{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:33:32Z","timestamp":1791898412896,"version":"4.3.4"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T00:00:00Z","timestamp":1723852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T00:00:00Z","timestamp":1723852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Swinburne University of Technology"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Rationale<\/jats:title>\n            <jats:p>Cannabidiol (CBD) is increasingly used as a sleep aid for insomnia; yet neurocognitive and subjective state effects following daily therapeutic use are unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objectives<\/jats:title>\n            <jats:p>To measure the effect of daily CBD use on neurocognitive performance and daily subjective mood in a population with primary insomnia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This study used a randomized, placebo-controlled, parallel design incorporating a single-blind placebo run-in week followed by a two-week double-blind dosing period, during which participants consumed 150\u00a0mg CBD (<jats:italic>N<\/jats:italic>\u2009=\u200915) or placebo (<jats:italic>N<\/jats:italic>\u2009=\u200915) sublingually 60-minutes daily before bed. Attention, executive function, reasoning, information processing, working and episodic memory were assessed using the CogPro system at the beginning of the placebo run-in, after 1-week and 2-weeks of dosing. Subjective states using visual analogue scales and side effects were recorded daily.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Cognitive performance was unaffected by nightly CBD supplementation (all <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). From baseline to trial conclusion, those receiving CBD reported greater experience of calmness, clear-headedness, coordination and were more likely to report side-effects of dry mouth relative to placebo (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Relative to placebo, daytime cognitive functioning following nightly supplementation as a therapeutic aid for primary insomnia was preserved under trial conditions. Results suggested an overall favourable safety profile, with larger controlled trials and thorough analyses of varying insomnia phenotypes necessary to corroborate these findings.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00213-024-06674-x","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T06:32:16Z","timestamp":1723876336000},"page":"297-308","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The effect of nightly use of 150\u00a0mg cannabidiol on daytime neurocognitive performance in primary insomnia: a randomized controlled pilot trial"],"prefix":"10.1007","volume":"242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8789-1701","authenticated-orcid":false,"given":"Andrea J.","family":"Narayan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4470-4718","authenticated-orcid":false,"given":"Amie C.","family":"Hayley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Di Natale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5670-3192","authenticated-orcid":false,"given":"Luke A.","family":"Downey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,17]]},"reference":[{"issue":"7","key":"6674_CR1","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1007\/s11606-020-06504-8","volume":"36","author":"P Balachandran","year":"2021","unstructured":"Balachandran P, Elsohly M, Hill KP (2021) Cannabidiol Interactions with medications, Illicit substances, and Alcohol: a Comprehensive Review. J Gen Intern Med 36(7):2074\u20132084","journal-title":"J Gen Intern Med"},{"key":"6674_CR2","doi-asserted-by":"crossref","unstructured":"Ballesio A, Aquino MRJV, Kyle SD et al (2019) Executive functions in Insomnia Disorder: a systematic review and exploratory Meta-analysis. Front Psychol 10","DOI":"10.3389\/fpsyg.2019.00101"},{"key":"6674_CR3","doi-asserted-by":"crossref","unstructured":"Batalla A, Bos J, Postma A et al (2021) The impact of Cannabidiol on human brain function: a systematic review. Front Pharmacol 11","DOI":"10.3389\/fphar.2020.618184"},{"issue":"1","key":"6674_CR4","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/0272-7358(88)90050-5","volume":"8","author":"AT Beck","year":"1988","unstructured":"Beck AT, Steer RA, Carbin