{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:55:55Z","timestamp":1781114155187,"version":"3.54.1"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Ningbo Top Medical and Health Research Program","award":["2022030410"],"award-info":[{"award-number":["2022030410"]}]},{"name":"Key Technologies Research and Development Program of Ningbo","award":["2023Z185"],"award-info":[{"award-number":["2023Z185"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Rationale<\/jats:title>\n                <jats:p>Clinical and preclinical studies have demonstrated that estradiol withdrawal after delivery is one of important factors involved in the pathogenesis of postpartum depression (PPD). The infralimbic cortex (IL) is related to anxiety and mood disorders. Whether IL neurons mediate PPD is still unclear.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>This study was to observe the antidepressant effect and expression of BDNF and \u03b2-catenin in IL by allopregnanolone (ALLO) treatment or the selective activation or inhibition of IL neurons using a chemogenetic approach in a pseudopregnancy model of PPD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Administration of estradiol combined with progesterone and the abrupt withdrawal of estradiol simulated the pregnancy and early postpartum periods to induce depression in ovariectomized rats. The relative expression levels of \u03b2-catenin and BDNF were observed by western blotting.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Immobility time was significantly increased in the forced swim test and open-arm movement was reduced in the elevated plus maze test in the estradiol-withdrawn rats. After ALLO treatment, the immobility time were lower and open-arm traveling times higher than those of the estradiol-withdrawn rats. Meanwhile, the expression level of BDNF or \u03b2-catenin in the IL was reduced significantly in estradiol-withdrawn rats, which was prevented by treatment with ALLO. The hM3Dq chemogenetic activation of pyramidal neurons in the IL reversed the immobility and open-arm travel time trends in the estradiol-withdrawal rat model, but chemogenetic inhibition of IL neurons failed to affect this. Upregulated BDNF and \u03b2-catenin expression and increased c-Fos in the basolateral amygdala were found following IL neuron excitation in model rats.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our results demonstrated that pseudopregnancy and estradiol withdrawal produced depressive-like behavior and anxiety. ALLO treatment or specific excitement of IL pyramidal neurons relieved abnormal behaviors and upregulated BDNF and \u03b2-catenin expression in the IL in the PPD model, suggesting that hypofunction of IL neurons may be involved in the pathogenesis of PPD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00213-024-06610-z","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T04:17:00Z","timestamp":1715660220000},"page":"1923-1935","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antidepressant effects of activation of infralimbic cortex via upregulation of BDNF and \u03b2-catenin in an estradiol withdrawal model"],"prefix":"10.1007","volume":"241","author":[{"given":"Jiali","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaojun","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingding","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4804-7559","authenticated-orcid":false,"given":"Wenhua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"6610_CR1","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1037\/0735-7044.121.3.515","volume":"121","author":"VM Afonso","year":"2007","unstructured":"Afonso VM, Sison M, Lovic V, Fleming AS (2007) Medial prefrontal cortex lesions in the female rat affect sexual and maternal behavior and their sequential organization. Behav Neurosci 