{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:20:44Z","timestamp":1777663244525,"version":"3.51.4"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100009697","name":"Hashemite University","doi-asserted-by":"publisher","award":["34\/2020"],"award-info":[{"award-number":["34\/2020"]}],"id":[{"id":"10.13039\/501100009697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1007\/s00213-024-06639-0","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T03:46:41Z","timestamp":1718682401000},"page":"2347-2362","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Scopoletin mitigates maternal separation-induced anxiety-like and depression-like behaviors in male mice through modulation of the Sirt1\/NF-\u03baB pathway"],"prefix":"10.1007","volume":"241","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3721-8225","authenticated-orcid":false,"given":"Abdelrahim","family":"Alqudah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esam","family":"Qnais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Gammoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousra","family":"Bseiso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Wedyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Alqudah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muna","family":"Oqal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rawan","family":"Abudalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taher","family":"Hatahet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"6639_CR1","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/J.BIOPSYCH.2016.01.009","volume":"80","author":"N Abe-Higuchi","year":"2016","unstructured":"Abe-Higuchi N, Uchida S, Yamagata H et al (2016) Hippocampal sirtuin 1 signaling mediates Depression-like Behavior. Biol Psychiatry 80:815\u2013826. https:\/\/doi.org\/10.1016\/J.BIOPSYCH.2016.01.009","journal-title":"Biol Psychiatry"},{"key":"6639_CR2","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1017\/S0954579415000103","volume":"27","author":"SL Andersen","year":"2015","unstructured":"Andersen SL (2015) Exposure to early adversity: points of cross-species translation that can lead to improved understanding of depression. Dev Psychopathol 27:477\u2013491. https:\/\/doi.org\/10.1017\/S0954579415000103","journal-title":"Dev Psychopathol"},{"key":"6639_CR3","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1097\/HRP.0000000000000325","volume":"30","author":"SL Andersen","year":"2022","unstructured":"Andersen SL (2022) Neuroinflammation, Early-Life Adversity, and Brain Development. Harv Rev Psychiatry 30:24\u201339. https:\/\/doi.org\/10.1097\/HRP.0000000000000325","journal-title":"Harv Rev Psychiatry"},{"key":"6639_CR4","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1515\/ZNC-2021-0193","volume":"77","author":"LD Antika","year":"2022","unstructured":"Antika LD, Tasfiyati AN, Hikmat H, Septama AW (2022) Scopoletin: a review of its source, biosynthesis, methods of extraction, and pharmacological activities. Z fur Naturforsch - Sect C J Biosci 77:303\u2013316. https:\/\/doi.org\/10.1515\/ZNC-2021-0193\/ASSET\/GRAPHIC\/J_ZNC-2021-0193_FIG_002.JPG","journal-title":"Z fur Naturforsch - Sect C J Biosci"},{"key":"6639_CR5","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.2147\/NDT.S185757","volume":"16","author":"M Atmaca","year":"2020","unstructured":"Atmaca M (2020) Selective serotonin reuptake inhibitor-induced sexual dysfunction: current management perspectives. Neuropsychiatr Dis Treat 16:1043\u20131050. https:\/\/doi.org\/10.2147\/NDT.S185757","journal-title":"Neuropsychiatr Dis Treat"},{"key":"6639_CR6","doi-asserted-by":"publisher","first-page":"100142","DOI":"10.1016\/J.BBIH.2020.100142","volume":"9","author":"S Bachiller","year":"2020","unstructured":"Bachiller S, Paulus A, V\u00e1zquez-Reyes S et al (2020) Maternal separation leads to regional hippocampal microglial activation and alters the behavior in the adolescence in a sex-specific manner. Brain Behav Immun - Heal 9:100142. https:\/\/doi.org\/10.1016\/J.BBIH.2020.100142","journal-title":"Brain Behav Immun - Heal"},{"key":"6639_CR7","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/J.NEUBIOREV.2004.03.004","volume":"28","author":"DM Bannerman","year":"2004","unstructured":"Bannerman DM, Rawlins JNP, McHugh SB et al (2004) Regional dissociations within the hippocampus\u2014memory and anxiety. Neurosci Biobehav Rev 28:273\u2013283. https:\/\/doi.org\/10.1016\/J.NEUBIOREV.2004.03.004","journal-title":"Neurosci Biobehav Rev"},{"key":"6639_CR8","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1002\/BDR2.1530","volume":"111","author":"NJ Bergman","year":"2019","unstructured":"Bergman NJ (2019) Birth practices: maternal-neonate separation as a source of toxic stress. Birth Defects Res 111:1087\u20131109. https:\/\/doi.org\/10.1002\/BDR2.1530","journal-title":"Birth Defects Res"},{"key":"6639_CR9","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1007\/S12640-022-00553-Z\/FIGURES\/8","volume":"40","author":"H Bian","year":"2022","unstructured":"Bian H, Xiao L, Liang L et al (2022) Polydatin prevents Neuroinflammation and relieves Depression via regulating