MG (1988) Psychometric properties of the Beck Depression Inventory: twenty-five years of evaluation. Clin Psychol Rev 8(1):77\u2013100","journal-title":"Clin Psychol Rev"},{"issue":"7","key":"6674_CR5","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1007\/s00213-018-4885-9","volume":"235","author":"DL Boggs","year":"2018","unstructured":"Boggs DL, Surti T, Gupta A et al (2018) The effects of cannabidiol (CBD) on cognition and symptoms in outpatients with chronic schizophrenia a randomized placebo controlled trial. Psychopharmacology 235(7):1923\u20131932","journal-title":"Psychopharmacology"},{"issue":"3","key":"6674_CR6","first-page":"180","volume":"42","author":"MB Bridgeman","year":"2017","unstructured":"Bridgeman MB, Abazia DT (2017) Medicinal Cannabis: history, Pharmacology, and implications for the Acute Care setting. P t 42(3):180\u2013188","journal-title":"P t"},{"issue":"1","key":"6674_CR7","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s00213-020-05712-8","volume":"238","author":"SC Britch","year":"2021","unstructured":"Britch SC, Babalonis S, Walsh SL (2021) Cannabidiol: pharmacology and therapeutic targets. Psychopharmacology 238(1):9\u201328","journal-title":"Psychopharmacology"},{"issue":"1","key":"6674_CR8","doi-asserted-by":"publisher","first-page":"251524592096035","DOI":"10.1177\/2515245920960351","volume":"4","author":"VA Brown","year":"2021","unstructured":"Brown VA (2021) An introduction to Linear mixed-effects modeling in R. Adv Methods Practices Psychol Sci 4(1):2515245920960351","journal-title":"Adv Methods Practices Psychol Sci"},{"issue":"1","key":"6674_CR9","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jsmc.2019.10.002","volume":"15","author":"JA Brownlow","year":"2020","unstructured":"Brownlow JA, Miller KE, Gehrman PR (2020) Insomnia and cognitive performance. Sleep Med Clin 15(1):71\u201376","journal-title":"Sleep Med Clin"},{"issue":"5","key":"6674_CR10","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1093\/bja\/aes022","volume":"108","author":"F Chung","year":"2012","unstructured":"Chung F, Subramanyam R, Liao P et al (2012) High STOP-Bang score indicates a high probability of obstructive sleep apnoea. Br J Anaesth 108(5):768\u2013775","journal-title":"Br J Anaesth"},{"issue":"1","key":"6674_CR11","doi-asserted-by":"publisher","first-page":"2045051","DOI":"10.1080\/23311908.2022.2045051","volume":"9","author":"M Cla\u00dfen","year":"2022","unstructured":"Cla\u00dfen M, Friedrich A, Schlarb AA (2022) Sleep better \u2013 think better! \u2013 the effect of CBT-I and HT-I on sleep and subjective and objective neurocognitive performance in university students with insomnia. Cogent Psychol 9(1):2045051","journal-title":"Cogent Psychol"},{"issue":"1","key":"6674_CR12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1177\/0269881110379283","volume":"25","author":"JAS Crippa","year":"2011","unstructured":"Crippa JAS, Derenusson GN, Ferrari TB et al (2011) Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. J Psychopharmacol 25(1):121\u2013130","journal-title":"J Psychopharmacol"},{"issue":"6","key":"6674_CR13","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1002\/cpt.1632","volume":"106","author":"TP Dumitrescu","year":"2019","unstructured":"Dumitrescu TP, McCune J, Schmith V (2019) Is placebo response responsible for many phase III failures? Clin Pharmacol Ther 106(6):1151\u20131154","journal-title":"Clin Pharmacol Ther"},{"key":"6674_CR14","doi-asserted-by":"crossref","unstructured":"Fitzgerald T, Vietri J (2015) Residual Effects of Sleep Medications Are Commonly Reported and Associated with Impaired Patient-Reported Outcomes among Insomnia Patients in the United States. Sleep Disord 2015: 607148","DOI":"10.1155\/2015\/607148"},{"issue":"1","key":"6674_CR15","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.smrv.2011.03.008","volume":"16","author":"\u00c9 Fortier-Brochu","year":"2012","unstructured":"Fortier-Brochu \u00c9, Beaulieu-Bonneau S, Ivers H et al (2012) Insomnia and daytime cognitive performance: a meta-analysis. Sleep Med Rev 16(1):83\u201394","journal-title":"Sleep Med Rev"},{"issue":"Supplement1","key":"6674_CR16","doi-asserted-by":"publisher","first-page":"A62","DOI":"10.1093\/sleep\/zsaa056.155","volume":"43","author":"AM Gencarelli","year":"2020","unstructured":"Gencarelli AM, Zurlinden