121:515\u2013526","journal-title":"Behav Neurosci"},{"key":"6610_CR2","doi-asserted-by":"publisher","first-page":"332","DOI":"10.4088\/JCP.v62n0504","volume":"62","author":"A Ahokas","year":"2001","unstructured":"Ahokas A, Kaukoranta J, Wahlbeck K, Aito M (2001) Estrogen deficiency in severe postpartum depression: successful treatment with sublingual physiologic 17beta-estradiol: a preliminary study. J Clin Psychiatry 62:332\u2013336","journal-title":"J Clin Psychiatry"},{"key":"6610_CR3","doi-asserted-by":"publisher","first-page":"100218","DOI":"10.1016\/j.ynstr.2020.100218","volume":"12","author":"FB Almeida","year":"2020","unstructured":"Almeida FB, Nin MS, Barros HMT (2020) The role of allopregnanolone in depressive-like behaviors: focus on neurotrophic proteins. Neurobiol Stress 12:100218","journal-title":"Neurobiol Stress"},{"key":"6610_CR4","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.biopsych.2021.07.017","volume":"91","author":"P Antonoudiou","year":"2022","unstructured":"Antonoudiou P, Colmers PLW, Walton NL, Weiss GL, Smith AC, Nguyen DP, Lewis M, Quirk MC, Barros L, Melon LC, Maguire JL (2022) Allopregnanolone mediates affective switching through modulation of Oscillatory States in the Basolateral Amygdala. Biol Psychiat 91:283\u2013293","journal-title":"Biol Psychiat"},{"key":"6610_CR5","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.pnpbp.2013.09.005","volume":"48","author":"A Bali","year":"2014","unstructured":"Bali A, Jaggi AS (2014) Multifunctional aspects of allopregnanolone in stress and related disorders. Prog Neuropsychopharmacol Biol Psychiatry 48:64\u201378","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"6610_CR6","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1176\/appi.ajp.157.6.924","volume":"157","author":"M Bloch","year":"2000","unstructured":"Bloch M, Schmidt PJ, Danaceau M, Murphy J, Nieman L, Rubinow DR (2000) Effects of gonadal steroids in women with a history of postpartum depression. Am J Psychiatry 157:924\u2013930","journal-title":"Am J Psychiatry"},{"key":"6610_CR7","doi-asserted-by":"publisher","first-page":"105682","DOI":"10.1016\/j.phrs.2021.105682","volume":"169","author":"S Chen","year":"2021","unstructured":"Chen S, Gao L, Li X, Ye Y (2021a) Allopregnanolone in mood disorders: mechanism and therapeutic development. Pharmacol Res 169:105682","journal-title":"Pharmacol Res"},{"key":"6610_CR8","doi-asserted-by":"crossref","unstructured":"Chen YH, Wu JL, Hu NY, Zhuang JP, Li WP, Zhang SR, Li XW, Yang JM, Gao TM (2021b) Distinct projections from the infralimbic cortex exert opposing effects in modulating anxiety and fear. J Clin Invest 131","DOI":"10.1172\/JCI145692"},{"key":"6610_CR9","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.encep.2016.02.003","volume":"42","author":"JF Costemale-Lacoste","year":"2016","unstructured":"Costemale-Lacoste JF, Guilloux JP, Gaillard R (2016) The role of GSK-3 in treatment-resistant depression and links with the pharmacological effects of lithium and ketamine: a review of the literature. Encephale 42:156\u2013164","journal-title":"Encephale"},{"key":"6610_CR10","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.neuron.2019.03.013","volume":"102","author":"RS Duman","year":"2019","unstructured":"Duman RS, Sanacora G, Krystal JH (2019) Altered connectivity in Depression: GABA and glutamate neurotransmitter deficits and reversal by Novel treatments. Neuron 102:75\u201390","journal-title":"Neuron"},{"key":"6610_CR11","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1016\/j.neuropharm.2012.08.012","volume":"63","author":"J Evans","year":"2012","unstructured":"Evans J, Sun Y, McGregor A, Connor B (2012) Allopregnanolone regulates neurogenesis and depressive\/anxiety-like behaviour in a social isolation rodent model of chronic stress. Neuropharmacology 