Sirt1\/HMGB1\/NF-\u03baB signaling in mice. Neurotox Res 40:1393\u20131404. https:\/\/doi.org\/10.1007\/S12640-022-00553-Z\/FIGURES\/8","journal-title":"Neurotox Res"},{"key":"6639_CR10","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/J.EJPHAR.2010.06.043","volume":"643","author":"JC Capra","year":"2010","unstructured":"Capra JC, Cunha MP, Machado DG et al (2010) Antidepressant-like effect of scopoletin, a coumarin isolated from Polygala sabulosa (Polygalaceae) in mice: evidence for the involvement of monoaminergic systems. Eur J Pharmacol 643:232\u2013238. https:\/\/doi.org\/10.1016\/J.EJPHAR.2010.06.043","journal-title":"Eur J Pharmacol"},{"key":"6639_CR11","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/595603","author":"TN Chang","year":"2012","unstructured":"Chang TN, Deng JS, Chang YC et al (2012) Ameliorative effects of scopoletin from Crossostephium chinensis against inflammation pain and its mechanisms in mice. Evidence-based Complement Altern Med. https:\/\/doi.org\/10.1155\/2012\/595603. 2012:","journal-title":"Evidence-based Complement Altern Med"},{"key":"6639_CR12","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/J.NEUBIOREV.2005.03.009","volume":"29","author":"JF Cryan","year":"2005","unstructured":"Cryan JF, Mombereau C, Vassout A (2005) The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci Biobehav Rev 29:571\u2013625. https:\/\/doi.org\/10.1016\/J.NEUBIOREV.2005.03.009","journal-title":"Neurosci Biobehav Rev"},{"key":"6639_CR13","doi-asserted-by":"publisher","first-page":"500866","DOI":"10.3389\/FPHAR.2020.00102\/BIBTEX","volume":"11","author":"Y Cui","year":"2020","unstructured":"Cui Y, Cao K, Lin H et al (2020) Early-life stress induces Depression-Like Behavior and synaptic-plasticity changes in a maternal separation rat model: gender difference and Metabolomics Study. Front Pharmacol 11:500866. https:\/\/doi.org\/10.3389\/FPHAR.2020.00102\/BIBTEX","journal-title":"Front Pharmacol"},{"key":"6639_CR14","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1080\/13880200802367155","volume":"46","author":"Z Ding","year":"2008","unstructured":"Ding Z, Dai Y, Hao H et al (2008) Anti-inflammatory effects of Scopoletin and underlying mechanisms. Pharm Biol 46:854\u2013860. https:\/\/doi.org\/10.1080\/13880200802367155","journal-title":"Pharm Biol"},{"key":"6639_CR15","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/laban0411-119","volume":"404 40","author":"S Drude","year":"2011","unstructured":"Drude S, Gei\u00dfler A, Olfe J et al (2011) Side effects of control treatment can conceal experimental data when studying stress responses to injection and psychological stress in mice. Lab Anim 2011 404 40:119\u2013128. https:\/\/doi.org\/10.1038\/laban0411-119","journal-title":"Lab Anim 2011"},{"key":"6639_CR16","doi-asserted-by":"publisher","first-page":"387","DOI":"10.3390\/NEUROLINT13030038","volume":"13","author":"AN Edinoff","year":"2021","unstructured":"Edinoff AN, Akuly HA, Hanna TA et al (2021a) Selective serotonin reuptake inhibitors and adverse effects: a narrative review. Neurol Int 2021 13:387\u2013401. https:\/\/doi.org\/10.3390\/NEUROLINT13030038","journal-title":"Neurol Int 2021"},{"key":"6639_CR17","doi-asserted-by":"publisher","unstructured":"Edinoff AN, Fort JM, Woo JJ et al (2021b) Selective Serotonin Reuptake Inhibitors and Clozapine: Clinically Relevant Interactions and Considerations. Neurol Int 2021, Vol 13, Pages 445\u2013463 13:445\u2013463. https:\/\/doi.org\/10.3390\/NEUROLINT13030044","DOI":"10.3390\/NEUROLINT13030044"},{"key":"6639_CR18","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/S00429-007-0169-6\/TABLES\/4","volume":"212","author":"K Fabricius","year":"2008","unstructured":"Fabricius K, W\u00f6rtwein G, Pakkenberg B (2008) The impact of maternal separation on adult mouse behaviour and on the total neuron number in the mouse hippocampus. Brain Struct Funct 212:403\u2013416. https:\/\/doi.org\/10.1007\/S00429-007-0169-6\/TABLES\/4","journal-title":"Brain Struct Funct"},{"key":"6639_CR19","doi-asserted-by":"publisher","first-page":"112909","DOI":"10.1016\/J.BBR.2020.112909","volume":"396","author":"J Francis-Oliveira","year":"2021","unstructured":"Francis-Oliveira J, Shieh IC, Vilar Higa GS et al (2021) Maternal separation induces changes in TREK-1 and 5HT1A expression in brain areas involved in the stress response in a sex-dependent way. Behav Brain Res 396:112909. https:\/\/doi.org\/10.1016\/J.BBR.2020.112909","journal-title":"Behav Brain Res"},{"key":"6639_CR20","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/J.DCN.2014.07.001","volume":"11","author":"P Ganguly","year":"2015","unstructured":"Ganguly P, Brenhouse HC (2015) Broken or maladaptive? Altered trajectories in neuroinflammation and behavior after early life adversity. Dev Cogn Neurosci 11:18\u201330. https:\/\/doi.org\/10.1016\/J.DCN.2014.07.001","journal-title":"Dev Cogn Neurosci"},{"key":"6639_CR21","doi-asserted-by":"publisher","first-page":"1268464","DOI":"10.3389\/FPHAR.2024.1268464\/BIBTEX","volume":"15","author":"XY Gao","year":"2024","unstructured":"Gao XY, Li XY, Zhang CY, Bai CY (2024) Scopoletin: a review of its