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In each condition, participants were exposed to cues before an fMRI scan during which they repeatedly chose between 0-6 cannabis puffs\/snacks and a set monetary amount, with randomly-selected choices implemented. The SV signal was operationalized as the neural correlates of the strength of preference for cannabis\/snack choices. fMRI data were analyzed for twenty participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Despite equivalent choice behavior, SV signals for cannabis, but not snacks, were observed in regions known to encode SV for various rewards (ventromedial prefrontal cortex, vmPFC; ventral striatum; dorsal posterior cingulate cortex, dPCC). SV encoding in vmPFC was stronger for cannabis than snacks. In the dPCC, the impact of cues on SV signals was moderated by reward type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PWUCF had expected neural value encoding for cannabis but disrupted non-drug SV encoding, despite equivalent choice behavior. This provides tentative support for theories that highlight dysregulated neural valuation of non-drug rewards as a hallmark of problematic cannabis use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00213-025-06746-6","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T04:29:49Z","timestamp":1739161789000},"page":"681-691","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Value signals guiding choices for cannabis versus non-drug rewards in people who use cannabis near-daily"],"prefix":"10.1007","volume":"242","author":[{"given":"Will","family":"Lawn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna B.","family":"Konova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Haney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziva D.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Van Dam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Glimcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6718-0099","authenticated-orcid":false,"given":"Gillinder","family":"Bedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"6746_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.neubiorev.2018.08.015","volume":"110","author":"SH Ahmed","year":"2020","unstructured":"Ahmed SH, Badiani A, Miczek KA, M\u00fcller CP (2020) Non-pharmacological factors that determine drug use and addiction. 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Outside of this work, ZDC reports receiving study drug from Canopy Growth Corp. WL provides ad-hoc consultancy for the CRO AxialBridge. GB has acted as an unpaid consultant to atai Life Sciences and Kinoxis Therapeutics. XH, ABK, NVD, and PG, reported no biomedical financial interests or potential conflicts of interest. The research described in this manuscript complies with the laws of the country in which it was performed (USA).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}