63:1315\u20131326","journal-title":"Neuropharmacology"},{"key":"6610_CR12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.brainres.2010.02.027","volume":"1325","author":"M Febo","year":"2010","unstructured":"Febo M, Felix-Ortiz AC, Johnson TR (2010) Inactivation or inhibition of neuronal activity in the medial prefrontal cortex largely reduces pup retrieval and grouping in maternal rats. Brain Res 1325:77\u201388","journal-title":"Brain Res"},{"key":"6610_CR13","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1177\/1073858415574728","volume":"22","author":"AM Fortress","year":"2016","unstructured":"Fortress AM, Frick KM (2016) Hippocampal wnt signaling: memory regulation and hormone interactions. Neuroscientist 22:278\u2013294","journal-title":"Neuroscientist"},{"key":"6610_CR14","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1006\/hbeh.2002.1763","volume":"41","author":"CA Frye","year":"2002","unstructured":"Frye CA, Walf AA (2002) Changes in progesterone metabolites in the hippocampus can modulate open field and forced swim test behavior of proestrous rats. Horm Behav 41:306\u2013315","journal-title":"Horm Behav"},{"key":"6610_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0166-4328(01)00170-X","volume":"122","author":"LA Galea","year":"2001","unstructured":"Galea LA, Wide JK, Barr AM (2001) Estradiol alleviates depressive-like symptoms in a novel animal model of post-partum depression. Behav Brain Res 122:1\u20139","journal-title":"Behav Brain Res"},{"key":"6610_CR16","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1038\/npp.2014.56","volume":"39","author":"C Galvin","year":"2014","unstructured":"Galvin C, Ninan I (2014) Regulation of the mouse medial prefrontal cortical synapses by endogenous estradiol. Neuropsychopharmacology 39:2086\u20132094","journal-title":"Neuropsychopharmacology"},{"key":"6610_CR17","doi-asserted-by":"publisher","first-page":"1140796","DOI":"10.3389\/fpsyt.2023.1140796","volume":"14","author":"Q Gao","year":"2023","unstructured":"Gao Q, Sun W, Wang YR, Li ZF, Zhao F, Geng XW, Xu KY, Chen D, Liu K, Xing Y, Liu W, Wei S (2023) Role of allopregnanolone-mediated gamma-aminobutyric acid A receptor sensitivity in the pathogenesis of premenstrual dysphoric disorder: toward precise targets for translational medicine and drug development. Front Psychiatry 14:1140796","journal-title":"Front Psychiatry"},{"key":"6610_CR18","doi-asserted-by":"publisher","first-page":"113598","DOI":"10.1016\/j.biopha.2022.113598","volume":"154","author":"A Garcia-Baos","year":"2022","unstructured":"Garcia-Baos A, Gallego-Landin I, Ferreres-Alvarez I, Puig-Reyne X, Castro-Zavala A, Valverde O, Martin-Sanchez A (2022) Effects of fast-acting antidepressant drugs on a postpartum depression mice model. Biomed Pharmacother 154:113598","journal-title":"Biomed Pharmacother"},{"key":"6610_CR19","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3389\/fendo.2016.00044","volume":"7","author":"JF Ge","year":"2016","unstructured":"Ge JF, Xu YY, Qin G, Cheng JQ, Chen FH (2016) Resveratrol ameliorates the anxiety- and Depression-Like Behavior of Subclinical Hypothyroidism Rat: possible involvement of the HPT Axis, HPA Axis, and Wnt\/beta-Catenin pathway. Front Endocrinol (Lausanne) 7:44","journal-title":"Front Endocrinol (Lausanne)"},{"key":"6610_CR20","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.2174\/1570159X20666220302101115","volume":"20","author":"A Ghuman","year":"2022","unstructured":"Ghuman A, McEwen A, Tran KH, Mitchell N, Hanstock C, Seres P, Jhangri G, Burgess D, Baker G, Le Melledo JM (2022) Prospective Investigation of Glutamate Levels and Percentage Gray Matter in the Medial Prefrontal Cortex in females at risk for Postpartum Depression. Curr Neuropharmacol 20:1988\u20132000","journal-title":"Curr Neuropharmacol"},{"key":"6610_CR21","doi-asserted-by":"publisher","first-page":"e13019","DOI":"10.1111\/jne.13019","volume":"34","author":"H