pharmacology, pharmacokinetics, and toxicity. Front Pharmacol 15:1268464. https:\/\/doi.org\/10.3389\/FPHAR.2024.1268464\/BIBTEX","journal-title":"Front Pharmacol"},{"key":"6639_CR22","doi-asserted-by":"publisher","first-page":"16593","DOI":"10.1039\/C9RA06056A","volume":"10","author":"NH Gay","year":"2020","unstructured":"Gay NH, Suwanjang W, Ruankham W et al (2020) Butein, isoliquiritigenin, and scopoletin attenuate neurodegeneration via antioxidant enzymes and SIRT1\/ADAM10 signaling pathway. RSC Adv 10:16593\u201316606. https:\/\/doi.org\/10.1039\/C9RA06056A","journal-title":"RSC Adv"},{"key":"6639_CR23","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/J.YHBEH.2018.03.005","volume":"100","author":"LD Godoy","year":"2018","unstructured":"Godoy LD, Umeoka EHL, Ribeiro DE et al (2018) Multimodal early-life stress induces biological changes associated to psychopathologies. Horm Behav 100:69\u201380. https:\/\/doi.org\/10.1016\/J.YHBEH.2018.03.005","journal-title":"Horm Behav"},{"key":"6639_CR24","doi-asserted-by":"publisher","first-page":"105940","DOI":"10.1016\/J.NBD.2022.105940","volume":"176","author":"A Gopinath","year":"2023","unstructured":"Gopinath A, Mackie PM, Phan LT et al (2023) The complex role of inflammation and gliotransmitters in Parkinson\u2019s disease. Neurobiol Dis 176:105940. https:\/\/doi.org\/10.1016\/J.NBD.2022.105940","journal-title":"Neurobiol Dis"},{"key":"6639_CR25","doi-asserted-by":"publisher","unstructured":"Grigoryan G, Segal M (2016) Lasting Differential effects on Plasticity Induced by prenatal stress in dorsal and ventral Hippocampus. https:\/\/doi.org\/10.1155\/2016\/2540462. Neural Plast 2016:","DOI":"10.1155\/2016\/2540462"},{"key":"6639_CR26","doi-asserted-by":"publisher","unstructured":"Grinchii D, Dremencov E (2020) Mechanism of Action of Atypical Antipsychotic Drugs in Mood Disorders. Int J Mol Sci 2020, Vol 21, Page 9532 21:9532. https:\/\/doi.org\/10.3390\/IJMS21249532","DOI":"10.3390\/IJMS21249532"},{"key":"6639_CR27","doi-asserted-by":"publisher","first-page":"e12765","DOI":"10.1111\/GBB.12765","volume":"20","author":"H Guo","year":"2021","unstructured":"Guo H, Deji C, Peng H et al (2021) The role of SIRT1 in the basolateral amygdala in depression-like behaviors in mice. Genes Brain Behav 20:e12765. https:\/\/doi.org\/10.1111\/GBB.12765","journal-title":"Genes Brain Behav"},{"key":"6639_CR28","doi-asserted-by":"publisher","first-page":"74","DOI":"10.9734\/jpri\/2021\/v33i331164","volume":"33","author":"M Gursahani","year":"2021","unstructured":"Gursahani M, Gawali N, Pai S et al (2021) Scopoletin ameliorates Lipopolysaccharide Induced Neuroinflammation, oxidative stress and cognitive dysfunction in mice: a mechanistic study. J Pharm Res Int 33:74\u201390. https:\/\/doi.org\/10.9734\/jpri\/2021\/v33i331164","journal-title":"J Pharm Res Int"},{"key":"6639_CR29","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/J.EXPNEUROL.2012.07.010","volume":"237","author":"N Haji","year":"2012","unstructured":"Haji N, Mandolesi G, Gentile A et al (2012) TNF-\u03b1-mediated anxiety in a mouse model of multiple sclerosis. Exp Neurol 237:296\u2013303. https:\/\/doi.org\/10.1016\/J.EXPNEUROL.2012.07.010","journal-title":"Exp Neurol"},{"key":"6639_CR30","doi-asserted-by":"publisher","first-page":"559962","DOI":"10.3389\/FNINS.2020.00923\/BIBTEX","volume":"14","author":"P Hepsomali","year":"2020","unstructured":"Hepsomali P, Groeger JA, Nishihira J, Scholey A (2020) Effects of oral Gamma-Aminobutyric Acid (GABA) administration on stress and sleep in humans: a systematic review. Front Neurosci 14:559962. https:\/\/doi.org\/10.3389\/FNINS.2020.00923\/BIBTEX","journal-title":"Front Neurosci"},{"key":"6639_CR31","doi-asserted-by":"publisher","first-page":"113389","DOI":"10.1016\/J.BBR.2021.113389","volume":"411","author":"H Huang","year":"2021","unstructured":"Huang H, Wang Q, Guan X et al (2021) Effects of enriched environment on depression and anxiety-like behavior induced by early life stress: a comparison between different periods. Behav Brain Res 411:113389. https:\/\/doi.org\/10.1016\/J.BBR.2021.113389","journal-title":"Behav Brain Res"},{"key":"6639_CR32","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/J.JAD.2015.09.006","volume":"190","author":"MR Infurna","year":"2016","unstructured":"Infurna MR, Reichl C, Parzer P et al (2016) Associations between depression and specific childhood experiences of abuse and neglect: a meta-analysis. J Affect Disord 190:47\u201355. https:\/\/doi.org\/10.1016\/J.JAD.2015.09.006","journal-title":"J Affect Disord"},{"key":"6639_CR33","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/J.INDCROP.2015.03.039","volume":"70","author":"S Jamuna","year":"2015","unstructured":"Jamuna S, Karthika K, Paulsamy S et al (2015) Confertin and scopoletin from leaf and root extracts of Hypochaeris radicata have anti-inflammatory and antioxidant activities. Ind Crops Prod 70:221\u2013230. https:\/\/doi.org\/10.1016\/J.INDCROP.2015.03.039","journal-title":"Ind Crops Prod"},{"key":"6639_CR34","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/J.EJPHAR.2018.07.032","volume":"834","author":"JH Jang","year":"2018","unstructured":"Jang