{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:18:09Z","timestamp":1789179489543,"version":"build-2803163510"},"reference-count":175,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the Natural Science Foundation of China","doi-asserted-by":"crossref","award":["U23A20421"],"award-info":[{"award-number":["U23A20421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82201338"],"award-info":[{"award-number":["82201338"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s00213-025-06840-9","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:37:55Z","timestamp":1750293475000},"page":"2353-2371","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Central neuropeptides as key modulators of astrocyte function in neurodegenerative and neuropsychiatric disorders"],"prefix":"10.1007","volume":"242","author":[{"given":"Meng-jie","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-ning","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"6840_CR1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.sjbs.2020.01.026","volume":"27","author":"OA Abiodun","year":"2020","unstructured":"Abiodun OA, Ola MS (2020) Role of brain Renin angiotensin system in neurodegeneration: an update. Saudi J Biol Sci 27:905\u2013912","journal-title":"Saudi J Biol Sci"},{"key":"6840_CR2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.npep.2016.08.003","volume":"60","author":"M Agersnap","year":"2016","unstructured":"Agersnap M, Zhang MD, Harkany T, H\u00f6kfelt T, Rehfeld JF (2016) Nonsulfated cholecystokinins in cerebral neurons. Neuropeptides 60:37\u201344","journal-title":"Neuropeptides"},{"key":"6840_CR3","doi-asserted-by":"crossref","first-page":"172","DOI":"10.2478\/enr-2020-0020","volume":"54","author":"MM Alanazi","year":"2020","unstructured":"Alanazi MM, Havranek T, Bakos J, Cubeddu LX, Castejon AM (2020) Cell proliferation and anti-oxidant effects of Oxytocin and Oxytocin receptors: role of extracellular signal-regulating kinase in astrocyte-like cells. Endocr Regul 54:172\u2013182","journal-title":"Endocr Regul"},{"key":"6840_CR4","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/biof.2081","volume":"50","author":"M Asim","year":"2024","unstructured":"Asim M, Wang H, Waris A, Qianqian G, Chen X (2024) Cholecystokinin neurotransmission in the central nervous system: insights into its role in health and disease. BioFactors 50:1060\u20131075","journal-title":"BioFactors"},{"key":"6840_CR5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.neuron.2020.07.039","volume":"108","author":"B Asrican","year":"2020","unstructured":"Asrican B, Wooten J, Li Y-D, Quintanilla L, Zhang F, Wander C, Bao H, Yeh C-Y, Luo Y-J, Olsen R, Lim S-A, Hu J, Jin P, Song J (2020) Neuropeptides modulate local astrocytes to regulate adult hippocampal neural stem cells. Neuron 108:349\u2013366e6","journal-title":"Neuron"},{"key":"6840_CR6","doi-asserted-by":"crossref","first-page":"3276383","DOI":"10.1155\/2016\/3276383","volume":"2016","author":"J Bakos","year":"2016","unstructured":"Bakos J, Zatkova M, Bacova Z, Ostatnikova D (2016) The role of hypothalamic neuropeptides in neurogenesis and neuritogenesis. Neural Plast 2016:3276383","journal-title":"Neural Plast"},{"key":"6840_CR7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/nure.12045","volume":"71","author":"B Beck","year":"2013","unstructured":"Beck B, Pouri\u00e9 G (2013) Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory. Nutr Rev 71:541\u2013561","journal-title":"Nutr Rev"},{"key":"6840_CR8","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12974-019-1447-y","volume":"16","author":"L Becquet","year":"2019","unstructured":"Becquet L, Abad C, Leclercq M, Miel C, Jean L, Riou G, Couvineau A, Boyer O, Tan Y-V (2019) Systemic administration of orexin A ameliorates established experimental autoimmune encephalomyelitis by diminishing neuroinflammation. J Neuroinflamm 16:64","journal-title":"J Neuroinflamm"},{"key":"6840_CR9","doi-asserted-by":"crossref","first-page":"172929","DOI":"10.1016\/j.pbb.2020.172929","volume":"194","author":"DF Berhe","year":"2020","unstructured":"Berhe DF, Gebre AK, Assefa BT (2020) Orexins role in neurodegenerative diseases: from pathogenesis to treatment. Pharmacol Biochem Behav 194:172929","journal-title":"Pharmacol Biochem Behav"},{"key":"6840_CR10","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1056\/NEJMoa2210639","volume":"387","author":"S Bhandari","year":"2022","unstructured":"Bhandari S, Mehta S, Khwaja A, Cleland JGF, Ives N, Brettell E, Chadburn M, Cockwell P (2022) Renin-Angiotensin system Inhibition in advanced chronic kidney disease. N Engl J Med 387:2021\u20132032","journal-title":"N Engl J Med"},{"key":"6840_CR11","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1007\/s12640-021-00403-4","volume":"39","author":"SA Bhat","year":"2021","unstructured":"Bhat SA, Fatima Z, Sood A, Shukla R, Hanif K (2021) The protective effects of AT2R agonist, CGP42112A, against angiotensin II-Induced oxidative stress and inflammatory response in astrocytes: role of AT2R\/PP2A\/NF\u03baB\/ROS