Gunduz-Bruce","year":"2022","unstructured":"Gunduz-Bruce H, Takahashi K, Huang MY (2022) Development of neuroactive steroids for the treatment of postpartum depression. J Neuroendocrinol 34:e13019","journal-title":"J Neuroendocrinol"},{"key":"6610_CR22","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.jad.2021.12.092","volume":"300","author":"JA Harder","year":"2022","unstructured":"Harder JA, Fichorova RN, Srivastava A, Wiley A, Burdick KE, Locascio JJ, Joffe H (2022) Brain-derived neurotrophic factor and mood in perimenopausal depression. J Affect Disord 300:145\u2013149","journal-title":"J Affect Disord"},{"key":"6610_CR23","doi-asserted-by":"publisher","first-page":"2742","DOI":"10.1038\/s41380-020-0685-9","volume":"25","author":"BD Hare","year":"2020","unstructured":"Hare BD, Duman RS (2020) Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions. Mol Psychiatry 25:2742\u20132758","journal-title":"Mol Psychiatry"},{"key":"6610_CR24","doi-asserted-by":"crossref","unstructured":"Holubova K, Nekovarova T, Pistovcakova J, Sulcova A, Stuchl\u00edk A, Vales K (2014) Pregnanolone glutamate, a novel use-dependent NMDA receptor inhibitor, exerts antidepressant-like properties in animal models. Front Behav Neurosci 8","DOI":"10.3389\/fnbeh.2014.00130"},{"key":"6610_CR25","doi-asserted-by":"publisher","first-page":"107899","DOI":"10.1016\/j.celrep.2020.107899","volume":"32","author":"WC Huang","year":"2020","unstructured":"Huang WC, Zucca A, Levy J, Page DT (2020) Social Behavior is modulated by Valence-Encoding mPFC-Amygdala sub-circuitry. Cell Rep 32:107899","journal-title":"Cell Rep"},{"key":"6610_CR26","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jad.2011.09.024","volume":"136","author":"F Karege","year":"2012","unstructured":"Karege F, Perroud N, Burkhardt S, Fernandez R, Ballmann E, La Harpe R, Malafosse A (2012) Protein levels of beta-catenin and activation state of glycogen synthase kinase-3beta in major depression. A study with postmortem prefrontal cortex. J Affect Disord 136:185\u2013188","journal-title":"J Affect Disord"},{"key":"6610_CR27","doi-asserted-by":"crossref","unstructured":"Ke YT, Bu SZ, Ma H, Gao L, Cai YJ, Zhang YS, Zhou WH (2020) Preventive and therapeutic effects of Astaxanthin on Depressive-Like behaviors in High-Fat Diet and Streptozotocin-treated rats. Frontiers in Pharmacology 10.","DOI":"10.3389\/fphar.2019.01621"},{"key":"6610_CR28","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0091-3057(00)00300-2","volume":"67","author":"RT Khisti","year":"2000","unstructured":"Khisti RT, Chopde CT, Jain SP (2000) Antidepressant-like effect of the neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one in mice forced swim test. Pharmacol Biochem Be 67:137\u2013143","journal-title":"Pharmacol Biochem Be"},{"key":"6610_CR29","doi-asserted-by":"publisher","first-page":"110245","DOI":"10.1016\/j.pnpbp.2021.110245","volume":"109","author":"Y Lee","year":"2021","unstructured":"Lee Y, Kim KH, Lee BH, Kim YK (2021) Plasma level of brain-derived neurotrophic factor (BDNF) in patients with postpartum depression. Prog Neuropsychopharmacol Biol Psychiatry 109:110245","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"6610_CR30","doi-asserted-by":"publisher","first-page":"445","DOI":"10.3109\/01612840.2012.673054","volume":"33","author":"NL Letourneau","year":"2012","unstructured":"Letourneau NL, Dennis CL, Benzies K, Duffett-Leger L, Stewart M, Tryphonopoulos PD, Este D, Watson W (2012) Postpartum depression is a family affair: addressing the impact on mothers, fathers, and children. Issues Ment Health Nurs 33:445\u2013457","journal-title":"Issues Ment Health Nurs"},{"key":"6610_CR31","doi-asserted-by":"publisher","first-page":"e89912","DOI":"10.1371\/journal.pone.0089912","volume":"9","author":"B Leuner","year":"2014","unstructured":"Leuner