JH, Park JE, Han JS (2018) Scopoletin inhibits \u03b1-glucosidase in vitro and alleviates postprandial hyperglycemia in mice with diabetes. Eur J Pharmacol 834:152\u2013156. https:\/\/doi.org\/10.1016\/J.EJPHAR.2018.07.032","journal-title":"Eur J Pharmacol"},{"issue":"12","key":"6639_CR35","doi-asserted-by":"publisher","first-page":"Page1921","DOI":"10.3390\/JPM12111921","volume":"2022","author":"Q Jarrar","year":"2022","unstructured":"Jarrar Q, Ayoub R, Alhussine K et al (2022) Prolonged maternal separation reduces anxiety state and increases compulsive burying activity in the offspring of BALB\/c mice. J Pers Med 2022(12):Page1921\u2013121921. https:\/\/doi.org\/10.3390\/JPM12111921","journal-title":"J Pers Med"},{"key":"6639_CR36","doi-asserted-by":"crossref","unstructured":"Kauppinen A, Suuronen T, Ojala J et al (2013) Antagonistic crosstalk between NF-\u03baB and SIRT1 in the regulation of inflammation and metabolic disorders. Cell. Signal","DOI":"10.1016\/j.cellsig.2013.06.007"},{"key":"6639_CR37","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1248\/BPB.B18-00355","volume":"42","author":"H Lagunas-Herrera","year":"2019","unstructured":"Lagunas-Herrera H, Tortoriello J, Herrera-Ruiz M et al (2019) Acute and chronic antihypertensive effect of fractions, Tiliroside and Scopoletin from Malva parviflora. Biol Pharm Bull 42:18\u201325. https:\/\/doi.org\/10.1248\/BPB.B18-00355","journal-title":"Biol Pharm Bull"},{"key":"6639_CR39","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.5352\/jls.2015.25.12.1377","volume":"25","author":"S-G Lee","year":"2015","unstructured":"Lee S-G, Kim M-M (2015) Anti-inflammatory effect of Scopoletin in RAW264.7 macrophages. J Life Sci 25:1377\u20131383. https:\/\/doi.org\/10.5352\/jls.2015.25.12.1377","journal-title":"J Life Sci"},{"key":"6639_CR38","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/J.TOXLET.2015.06.016","volume":"237","author":"HI Lee","year":"2015","unstructured":"Lee HI, Lee MK (2015) Coordinated regulation of scopoletin at adipose tissue\u2013liver axis improved alcohol-induced lipid dysmetabolism and inflammation in rats. Toxicol Lett 237:210\u2013218. https:\/\/doi.org\/10.1016\/J.TOXLET.2015.06.016","journal-title":"Toxicol Lett"},{"key":"6639_CR40","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/J.JAAC.2019.10.011","volume":"59","author":"J LeMoult","year":"2020","unstructured":"LeMoult J, Humphreys KL, Tracy A et al (2020) Meta-analysis: exposure to early life stress and risk for Depression in Childhood and Adolescence. J Am Acad Child Adolesc Psychiatry 59:842\u2013855. https:\/\/doi.org\/10.1016\/J.JAAC.2019.10.011","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"6639_CR41","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1017\/S0033291715002743","volume":"46","author":"M Li","year":"2016","unstructured":"Li M, D\u2019Arcy C, Meng X (2016a) Maltreatment in childhood substantially increases the risk of adult depression and anxiety in prospective cohort studies: systematic review, meta-analysis, and proportional attributable fractions. Psychol Med 46:717\u2013730. https:\/\/doi.org\/10.1017\/S0033291715002743","journal-title":"Psychol Med"},{"key":"6639_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/S11357-016-9920-3\/FIGURES\/10","volume":"38","author":"XY Li","year":"2016","unstructured":"Li XY, Wang F, Chen GH et al (2016b) Inflammatory insult during pregnancy accelerates age-related behavioral and neurobiochemical changes in CD-1 mice. Age (Omaha) 38:1\u201316. https:\/\/doi.org\/10.1007\/S11357-016-9920-3\/FIGURES\/10","journal-title":"Age (Omaha)"},{"key":"6639_CR43","doi-asserted-by":"publisher","first-page":"3838","DOI":"10.1021\/ACSCHEMNEURO.0C00628\/ASSET","volume":"11","author":"Y Li","year":"2020","unstructured":"Li Y, Jiao Q, Du X, Jiang H (2020) Sirt1\/FoxO1-Associated MAO-A Upregulation promotes depressive-like Behavior in Transgenic mice expressing human A53T \u03b1-Synuclein. ACS Chem Neurosci 11:3838\u20133848. https:\/\/doi.org\/10.1021\/ACSCHEMNEURO.0C00628\/ASSET\/IMAGES\/MEDIUM\/CN0C00628_0006.GIF.","journal-title":"ACS Chem Neurosci"},{"key":"6639_CR44","doi-asserted-by":"publisher","first-page":"481","DOI":"10.2174\/1570159x1304150831122734","volume":"13","author":"L Liu","year":"2015","unstructured":"Liu L, Liu C, Wang Y et al (2015) Herbal medicine for anxiety, Depression and Insomnia. Curr Neuropharmacol 13:481\u2013493. https:\/\/doi.org\/10.2174\/1570159x1304150831122734","journal-title":"Curr Neuropharmacol"},{"key":"6639_CR45","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/METH.