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However, the neurobiological mechanisms linking chronic opioid use, withdrawal, and the development of PTSD are poorly understood. Our previous research has shown that proinflammatory cytokines, expressed primarily by astrocytes in the dorsal hippocampus (DH), play a role in the development of heroin withdrawal-enhanced fear learning (HW-EFL), an animal model of PTSD-OUD comorbidity. Given the role of astrocytes in memory, fear learning, and opioid use, our experiments aimed to investigate their involvement in HW-EFL. Experiment 1 examined the effect of withdrawal from chronic heroin administration on GFAP surface area and volume, and identified increased surface area and volume of GFAP immunoreactivity in the dentate gyrus (DG) following 24-hour heroin withdrawal. Experiment 2 examined astrocyte morphology and synaptic interactions at the 24-hour withdrawal timepoint using an astroglial membrane-bound GFP (AAV5-GfaABC1D-lck-GFP). Although we did not detect significant changes in surface area and volume of GfaABC1D-Lck-GFP labelled astrocytes, we did observe a significant increase in the colocalization of astrocyte membranes with PSD-95 (postsynaptic density protein 95) in the DG. Experiment 3 tested if stimulating astroglial G<jats:sub>i<\/jats:sub> signaling in the DH alters HW-EFL, and our results demonstrate this manipulation attenuates HW-EFL. Collectively, these findings contribute to our current understanding of the effects of heroin withdrawal on astrocytes and support the involvement of astrocytes in the comorbid relationship between opioid use and anxiety disorders.<\/jats:p>","DOI":"10.1007\/s00213-024-06562-4","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T01:06:49Z","timestamp":1708736809000},"page":"1265-1275","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dorsal hippocampal astrocytes mediate the development of heroin withdrawal-enhanced fear learning"],"prefix":"10.1007","volume":"241","author":[{"given":"Shveta V.","family":"Parekh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia O.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian A.","family":"Barkell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline E.","family":"Paniccia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn J.","family":"Reissner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5404-7910","authenticated-orcid":false,"given":"Donald T.","family":"Lysle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,24]]},"reference":[{"key":"6562_CR1","doi-asserted-by":"publisher","unstructured":"Badia-Soteras A et al (2022) Retraction of astrocyte leaflets from the Synapse enhances fear memory Biol Psychiatry. https:\/\/doi.org\/10.1016\/j.biopsych.2022.10.013","DOI":"10.1016\/j.biopsych.2022.10.013"},{"key":"6562_CR2","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1111\/j.1471-4159.1993.tb09814.x","volume":"61","author":"D Beitner-Johnson","year":"1993","unstructured":"Beitner-Johnson D, Guitart X, Nestler EJ (1993) Glial fibrillary acidic protein and the mesolimbic dopamine system: regulation by chronic morphine and Lewis-Fischer strain differences in the rat ventral tegmental area. 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