretta A, Bonaccorso CM, Bruno V, Aronica E, Nicoletti F, Catania MV (2008) Metabotropic glutamate receptors in glial cells. Neurochem Res 33(12):2436\u20132443. https:\/\/doi.org\/10.1007\/s11064-008-9694-9","journal-title":"Neurochem Res"},{"key":"6457_CR20","doi-asserted-by":"publisher","unstructured":"D'Antoni S, Spatuzza M, Bonaccorso CM, Musumeci SA, Ciranna L, Nicoletti, Huber KM, Catania MV (2014) Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism. Neurosci Biobehav Rev 46 Pt 2(Pt 2): 228\u201341. https:\/\/doi.org\/10.1016\/j.neubiorev.2014.02.003.","DOI":"10.1016\/j.neubiorev.2014.02.003"},{"issue":"7","key":"6457_CR21","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1002\/jdn.10137","volume":"81","author":"I Deckmann","year":"2021","unstructured":"Deckmann I, Santos-Terra J, Fontes-Dutra M, K\u00f6rbes-Rockenbach M, Bauer-Negrini G, Schwingel GB, Riesgo R, Bambini-Junior V, Gottfried C (2021) Resveratrol prevents brainedema, blood-brain barrier permeability, and altered aquaporin profile in autism animal model. Int J Dev Neurosci 81(7):579\u2013604. https:\/\/doi.org\/10.1002\/jdn.10137","journal-title":"Int J Dev Neurosci"},{"key":"6457_CR22","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.neuropharm.2017.10.026","volume":"128","author":"L Di Menna","year":"2018","unstructured":"Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gress\u00e8ns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F (2018) Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system. Neuropharmacol 128:301\u2013313. https:\/\/doi.org\/10.1016\/j.neuropharm.2017.10.026","journal-title":"Neuropharmacol"},{"key":"6457_CR23","doi-asserted-by":"publisher","first-page":"109642","DOI":"10.1016\/j.neuropharm.2023.109642","volume":"238","author":"L Di Menna","year":"2023","unstructured":"Di Menna L, Orlando R, D\u2019Errico G, Ginerete RP, Machaczka A, Bonaccorso CM, Arena A, Spatuzza M, Celli R, Alborghetti M, Ciocca E, Zuena AR, Scioli MR, Bruno V, Battaglia G, Nicoletti F, Catania MV (2023) Blunted type-5 metabotropic glutamate receptor-mediated polyphosphoinositide hydrolysis in two mouse models of monogenic autism. Neuropharmacol 238:109642. https:\/\/doi.org\/10.1016\/j.neuropharm.2023.109642","journal-title":"Neuropharmacol"},{"issue":"6","key":"6457_CR24","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.biopsych.2021.02.970","volume":"90","author":"S Dogra","year":"2021","unstructured":"Dogra S, Stansley BJ, Xiang Z, Qian W, Gogliotti RG, Nicoletti F, Lindsley CW, Niswender CM, Joffe ME, Conn PJ (2021) Activating mGlu3 metabotropic glutamate receptors rescues schizophrenia-like cognitive deficits through metaplastic adaptations within the hippocampus. Biol Psychiatry 90(6):385\u2013398. https:\/\/doi.org\/10.1016\/j.biopsych.2021.02.970","journal-title":"Biol Psychiatry"},{"issue":"2","key":"6457_CR25","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1097\/WCO.0000000000000186","volume":"28","author":"D Ebrahimi-Fakhari","year":"2015","unstructured":"Ebrahimi-Fakhari D, Sahin M (2015) Autism and the synapse: emerging mechanisms and mechanism-based therapies. Curr Opin Neurol 28(2):91\u2013102. https:\/\/doi.org\/10.1097\/WCO.0000000000000186","journal-title":"Curr Opin Neurol"},{"issue":"6","key":"6457_CR26","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1080\/13543776.2017.1280466","volume":"27","author":"KA Emmitte","year":"2017","unstructured":"Emmitte KA (2017) mGlu5 negative allosteric modulators: a patent review (2013\u20132016). Expert Opin Ther Pat 27(6):691\u2013706. https:\/\/doi.org\/10.1080\/13543776.2017.1280466","journal-title":"Expert Opin Ther Pat"},{"key":"6457_CR27","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1002\/ar.21299","volume":"294","author":"SH Fatemi","year":"2011","unstructured":"Fatemi SH, Folsom TD, Kneeland RE, Liesch SB (2011) Metabotropic glutamate receptor 5 upregulation in children with autism is associated with underexpression of both Fragile X mental retardation protein and GABAA receptor beta 3 in adults with autism. Anat Rec (hoboken) 294:1635\u20131645. https:\/\/doi.org\/10.1002\/ar.21299","journal-title":"Anat Rec (hoboken)"},{"key":"6457_CR28","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40673-018-0082-1","volume":"5","author":"SH Fatemi","year":"2018","unstructured":"Fatemi SH, Wong DF, Bra\u0161i\u0107 JR, Kuwabara H, Mathur A, Folsom TD, Jacob S, Realmuto GM, Pardo JV, Lee S (2018) Metabotropic glutamate receptor 5 tracer [18F]-FPEB displays increased binding potential in postcentral gyrus and cerebellum of male individuals with autism: a pilot PET study. Cerebellum Ataxias 5:3. https:\/\/doi.org\/10.1186\/s40673-018-0082-1","journal-title":"Cerebellum Ataxias"},{"key":"6457_CR29","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3389\/fnmol.2019.00261","volume":"12","author":"CR Fuentealba","year":"2019","unstructured":"Fuentealba CR, Fiedler JL, Peralta FA, Avalos AM, Aguayo FI, Morgado-Gallardo KP, Aliaga EE (2019) Region-specific reduction of BDNF protein and transcripts in the