signaling. Neurotox Res 39:1991\u20132006","journal-title":"Neurotox Res"},{"key":"6840_CR12","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.1038\/s41467-024-49299-6","volume":"15","author":"P Bielefeld","year":"2024","unstructured":"Bielefeld P, Martirosyan A, Mart\u00edn-Su\u00e1rez S, Apresyan A, Meerhoff GF, Pestana F, Poovathingal S, Reijner N, Koning W, Clement RA, Van der Veen I, Toledo EM, Polzer O, Dur\u00e1 I, Hovhannisyan S, Nilges BS, Bogdoll A, Kashikar ND, Lucassen PJ, Belgard TG, Encinas JM, Holt MG, Fitzsimons CP (2024) Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice. Nat Commun 15:5222","journal-title":"Nat Commun"},{"key":"6840_CR13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0143-4179(03)00022-2","volume":"37","author":"DE Brenneman","year":"2003","unstructured":"Brenneman DE, Phillips TM, Hauser J, Hill JM, Spong CY, Gozes I (2003) Complex array of cytokines released by vasoactive intestinal peptide. Neuropeptides 37:111\u2013119","journal-title":"Neuropeptides"},{"key":"6840_CR14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12884-022-05221-w","volume":"23","author":"S Buckley","year":"2023","unstructured":"Buckley S, Uvn\u00e4s-Moberg K, Pajalic Z, Luegmair K, Ekstr\u00f6m-Bergstr\u00f6m A, Dencker A, Massarotti C, Kotlowska A, Callaway L, Morano S, Olza I, Magistretti CM (2023) Maternal and newborn plasma Oxytocin levels in response to maternal synthetic Oxytocin administration during labour, birth and postpartum - a systematic review with implications for the function of the Oxytocinergic system. BMC Pregnancy Childbirth 23:137","journal-title":"BMC Pregnancy Childbirth"},{"key":"6840_CR15","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1900\/RDS.2011.8.418","volume":"8","author":"C Cabou","year":"2011","unstructured":"Cabou C, Burcelin R (2011) GLP-1, the gut-brain, and brain-periphery axes. Rev Diabet Stud 8:418\u2013431","journal-title":"Rev Diabet Stud"},{"key":"6840_CR16","doi-asserted-by":"crossref","first-page":"796443","DOI":"10.3389\/fncir.2022.796443","volume":"16","author":"SM Casello","year":"2022","unstructured":"Casello SM, Flores RJ, Yarur HE, Wang H, Awanyai M, Arenivar MA, Jaime-Lara RB, Bravo-Rivera H, Tejeda HA (2022) Neuropeptide system regulation of prefrontal cortex circuitry: implications for neuropsychiatric disorders. Front Neural Circuits 16:796443","journal-title":"Front Neural Circuits"},{"key":"6840_CR17","doi-asserted-by":"crossref","first-page":"6703","DOI":"10.1523\/JNEUROSCI.0215-08.2008","volume":"28","author":"B Cebolla","year":"2008","unstructured":"Cebolla B, Fern\u00e1ndez-P\u00e9rez A, Perea G, Araque A, Vallejo M (2008) DREAM mediates cAMP-dependent, Ca2+-induced stimulation of GFAP gene expression and regulates cortical astrogliogenesis. J Neurosci 28:6703\u20136713","journal-title":"J Neurosci"},{"key":"6840_CR18","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.neuron.2017.06.029","volume":"95","author":"H Chai","year":"2017","unstructured":"Chai H, Diaz-Castro B, Shigetomi E, Monte E, Octeau JC, Yu X, Cohn W, Rajendran PS, Vondriska TM, Whitelegge JP, Coppola G, Khakh BS (2017) Neural Circuit-Specialized astrocytes: transcriptomic, proteomic, morphological, and functional evidence. Neuron 95:531\u2013549e9","journal-title":"Neuron"},{"key":"6840_CR19","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/glia.23013","volume":"64","author":"VT Cheli","year":"2016","unstructured":"Cheli VT, Santiago Gonz\u00e1lez DA, Smith J, Spreuer V, Murphy GG, Paez PM (2016) L-type voltage-operated calcium channels contribute to astrocyte activation in vitro. Glia 64:1396\u20131415","journal-title":"Glia"},{"key":"6840_CR20","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1053\/j.gastro.2003.11.012","volume":"126","author":"D Chen","year":"2004","unstructured":"Chen D, Zhao CM, H\u00e5kanson R, Samuelson LC, Rehfeld JF, Friis-Hansen L (2004) Altered control of gastric acid secretion in gastrin-cholecystokinin double mutant mice. Gastroenterology 126:476\u2013487","journal-title":"Gastroenterology"},{"key":"6840_CR21","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1111\/cns.13718","volume":"27","author":"L Chen","year":"2021","unstructured":"Chen L, Yang N, Li Y, Li Y, Hong J, Wang Q, Liu K, Han D, Han Y, Mi X, Shi C, Zhou Y, Li Z, Liu T, Guo X (2021) Cholecystokinin octapeptide improves hippocampal glutamatergic synaptogenesis and postoperative cognition by inhibiting induction of A1 reactive astrocytes in aged mice. CNS Neurosci Ther 27:1374\u20131384","journal-title":"CNS Neurosci Ther"},{"key":"6840_CR22","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1021\/acs.jnatprod.2c00158","volume":"85","author":"Q Chen","year":"2022","unstructured":"Chen Q, Liang Z, Yue Q, Wang X, Siu SWI, Pui-Man Hoi M, Lee SM (2022) A neuropeptide Y\/F-like polypeptide derived from the transcriptome of Turbinaria peltata suppresses LPS-Induced astrocytic inflammation. J Nat Prod 85:1569\u20131580","journal-title":"J Nat Prod"},{"key":"6840_CR23","doi-asserted-by":"crossref","first-page":"102489","DOI":"10.1016\/j.pneurobio.2023.102489","volume":"228","author":"X