T, Nicoletta A et al (2020) 0157 the relationship between reaction time, Insomnia Severity, Sleepiness, and dysfunctional beliefs about Sleep. Sleep 43(Supplement1):A62\u2013A62","journal-title":"Sleep"},{"issue":"1","key":"6674_CR17","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1590\/S1516-44462010000100011","volume":"32","author":"JE Hallak","year":"2010","unstructured":"Hallak JE, Machado-de-Sousa JP, Crippa JA et al (2010) Performance of schizophrenic patients in the Stroop Color Word Test and electrodermal responsiveness after acute administration of cannabidiol (CBD). Braz J Psychiatry 32(1):56\u201361","journal-title":"Braz J Psychiatry"},{"issue":"3","key":"6674_CR18","doi-asserted-by":"publisher","first-page":"e026478","DOI":"10.1136\/bmjopen-2018-026478","volume":"9","author":"BK Helle","year":"2019","unstructured":"Helle BK, Ole Jakob S, Erlend F et al (2019) Methodological advantages and disadvantages of parallel and crossover randomised clinical trials on methylphenidate for attention deficit hyperactivity disorder: a systematic review and meta-analyses. BMJ Open 9(3):e026478","journal-title":"BMJ Open"},{"issue":"10","key":"6674_CR19","doi-asserted-by":"publisher","first-page":"974","DOI":"10.2174\/1570159X17666190603171901","volume":"17","author":"MA Huestis","year":"2019","unstructured":"Huestis MA, Solimini R, Pichini S et al (2019) Cannabidiol adverse effects and Toxicity. Curr Neuropharmacol 17(10):974\u2013989","journal-title":"Curr Neuropharmacol"},{"issue":"11","key":"6674_CR20","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.3390\/ph14111165","volume":"14","author":"\u00c9 Jones","year":"2021","unstructured":"Jones \u00c9, Vlachou S (2021) Cannabidiol does not cause significant changes to Working Memory performance in the N-Back Task. Pharmaceuticals 14(11):1165","journal-title":"Pharmaceuticals"},{"key":"6674_CR21","doi-asserted-by":"crossref","unstructured":"K\u00e4rpp\u00e4 M, Yardley J, Pinner K et al (2020) Long-term efficacy and tolerability of lemborexant compared with placebo in adults with insomnia disorder: results from the phase 3 randomized clinical trial SUNRISE 2. Sleep 43(9)","DOI":"10.1093\/sleep\/zsaa123"},{"issue":"1","key":"6674_CR22","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1159\/000507998","volume":"3","author":"PT Kocis","year":"2020","unstructured":"Kocis PT, Vrana KE (2020) Delta-9-Tetrahydrocannabinol and Cannabidiol Drug-Drug interactions. Med Cannabis Cannabinoids 3(1):61\u201373","journal-title":"Med Cannabis Cannabinoids"},{"key":"6674_CR23","doi-asserted-by":"crossref","unstructured":"Linares IM, Zuardi AW, Pereira LC et al (2019) Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test. Brazilian J Psychiatry 41","DOI":"10.1590\/1516-4446-2017-0015"},{"issue":"null","key":"6674_CR24","doi-asserted-by":"publisher","first-page":"957","DOI":"10.2147\/NSS.S340949","volume":"14","author":"KJ Maddison","year":"2022","unstructured":"Maddison KJ, Kosky C, Walsh JH (2022) Is there a place for Medicinal Cannabis in treating patients with Sleep disorders? What we know so far. Nat Sci Sleep 14(null):957\u2013968","journal-title":"Nat Sci Sleep"},{"key":"6674_CR25","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.yebeh.2019.04.044","volume":"97","author":"RC Martin","year":"2019","unstructured":"Martin RC, Gaston TE, Thompson M et al (2019) Cognitive functioning following long-term cannabidiol use in adults with treatment-resistant epilepsy. Epilepsy Behav 97:105\u2013110","journal-title":"Epilepsy Behav"},{"issue":"12","key":"6674_CR26","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1177\/02698811221095356","volume":"36","author":"D McCartney","year":"2022","unstructured":"McCartney D, Suraev AS, Doohan PT et al (2022) Effects of cannabidiol on simulated driving and cognitive performance: a dose-ranging randomised controlled trial. J Psychopharmacol 36(12):1338\u20131349","journal-title":"J Psychopharmacol"},{"key":"6674_CR27","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.3389\/fphar.2018.01365","volume":"9","author":"SA Millar","year":"2018","unstructured":"Millar SA, Stone NL, Yates AS et al (2018) A systematic review on the pharmacokinetics of Cannabidiol in humans. Front Pharmacol 9:1365","journal-title":"Front