hippocampus of juvenile rats prenatally treated with sodium valproate. Front Mol Neurosci 12:261. https:\/\/doi.org\/10.3389\/fnmol.2019.00261","journal-title":"Front Mol Neurosci"},{"issue":"2","key":"6457_CR30","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1038\/s41380-022-01860-9","volume":"28","author":"L Galineau","year":"2023","unstructured":"Galineau L, Arlicot N, Dupont AC, Briend F, Houy-Durand E, Tauber C, Gomot M, Gissot V, Barantin L, Lefevre A, Vercouillie J, Roussel C, Roux S, Nadal L, Mavel S, Laumonnier F, Belzung C, Chalon S, Emond P, Santiago-Ribeiro MJ, Bonnet-Brilhault F (2023) Glutamatergic synapse in autism: a complex story for a complex disorder. Mol Psychiatry 28(2):801\u2013809. https:\/\/doi.org\/10.1038\/s41380-022-01860-9","journal-title":"Mol Psychiatry"},{"key":"6457_CR31","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.bbr.2012.10.059","volume":"239","author":"I Gantois","year":"2013","unstructured":"Gantois I, Pop AS, de Esch CE, Buijsen RA, Pooters T, Gomez-Mancilla B, Gasparini F, Oostra BA, D\u2019Hooge R, Willemsen R (2013) Chronic administration of AFQ056\/mavoglurant restores social behaviour in Fmr1 knockout mice. Behav Brain Res 239:72\u201379. https:\/\/doi.org\/10.1016\/j.bbr.2012.10.059","journal-title":"Behav Brain Res"},{"issue":"2","key":"6457_CR32","doi-asserted-by":"publisher","first-page":"146","DOI":"10.2174\/1566524015666150303003028","volume":"15","author":"R Gao","year":"2015","unstructured":"Gao R, Penzes P (2015) Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders. Curr Mol Med 15(2):146\u2013167. https:\/\/doi.org\/10.2174\/1566524015666150303003028","journal-title":"Curr Mol Med"},{"issue":"39","key":"6457_CR33","doi-asserted-by":"publisher","first-page":"8908","DOI":"10.2174\/1566524015666150303003028","volume":"25","author":"R Giuffrida","year":"2005","unstructured":"Giuffrida R, Musumeci S, D\u2019Antoni S, Bonaccorso CM, Giuffrida-Stella AM, Oostra BA, Catania MV (2005) A reduced number of metabotropic glutamate subtype 5 receptors are associated with constitutive Homer proteins in a mouse model of fragile X syndrome. J Neurosci 25(39):8908\u20138916. https:\/\/doi.org\/10.2174\/1566524015666150303003028","journal-title":"J Neurosci"},{"issue":"10","key":"6457_CR34","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1093\/hmg\/ddw074","volume":"25","author":"RG Gogliotti","year":"2016","unstructured":"Gogliotti RG, Senter RK, Rook JM, Ghoshal A, Zamorano R, Malosh C, Stauffer SR, Bridges TM, Bartolome JM, Daniels JS, Jones CK, Lindsley CW, Conn PJ, Niswender CM (2016) mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome. Hum Mol Genet 25(10):1990\u20132004. https:\/\/doi.org\/10.1093\/hmg\/ddw074","journal-title":"Hum Mol Genet"},{"key":"6457_CR35","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13229-019-0270-8.eCollection","volume":"10","author":"EM Guimar\u00e3es-Souza","year":"2019","unstructured":"Guimar\u00e3es-Souza EM, Joselevitch C, Britto LRG (2019) Chiavegatto S (2019) Retinal alterations in a pre-clinical model ofan autism spectrum disorder. Molecular Autism 10:19. https:\/\/doi.org\/10.1186\/s13229-019-0270-8.eCollection","journal-title":"Molecular Autism"},{"key":"6457_CR36","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1177\/0269881108089818","volume":"22","author":"PJ Harrison","year":"2008","unstructured":"Harrison PJ, Lyon L, Sartorius LJ, Burnet PWJ, Lane TA (2008) The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia. J Psychopharmacol 22:308\u2013322. https:\/\/doi.org\/10.1177\/0269881108089818","journal-title":"J Psychopharmacol"},{"issue":"Pt 3","key":"6457_CR37","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1042\/0264-6021:3590465","volume":"359","author":"E Hermans","year":"2001","unstructured":"Hermans E, Challiss RA (2001) Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors. Biochem J 359(Pt 3):465\u2013484. https:\/\/doi.org\/10.1042\/0264-6021:3590465","journal-title":"Biochem J"},{"issue":"3","key":"6457_CR38","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.pbb.2007.09.005","volume":"88","author":"RA Hodgson","year":"2008","unstructured":"Hodgson RA, Guthrie DH, Varty GB (2008) Duration of ultrasonic vocalizations in the isolated rat pup as a behavioral measure: sensitivity to anxiolytic and antidepressant drugs. Pharmacol Biochem Behav 88(3):341\u2013348. https:\/\/doi.org\/10.1016\/j.pbb.2007.09.005","journal-title":"Pharmacol Biochem Behav"},{"key":"6457_CR39","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.phrs.2018.11.019","volume":"139","author":"BW Howell","year":"2019","unstructured":"Howell BW, Smith KM (2019) Synaptic structural protein dysfunction leads to altered excitation inhibition ratios in models of autism spectrum disorder. Pharmacol Res 139:207\u2013214. https:\/\/doi.org\/10.1016\/j.phrs.2018.11.019","journal-title":"Pharmacol Res"},{"issue":"4","key":"6457_CR40","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.pbb.2005.11.005","volume":"82","author":"M Iijima","year":"2005","unstructured":"Iijima