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2009\u2013 \u2206\u2206CT method. Methods 25:402\u2013408. https:\/\/doi.org\/10.1006\/METH.2001.1262","journal-title":"Methods"},{"key":"6639_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S13041-020-0560-2\/FIGURES\/8","volume":"13","author":"L Luo","year":"2020","unstructured":"Luo L, Sun T, Yang L et al (2020) Scopoletin ameliorates anxiety-like behaviors in complete Freund\u2019s adjuvant-induced mouse model. Mol Brain 13:1\u201313. https:\/\/doi.org\/10.1186\/S13041-020-0560-2\/FIGURES\/8","journal-title":"Mol Brain"},{"key":"6639_CR47","doi-asserted-by":"publisher","first-page":"733","DOI":"10.3390\/IJMS17050733","volume":"17","author":"K Ma","year":"2016","unstructured":"Ma K, Zhang H, Baloch Z (2016) Pathogenetic and therapeutic applications of Tumor Necrosis Factor-\u03b1 (TNF-\u03b1) in major depressive disorder: a systematic review. Int J Mol Sci 2016 17:733. https:\/\/doi.org\/10.3390\/IJMS17050733","journal-title":"Int J Mol Sci 2016"},{"key":"6639_CR48","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/J.EURPSY.2015.04.007","volume":"30","author":"L Mandelli","year":"2015","unstructured":"Mandelli L, Petrelli C, Serretti A (2015) The role of specific early trauma in adult depression: a meta-analysis of published literature. Childhood trauma and adult depression. Eur Psychiatry 30:665\u2013680. https:\/\/doi.org\/10.1016\/J.EURPSY.2015.04.007","journal-title":"Eur Psychiatry"},{"key":"6639_CR49","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1177\/1947601912474893\/ASSET\/IMAGES\/LARGE\/10.1177_1947601912474893-FIG1.JPEG","volume":"4","author":"MW McBurney","year":"2013","unstructured":"McBurney MW, Clark-Knowles KV, Caron AZ, Gray DA (2013) SIRT1 is a highly networked protein that mediates the adaptation to chronic physiological stress. Genes Cancer 4:125\u2013134. https:\/\/doi.org\/10.1177\/1947601912474893\/ASSET\/IMAGES\/LARGE\/10.1177_1947601912474893-FIG1.JPEG","journal-title":"Genes Cancer"},{"key":"6639_CR50","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1016\/J.METABOL.2008.07.006","volume":"57","author":"BS McEwen","year":"2008","unstructured":"McEwen BS (2008) Understanding the potency of stressful early life experiences on brain and body function. Metabolism 57:S11\u2013S15. https:\/\/doi.org\/10.1016\/J.METABOL.2008.07.006","journal-title":"Metabolism"},{"key":"6639_CR51","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1523\/JNEUROSCI.2394-15.2016","volume":"36","author":"DB McKim","year":"2016","unstructured":"McKim DB, Niraula A, Tarr AJ et al (2016) Neuroinflammatory Dynamics Underlie Memory Impairments after repeated Social Defeat. J Neurosci 36:2590\u20132604. https:\/\/doi.org\/10.1523\/JNEUROSCI.2394-15.2016","journal-title":"J Neurosci"},{"key":"6639_CR52","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.3390\/NU14112268\/S1","volume":"14","author":"X Mi","year":"2022","unstructured":"Mi X, Zeng GR, Liu JQ et al (2022) Ganoderma Lucidum triterpenoids improve maternal separation-Induced anxiety-and depression-like behaviors in mice by mitigating inflammation in the periphery and brain. Nutrients 14:2268. https:\/\/doi.org\/10.3390\/NU14112268\/S1","journal-title":"Nutrients"},{"key":"6639_CR53","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/J.NEUBIOREV.2006.05.003","volume":"31","author":"RA Millstein","year":"2007","unstructured":"Millstein RA, Holmes A (2007) Effects of repeated maternal separation on anxiety- and depression-related phenotypes in different mouse strains. Neurosci Biobehav Rev 31:3\u201317. https:\/\/doi.org\/10.1016\/J.NEUBIOREV.2006.05.003","journal-title":"Neurosci Biobehav Rev"},{"key":"6639_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2008-2231-21-51\/FIGURES\/6","volume":"21","author":"HR Monsef-Esfahani","year":"2013","unstructured":"Monsef-Esfahani HR, Amini M, Goodarzi N et al (2013) Coumarin compounds of Biebersteinia multifida roots show potential anxiolytic effects in mice. DARU. J Pharm Sci 21:1\u20138. https:\/\/doi.org\/10.1186\/2008-2231-21-51\/FIGURES\/6","journal-title":"J Pharm Sci"},{"key":"6639_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12916-014-0259-2\/FIGURES\/3","volume":"13","author":"G Morris","year":"2015","unstructured":"Morris G, Berk M, Walder K, Maes M (2015) Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses. BMC Med 13:1\u201323. https:\/\/doi.org\/10.1186\/S12916-014-0259-2\/FIGURES\/3","journal-title":"BMC Med"},{"key":"6639_CR56","doi-asserted-by":"publisher","first-page":"87697","DOI":"10.3389\/FNINS.2014.00166\/BIBTEX","volume":"8","author":"M Nishi","year":"2014","unstructured":"Nishi M, Horii-Hayashi N, Sasagawa T (2014) Effects of early life adverse experiences on the brain: implications from maternal separation models in rodents. Front Neurosci 8:87697. https:\/\/doi.org\/10.3389\/FNINS.2014.00166\/BIBTEX","journal-title":"Front Neurosci"},{"key":"6639_CR57","doi-asserted-by":"publisher","first-page":"S81","DOI":"10.1016\/S0924-977X(99)00030-9","volume":"9","author":"DJ Nutt","year":"1999","unstructured":"Nutt DJ, Forshall S, Bell C et al (1999) Mechanisms of action of selective serotonin reuptake inhibitors in the treatment of psychiatric disorders. Eur Neuropsychopharmacol 9:S81\u2013S86. https:\/\/doi.org\/10.1016\/S0924-977X(99)00030-9","journal-title":"Eur Neuropsychopharmacol"},{"key":"6639_CR58","doi-asserted-by":"publisher","first-page":"67","DOI":"10.24875\/RMN.20000050","volume":"22","author":"LD Ochoa-de la Paz","year":"2021","unstructured":"Ochoa-de la Paz LD, Gulias-Ca\u00f1izo R, Ru\u00edz-Leyja ED et al (2021) The role of GABA neurotransmitter in the human central nervous system, physiology, and pathophysiology. Rev