Chen","year":"2023","unstructured":"Chen X, Gao R, Song Y, Xu T, Jin L, Zhang W, Chen Z, Wang H, Wu W, Zhang S, Zhang G, Zhang N, Chang L, Liu H, Li H, Wu Y (2023) Astrocytic AT1R deficiency ameliorates A\u03b2-induced cognitive deficits and synaptotoxicity through \u03b2-arrestin2 signaling. Prog Neurobiol 228:102489","journal-title":"Prog Neurobiol"},{"key":"6840_CR24","doi-asserted-by":"crossref","first-page":"e2405354","DOI":"10.1002\/advs.202405354","volume":"11","author":"B Chen","year":"2024","unstructured":"Chen B, Jin K, Dong J, Cheng S, Kong L, Hu S, Chen Z, Lu J (2024) Hypocretin-1\/Hypocretin receptor 1 regulates neuroplasticity and cognitive function through hippocampal lactate homeostasis in depressed model. Adv Sci (Weinh) 11:e2405354","journal-title":"Adv Sci (Weinh)"},{"key":"6840_CR25","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1054\/npep.1999.0757","volume":"33","author":"JA Chowen","year":"1999","unstructured":"Chowen JA, de Fonseca FR, Alvarez E, Navarro M, Garc\u00eda-Segura LM, Bl\u00e1zquez E (1999) Increased glucagon-like peptide-1 receptor expression in glia after mechanical lesion of the rat brain. Neuropeptides 33:212\u2013215","journal-title":"Neuropeptides"},{"key":"6840_CR26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.regpep.2007.02.008","volume":"143","author":"MA Clark","year":"2007","unstructured":"Clark MA, Gonzalez N (2007) Src and Pyk2 mediate angiotensin II effects in cultured rat astrocytes. Regul Pept 143:47\u201355","journal-title":"Regul Pept"},{"key":"6840_CR27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.brainresbull.2007.07.028","volume":"75","author":"MA Clark","year":"2008","unstructured":"Clark MA, Guillaume G, Pierre-Louis HC (2008) Angiotensin II induces proliferation of cultured rat astrocytes through c-Jun N-terminal kinase. Brain Res Bull 75:101\u2013106","journal-title":"Brain Res Bull"},{"key":"6840_CR28","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s11064-012-0738-9","volume":"37","author":"MA Clark","year":"2012","unstructured":"Clark MA, Nguyen C, Tran H (2012) Angiotensin III induces c-Jun N-terminal kinase leading to proliferation of rat astrocytes. Neurochem Res 37:1475\u20131481","journal-title":"Neurochem Res"},{"key":"6840_CR29","first-page":"E1896","volume":"115","author":"LE Clarke","year":"2018","unstructured":"Clarke LE, Liddelow SA, Chakraborty C, M\u00fcnch AE, Heiman M, Barres BA (2018) Normal aging induces A1-like astrocyte reactivity. Proc Natl Acad Sci USA 115:E1896-e1905","journal-title":"Proc Natl Acad Sci USA"},{"key":"6840_CR30","doi-asserted-by":"crossref","first-page":"8515","DOI":"10.1523\/JNEUROSCI.0569-18.2018","volume":"38","author":"KM Crosby","year":"2018","unstructured":"Crosby KM, Murphy-Royal C, Wilson SA, Gordon GR, Bains JS, Pittman QJ (2018) Cholecystokinin switches the plasticity of GABA synapses in the dorsomedial hypothalamus via astrocytic ATP release. J Neurosci 38:8515\u20138525","journal-title":"J Neurosci"},{"key":"6840_CR31","doi-asserted-by":"crossref","first-page":"2256043","DOI":"10.1080\/19490976.2023.2256043","volume":"15","author":"HA Danhof","year":"2023","unstructured":"Danhof HA, Lee J, Thapa A, Britton RA, Di Rienzi SC (2023) Microbial stimulation of Oxytocin release from the intestinal epithelium via secretin signaling. Gut Microbes 15:2256043","journal-title":"Gut Microbes"},{"key":"6840_CR32","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.pnpbp.2017.06.021","volume":"79","author":"PB de la Tremblaye","year":"2017","unstructured":"de la Tremblaye PB, Benoit SM, Schock S, Plamondon H (2017) CRHR1 exacerbates the glial inflammatory response and alters bdnf\/trkb\/pcreb signaling in a rat model of global cerebral ischemia: implications for neuroprotection and cognitive recovery. Prog Neuropsychopharmacol Biol Psychiatry 79:234\u2013248","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"6840_CR33","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.nbd.2009.02.017","volume":"34","author":"M Decressac","year":"2009","unstructured":"Decressac M, Prestoz L, Veran J, Cantereau A, Jaber M, Gaillard A (2009) Neuropeptide Y stimulates proliferation, migration and differentiation of neural precursors from the subventricular zone in adult mice. Neurobiol Dis 34:441\u2013449","journal-title":"Neurobiol Dis"},{"key":"6840_CR34","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/j.neurobiolaging.2011.06.018","volume":"33","author":"M Decressac","year":"2012","unstructured":"Decressac M, Pain S, Chabeauti PY, Frangeul L, Thiriet N, Herzog H, Vergote J, Chalon S, Jaber M, Gaillard A (2012) Neuroprotection by neuropeptide Y in cell and animal models of parkinson\u2019s disease. Neurobiol Aging 33:2125\u20132137","journal-title":"Neurobiol Aging"},{"key":"6840_CR35","first-page":"307","volume":"57","author":"A Dejda","year":"2005","unstructured":"Dejda A, Soko\u0142owska P, Nowak JZ (2005) Neuroprotective potential of three neuropeptides PACAP, VIP and PHI. Pharmacol