M, Chaki S (2005) Separation-induced ultrasonic vocalization in rat pups: further pharmacological characterization. Pharmacol Biochem Behav 82(4):652\u2013657. https:\/\/doi.org\/10.1016\/j.pbb.2005.11.005","journal-title":"Pharmacol Biochem Behav"},{"issue":"5","key":"6457_CR41","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1124\/dmd.122.001116","volume":"51","author":"S Inatani","year":"2023","unstructured":"Inatani S, Ochi M, Kinoshita K, Yamaguchi JI, Endo H (2023) Preclinical metabolism and disposition of TP0473292, a novel oral prodrug of the potent metabotropic glutamate 2\/3 receptor antagonist TP0178894 for the treatment of depression. Drug Metab Dispos 51(5):572\u2013582. https:\/\/doi.org\/10.1124\/dmd.122.001116","journal-title":"Drug Metab Dispos"},{"issue":"64","key":"6457_CR42","doi-asserted-by":"publisher","first-page":"64ra1","DOI":"10.1126\/scitranslmed.3001708","volume":"3","author":"S Jacquemont","year":"2011","unstructured":"Jacquemont S, Curie A, Des Portes V, Torrioli MG, Berry-Kravis E, Hagerman RJ, Ramos FJ, Cornish K, He Y, Paulding C, Neri G, Chen F, Hadjikhani N, Martinet D, Meyer J, Beckmann JS, Delange K, Brun A, Bussy G, Gasparini F, Hilse T, Floesser A, Branson J, Bilbe G, Johns D, Gomez-Mancilla B (2011) Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056. Sci Transl Med 3(64):64ra1. https:\/\/doi.org\/10.1126\/scitranslmed.3001708","journal-title":"Sci Transl Med"},{"issue":"12","key":"6457_CR43","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1038\/s41386-021-01041-2","volume":"46","author":"ME Joffe","year":"2021","unstructured":"Joffe ME, Santiago CI, Vermudez SAD, Fisher NM, Dogra S, Niswender CM, Jeffrey Conn P (2021) Frontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mGlu3) impairs postsynaptic plasticity and modulates affective behaviors. Neuropsychopharmacol 46(12):2148\u20132157. https:\/\/doi.org\/10.1038\/s41386-021-01041-2","journal-title":"Neuropsychopharmacol"},{"issue":"19","key":"6457_CR44","doi-asserted-by":"publisher","first-page":"7238","DOI":"10.1523\/JNEUROSCI.20-19-07238.2000","volume":"20","author":"PJ Kammermeier","year":"2000","unstructured":"Kammermeier PJ, Xiao B, Tu JC, Worley PF, Ikeda SR (2000) Homer proteins regulate coupling of group I metabotropic glutamate receptors to N-type calcium and Mtype potassium channel. J Neurosci 20(19):7238\u20137245. https:\/\/doi.org\/10.1523\/JNEUROSCI.20-19-07238.2000","journal-title":"J Neurosci"},{"key":"6457_CR45","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1007\/s12035-013-8535-2","volume":"49","author":"KC Kim","year":"2014","unstructured":"Kim KC, Lee D-K, Go HS, Kim P, Choi CS, Kim J-W, Jeon SJ, Song M-R, Shin CY (2014) Pax6-dependent cortical glutamatergic neuronal differentiation regulates autism-like behavior in prenatally valproic acid-exposed rat offspring. Mol Neurobiol 49:512\u2013528. https:\/\/doi.org\/10.1007\/s12035-013-8535-2","journal-title":"Mol Neurobiol"},{"issue":"1","key":"6457_CR46","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s12035-014-8987-z","volume":"53","author":"KC Kim","year":"2016","unstructured":"Kim KC, Choi CS, Kim JW, Han SH, Cheong JH, Ryu JH, Shin CY (2016) MeCP2 modulates sex differences in the postsynaptic development of the valproate animal model of autism. Mol Neurobiol 53(1):40\u201356. https:\/\/doi.org\/10.1007\/s12035-014-8987-z","journal-title":"Mol Neurobiol"},{"issue":"Pt A","key":"6457_CR47","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.neuropharm.2016.09.014","volume":"113","author":"JW Kim","year":"2017","unstructured":"Kim JW, Seung H, Kim KC, Gonzales ELT, Oh HA, Yang SM, Ko MJ, Han SH, Banerjee S, Shin CY (2017) Agmatine rescues autistic behaviors in the valproic acid-induced animal model of autism. Neuropharmacol 113(Pt A):71\u201381. https:\/\/doi.org\/10.1016\/j.neuropharm.2016.09.014","journal-title":"Neuropharmacol"},{"issue":"3","key":"6457_CR48","doi-asserted-by":"publisher","first-page":"560","DOI":"10.3390\/biomedicines10030560","volume":"10","author":"HY Kuo","year":"2022","unstructured":"Kuo HY, Liu FC (2022) Pathophysiological studies of monoaminergic neurotransmission systems in valproic acid-induced model of autism spectrum disorder. Biomedicines 10(3):560. https:\/\/doi.org\/10.3390\/biomedicines10030560","journal-title":"Biomedicines"},{"key":"6457_CR49","doi-asserted-by":"publisher","first-page":"13214","DOI":"10.1073\/pnas.0604691103","volume":"103","author":"J-V Le Be","year":"2006","unstructured":"Le Be J-V, Markram H (2006) Spontaneous and evoked synaptic rewiring in the neonatal neocortex. Proc Natl Acad Sci USA 103:13214\u201313219. https:\/\/doi.org\/10.1073\/pnas.0604691103","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"6457_CR50","doi-asserted-by":"publisher","first-page":"e22097","DOI":"10.1002\/syn.22097","volume":"73","author":"K Lee","year":"2019","unstructured":"Lee K, Vyas Y, Garner CC, Montgomery JM (2019) Autism-associated Shank3 mutations alter mGluR expression and mGluR-dependent but not NMDA receptor-dependent long-term