Mex Neurocienc 22:67\u201376. https:\/\/doi.org\/10.24875\/RMN.20000050","journal-title":"Rev Mex Neurocienc"},{"key":"6639_CR59","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1159\/000470809","volume":"31","author":"GN Pandey","year":"2017","unstructured":"Pandey GN (2017) Inflammatory and innate Immune markers of neuroprogression in depressed and teenage suicide brain. Mod Trends Pharmacopsychiatry 31:79\u201395. https:\/\/doi.org\/10.1159\/000470809","journal-title":"Mod Trends Pharmacopsychiatry"},{"key":"6639_CR60","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1080\/08923973.2016.1203929","volume":"38","author":"MV Pereira dos Santos Nascimento","year":"2016","unstructured":"Pereira dos Santos Nascimento MV, Arruda-Silva F, Gobbo Luz AB et al (2016) Inhibition of the NF-\u03baB and p38 MAPK pathways by scopoletin reduce the inflammation caused by carrageenan in the mouse model of pleurisy. Immunopharmacol Immunotoxicol 38:344\u2013352. https:\/\/doi.org\/10.1080\/08923973.2016.1203929","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"6639_CR61","doi-asserted-by":"publisher","first-page":"102504","DOI":"10.1016\/J.AUTREV.2020.102504","volume":"19","author":"MC Petralia","year":"2020","unstructured":"Petralia MC, Mazzon E, Fagone P et al (2020) The cytokine network in the pathogenesis of major depressive disorder. Close to translation? Autoimmun Rev 19:102504. https:\/\/doi.org\/10.1016\/J.AUTREV.2020.102504","journal-title":"Autoimmun Rev"},{"key":"6639_CR62","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/266730a0","volume":"2665604 266","author":"RD Porsolt","year":"1977","unstructured":"Porsolt RD, Le Pichon M, Jalfre M (1977) Depression: a new animal model sensitive to antidepressant treatments. Nat 1977 2665604 266:730\u2013732. https:\/\/doi.org\/10.1038\/266730a0","journal-title":"Nat 1977"},{"key":"6639_CR63","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1126\/SCIENCE.AAG2590","volume":"353","author":"RM Ransohoff","year":"2016","unstructured":"Ransohoff RM (2016) How neuroinflammation contributes to neurodegeneration. Sci (80-) 353:777\u2013783. https:\/\/doi.org\/10.1126\/SCIENCE.AAG2590","journal-title":"Sci (80-)"},{"key":"6639_CR64","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/J.BBI.2019.09.016","volume":"83","author":"M Roman","year":"2020","unstructured":"Roman M, Irwin MR (2020) Novel neuroimmunologic therapeutics in depression: a clinical perspective on what we know so far. Brain Behav Immun 83:7\u201321. https:\/\/doi.org\/10.1016\/J.BBI.2019.09.016","journal-title":"Brain Behav Immun"},{"key":"6639_CR65","first-page":"515","volume":"66","author":"HF Sakr","year":"2015","unstructured":"Sakr HF, Abbas AM, Elsamanoudy AZ, Ghoneim FM (2015) Effect of fluoxetine and resveratrol on testicular functions and oxidative stress in a rat model of chronic mild stress-induced depression. J Physiol Pharmacol 66:515\u2013527","journal-title":"J Physiol Pharmacol"},{"key":"6639_CR66","doi-asserted-by":"publisher","first-page":"496","DOI":"10.3390\/MOLECULES21040496","volume":"21","author":"EJ Seo","year":"2016","unstructured":"Seo EJ, MohamedSaeed, Law BYK et al (2016) Pharmacogenomics of Scopoletin in Tumor cells. Mol 2016 21:496. https:\/\/doi.org\/10.3390\/MOLECULES21040496","journal-title":"Mol 2016"},{"key":"6639_CR67","doi-asserted-by":"publisher","first-page":"201","DOI":"10.4103\/JPBS.JPBS_333_22","volume":"14","author":"S Sharma","year":"2022","unstructured":"Sharma S, Anand A, Bhatia A et al (2022) Pharmacological evaluation of Scopoletin in the Carbon Tetrachloride-Induced Hepatotoxicity Model in Wistar rats. J Pharm Bioallied Sci 14:201. https:\/\/doi.org\/10.4103\/JPBS.JPBS_333_22","journal-title":"J Pharm Bioallied Sci"},{"key":"6639_CR68","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1002\/PTR.1170","volume":"17","author":"CY Shaw","year":"2003","unstructured":"Shaw CY, Chen CH, Hsu CC et al (2003) Antioxidant properties of scopoletin isolated from Sinomonium Acutum. Phyther Res 17:823\u2013825. https:\/\/doi.org\/10.1002\/PTR.1170","journal-title":"Phyther Res"},{"key":"6639_CR69","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/BF00428203\/METRICS","volume":"85","author":"L Steru","year":"1985","unstructured":"Steru L, Chermat R, Thierry B, Simon P (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology 85:367\u2013370. https:\/\/doi.org\/10.1007\/BF00428203\/METRICS","journal-title":"Psychopharmacology"},{"key":"6639_CR70","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1074\/jbc.M305884200","volume":"279","author":"P Storici","year":"2004","unstructured":"Storici P, De Biase D, Bossa F et al (2004) Structures of \u03b3-Aminobutyric acid (GABA) aminotransferase, a pyridoxal 5\u2032-Phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with \u03b3-Ethynyl-GABA and with the Antiepilepsy Drug Vigabatrin. J Biol Chem 279:363\u2013373. https:\/\/doi.org\/10.1074\/jbc.M305884200","journal-title":"J Biol Chem"},{"key":"6639_CR71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41398-019-0605-4","volume":"91 9","author":"M Tang","year":"2019","unstructured":"Tang M, Huang H, Li