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However, the molecular mechanisms that govern this coping strategy have yet to be fully discovered.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objectives<\/jats:title>\n            <jats:p>This study aims to investigate the effects of poly ADP-ribosylation (PARylation) on stress-coping strategies following\u00a0acute stress and to identify the target genes influenced by Parp1-induced histone PARylation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Mice were subjected to a forced swim test, a well-established acute stress paradigm, to evaluate cortical PARylation\u00a0and assess the expression of activity-dependent genes. The pharmacological inhibition of Parp1 was conducted using\u00a0ABT888 (Veliparib) to determine its effects on stress-coping behavior and related molecular changes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The forced swim test increased cortical PARylation and upregulated the expression of activity-dependent genes.\u00a0Systemic inhibition of Parp1 with ABT888 led to impaired stress-coping behavior, evidenced by a reduced immobility\u00a0response during a subsequent forced swim test done 24 hours later. This impairment was associated with decreased\u00a0chromatin PARylation and histone H4 acetylation at the Arc promoter and reduced Arc expression observed one hour\u00a0after Parp1 inhibition.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Our findings indicate that chromatin PARylation at the Arc promoters regulates histone H4 acetylation and Arc gene\u00a0expression, and a subsequent impact on successful stress-coping behavior in response to acute stress.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00213-025-06744-8","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T06:28:59Z","timestamp":1736836139000},"page":"741-750","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Poly ADP\u2010ribosylation regulates Arc expression and promotes adaptive stress-coping"],"prefix":"10.1007","volume":"242","author":[{"given":"Eliyahu","family":"Dahan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Pergamenshik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze\u2019ela","family":"Taub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Vovk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Manier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Avneri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0310-0520","authenticated-orcid":false,"given":"Elad","family":"Lax","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"issue":"3","key":"6744_CR1","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.nlm.2007.08.007","volume":"89","author":"CM Alberini","year":"2008","unstructured":"Alberini CM (2008) The role of protein synthesis during the labile phases of memory: Revisiting the skepticism. 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