B, Fredericks PJ, Nealer C, Albin-Brooks C (2014) Chronic gestational stress leads to depressive-like behavior and compromises medial prefrontal cortex structure and function during the postpartum period. PLoS ONE 9:e89912","journal-title":"PLoS ONE"},{"key":"6610_CR32","doi-asserted-by":"publisher","first-page":"588","DOI":"10.3389\/fpsyt.2018.00588","volume":"9","author":"H Li","year":"2018","unstructured":"Li H, Wang T, Shi C, Yang Y, Li X, Wu Y, Xu ZD (2018) Inhibition of GALR1 in PFC alleviates Depressive-Like behaviors in Postpartum Depression Rat Model by upregulating CREB-BNDF and 5-HT levels. Front Psychiatry 9:588","journal-title":"Front Psychiatry"},{"key":"6610_CR33","doi-asserted-by":"crossref","unstructured":"Licheri V, Talani G, Gorule AA, Mostallino MC, Biggio G, Sanna E (2015) Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function. Neural Plast 2015: 170435","DOI":"10.1155\/2015\/170435"},{"key":"6610_CR34","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.neuroscience.2012.10.019","volume":"239","author":"V Luine","year":"2013","unstructured":"Luine V, Frankfurt M (2013) Interactions between Estradiol, Bdnf and dendritic spines in promoting memory. Neuroscience 239:34\u201345","journal-title":"Neuroscience"},{"key":"6610_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fncel.2019.00083","volume":"13","author":"J Maguire","year":"2019","unstructured":"Maguire J (2019) Neuroactive steroids and GABAergic involvement in the neuroendocrine dysfunction Associated with Major Depressive Disorder and Postpartum Depression. Front Cell Neurosci 13:1\u201315","journal-title":"Front Cell Neurosci"},{"key":"6610_CR36","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.neuron.2008.06.019","volume":"59","author":"J Maguire","year":"2008","unstructured":"Maguire J, Mody I (2008) GABA(A)R plasticity during pregnancy: relevance to postpartum depression. Neuron 59:207\u2013213","journal-title":"Neuron"},{"key":"6610_CR37","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.neuron.2013.06.028","volume":"79","author":"BS McEwen","year":"2013","unstructured":"McEwen BS, Morrison JH (2013) The brain on stress: vulnerability and plasticity of the prefrontal cortex over the life course. Neuron 79:16\u201329","journal-title":"Neuron"},{"key":"6610_CR38","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/S0140-6736(18)31551-4","volume":"392","author":"S Meltzer-Brody","year":"2018","unstructured":"Meltzer-Brody S, Colquhoun H, Riesenberg R, Epperson CN, Deligiannidis KM, Rubinow DR, Li H, Sankoh AJ, Clemson C, Schacterle A, Jonas J, Kanes S (2018) Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials. Lancet 392:1058\u20131070","journal-title":"Lancet"},{"key":"6610_CR39","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.biopsych.2021.11.006","volume":"91","author":"AL Morrow","year":"2022","unstructured":"Morrow AL, Balan I, Boero G (2022) Mechanisms underlying recovery from Postpartum Depression following Brexanolone Therapy. Biol Psychiatry 91:252\u2013253","journal-title":"Biol Psychiatry"},{"key":"6610_CR40","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1176\/appi.ajp.2010.09081235","volume":"167","author":"EL Moses-Kolko","year":"2010","unstructured":"Moses-Kolko EL, Perlman SB, Wisner KL, James J, Saul AT, Phillips ML (2010) Abnormally reduced dorsomedial prefrontal cortical activity and effective connectivity with amygdala in response to negative emotional faces in postpartum depression. Am J Psychiatry 167:1373\u20131380","journal-title":"Am J Psychiatry"},{"issue":"Suppl 1","key":"6610_CR41","doi-asserted-by":"publisher","first-page":"S74","DOI":"10.1016\/j.psyneuen.2009.06.013","volume":"34","author":"MC Mostallino","year":"2009","unstructured":"Mostallino MC, Sanna E, Concas A, Biggio G, Follesa P (2009) Plasticity and function of