S et al (2019) Hippocampal proteomic changes of susceptibility and resilience to depression or anxiety in a rat model of chronic mild stress. Transl Psychiatry 2019 91 9:1\u201312. https:\/\/doi.org\/10.1038\/s41398-019-0605-4","journal-title":"Transl Psychiatry 2019"},{"key":"6639_CR72","doi-asserted-by":"publisher","first-page":"5844","DOI":"10.1074\/jbc.M115.675264","volume":"291","author":"AM Toorie","year":"2016","unstructured":"Toorie AM, Cyr NE, Steger JS et al (2016) The nutrient and energy sensor Sirt1 regulates the hypothalamic-pituitary-adrenal (HPA) axis by altering the production of the Prohormone Convertase 2 (PC2) essential in the maturation of corticotropin-releasing hormone (CRH) from its prohormone in male rats. J Biol Chem 291:5844\u20135859. https:\/\/doi.org\/10.1074\/jbc.M115.675264","journal-title":"J Biol Chem"},{"key":"6639_CR73","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/J.NEUBIOREV.2016.06.021","volume":"68","author":"SG Tractenberg","year":"2016","unstructured":"Tractenberg SG, Levandowski ML, de Azeredo LA et al (2016) An overview of maternal separation effects on behavioural outcomes in mice: evidence from a four-stage methodological systematic review. Neurosci Biobehav Rev 68:489\u2013503. https:\/\/doi.org\/10.1016\/J.NEUBIOREV.2016.06.021","journal-title":"Neurosci Biobehav Rev"},{"key":"6639_CR74","doi-asserted-by":"publisher","first-page":"4550","DOI":"10.1111\/EJN.15358","volume":"54","author":"G Tsotsokou","year":"2021","unstructured":"Tsotsokou G, Nikolakopoulou M, Kouvelas ED, Mitsacos A (2021) Neonatal maternal separation affects metabotropic glutamate receptor 5 expression and anxiety-related behavior of adult rats. Eur J Neurosci 54:4550\u20134564. https:\/\/doi.org\/10.1111\/EJN.15358","journal-title":"Eur J Neurosci"},{"key":"6639_CR75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-022-12986-9","volume":"121 12","author":"H Ueno","year":"2022","unstructured":"Ueno H, Takahashi Y, Murakami S et al (2022) Effect of simultaneous testing of two mice in the tail suspension test and forced swim test. Sci Rep 2022 121 12:1\u201314. https:\/\/doi.org\/10.1038\/s41598-022-12986-9","journal-title":"Sci Rep 2022"},{"key":"6639_CR77","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/J.IJDEVNEU.2017.07.007","volume":"62","author":"Q Wang","year":"2017","unstructured":"Wang Q, Dong X, Wang Y et al (2017) Adolescent escitalopram prevents the effects of maternal separation on depression- and anxiety-like behaviours and regulates the levels of inflammatory cytokines in adult male mice. Int J Dev Neurosci 62:37\u201345. https:\/\/doi.org\/10.1016\/J.IJDEVNEU.2017.07.007","journal-title":"Int J Dev Neurosci"},{"key":"6639_CR76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41398-020-0856-0","volume":"101 10","author":"D Wang","year":"2020","unstructured":"Wang D, Levine JLS, Avila-Quintero V et al (2020a) Systematic review and meta-analysis: effects of maternal separation on anxiety-like behavior in rodents. Transl Psychiatry 2020 101 10:1\u201312. https:\/\/doi.org\/10.1038\/s41398-020-0856-0","journal-title":"Transl Psychiatry 2020"},{"key":"6639_CR78","doi-asserted-by":"publisher","first-page":"113254","DOI":"10.1016\/J.EXPNEUROL.2020.113254","volume":"328","author":"R Wang","year":"2020","unstructured":"Wang R, Wang W, Xu J et al (2020b) Jmjd3 is involved in the susceptibility to depression induced by maternal separation via enhancing the neuroinflammation in the prefrontal cortex and hippocampus of male rats. Exp Neurol 328:113254. https:\/\/doi.org\/10.1016\/J.EXPNEUROL.2020.113254","journal-title":"Exp Neurol"},{"key":"6639_CR79","doi-asserted-by":"publisher","first-page":"1066725","DOI":"10.3389\/fnbeh.2022.1066725","volume":"16","author":"RM Wei","year":"2022","unstructured":"Wei RM, Zhang YM, Li Y et al (2022) Altered cognition and anxiety in adolescent offspring whose mothers underwent different-pattern maternal sleep deprivation, and cognition link to hippocampal expressions of Bdnf and Syt-1. Front Behav Neurosci 16:1066725. https:\/\/doi.org\/10.3389\/FNBEH.2022.1066725\/BIBTEX","journal-title":"Front Behav Neurosci"},{"key":"6639_CR80","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/J.PHRS.2012.10.010","volume":"67","author":"J Xie","year":"2013","unstructured":"Xie J, Zhang X, Zhang L (2013) Negative regulation of inflammation by SIRT1. Pharmacol Res 67:60\u201367. https:\/\/doi.org\/10.1016\/J.PHRS.2012.10.010","journal-title":"Pharmacol Res"},{"key":"6639_CR81","doi-asserted-by":"publisher","first-page":"445064","DOI":"10.3389\/FPHAR.2019.00501\/BIBTEX","volume":"10","author":"J Yang","year":"2019","unstructured":"Yang J, Liu R, Lu F et al (2019) Fast green FCF attenuates lipopolysaccharide-induced depressive-like behavior and downregulates TLR4\/Myd88\/NF-\u03baB signal pathway in the mouse hippocampus. Front Pharmacol 10:445064. https:\/\/doi.org\/10.3389\/FPHAR.2019.00501\/BIBTEX","journal-title":"Front Pharmacol"},{"key":"6639_CR82","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1038\/SJ.EMBOJ.7600244\/ASSET\/D1ECDA08-8839-406E-8C1D-16A7AAF687EA\/ASSETS\/GRAPHIC\/EMBJ7600244-FIG-0008-M.JPG","volume":"23","author":"F