Pharmacol"},{"issue":"2","key":"6674_CR28","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jsmc.2022.03.003","volume":"17","author":"CM Morin","year":"2022","unstructured":"Morin CM, Jarrin DC (2022) Epidemiology of Insomnia: prevalence, course, risk factors, and Public Health Burden. Sleep Med Clin 17(2):173\u2013191","journal-title":"Sleep Med Clin"},{"key":"6674_CR29","doi-asserted-by":"publisher","first-page":"104941","DOI":"10.1016\/j.neubiorev.2022.104941","volume":"143","author":"AJ Narayan","year":"2022","unstructured":"Narayan AJ, Downey LA, Manning B et al (2022) Cannabinoid treatments for anxiety: a systematic review and consideration of the impact of sleep disturbance. Neurosci Biobehavioral Reviews 143:104941","journal-title":"Neurosci Biobehavioral Reviews"},{"key":"6674_CR30","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.10998","author":"AJ Narayan","year":"2024","unstructured":"Narayan AJ, Downey LA, Rose S et al (2024) Cannabidiol for moderate-severe insomnia: a randomized controlled pilot trial of 150\u00a0mg of nightly dosing. J Clin Sleep Med. Epub ahead of print 2024\/01\/04 https:\/\/doi.org\/10.5664\/jcsm.10998","journal-title":"J Clin Sleep Med"},{"issue":"3","key":"6674_CR31","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/01.jcp.0000125688.05091.8f","volume":"24","author":"AN Nicholson","year":"2004","unstructured":"Nicholson AN, Turner C, Stone BM et al (2004) Effect of \u2206-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. J Clin Psychopharmacol 24(3):305\u2013313","journal-title":"J Clin Psychopharmacol"},{"issue":"4","key":"6674_CR32","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1017\/S0033291719003519","volume":"51","author":"A O\u2019Neill","year":"2021","unstructured":"O\u2019Neill A, Wilson R, Blest-Hopley G et al (2021) Normalization of mediotemporal and prefrontal activity, and mediotemporal-striatal connectivity, may underlie antipsychotic effects of cannabidiol in psychosis. Psychol Med 51(4):596\u2013606","journal-title":"Psychol Med"},{"issue":"3","key":"6674_CR33","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S0022-3956(97)00002-2","volume":"31","author":"MM Ohayon","year":"1997","unstructured":"Ohayon MM (1997) Prevalence of DSM-IV diagnostic criteria of insomnia: distinguishing insomnia related to mental disorders from sleep disorders. J Psychiatr Res 31(3):333\u2013346","journal-title":"J Psychiatr Res"},{"issue":"5","key":"6674_CR34","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.smrv.2005.05.001","volume":"9","author":"ML Perlis","year":"2005","unstructured":"Perlis ML, McCall WV, Jungquist CR et al (2005) Placebo effects in primary insomnia. Sleep Med Rev 9(5):381\u2013389","journal-title":"Sleep Med Rev"},{"issue":"2","key":"6674_CR35","first-page":"213","volume":"8","author":"RM Ranum","year":"2022","unstructured":"Ranum RM, Whipple MO, Croghan I et al (2022) Use of Cannabidiol in the management of Insomnia: a systematic review. Cannabis Cannabinoid Res 8(2):213\u2013229","journal-title":"Cannabis Cannabinoid Res"},{"issue":"9","key":"6674_CR36","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1111\/2041-210X.13434","volume":"11","author":"H Schielzeth","year":"2020","unstructured":"Schielzeth H, Dingemanse NJ, Nakagawa S et al (2020) Robustness of linear mixed-effects models to violations of distributional assumptions. Methods Ecol Evol 11(9):1141\u20131152","journal-title":"Methods Ecol Evol"},{"issue":"1","key":"6674_CR37","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1089\/can.2017.0043","volume":"3","author":"N Solowij","year":"2018","unstructured":"Solowij N, Broyd SJ, Beale C et al (2018) Therapeutic effects of prolonged Cannabidiol Treatment on psychological symptoms and cognitive function in regular Cannabis users: a pragmatic open-label clinical trial. Cannabis Cannabinoid Res 3(1):21\u201334","journal-title":"Cannabis Cannabinoid Res"},{"issue":"3","key":"6674_CR38","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1053\/smrv.2001.0246","volume":"7","author":"EJ Stepanski","year":"2003","unstructured":"Stepanski EJ, Wyatt JK (2003) Use of sleep hygiene in the treatment of insomnia. Sleep Med Rev 7(3):215\u2013225","journal-title":"Sleep Med Rev"},{"issue":"Suppl 2","key":"6674_CR39","first-page":"9","volume":"66","author":"SA Stewart","year":"2005","unstructured":"Stewart SA (2005) The effects of