depression. Synapse 73(8):e22097. https:\/\/doi.org\/10.1002\/syn.22097","journal-title":"Synapse"},{"key":"6457_CR51","doi-asserted-by":"publisher","first-page":"152500","DOI":"10.1016\/j.tox.2020.152500","volume":"440","author":"J Lenart","year":"2020","unstructured":"Lenart J, Augustyniakm J, Lazarewicz JW, Zieminska E (2020) Altered expression of glutamatergic and GABAergic genes in the valproic acid-induced rat model of autism: a screening test. Toxicology 440:152500. https:\/\/doi.org\/10.1016\/j.tox.2020.152500","journal-title":"Toxicology"},{"issue":"1","key":"6457_CR52","doi-asserted-by":"publisher","first-page":"e55248","DOI":"10.1371\/journal.pone.0055248","volume":"8","author":"HC Lin","year":"2013","unstructured":"Lin HC, Gean PW, Wang CC, Chan YH, Chen PS (2013) The amygdala excitatory\/inhibitory balance in a valproate-induced rat autism model. PLoS One 8(1):e55248. https:\/\/doi.org\/10.1371\/journal.pone.0055248","journal-title":"PLoS One"},{"key":"6457_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2040-2392-4-15","volume":"4","author":"TG Lohith","year":"2013","unstructured":"Lohith TG, Osterweil EK, Fujita M, Jenko KJ, Bear MF, Innis RB (2013) Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome? Mol Autism 4:1\u20131. https:\/\/doi.org\/10.1186\/2040-2392-4-15","journal-title":"Mol Autism"},{"issue":"1","key":"6457_CR54","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/S0140-6736(18)31129-2","volume":"6","author":"C Lord","year":"2020","unstructured":"Lord C, Brugha TS, Charman T, Cusack J, Dumas G, Frazier T, Jones EJH, Jones RM, Pickles A, State MW, Taylor JL, Veenstra-VanderWeele J (2020) Autism spectrum disorder. Nat Rev Dis Primers 6(1):5. https:\/\/doi.org\/10.1016\/S0140-6736(18)31129-2","journal-title":"Nat Rev Dis Primers"},{"issue":"10","key":"6457_CR55","doi-asserted-by":"publisher","first-page":"669","DOI":"10.2165\/00023210-200216100-00003","volume":"16","author":"W L\u00f6scher","year":"2002","unstructured":"L\u00f6scher W (2002) Basic pharmacology of valproate. CNS Drugs 16(10):669\u2013694. https:\/\/doi.org\/10.2165\/00023210-200216100-00003","journal-title":"CNS Drugs"},{"key":"6457_CR56","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13041-017-0293-z","volume":"10","author":"J Maksymetz","year":"2017","unstructured":"Maksymetz J, Moran SP, Conn PJ (2017) Targeting metabotropic glutamate receptors for novel treatments of schizophrenia. Mol Brain 10:15. https:\/\/doi.org\/10.1186\/s13041-017-0293-z","journal-title":"Mol Brain"},{"key":"6457_CR57","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3389\/fncel.2014.00023","volume":"8","author":"HG Martin","year":"2014","unstructured":"Martin HG, Manzoni OJ (2014) Late onset deficits in synaptic plasticity in the valproic acid rat model of autism. Front Cell Neurosci 8:23. https:\/\/doi.org\/10.3389\/fncel.2014.00023","journal-title":"Front Cell Neurosci"},{"issue":"12","key":"6457_CR58","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.2174\/1567202619999220209112609","volume":"20","author":"F Matrisciano","year":"2022","unstructured":"Matrisciano F, Locci V, Dong E, Nicoletti F, Guidotti A, Grayson DR (2022) Altered expression and in vivo activity of mGlu5 Variant a receptors in the striatum of BTBR mice: novel insights into the pathophysiology of adult idiopathic forms of autism spectrum disorders. Curr Neuropharmacol 20(12):2354\u20132368. https:\/\/doi.org\/10.2174\/1567202619999220209112609","journal-title":"Curr Neuropharmacol"},{"issue":"10","key":"6457_CR59","doi-asserted-by":"publisher","first-page":"e26077","DOI":"10.1371\/journal.pone.0026077","volume":"6","author":"MV Mehta","year":"2011","unstructured":"Mehta MV, Gandal MJ, Siegel SJ (2011) mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism. PLoS One 6(10):e26077. https:\/\/doi.org\/10.1371\/journal.pone.0026077","journal-title":"PLoS One"},{"issue":"18","key":"6457_CR60","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.1111\/bph.14435","volume":"175","author":"F Melancia","year":"2018","unstructured":"Melancia F, Schiavi S, Servadio M, Cartocci V, Campolongo P, Palmery M, Pallottini V, Trezza V (2018) Sex-specific autistic endophenotypes induced by prenatal exposure to valproic acid involve anandamide signalling. Br J Pharmacol 175(18):3699\u20133712. https:\/\/doi.org\/10.1111\/bph.14435","journal-title":"Br J Pharmacol"},{"issue":"1","key":"6457_CR61","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.neuron.2012.03.009","volume":"74","author":"A Michalon","year":"2012","unstructured":"Michalon A, Sidorov M, Ballard TM, Ozmen L, Spooren W, Wettstein JG, Jaeschke G, Bear MF, Lindemann L (2012) Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice. Neuron 74(1):49\u201356. https:\/\/doi.org\/10.1016\/j.neuron.2012.03.009","journal-title":"Neuron"},{"issue":"3","key":"6457_CR62","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.biopsych.2013.05.038","volume":"75","author":"A Michalon","year":"2014","unstructured":"Michalon A, Bruns A, Risterucci C, Honer M, Ballard TM, Ozmen L, Jaeschke