extrasynaptic GABA(A) receptors during pregnancy and after delivery. Psychoneuroendocrinology 34(Suppl 1):S74\u201383","journal-title":"Psychoneuroendocrinology"},{"key":"6610_CR42","doi-asserted-by":"publisher","first-page":"113948","DOI":"10.1016\/j.bbr.2022.113948","volume":"430","author":"RF Narvaes","year":"2022","unstructured":"Narvaes RF, Nachtigall EG, Marcondes LA, Izquierdo I, Myskiw JC, Furini CRG (2022) Involvement of medial prefrontal cortex canonical Wnt\/beta-catenin and non-canonical Wnt\/Ca(2+) signaling pathways in contextual fear memory in male rats. Behav Brain Res 430:113948","journal-title":"Behav Brain Res"},{"key":"6610_CR43","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1001\/jamapsychiatry.2017.4363","volume":"75","author":"E Netsi","year":"2018","unstructured":"Netsi E, Pearson RM, Murray L, Cooper P, Craske MG, Stein A (2018) Association of persistent and severe postnatal Depression with Child outcomes. JAMA Psychiatry 75:247\u2013253","journal-title":"JAMA Psychiatry"},{"key":"6610_CR44","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1146\/annurev-clinpsy-050212-185612","volume":"9","author":"MW O\u2019Hara","year":"2013","unstructured":"O\u2019Hara MW, McCabe JE (2013) Postpartum depression: current status and future directions. Annu Rev Clin Psychol 9:379\u2013407","journal-title":"Annu Rev Clin Psychol"},{"key":"6610_CR45","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.genhosppsych.2015.03.001","volume":"37","author":"E Oral","year":"2015","unstructured":"Oral E, Kirkan TS, Yildirim A, Kotan Z, Cansever Z, Ozcan H, Aliyev E, Gulec M (2015) Serum brain-derived neurotrophic factor differences between the luteal and follicular phases in premenstrual dysphoric disorder. Gen Hosp Psychiatry 37:266\u2013272","journal-title":"Gen Hosp Psychiatry"},{"key":"6610_CR46","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1007\/s12035-019-01741-3","volume":"57","author":"K Park","year":"2020","unstructured":"Park K, Chung C (2020) Differential alterations in Cortico-Amygdala Circuitry in mice with impaired fear extinction. Mol Neurobiol 57:710\u2013721","journal-title":"Mol Neurobiol"},{"key":"6610_CR47","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.yfrne.2018.12.001","volume":"52","author":"JL Payne","year":"2019","unstructured":"Payne JL, Maguire J (2019) Pathophysiological mechanisms implicated in postpartum depression. Front Neuroendocrinol 52:165\u2013180","journal-title":"Front Neuroendocrinol"},{"key":"6610_CR48","doi-asserted-by":"publisher","first-page":"S187","DOI":"10.33549\/physiolres.935001","volume":"71","author":"M Pillerova","year":"2022","unstructured":"Pillerova M, Pastorek M, Borbelyova V, Riljak V, Frick KM, Hodosy J, Tothova L (2022) Sex steroid hormones in depressive disorders as a basis for new potential treatment strategies. Physiol Res 71:S187\u2013S202","journal-title":"Physiol Res"},{"key":"6610_CR49","doi-asserted-by":"publisher","first-page":"e12701","DOI":"10.1111\/jne.12701","volume":"31","author":"S Pose","year":"2019","unstructured":"Pose S, Zuluaga MJ, Ferreno M, Agrati D, Bedo G, Uriarte N (2019) Raising overlapping litters: Differential activation of rat maternal neural circuitry after interacting with newborn or juvenile pups. J Neuroendocrinol 31:e12701","journal-title":"J Neuroendocrinol"},{"key":"6610_CR50","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.bbr.2018.12.017","volume":"360","author":"A Puga-Olguin","year":"2019","unstructured":"Puga-Olguin A, Rodriguez-Landa JF, Rovirosa-Hernandez MD, German-Ponciano LJ, Caba M, Meza E, Guillen-Ruiz G, Olmos-Vazquez OJ (2019) Long-term ovariectomy increases anxiety- and despair-like behaviors associated with lower Fos immunoreactivity in the lateral septal nucleus in rats. Behav Brain Res 360:185\u2013195","journal-title":"Behav Brain