Rep 57:307\u2013320","journal-title":"Pharmacol Rep"},{"key":"6840_CR36","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/01616412.2016.1250458","volume":"39","author":"G Deng","year":"2017","unstructured":"Deng G, Jin L (2017) The effects of vasoactive intestinal peptide in neurodegenerative disorders. Neurol Res 39:65\u201372","journal-title":"Neurol Res"},{"key":"6840_CR37","doi-asserted-by":"crossref","first-page":"110844","DOI":"10.1016\/j.pnpbp.2023.110844","volume":"128","author":"S Deng","year":"2024","unstructured":"Deng S, Guo A, Huang Z, Guan K, Zhu Y, Chan C, Gui J, Song C, Li X (2024a) The exploration of neuroinflammatory mechanism by which CRHR2 deficiency induced anxiety disorder. Prog Neuropsychopharmacol Biol Psychiatry 128:110844","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"6840_CR38","doi-asserted-by":"crossref","first-page":"110844","DOI":"10.1016\/j.pnpbp.2023.110844","volume":"128","author":"S Deng","year":"2024","unstructured":"Deng S, Guo A, Huang Z, Guan K, Zhu Y, Chan C, Gui J, Song C, Li X (2024b) The exploration of neuroinflammatory mechanism by which CRHR2 deficiency induced anxiety disorder. Prog Neuropsychopharmacol Biol Psychiatry 128:110844","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"Pt 2","key":"6840_CR39","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1042\/bj2840491","volume":"284","author":"D Di Scala-Guenot","year":"1992","unstructured":"Di Scala-Guenot D, Strosser MT (1992) Oxytocin receptors on cultured astroglial cells. Kinetic and Pharmacological characterization of oxytocin-binding sites on intact hypothalamic and hippocampic cells from foetal rat brain. Biochem J 284(Pt 2):491\u2013497","journal-title":"Biochem J"},{"key":"6840_CR40","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/glia.440110308","volume":"11","author":"D Di Scala-Guenot","year":"1994","unstructured":"Di Scala-Guenot D, Mouginot D, Strosser MT (1994) Increase of intracellular calcium induced by Oxytocin in hypothalamic cultured astrocytes. Glia 11:269\u2013276","journal-title":"Glia"},{"key":"6840_CR41","doi-asserted-by":"crossref","unstructured":"Diz-Chaves Y, Mastoor Z, Spuch C, Gonz\u00e1lez-Mat\u00edas LC, Mallo F (2022) Anti-Inflammatory effects of GLP-1 receptor activation in the brain in neurodegenerative diseases. Int J Mol Sci 23:9583","DOI":"10.3390\/ijms23179583"},{"key":"6840_CR42","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bbr.2013.01.039","volume":"244","author":"VV dos Santos","year":"2013","unstructured":"dos Santos VV, Santos DB, Lach G, Rodrigues AL, Farina M, De Lima TC, Prediger RD (2013) Neuropeptide Y (NPY) prevents depressive-like behavior, Spatial memory deficits and oxidative stress following amyloid-\u03b2 (A\u03b2(1\u201340)) administration in mice. Behav Brain Res 244:107\u2013115","journal-title":"Behav Brain Res"},{"key":"6840_CR43","doi-asserted-by":"crossref","first-page":"7007","DOI":"10.2147\/JIR.S343575","volume":"14","author":"R Duan","year":"2021","unstructured":"Duan R, Wang SY, Wei B, Deng Y, Fu XX, Gong PY, E Y, Sun XJ, Cao HM, Shi JQ, Jiang T, Zhang YD (2021) Angiotensin-(1\u20137) analogue AVE0991 modulates Astrocyte-Mediated neuroinflammation via LncRNA SNHG14\/miR-223-3p\/NLRP3 pathway and offers neuroprotection in a Transgenic mouse model of alzheimer\u2019s disease. J Inflamm Res 14:7007\u20137019","journal-title":"J Inflamm Res"},{"key":"6840_CR44","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.nbd.2016.07.022","volume":"95","author":"J Duarte-Neves","year":"2016","unstructured":"Duarte-Neves J, Pereira de Almeida L, Cavadas C (2016) Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases. Neurobiol Dis 95:210\u2013224","journal-title":"Neurobiol Dis"},{"key":"6840_CR45","doi-asserted-by":"crossref","first-page":"eadc9020","DOI":"10.1126\/science.adc9020","volume":"378","author":"F Endo","year":"2022","unstructured":"Endo F, Kasai A, Soto JS, Yu X, Qu Z, Hashimoto H, Gradinaru V, Kawaguchi R, Khakh BS (2022) Molecular basis of astrocyte diversity and morphology across the CNS in health and disease. Science 378:eadc9020","journal-title":"Science"},{"key":"6840_CR46","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/jmwh.12601","volume":"62","author":"EN Erickson","year":"2017","unstructured":"Erickson EN, Emeis CL (2017) Breastfeeding outcomes after Oxytocin use during childbirth: an integrative review. J Midwifery Womens Health 62:397\u2013417","journal-title":"J Midwifery Womens Health"},{"key":"6840_CR47","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41593-020-00783-4","volume":"24","author":"C Escartin","year":"2021","unstructured":"Escartin C, Galea E, Lakatos A, O\u2019Callaghan JP, Petzold GC, Serrano-Pozo A, Steinh\u00e4user C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, D\u00edaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, G\u00f6tz M, Guti\u00e9rrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, P\u00e9rez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A (2021) Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci 24:312\u2013325","journal-title":"Nat Neurosci"},{"key":"6840_CR48","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1385\/JMN\/31:02:139","volume":"31","author":"J Fahrenkrug","year":"2007","unstructured":"Fahrenkrug J, Popovic N, Georg B, Brundin P, Hannibal J (2007) Decreased VIP and VPAC2 receptor expression in the biological clock of the R6\/2 huntington\u2019s disease mouse. J Mol Neurosci 31:139\u2013148","journal-title":"J Mol Neurosci"},{"key":"6840_CR49","doi-asserted-by":"crossref","first-page":"105080","DOI":"10.1016\/j.neuint.2021.105080","volume":"148","author":"YY Fan","year":"2021","unstructured":"Fan YY, Huo J (2021) A1\/A2 astrocytes in central nervous system injuries and diseases: angels or devils? Neurochem Int 148:105080","journal-title":"Neurochem Int"},{"key":"6840_CR50","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1172\/JCI990","volume":"101","author":"A Flint","year":"1998","unstructured":"Flint A, Raben A, Astrup A, Holst JJ (1998) Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J Clin Invest 101:515\u2013520","journal-title":"J Clin Invest"},{"key":"6840_CR51","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","volume":"98","author":"SJ Forrester","year":"2018","unstructured":"Forrester SJ, Booz GW, Sigmund CD, Coffman TM, Kawai T, Rizzo V, Scalia R, Eguchi S (2018) Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology. Physiol Rev 98:1627\u20131738","journal-title":"Physiol Rev"},{"key":"6840_CR52","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/B978-0-12-820107-7.00021-5","volume":"180","author":"R Fronczek","year":"2021","unstructured":"Fronczek R, Schinkelshoek M, Shan L, Lammers GJ (2021) The orexin\/hypocretin system in neuropsychiatric disorders: relation to signs and symptoms. Handb Clin Neurol 180:343\u2013358","journal-title":"Handb Clin Neurol"},{"key":"6840_CR53","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fncel.2015.00085","volume":"9","author":"MC Geloso","year":"2015","unstructured":"Geloso MC, Corvino V, Di Maria V, Marchese E, Michetti F (2015) Cellular targets for neuropeptide Y-mediated control of adult neurogenesis. Front Cell Neurosci 9:85","journal-title":"Front Cell Neurosci"},{"key":"6840_CR54","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/112_2022_72","volume":"186","author":"AA Ghazy","year":"2023","unstructured":"Ghazy AA, Soliman OA, Elbahnasi AI, Alawy AY, Mansour AM, Gowayed MA (2023) Role of Oxytocin in different neuropsychiatric, neurodegenerative, and neurodevelopmental disorders. Rev Physiol Biochem Pharmacol 186:95\u2013134","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"6840_CR55","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.npep.2015.09.010","volume":"55","author":"CR G\u00f8tzsche","year":"2016","unstructured":"G\u00f8tzsche CR, Woldbye DPD (2016) The role of NPY in learning and memory. Neuropeptides 55:79\u201389","journal-title":"Neuropeptides"},{"key":"6840_CR56","doi-asserted-by":"crossref","first-page":"e70096","DOI":"10.1111\/cns.70096","volume":"30","author":"J Guo","year":"2024","unstructured":"Guo J, Kong D, Luo J, Xiong T, Wang F, Deng M, Kong Z, Yang S, Da J, Chen C, Lan J, Chu L, Han G, Liu J, Tan Y, Zhang J (2024a) Orexin-A attenuates the inflammatory response in Sepsis-Associated encephalopathy by modulating oxidative stress and inhibiting the ERK\/NF-\u03baB signaling pathway in microglia and astrocytes. CNS Neurosci Ther 30:e70096","journal-title":"CNS Neurosci Ther"},{"key":"6840_CR57","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12974-024-03111-w","volume":"21","author":"J Guo","year":"2024","unstructured":"Guo J, Kong Z, Yang S, Da J, Chu L, Han G, Liu J, Tan Y, Zhang J (2024b) Therapeutic effects of orexin-A in sepsis-associated encephalopathy in mice. J Neuroinflammation 21:131","journal-title":"J Neuroinflammation"},{"key":"6840_CR58","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1021\/acschemneuro.1c00797","volume":"13","author":"S Gupta","year":"2022","unstructured":"Gupta S, Tiwari V, Tiwari P, Parul, Mishra A, Hanif K, Shukla S (2022) Angiotensin-Converting enzyme 2 activation mitigates behavioral deficits and neuroinflammatory burden in 6-OHDA induced experimental models of parkinson\u2019s disease. ACS Chem Neurosci 13:1491\u20131504","journal-title":"ACS Chem Neurosci"},{"key":"6840_CR59","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.1007\/s12035-023-03502-9","volume":"60","author":"R Gupta","year":"2023","unstructured":"Gupta R, Advani D, Yadav D, Ambasta RK, Kumar P (2023) Dissecting the relationship between neuropsychiatric and neurodegenerative disorders. Mol Neurobiol 60:6476\u20136529","journal-title":"Mol Neurobiol"},{"key":"6840_CR60","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/1097-4547(20001215)62:6<789::AID-JNR5>3.0.CO;2-5","volume":"62","author":"BK Ha","year":"2000","unstructured":"Ha BK, Bishop GA, King JS, Burry RW (2000) Corticotropin releasing factor induces proliferation of cerebellar astrocytes. J Neurosci Res 62:789\u2013798","journal-title":"J Neurosci