G, Wettstein JG, von Kienlin M, K\u00fcnnecke B, Lindemann L (2014) Chronic metabotropic glutamate receptor 5 inhibition corrects local alterations of brain activity and improves cognitive performance in fragile X mice. Biol Psychiatry 75(3):189\u2013197. https:\/\/doi.org\/10.1016\/j.biopsych.2013.05.038","journal-title":"Biol Psychiatry"},{"key":"6457_CR63","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3389\/fnmol.2018.00107.eCollection","volume":"11","author":"ME Modi","year":"2018","unstructured":"Modi ME, Brooks JM, Guilmette ER, Beyna M, Graf R, Reim D, Schmeisser MJ, Boeckers TM, O\u2019Donnell P (2018) Buhl DL (2018) Hyperactivity and hypermotivation associated with increased striatal mGluR1 signaling in a Shank2 rat model of autism. Front Mol Neurosci 11:107. https:\/\/doi.org\/10.3389\/fnmol.2018.00107.eCollection","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"6457_CR64","doi-asserted-by":"publisher","first-page":"15897","DOI":"10.1038\/s41598-021-94967-y","volume":"11","author":"M Mody","year":"2021","unstructured":"Mody M, Petibon Y, Han P, Kuruppu D, Ma C, Yokell D, Neelamegam R, Normandin MD, Fakhri GE, Brownell AL (2021) In vivo imaging of mGlu5 receptor expression in humans with fragile X syndrome towards development of a potential biomarker. Sci Rep 11(1):15897. https:\/\/doi.org\/10.1038\/s41598-021-94967-y","journal-title":"Sci Rep"},{"key":"6457_CR65","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.brainres.2007.11.043","volume":"1193","author":"A Nakasato","year":"2008","unstructured":"Nakasato A, Nakatani Y, Seki Y, Tsujino N, Umino M, Arita H (2008) Swim stress exaggerates the hyperactive mesocortical dopamine system in a rodent model of autism. Brain Res 1193:128\u2013135. https:\/\/doi.org\/10.1016\/j.brainres.2007.11.043","journal-title":"Brain Res"},{"issue":"7\u20138","key":"6457_CR66","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.neuropharm.2010.10.022","volume":"60","author":"F Nicoletti","year":"2011","unstructured":"Nicoletti F, Bockaert J, Collingridge GL, Conn PJ, Ferraguti F, Schoepp DD, Wroblewski JT, Pin JP (2011) Metabotropic glutamate receptors: from the workbench to the bedside. Neuropharmacol 60(7\u20138):1017\u20131041. https:\/\/doi.org\/10.1016\/j.neuropharm.2010.10.022","journal-title":"Neuropharmacol"},{"issue":"Pt A","key":"6457_CR67","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.expneurol.2017.04.017","volume":"299","author":"C Nicolini","year":"2018","unstructured":"Nicolini C, Fahnestock M (2018) The valproic acid-induced rodent model of autism. Exp Neurol 299(Pt A):217\u2013227. https:\/\/doi.org\/10.1016\/j.expneurol.2017.04.017","journal-title":"Exp Neurol"},{"issue":"5","key":"6457_CR68","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.1038\/s41380-022-01506-w","volume":"27","author":"S Nisar","year":"2022","unstructured":"Nisar S, Bhat AA, Masoodi T, Hashem S, Akhtar S, Ali TA, Amjad S, Chawla S, Bagga P, Frenneaux MP, Reddy R, Fakhro K, Haris M (2022) Genetics of glutamate and its receptors in autism spectrum disorder. Mol Psychiatry 27(5):2380\u20132392. https:\/\/doi.org\/10.1038\/s41380-022-01506-w","journal-title":"Mol Psychiatry"},{"key":"6457_CR69","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.neuron.2008.05.023","volume":"59","author":"S Park","year":"2008","unstructured":"Park S, Park JM, Kim S, Kim JA, Shepherd JD, Smith-Hicks CL, Chowdhury S, Kaufmann W, Kuhl D, Ryazanov AG, Huganir RL, Linden DJ, Worley PF (2008) Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc\/Arg3.1 essential for mGluR-LTD. Neuron 59:70\u201383. https:\/\/doi.org\/10.1016\/j.neuron.2008.05.023","journal-title":"Neuron"},{"issue":"3","key":"6457_CR70","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.3892\/mmr.2016.5529","volume":"14","author":"F Peralta","year":"2016","unstructured":"Peralta F, Fuentealba C, Fiedler J, Aliaga E (2016) Prenatal valproate treatment produces autistic-like behavior and increases metabotropic glutamate receptor 1A-immunoreactivity in the hippocampus of juvenile rats. Mol Med Rep 14(3):2807\u20132814. https:\/\/doi.org\/10.3892\/mmr.2016.5529","journal-title":"Mol Med Rep"},{"key":"6457_CR71","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.conb.2017.12.014","volume":"48","author":"F Petrelli","year":"2018","unstructured":"Petrelli F, Bezzi P (2018) mGlu5-mediated signalling in developing astrocyte and the pathogenesis of autism spectrum disorders. Curr Opin Neurobiol 48:139\u2013145. https:\/\/doi.org\/10.1016\/j.conb.2017.12.014","journal-title":"Curr Opin Neurobiol"},{"issue":"13","key":"6457_CR72","doi-asserted-by":"publisher","first-page":"4558","DOI":"10.1523\/JNEUROSCI.1846-13.2014","volume":"34","author":"M Pignatelli","year":"2014","unstructured":"Pignatelli M, Piccinin S, Molinaro G, Di Menna L, Riozzi B, Cannella M, Motolese M, Vetere G, Catania MV, Battaglia G, Nicoletti F, Nistic\u00f2 R, Bruno V (2014) Changes in mGlu5 receptor-dependent synaptic plasticity and coupling to Homer proteins in the hippocampus of Ube3A hemizygous mice