Res"},{"key":"6610_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnbeh.2022.829274","volume":"16","author":"JF Rodriguez-Landa","year":"2022","unstructured":"Rodriguez-Landa JF (2022) Considerations of timing post-ovariectomy in mice and rats in studying anxiety- and Depression-Like behaviors Associated with Surgical Menopause in Women. Front Behav Neurosci 16:1\u20139","journal-title":"Front Behav Neurosci"},{"key":"6610_CR52","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1177\/0269881106064203","volume":"21","author":"JF Rodriguez-Landa","year":"2007","unstructured":"Rodriguez-Landa JF, Contreras CM, Bernal-Morales B, Gutierrez-Garcia AG, Saavedra M (2007) Allopregnanolone reduces immobility in the forced swimming test and increases the firing rate of lateral septal neurons through actions on the GABAA receptor in the rat. J Psychopharmacol 21:76\u201384","journal-title":"J Psychopharmacol"},{"key":"6610_CR53","doi-asserted-by":"publisher","first-page":"112508","DOI":"10.1016\/j.bbr.2020.112508","volume":"383","author":"OK Sial","year":"2020","unstructured":"Sial OK, Parise EM, Parise LF, Gnecco T, Bolanos-Guzman CA (2020) Ketamine: the final frontier or another depressing end? Behav Brain Res 383:112508","journal-title":"Behav Brain Res"},{"key":"6610_CR54","doi-asserted-by":"publisher","first-page":"e0152991","DOI":"10.1371\/journal.pone.0152991","volume":"11","author":"NN Soe","year":"2016","unstructured":"Soe NN, Wen DJ, Poh JS, Li Y, Broekman BF, Chen H, Chong YS, Kwek K, Saw SM, Gluckman PD, Meaney MJ, Rifkin-Graboi A, Qiu A (2016) Pre- and post-natal maternal depressive symptoms in relation with infant frontal function, Connectivity, and behaviors. PLoS ONE 11:e0152991","journal-title":"PLoS ONE"},{"key":"6610_CR55","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.physbeh.2004.08.033","volume":"83","author":"EC Stoffel","year":"2004","unstructured":"Stoffel EC, Craft RM (2004) Ovarian hormone withdrawal-induced depression in female rats. Physiol Behav 83:505\u2013513","journal-title":"Physiol Behav"},{"key":"6610_CR56","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.biopsych.2008.03.029","volume":"64","author":"S Suda","year":"2008","unstructured":"Suda S, Segi-Nishida E, Newton SS, Duman RS (2008) A postpartum model in rat: behavioral and gene expression changes induced by ovarian steroid deprivation. Biol Psychiatry 64:311\u2013319","journal-title":"Biol Psychiatry"},{"key":"6610_CR57","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1177\/02698811211013579","volume":"35","author":"GH Vazquez","year":"2021","unstructured":"Vazquez GH, Bahji A, Undurraga J, Tondo L, Baldessarini RJ (2021) Efficacy and tolerability of combination treatments for Major Depression: antidepressants plus Second-Generation antipsychotics vs. esketamine vs. Lithium J Psychopharmacol 35:890\u2013900","journal-title":"Lithium J Psychopharmacol"},{"key":"6610_CR58","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.yhbeh.2012.01.010","volume":"61","author":"DA Velazquez-Zamora","year":"2012","unstructured":"Velazquez-Zamora DA, Garcia-Segura LM, Gonzalez-Burgos I (2012) Effects of selective estrogen receptor modulators on allocentric working memory performance and on dendritic spines in medial prefrontal cortex pyramidal neurons of ovariectomized rats. Horm Behav 61:512\u2013517","journal-title":"Horm Behav"},{"key":"6610_CR59","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/clpt.2011.296","volume":"91","author":"B Voleti","year":"2012","unstructured":"Voleti B, Duman RS (2012) The roles of neurotrophic factor and wnt signaling in depression. Clin Pharmacol Ther 91:333\u2013338","journal-title":"Clin Pharmacol Ther"},{"key":"6610_CR60","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.2147\/DDDT.S240856","volume":"15","author":"A Walkery","year":"2021","unstructured":"Walkery