Res"},{"key":"6840_CR61","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1080\/01616412.2017.1352185","volume":"39","author":"Z Hadadianpour","year":"2017","unstructured":"Hadadianpour Z, Fatehi F, Ayoobi F, Kaeidi A, Shamsizadeh A, Fatemi I (2017) The effect of orexin-A on motor and cognitive functions in a rat model of parkinson\u2019s disease. Neurol Res 39:845\u2013851","journal-title":"Neurol Res"},{"key":"6840_CR62","doi-asserted-by":"crossref","first-page":"382","DOI":"10.14283\/jpad.2024.6","volume":"11","author":"L Hao","year":"2024","unstructured":"Hao L, Shi M, Ma J, Shao S, Yuan Y, Liu J, Yu Z, Zhang Z, H\u00f6lscher C, Zhang Z (2024) A cholecystokinin analogue ameliorates cognitive deficits and regulates mitochondrial dynamics via the AMPK\/Drp1 pathway in APP\/PS1 mice. J Prev Alzheimer\u2019s Disease 11:382\u2013401","journal-title":"J Prev Alzheimer\u2019s Disease"},{"key":"6840_CR63","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/s41380-024-02858-1","volume":"30","author":"K Hashimoto","year":"2025","unstructured":"Hashimoto K (2025) Evaluating the safety of orexin receptor antagonists on reproductive health and sexual function. Mol Psychiatry 30:1161\u20131163","journal-title":"Mol Psychiatry"},{"key":"6840_CR64","doi-asserted-by":"crossref","first-page":"91","DOI":"10.14712\/fb2017063030091","volume":"63","author":"T Havr\u00e1nek","year":"2017","unstructured":"Havr\u00e1nek T, Le\u0161\u0165anov\u00e1 Z, Mravec B, \u0160trb\u00e1k V, Bako\u0161 J, Ba\u010dov\u00e1 Z (2017) Oxytocin modulates expression of neuron and glial markers in the rat Hippocampus. Folia Biol (Praha) 63:91\u201397","journal-title":"Folia Biol (Praha)"},{"key":"6840_CR65","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1152\/physrev.00034.2006","volume":"87","author":"JJ Holst","year":"2007","unstructured":"Holst JJ (2007) The physiology of glucagon-like peptide 1. Physiol Rev 87:1409\u20131439","journal-title":"Physiol Rev"},{"key":"6840_CR66","first-page":"91","volume":"21","author":"M Iovino","year":"2021","unstructured":"Iovino M, Messana T, Tortora A, Giusti C, Lisco G, Giagulli VA, Guastamacchia E, De Pergola G, Triggiani V (2021) Oxytocin signaling pathway: from cell biology to clinical implications. Endocr Metab Immune Disord Drug Targets 21:91\u2013110","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"6840_CR67","doi-asserted-by":"crossref","unstructured":"Iwasaki M, Akiba Y, Kaunitz JD (2019) Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system. F1000Res 8","DOI":"10.12688\/f1000research.18039.1"},{"key":"6840_CR68","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1111\/jnc.16199","volume":"168","author":"MI Jansen","year":"2024","unstructured":"Jansen MI, Mahmood Y, Lee J, Broome ST, Waschek JA, Castorina A (2024) Targeting the PAC1 receptor mitigates degradation of Myelin and synaptic markers and diminishes locomotor deficits in the Cuprizone demyelination model. J Neurochem 168:3250\u20133267","journal-title":"J Neurochem"},{"key":"6840_CR69","doi-asserted-by":"crossref","first-page":"109067","DOI":"10.1016\/j.isci.2024.109067","volume":"27","author":"H Jiao","year":"2024","unstructured":"Jiao H, Wang Y, Fu K, Xiao X, Jia MQ, Sun J, Wang J, Zhu G, Lyu D, Lu Q, Peng Y, Lv J, Su L, Gao Y (2024) An orexin-receptor-2-mediated heart-brain axis in cardiac pain. iScience 27:109067","journal-title":"iScience"},{"key":"6840_CR70","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nm.2075","volume":"16","author":"PL Johnson","year":"2010","unstructured":"Johnson PL, Truitt W, Fitz SD, Minick PE, Dietrich A, Sanghani S, Tr\u00e4skman-Bendz L, Goddard AW, Brundin L, Shekhar A (2010) A key role for orexin in panic anxiety. Nat Med 16:111\u2013115","journal-title":"Nat Med"},{"key":"6840_CR71","doi-asserted-by":"crossref","unstructured":"Jurga AM, Paleczna M, Kadluczka J, Kuter KZ (2021) Beyond the GFAP-Astrocyte protein markers in the brain. Biomolecules 11","DOI":"10.3390\/biom11091361"},{"key":"6840_CR72","doi-asserted-by":"crossref","unstructured":"Katzman MA, Katzman MP (2022) Neurobiology of the orexin system and its potential role in the regulation of hedonic tone. Brain Sci 12:150","DOI":"10.3390\/brainsci12020150"},{"key":"6840_CR73","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s10571-020-01003-0","volume":"42","author":"F Khodagholi","year":"2022","unstructured":"Khodagholi F, Maleki A, Motamedi F, Mousavi MA, Rafiei S, Moslemi M (2022) Oxytocin prevents the development of 3-NP-Induced anxiety and depression in male and female rats: possible interaction of OXTR and mGluR2. Cell Mol Neurobiol 42:1105\u20131123","journal-title":"Cell Mol Neurobiol"},{"key":"6840_CR74","doi-asserted-by":"crossref","unstructured":"Knoop M, Possovre ML, Jacquens A, Charlet A, Baud O, Darbon P (2022) The role of oxytocin in abnormal brain development: effect on glial cells and neuroinflammation. Cells 11:3899","DOI":"10.3390\/cells11233899"},{"key":"6840_CR75","doi-asserted-by":"crossref","first-page":"106550","DOI":"10.1016\/j.phrs.2022.106550","volume":"186","author":"KO