modeling angelman syndrome. J Neurosci 34(13):4558\u20134566. https:\/\/doi.org\/10.1523\/JNEUROSCI.1846-13.2014","journal-title":"J Neurosci"},{"issue":"6","key":"6457_CR73","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1016\/j.neuron.2018.05.018","volume":"98","author":"A Reiner","year":"2018","unstructured":"Reiner A, Levitz J (2018) Glutamatergic signaling in the central nervous system: ionotropic and metabotropic receptors in concert. Neuron 98(6):1080\u20131098. https:\/\/doi.org\/10.1016\/j.neuron.2018.05.018","journal-title":"Neuron"},{"key":"6457_CR74","doi-asserted-by":"publisher","first-page":"13501","DOI":"10.1073\/pnas.0704391104","volume":"104","author":"T Rinaldi","year":"2007","unstructured":"Rinaldi T, Kulangara K, Antoniello K, Markram H (2007) Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid. Proc Natl Acad Sci 104:13501\u201313506. https:\/\/doi.org\/10.1073\/pnas.0704391104","journal-title":"Proc Natl Acad Sci"},{"issue":"4","key":"6457_CR75","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1093\/cercor\/bhm117","volume":"18","author":"T Rinaldi","year":"2008","unstructured":"Rinaldi T, Silberberg G, Markram H (2008) Hyperconnectivity of local neocortical microcircuitry induced by prenatal exposure to valproic acid. Cereb Cortex 18(4):763\u2013770. https:\/\/doi.org\/10.1093\/cercor\/bhm117","journal-title":"Cereb Cortex"},{"key":"6457_CR76","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1034\/j.1601-183x.2003.00037.x","volume":"2","author":"JL Rubenstein","year":"2003","unstructured":"Rubenstein JL, Merzenich MM (2003) Model of autism: increased ratio of excitation\/inhibition in key neural systems. Genes Brain Behav 2:255\u2013267. https:\/\/doi.org\/10.1034\/j.1601-183x.2003.00037.x","journal-title":"Genes Brain Behav"},{"key":"6457_CR77","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.coph.2014.11.004","volume":"20","author":"SH Scharf","year":"2015","unstructured":"Scharf SH, Jaeschke G, Wettstein JG, Lindemann L (2015) Metabotropic glutamate receptor 5 as drug target for Fragile X syndrome. Curr Opin Pharmacol 20:124\u2013134. https:\/\/doi.org\/10.1016\/j.coph.2014.11.004","journal-title":"Curr Opin Pharmacol"},{"key":"6457_CR78","doi-asserted-by":"publisher","first-page":"479","DOI":"10.3389\/fncel.2019.00479.eCollection","volume":"13","author":"S Schiavi","year":"2019","unstructured":"Schiavi S, Iezzi D, Manduca A, Leone S, Melancia F, Carbone C, Petrella M, Mannaioni G, Masi A (2019) Trezza V (2019) Reward-related behavioral, neurochemical and electrophysiological changes in a rat model of autism based on prenatal exposure to valproic acid. Front Cell Neurosci 13:479. https:\/\/doi.org\/10.3389\/fncel.2019.00479.eCollection","journal-title":"Front Cell Neurosci"},{"key":"6457_CR79","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.851679","volume":"13","author":"S Schiavi","year":"2022","unstructured":"Schiavi S, La Rosa P, Petrillo S, Carbone E, D\u2019Amico J, Piemonte F, Trezza V (2022) N-Acetylcysteine mitigates social dysfunction in a rat model of autism normalizing glutathione imbalance and the altered expression of genes related to synaptic function in specific brain areas. Front Psychiatry 13:851679","journal-title":"Front Psychiatry"},{"issue":"10","key":"6457_CR80","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1016\/s0028-3908(99)00092-1","volume":"38","author":"DD Schoepp","year":"1999","unstructured":"Schoepp DD, Jane DE, Monn JA (1999) Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacol 38(10):1431\u20131476. https:\/\/doi.org\/10.1016\/s0028-3908(99)00092-1","journal-title":"Neuropharmacol"},{"key":"6457_CR81","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.envint.2015.12.021","volume":"88","author":"LA Sealey","year":"2016","unstructured":"Sealey LA, Hughes BW, Sriskanda AN, Guest JR, Gibson AD, Johnson-Williams L, Pace DG, Bagasra O (2016) Environmental factors in the development of autism spectrum disorders. Environ Int 88:288\u2013298. https:\/\/doi.org\/10.1016\/j.envint.2015.12.021","journal-title":"Environ Int"},{"issue":"6","key":"6457_CR82","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1097\/FBP.0000000000000163","volume":"26","author":"M Servadio","year":"2015","unstructured":"Servadio M, Vanderschuren LJ, Trezza V (2015) Modeling autism-relevant behavioral phenotypes in rats and mice: Do \u2018autistic\u2019 rodents exist? Behav Pharmacol 26(6):522\u2013540. https:\/\/doi.org\/10.1097\/FBP.0000000000000163","journal-title":"Behav Pharmacol"},{"key":"6457_CR83","doi-asserted-by":"publisher","first-page":"e902","DOI":"10.1038\/tp.2016.182","volume":"6","author":"M Servadio","year":"2016","unstructured":"Servadio M, Melancia F, Manduca A, di Masi A, Schiavi S, Cartocci V, Pallottini V, Campolongo P, Ascenzi P, Trezza V (2016) Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid. Transl Psychiatry 6:e902. https:\/\/doi.org\/10.1038\/tp.2016.182","journal-title":"Transl Psychiatry"},{"key":"6457_CR84","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/neuro.19.001.2009.eCollection","volume":"1","author":"GT