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Although it is known that cannabis can cause several adverse effects, in recent years there has been great interest in the medical application of cannabis derivatives for obsessive-compulsive related disorders.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>The present study investigated the effects of repeated THC administration on rates of previously acquired SID, as well as the possible alteration of its temporal distribution along inter-food intervals.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Male Wistar rats acquired SID under a 30\u00a0min fixed-time 30-sec food delivery schedule (from 30 to 43 sessions to reach a stable level). Thereafter, 5 or 10\u00a0mg\/kg daily i.p. injections of THC or vehicle were repeatedly administered for 7 days to evaluate the effects on SID.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Repeated THC administration at a dose of 5\u00a0mg\/kg resulted in an increase on licking. Surprisingly, no effects on SID were observed with the 10\u00a0mg\/kg dose. However, magazine entries were reduced with both THC doses. THC also modified the temporal distributions of licking and magazine entries during inter-food intervals.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The present results show that repeated THC administration may (i) increase induced licking at moderate doses, (ii) reduce magazine entries, and (iii) affect the temporal pattern of SID. These findings suggest that THC does not appear to be beneficial to reduce compulsive behaviour in this animal model, while another collateral effect of THC \u2014such as a greater habitual-like behaviour\u2014 needs to be considered.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00213-024-06563-3","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T01:02:03Z","timestamp":1709082123000},"page":"1277-1286","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Repeated \u0394-9-Tetrahydrocannabinol administration dose dependently increases stablished schedule-induced drinking"],"prefix":"10.1007","volume":"241","author":[{"given":"Esmeralda","family":"Fuentes-Verdugo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Pell\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7320-822X","authenticated-orcid":false,"given":"Miguel","family":"Migu\u00e9ns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"6563_CR2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and statistical manual of mental disorders: DSM-5","author":"American Psychiatric Asociation","year":"2013","unstructured":"American Psychiatric Asociation (2013) Diagnostic and statistical manual of mental disorders: DSM-5. 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