Kopp","year":"2022","unstructured":"Kopp KO, Glotfelty EJ, Li Y, Greig NH (2022) Glucagon-like peptide-1 (GLP-1) receptor agonists and neuroinflammation: implications for neurodegenerative disease treatment. Pharmacol Res 186:106550","journal-title":"Pharmacol Res"},{"key":"6840_CR76","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/ana.410230202","volume":"23","author":"NW Kowall","year":"1988","unstructured":"Kowall NW, Beal MF (1988) Cortical somatostatin, neuropeptide Y, and NADPH diaphorase neurons: normal anatomy and alterations in alzheimer\u2019s disease. Ann Neurol 23:105\u2013114","journal-title":"Ann Neurol"},{"key":"6840_CR77","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s13195-024-01573-x","volume":"16","author":"I Koychev","year":"2024","unstructured":"Koychev I, Reid G, Nguyen M, Mentz RJ, Joyce D, Shah SH, Holman RR (2024) Inflammatory proteins associated with alzheimer\u2019s disease reduced by a GLP1 receptor agonist: a post hoc analysis of the EXSCEL randomized placebo controlled trial. Alzheimers Res Ther 16:212","journal-title":"Alzheimers Res Ther"},{"key":"6840_CR78","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0074-7696(08)62407-9","volume":"148","author":"B Krisch","year":"1994","unstructured":"Krisch B, Mentlein R (1994) Neuropeptide receptors and astrocytes. Int Rev Cytol 148:119\u2013169","journal-title":"Int Rev Cytol"},{"key":"6840_CR79","doi-asserted-by":"crossref","unstructured":"Langer I, Jeandriens J, Couvineau A, Sanmukh S, Latek D (2022) Signal transduction by VIP and PACAP receptors. Biomedicines 10","DOI":"10.3390\/biomedicines10020406"},{"key":"6840_CR80","doi-asserted-by":"crossref","first-page":"105440","DOI":"10.1016\/j.neuint.2022.105440","volume":"162","author":"SH Lau","year":"2023","unstructured":"Lau SH, Young CH, Zheng Y, Chen X (2023) The potential role of the cholecystokinin system in declarative memory. Neurochem Int 162:105440","journal-title":"Neurochem Int"},{"key":"6840_CR81","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1073\/pnas.0806720106","volume":"106","author":"Y Li","year":"2009","unstructured":"Li Y, Perry T, Kindy MS, Harvey BK, Tweedie D, Holloway HW, Powers K, Shen H, Egan JM, Sambamurti K, Brossi A, Lahiri DK, Mattson MP, Hoffer BJ, Wang Y, Greig NH (2009) GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and parkinsonism. Proc Natl Acad Sci U S A 106:1285\u20131290","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6840_CR82","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s12974-020-01841-1","volume":"17","author":"T Li","year":"2020","unstructured":"Li T, Xu W, Ouyang J, Lu X, Sherchan P, Lenahan C, Irio G, Zhang JH, Zhao J, Zhang Y, Tang J (2020) Orexin A alleviates neuroinflammation via OXR2\/CaMKK\u03b2\/AMPK signaling pathway after ICH in mice. J Neuroinflammation 17:187","journal-title":"J Neuroinflammation"},{"key":"6840_CR83","doi-asserted-by":"crossref","first-page":"107179","DOI":"10.1016\/j.intimp.2020.107179","volume":"90","author":"S Li","year":"2021","unstructured":"Li S, Zhou C, Zhu Y, Chao Z, Sheng Z, Zhang Y, Zhao Y (2021) Ferrostatin-1 alleviates angiotensin II (Ang II)- induced inflammation and ferroptosis in astrocytes. Int Immunopharmacol 90:107179","journal-title":"Int Immunopharmacol"},{"key":"6840_CR84","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neurobiolaging.2023.01.008","volume":"124","author":"YY Li","year":"2023","unstructured":"Li YY, Yu KY, Cui YJ, Wang ZJ, Cai HY, Cao JM, Wu MN (2023) Orexin-A aggravates cognitive deficits in 3xTg-AD mice by exacerbating synaptic plasticity impairment and affecting amyloid \u03b2 metabolism. Neurobiol Aging 124:71\u201384","journal-title":"Neurobiol Aging"},{"key":"6840_CR85","doi-asserted-by":"crossref","unstructured":"Li H, Feng J, Chen M, Xin M, Chen X, Liu W, Wang L, Wang KH, He J (2024) Cholecystokinin facilitates motor skill learning by modulating neuroplasticity in the motor cortex. Elife 13:e83897","DOI":"10.7554\/eLife.83897"},{"key":"6840_CR86","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1001\/jamaneurol.2014.2510","volume":"71","author":"C Liguori","year":"2014","unstructured":"Liguori C, Romigi A, Nuccetelli M, Zannino S, Sancesario G, Martorana A, Albanese M, Mercuri NB, Izzi F, Bernardini S, Nitti A, Sancesario GM, Sica F, Marciani MG, Placidi F (2014) Orexinergic system dysregulation, sleep impairment, and cognitive decline in alzheimer disease. JAMA Neurol 71:1498\u20131505","journal-title":"JAMA Neurol"},{"key":"6840_CR87","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.neuron.2020.08.012","volume":"108","author":"M Linnerbauer","year":"2020","unstructured":"Linnerbauer M, Wheeler MA, Quintana FJ (2020) Astrocyte crosstalk in CNS inflammation. Neuron 108:608\u2013622","journal-title":"Neuron"},{"key":"6840_CR88","doi-asserted-by":"crossref","first-page":"114822","DOI":"10.1016\/j.expneurol.2024.114822","volume":"378","author":"H Liu","year":"2024","unstructured":"Liu H, Zhang Y, Hou X, Zhu C, Yang Q, Li K, Fan L, Zhang X, Jiang X, Jin