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Hair samples were provided to quantify \u03949-THC, CBD, and CBN using LC\u2013MS\/MS and THC-consumption was verified by analyzing THC-COOH in hair using GC\u2013MS\/MS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Cannabinoids were detectable in 95.95% of the hair samples from individuals who tested positive on a urine screen for cannabis. \u03949-THC concentrations were positively associated with measures of self-reported potency (relative potency, potency category, and perceived \u2018high\u2019), but \u03949-THC, CBD, CBN concentrations and THC\/CBD ratio were not associated with self-reported quantity of use. Self-reported potency, but not hair-derived concentrations, were associated with withdrawal and craving. Self-reported quantity of cannabis use, but not cannabinoid concentrations, were associated with cannabis use-related problems.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The use of hair-derived cannabinoid quantification is supported for detecting cannabis use in near-daily users, but the lack of associations between hair-derived cannabinoid concentrations and self-report measures of use does not support the use of hair analyses alone for quantification of cannabinoid exposure. Further research comparing hair-derived cannabinoid concentrations with other biological matrices (e.g. plasma) and self-report is necessary to further evaluate the validity of hair analyses for this purpose.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00213-024-06558-0","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T06:02:10Z","timestamp":1708927330000},"page":"1237-1244","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Associations between hair-derived cannabinoid levels, self-reported use, and cannabis-related problems"],"prefix":"10.1007","volume":"241","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1803-9336","authenticated-orcid":false,"given":"Emese","family":"Kroon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janna","family":"Cousijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Filbey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Berchtold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina M.","family":"Binz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Kuhns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"6558_CR1","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.drugalcdep.2010.02.017","volume":"110","author":"SJ Adamson","year":"2010","unstructured":"Adamson SJ, Kay-Lambkin FJ, Baker AL et al (2010) An improved brief measure of cannabis misuse: The cannabis use disorders identification test-revised (CUDIT-R). 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