Yeung","year":"2004","unstructured":"Yeung F, Hoberg JE, Ramsey CS et al (2004) Modulation of NF-\u03baB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 23:2369\u20132380. https:\/\/doi.org\/10.1038\/SJ.EMBOJ.7600244\/ASSET\/D1ECDA08-8839-406E-8C1D-16A7AAF687EA\/ASSETS\/GRAPHIC\/EMBJ7600244-FIG-0008-M.JPG","journal-title":"EMBO J"},{"key":"6639_CR83","doi-asserted-by":"publisher","unstructured":"Yu D, Homiack DR, Sawyer EJ, Schrader LA (2018) BK channel deacetylation by SIRT1 in dentate gyrus regulates anxiety and response to stress. Commun Biol 2018 11 1:1\u201314. https:\/\/doi.org\/10.1038\/s42003-018-0088-5","DOI":"10.1038\/s42003-018-0088-5"},{"key":"6639_CR84","doi-asserted-by":"publisher","first-page":"456839","DOI":"10.3389\/FPHAR.2019.00863\/BIBTEX","volume":"10","author":"F Zhang","year":"2019","unstructured":"Zhang F, Zhang Y, Yang T et al (2019) Scopoletin suppresses activation of dendritic cells and pathogenesis of experimental autoimmune encephalomyelitis by inhibiting NF-\u03baB signaling. Front Pharmacol 10:456839. https:\/\/doi.org\/10.3389\/FPHAR.2019.00863\/BIBTEX","journal-title":"Front Pharmacol"},{"key":"6639_CR85","doi-asserted-by":"publisher","unstructured":"Zhang Wyuan, Guo Y, jin, Wang K et al (2020a) yi, Neuroprotective effects of vitamin D and 17\u00df-estradiol against ovariectomy-induced neuroinflammation and depressive-like state: Role of the AMPK\/NF-\u03baB pathway. Int Immunopharmacol 86:106734. https:\/\/doi.org\/10.1016\/J.INTIMP.2020.106734","DOI":"10.1016\/J.INTIMP.2020.106734"},{"key":"6639_CR86","doi-asserted-by":"publisher","first-page":"543328","DOI":"10.3389\/FPSYT.2020.00709\/BIBTEX","volume":"11","author":"X Zhang","year":"2020","unstructured":"Zhang X, Li H, Sun H et al (2020b) Effects of BDNF signaling on anxiety-related behavior and spatial memory of adolescent rats in different length of maternal separation. Front Psychiatry 11:543328. https:\/\/doi.org\/10.3389\/FPSYT.2020.00709\/BIBTEX","journal-title":"Front Psychiatry"},{"key":"6639_CR87","doi-asserted-by":"publisher","unstructured":"Zhang Y, Anoopkumar-Dukie S, Davey AK (2021) SIRT1 and SIRT2 Modulators: Potential Anti-Inflammatory Treatment for Depression? Biomol 2021, Vol 11, Page 353 11:353. https:\/\/doi.org\/10.3390\/BIOM11030353","DOI":"10.3390\/BIOM11030353"},{"key":"6639_CR88","doi-asserted-by":"publisher","first-page":"943900","DOI":"10.3389\/FNBEH.2022.943900\/BIBTEX","volume":"16","author":"YM Zhang","year":"2022","unstructured":"Zhang YM, Cheng YZ, Wang YT et al (2022) Environmental Enrichment reverses maternal Sleep Deprivation-Induced anxiety-like Behavior and Cognitive Impairment in CD-1 mice. Front Behav Neurosci 16:943900. https:\/\/doi.org\/10.3389\/FNBEH.2022.943900\/BIBTEX","journal-title":"Front Behav Neurosci"},{"key":"6639_CR89","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/J.BBI.2020.11.007","volume":"91","author":"ZH Zheng","year":"2021","unstructured":"Zheng ZH, Tu JL, Li XH et al (2021) Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala. Brain Behav Immun 91:505\u2013518. https:\/\/doi.org\/10.1016\/J.BBI.2020.11.007","journal-title":"Brain Behav Immun"},{"key":"6639_CR91","doi-asserted-by":"publisher","first-page":"172953","DOI":"10.1016\/J.PBB.2020.172953","volume":"196","author":"L Zhou","year":"2020","unstructured":"Zhou L, Wu Z, Wang G et al (2020) Long-term maternal separation potentiates depressive-like behaviours and neuroinflammation in adult male C57\/BL6J mice. Pharmacol Biochem Behav 196:172953. https:\/\/doi.org\/10.1016\/J.PBB.2020.172953","journal-title":"Pharmacol Biochem Behav"},{"key":"6639_CR90","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.3390\/BRAINSCI12091250","volume":"12","author":"L Zhou","year":"2022","unstructured":"Zhou L, Wu Z, Li Y et al (2022) Brief maternal separation promotes resilience to anxiety-like and depressive-like behaviors in female C57BL\/6J offspring with Imiquimod-Induced Psoriasis. Brain Sci 2022 12:1250. https:\/\/doi.org\/10.3390\/BRAINSCI12091250","journal-title":"Brain Sci 2022"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-024-06639-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-024-06639-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-024-06639-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T08:43:16Z","timestamp":1730104996000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-024-06639-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,18]]},"references-count":91,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["6639"],"URL":"https:\/\/doi.org\/10.1007\/s00213-024-06639-0","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,18]]},"assertion":[{"value":"5 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal experimental procedures were approved by the animal ethics committee at the Hashemite University (IRB number: 14\/4\/2021\/2022, 14 April 2022), and were in accordance with the guidelines of the US National Institutes of Health on the use and care of laboratory animals, and with the Animal Research: Reporting of in Vivo Experiments (ARRIVE) guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}