Silva","year":"2009","unstructured":"Silva GT, Le B\u00e9 JV, Riachi I, Rinaldi T, Markram K (2009) Markram H (2009) Enhanced long-term microcircuit plasticity in the valproic acid animal model of autism. Front Synaptic Neurosci 1:1. https:\/\/doi.org\/10.3389\/neuro.19.001.2009.eCollection","journal-title":"Front Synaptic Neurosci"},{"issue":"4","key":"6457_CR85","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1038\/npp.2009.201","volume":"35","author":"JL Silverman","year":"2010","unstructured":"Silverman JL, Tolu SS, Barkan CL, Crawley JN (2010) Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP. Neuropsychopharmacology 35(4):976\u2013989. https:\/\/doi.org\/10.1038\/npp.2009.201","journal-title":"Neuropsychopharmacology"},{"issue":"131","key":"6457_CR86","doi-asserted-by":"publisher","first-page":"131ra51","DOI":"10.1126\/scitranslmed.3003501","volume":"4","author":"JL Silverman","year":"2012","unstructured":"Silverman JL, Smith DG, Rizzo SJ, Karras MN, Turner SM, Tolu SS, Bryce DK, Smith DL, Fonseca K, Ring RH, Crawley JN (2012) Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism. Sci Transl Med 4(131):131ra51. https:\/\/doi.org\/10.1126\/scitranslmed.3003501","journal-title":"Sci Transl Med"},{"key":"6457_CR87","doi-asserted-by":"publisher","first-page":"414","DOI":"10.3389\/fnmol.2018.00414","volume":"11","author":"SF Spampinato","year":"2018","unstructured":"Spampinato SF, Copani A, Nicoletti F, Sortino MA, Caraci F (2018) Metabotropic glutamate receptors in glial cells: a new potential target for neuroprotection? Front Mol Neurosci 11:414. https:\/\/doi.org\/10.3389\/fnmol.2018.00414","journal-title":"Front Mol Neurosci"},{"key":"6457_CR88","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.peptides.2017.01.007","volume":"89","author":"S Suzuki","year":"2017","unstructured":"Suzuki S, Koshimizu H, Adachi N, Matsuoka H, Fushimi S, Ono J, Ohta KI, Miki T (2017) Functional interaction between BDNF and mGluR II in vitro: BDNF down-regulated mGluR II gene expression and an mGluR II agonist enhanced BDNF-induced BDNF gene expression in rat cerebral cortical neurons. Peptides 89:42\u201349. https:\/\/doi.org\/10.1016\/j.peptides.2017.01.007","journal-title":"Peptides"},{"key":"6457_CR89","doi-asserted-by":"publisher","first-page":"107477","DOI":"10.1016\/j.neuropharm.2018.12.024","volume":"159","author":"AM Tartaglione","year":"2019","unstructured":"Tartaglione AM, Schiavi S, Calamandrei G, Trezza V (2019) Prenatal valproate in rodents as a tool to understand the neural underpinnings of social dysfunctions in autism spectrum disorder. Neuropharmacol 159:107477. https:\/\/doi.org\/10.1016\/j.neuropharm.2018.12.024","journal-title":"Neuropharmacol"},{"issue":"1","key":"6457_CR90","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00213-011-2375-4","volume":"219","author":"AM Thomas","year":"2012","unstructured":"Thomas AM, Bui N, Perkins JR, Yuva-Paylor LA, Paylor R (2012) Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome. Psychopharmacol 219(1):47\u201358. https:\/\/doi.org\/10.1007\/s00213-011-2375-4","journal-title":"Psychopharmacol"},{"issue":"2","key":"6457_CR91","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/nn.3911","volume":"18","author":"D Tian","year":"2015","unstructured":"Tian D, Stoppel LJ, Heynen AJ, Lindemann L, Jaeschke G, Mills AA, Bear MF (2015) Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion. Nat Neurosci 18(2):182\u20134. https:\/\/doi.org\/10.1038\/nn.3911","journal-title":"Nat Neurosci"},{"issue":"3","key":"6457_CR92","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1124\/pr.109.002451","volume":"62","author":"SF Traynelis","year":"2010","unstructured":"Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R (2010) Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev 62(3):405\u2013496. https:\/\/doi.org\/10.1124\/pr.109.002451","journal-title":"Pharmacol Rev"},{"key":"6457_CR93","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1126\/science.1247190","volume":"343","author":"R Tyzio","year":"2014","unstructured":"Tyzio R, Nardou R, Ferrari DC, Tsintsadze T, Shahrokhi A, Eftekhari S, Khalilov I, Tsintsadze V, Brouchoud C, Chazal G, Lemonnier E, Lozovaya N, Burnashev N, Ben-Ari Y (2014) Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. Science 343:675\u2013679. https:\/\/doi.org\/10.1126\/science.1247190","journal-title":"Science"},{"key":"6457_CR94","doi-asserted-by":"publisher","first-page":"109022","DOI":"10.1016\/j.neuropharm.2022.109022","volume":"209","author":"SAD Vermudez","year":"2022","unstructured":"Vermudez SAD, Buch A, Weiss K, Gogliotti RG, Niswender CM (2022) Exploration of group II metabotropic glutamate receptor modulation in mouse models of Rett syndrome andMECP2 Duplication syndrome. Neuropharmacol 209:109022. https:\/\/doi.org\/10.1016\/j.neuropharm.2022.109022","journal-title":"Neuropharmacol"},{"issue":"40","key":"6457_CR95","doi-asserted-by":"publisher","first-page":"34839","DOI":"10.1074\/jbc.M111.258384","volume":"286","author":"C