A, Leader LD, Cooke E, VandenBerg A (2021) Review of Allopregnanolone Agonist Therapy for the treatment of Depressive disorders. Drug Des Devel Ther 15:3017\u20133026","journal-title":"Drug Des Devel Ther"},{"key":"6610_CR61","doi-asserted-by":"publisher","first-page":"6197","DOI":"10.1007\/s12035-019-1524-3","volume":"56","author":"JQ Wang","year":"2019","unstructured":"Wang JQ, Mao L (2019) The ERK Pathway: Molecular mechanisms and Treatment of Depression. Mol Neurobiol 56:6197\u20136205","journal-title":"Mol Neurobiol"},{"key":"6610_CR62","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.brainresbull.2017.12.011","volume":"137","author":"S Wang","year":"2018","unstructured":"Wang S, Zhu J, Xu T (2018) 17beta-estradiol (E2) promotes growth and stability of new dendritic spines via estrogen receptor beta pathway in intact mouse cortex. Brain Res Bull 137:241\u2013248","journal-title":"Brain Res Bull"},{"key":"6610_CR63","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jad.2017.05.003","volume":"219","author":"CA Woody","year":"2017","unstructured":"Woody CA, Ferrari AJ, Siskind DJ, Whiteford HA, Harris MG (2017) A systematic review and meta-regression of the prevalence and incidence of perinatal depression. J Affect Disord 219:86\u201392","journal-title":"J Affect Disord"},{"key":"6610_CR64","doi-asserted-by":"publisher","first-page":"e05180","DOI":"10.1016\/j.heliyon.2020.e05180","volume":"6","author":"S Wu","year":"2020","unstructured":"Wu S, Ye M, Li Z, Bu S, Zhang Y (2020) Long-term supplementation of dehydroepiandrosterone improved depressive-like behaviors by increasing BDNF expression in the hippocampus in ovariectomized rats. Heliyon 6:e05180","journal-title":"Heliyon"},{"key":"6610_CR65","first-page":"83","volume":"20","author":"LZ Xu","year":"2017","unstructured":"Xu LZ, Xu DF, Han Y, Liu LJ, Sun CY, Deng JH, Zhang RX, Yuan M, Zhang SZ, Li ZM, Xu Y, Li JS, Xie SH, Li SX, Zhang HY, Lu L (2017) BDNF-GSK-3beta-beta-catenin pathway in the mPFC is involved in antidepressant-like effects of Morinda Officinalis oligosaccharides in rats. Int J Neuropsychopharmacol 20:83\u201393","journal-title":"Int J Neuropsychopharmacol"},{"key":"6610_CR66","doi-asserted-by":"publisher","first-page":"763562","DOI":"10.3389\/fpsyt.2021.763562","volume":"12","author":"S Yap","year":"2021","unstructured":"Yap S, Luki J, Hanstock CC, Seres P, Shandro T, Hanstock SEC, Lirette A, Zhao HH, Aitchison KJ, Le Melledo JM (2021) Decreased medial prefrontal cortex glutamate levels in Perimenopausal Women. Front Psychiatry 12:763562","journal-title":"Front Psychiatry"},{"key":"6610_CR67","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1038\/nn1132","volume":"6","author":"X Yu","year":"2003","unstructured":"Yu X, Malenka RC (2003) Beta-catenin is critical for dendritic morphogenesis. Nat Neurosci 6:1169\u20131177","journal-title":"Nat Neurosci"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-024-06610-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-024-06610-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-024-06610-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T08:43:20Z","timestamp":1724402600000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-024-06610-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,14]]},"references-count":67,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["6610"],"URL":"https:\/\/doi.org\/10.1007\/s00213-024-06610-z","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,14]]},"assertion":[{"value":"7 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All rat studies and experimental procedures in accordance with approved protocols from the Ethics Committee of Laboratory Animal Use and Care of Ningbo University. Efforts were made to minimize animal suffering and the number of animals used.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}