benzodiazepines on cognition. J Clin Psychiatry 66(Suppl 2):9\u201313","journal-title":"J Clin Psychiatry"},{"key":"6674_CR40","doi-asserted-by":"publisher","first-page":"101339","DOI":"10.1016\/j.smrv.2020.101339","volume":"53","author":"AS Suraev","year":"2020","unstructured":"Suraev AS, Marshall NS, Vandrey R et al (2020) Cannabinoid therapies in the management of sleep disorders: a systematic review of preclinical and clinical studies. Sleep Med Rev 53:101339","journal-title":"Sleep Med Rev"},{"key":"6674_CR41","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.enbuild.2019.05.044","volume":"197","author":"M Tao","year":"2019","unstructured":"Tao M, Yang D, Liu W (2019) Learning effect and its prediction for cognitive tests used in studies on indoor environmental quality. Energy Build 197:87\u201398","journal-title":"Energy Build"},{"issue":"1","key":"6674_CR42","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/npp.1994.63","volume":"11","author":"MH Trivedi","year":"1994","unstructured":"Trivedi MH, Rush H (1994) Does a placebo run-in or a placebo treatment cell affect the efficacy of antidepressant medications? Neuropsychopharmacology 11(1):33\u201343","journal-title":"Neuropsychopharmacology"},{"key":"6674_CR43","doi-asserted-by":"publisher","first-page":"101205","DOI":"10.1016\/j.smrv.2019.07.008","volume":"48","author":"S Wardle-Pinkston","year":"2019","unstructured":"Wardle-Pinkston S, Slavish DC, Taylor DJ (2019) Insomnia and cognitive performance: a systematic review and meta-analysis. Sleep Med Rev 48:101205","journal-title":"Sleep Med Rev"},{"issue":"12","key":"6674_CR44","doi-asserted-by":"publisher","first-page":"e83","DOI":"10.1002\/gps.4659","volume":"32","author":"KA Wesnes","year":"2017","unstructured":"Wesnes KA, Brooker H, Ballard C et al (2017) Utility, reliability, sensitivity and validity of an online test system designed to monitor changes in cognitive function in clinical trials. Int J Geriatr Psychiatry 32(12):e83\u2013e92","journal-title":"Int J Geriatr Psychiatry"},{"key":"6674_CR45","doi-asserted-by":"crossref","unstructured":"Woelfl T, Rohleder C, Mueller JK et al (2020) Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on emotion, cognition, and attention: a Double-Blind, Placebo-Controlled, randomized experimental trial in healthy volunteers. Front Psychiatry 11","DOI":"10.3389\/fpsyt.2020.576877"},{"key":"6674_CR46","doi-asserted-by":"publisher","first-page":"8961748","DOI":"10.1155\/2019\/8961748","volume":"2019","author":"H Xu","year":"2019","unstructured":"Xu H, Shi Y, Xiao Y et al (2019) Efficacy comparison of different acupuncture treatments for primary insomnia: a bayesian analysis. Evidence-Based Complement Altern Med 2019:8961748","journal-title":"Evidence-Based Complement Altern Med"},{"key":"6674_CR47","doi-asserted-by":"crossref","unstructured":"Zuardi AW, Rodrigues NP, Silva AL et al (2017) Inverted U-Shaped dose-response curve of the Anxiolytic Effect of Cannabidiol during Public speaking in Real Life. Front Pharmacol 8","DOI":"10.3389\/fphar.2017.00259"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-024-06674-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-024-06674-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-024-06674-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T08:47:49Z","timestamp":1738054069000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-024-06674-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,17]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["6674"],"URL":"https:\/\/doi.org\/10.1007\/s00213-024-06674-x","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,17]]},"assertion":[{"value":"14 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"AH is supported by a Rebecca L Cooper Al and Val Rosenstrauss Fellowship (GNT: F2021894) and was previously supported by an NHMRC Early Career Fellowship (GNT:1119960) during this study. Other authors have no conflicts of interests to declare. The authors acknowledge study funding and the supply of investigational products by Brains Bioceuticals, UK, who had no role in the design of this study and did not have any role during its execution, analyses, interpretation of the data, or decision to submit results. No actual or perceived conflicts of interest are reported.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}