Verpelli","year":"2011","unstructured":"Verpelli C, Dvoretskova E, Vicidomini C, Rossi F, Chiappalone M, Schoen M, Di Stefano B, Mantegazza R, Broccoli V, B\u00f6ckers TM, Dityatev A, Sala C (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J Biol Chem 286(40):34839\u201334850","journal-title":"J Biol Chem"},{"issue":"5","key":"6457_CR96","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/mp.2016.30","volume":"22","author":"C Vicidomini","year":"2017","unstructured":"Vicidomini C, Ponzoni L, Lim D, Schmeisser MJ, Reim D, Morello N, Orellana D, Tozzi A, Durante V, Scalmani P, Mantegazza M, Genazzani AA, Giustetto M, Sala M, Calabresi P, Boeckers TM, Sala C, Verpelli C (2017) Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice. Mol Psychiatry 22(5):689\u2013702. https:\/\/doi.org\/10.1038\/mp.2016.30","journal-title":"Mol Psychiatry"},{"key":"6457_CR97","doi-asserted-by":"publisher","first-page":"13097","DOI":"10.1523\/JNEUROSCI.1341-11.2011","volume":"31","author":"EC Walcott","year":"2011","unstructured":"Walcott EC, Higgins EA, Desai NS (2011) Synaptic and intrinsic balancing during postnatal development in rat pups exposed to valproic acid in utero. J Neurosci 31:13097\u201313109. https:\/\/doi.org\/10.1523\/JNEUROSCI.1341-11.2011","journal-title":"J Neurosci"},{"issue":"5959","key":"6457_CR98","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1126\/science.1178496","volume":"326","author":"H Wang","year":"2009","unstructured":"Wang H, Westin L, Nong Y, Birnbaum S, Bendor J, Brismar H, Nestler E, Aperia A, Flajolet M, Greengard P (2009) Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling. Science 326(5959):1554\u20131557. https:\/\/doi.org\/10.1126\/science.1178496","journal-title":"Science"},{"key":"6457_CR99","doi-asserted-by":"publisher","first-page":"689611","DOI":"10.3389\/fncel.2021.689611.eCollection","volume":"15","author":"X Wang","year":"2021","unstructured":"Wang X, Gao C, Zhang Y, Hu S, Qiao Y, Zhao Z, Gou L, Song J (2021) Wang Q (2021) Overexpression of mGluR7 in the prefrontal cortex attenuates autistic behaviors in mice. Frot Cell Neurosci 15:689611. https:\/\/doi.org\/10.3389\/fncel.2021.689611.eCollection","journal-title":"Frot Cell Neurosci"},{"issue":"2","key":"6457_CR100","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1093\/ijnp\/pyab062","volume":"25","author":"M Watanabe","year":"2022","unstructured":"Watanabe M, Marcy B, Hiroki A, Watase H, Kinoshita K, Iijima M, Marumo T, Zarate CA, Chaki S (2022) Evaluation of the safety, tolerability, and pharmacokinetic profiles of TP0473292 (TS-161), a prodrug of a novel orthosteric mGlu2\/3 receptor antagonist TP0178894, in healthy subjects and its antidepressant-like effects in rodents. Int J Neuropsychopharmacol 25(2):106\u2013117. https:\/\/doi.org\/10.1093\/ijnp\/pyab062","journal-title":"Int J Neuropsychopharmacol"},{"key":"6457_CR101","doi-asserted-by":"publisher","first-page":"173446","DOI":"10.1016\/j.pbb.2022.173446","volume":"219","author":"JM Witkin","year":"2022","unstructured":"Witkin JM, Pandey KP, Smith JL (2022) Clinical investigations of compounds targeting metabotropic glutamate receptors. Pharmacol Biochem Behav 219:173446. https:\/\/doi.org\/10.1016\/j.pbb.2022.173446","journal-title":"Pharmacol Biochem Behav"},{"key":"6457_CR102","doi-asserted-by":"publisher","first-page":"113094","DOI":"10.1016\/j.bbr.2020.113094","volume":"403","author":"JQ Yang","year":"2021","unstructured":"Yang JQ, Yang C-H, Yin B-Q (2021) Combined the GABA-A and GABA-B receptor agonists attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism. Behav Brain Res 403:113094. https:\/\/doi.org\/10.1016\/j.bbr.2020.113094","journal-title":"Behav Brain Res"},{"key":"6457_CR103","doi-asserted-by":"publisher","unstructured":"Zoghbi HY, Bear MF (2012) Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. Cold Spring Harb Perspect Biol 4(3): a009886. https:\/\/doi.org\/10.1101\/cshperspect.a009886.","DOI":"10.1101\/cshperspect.a009886"}],"updated-by":[{"DOI":"10.1007\/s00213-023-06494-5","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000}}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-023-06457-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-023-06457-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-023-06457-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T05:58:44Z","timestamp":1709877524000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-023-06457-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,14]]},"references-count":103,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["6457"],"URL":"https:\/\/doi.org\/10.1007\/s00213-023-06457-w","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s00213-023-06494-5","asserted-by":"object"}]},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,14]]},"assertion":[{"value":"1 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2023","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00213-023-06494-5","URL":"https:\/\/doi.org\/10.1007\/s00213-023-06494-5","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}