X, Lei H, Chen T, Zhang F, Zhang Z, Song J (2024a) CRHR1 antagonist alleviated depression-like behavior by downregulating p62 in a rat model of post-stroke depression. Exp Neurol 378:114822","journal-title":"Exp Neurol"},{"key":"6840_CR89","doi-asserted-by":"crossref","first-page":"109769","DOI":"10.1016\/j.neuropharm.2023.109769","volume":"242","author":"R Liu","year":"2024","unstructured":"Liu R, Sun D, Xing X, Chen Q, Lu B, Meng B, Yuan H, Mo L, Sheng L, Zheng J, Wang Q, Chen J, Chen X (2024b) Intranasal Oxytocin alleviates comorbid depressive symptoms in neuropathic pain via elevating hippocampal BDNF production in both female and male mice. Neuropharmacology 242:109769","journal-title":"Neuropharmacology"},{"key":"6840_CR90","doi-asserted-by":"crossref","first-page":"eadj4196","DOI":"10.1126\/sciadv.adj4196","volume":"10","author":"SS Lv","year":"2024","unstructured":"Lv SS, Lv XJ, Cai YQ, Hou XY, Zhang ZZ, Wang GH, Chen LQ, Lv N, Zhang YQ (2024) Corticotropin-releasing hormone neurons control trigeminal neuralgia-induced anxiodepression via a hippocampus-to-prefrontal circuit. Sci Adv 10:eadj4196","journal-title":"Sci Adv"},{"key":"6840_CR91","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bbr.2014.02.039","volume":"266","author":"Y Ma","year":"2014","unstructured":"Ma Y, Zhan M, OuYang L, Li Y, Chen S, Wu J, Chen J, Luo C, Lei W (2014) The effects of unilateral 6-OHDA lesion in medial forebrain bundle on the motor, cognitive dysfunctions and vulnerability of different striatal interneuron types in rats. Behav Brain Res 266:37\u201345","journal-title":"Behav Brain Res"},{"key":"6840_CR92","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbi.2024.11.023","volume":"124","author":"L Ma","year":"2025","unstructured":"Ma L, Wang HB, Hashimoto K (2025) The vagus nerve: an old but new player in brain-body communication. Brain Behav Immun 124:28\u201339","journal-title":"Brain Behav Immun"},{"key":"6840_CR93","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1177\/1073858420960111","volume":"27","author":"N Marsh","year":"2021","unstructured":"Marsh N, Marsh AA, Lee MR, Hurlemann R (2021) Oxytocin and the neurobiology of prosocial behavior. Neuroscientist 27:604\u2013619","journal-title":"Neuroscientist"},{"key":"6840_CR94","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.peptides.2007.05.015","volume":"28","author":"O Masmoudi-Kouki","year":"2007","unstructured":"Masmoudi-Kouki O, Gandolfo P, Castel H, Leprince J, Fournier A, Dejda A, Vaudry H, Tonon M-C (2007) Role of PACAP and VIP in astroglial functions. Peptides 28:1753\u20131760","journal-title":"Peptides"},{"key":"6840_CR95","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.2174\/1381612824666181112111746","volume":"24","author":"O Masmoudi-Kouki","year":"2018","unstructured":"Masmoudi-Kouki O, Hamdi Y, Ghouili I, Bahdoudi S, Kaddour H, Leprince J, Castel H, Vaudry H, Amri M, Vaudry D, Tonon MC (2018) Neuroprotection with the endozepine octadecaneuropeptide, ODN. Curr Pharm Des 24:3918\u20133925","journal-title":"Curr Pharm Des"},{"key":"6840_CR96","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/ijnp\/pyaa054","volume":"23","author":"AA Math\u00e9","year":"2020","unstructured":"Math\u00e9 AA, Michaneck M, Berg E, Charney DS, Murrough JW (2020) A randomized controlled trial of intranasal neuropeptide Y in patients with major depressive disorder. Int J Neuropsychopharmacol 23:783\u2013790","journal-title":"Int J Neuropsychopharmacol"},{"key":"6840_CR97","doi-asserted-by":"crossref","unstructured":"Matsoukas MT, Panagiotopoulos V, Karageorgos V, Chrousos GP, Venihaki M, Liapakis G (2024) Structural and functional insights into CRF peptides and their receptors. Biology (Basel) 13:120","DOI":"10.3390\/biology13020120"},{"key":"6840_CR98","doi-asserted-by":"crossref","unstructured":"Mehdi SF, Pusapati S, Anwar MS, Lohana D, Kumar P, Nandula SA, Nawaz FK, Tracey K, Yang H, LeRoith D, Brownstein MJ, Roth J (2023) Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent. Front Immunol 14:1148209","DOI":"10.3389\/fimmu.2023.1148209"},{"key":"6840_CR99","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jchemneu.2011.02.001","volume":"42","author":"A Merighi","year":"2011","unstructured":"Merighi A, Salio C, Ferrini F, Lossi L (2011) Neuromodulatory function of neuropeptides in the normal CNS. J Chem Neuroanat 42:276\u2013287","journal-title":"J Chem Neuroanat"},{"key":"6840_CR100","first-page":"5388","volume":"6","author":"MA Meyer","year":"2014","unstructured":"Meyer MA (2014) Highly expressed genes within hippocampal sector CA1: implications for the physiology of memory. Neurol Int 6:5388","journal-title":"Neurol Int"},{"key":"6840_CR101","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s10557-019-06895-9","volume":"33","author":"C Monteiro-Pinto","year":"2019","unstructured":"Monteiro-Pinto C, Ad\u00e3o R, Leite-Moreira AF, Br\u00e1s-Silva C (2019) Cardiovascular effects of Urocortin-2: pathophysiological mechanisms and therapeutic potential. Cardiovasc Drugs Ther 33:599\u2013613","journal-title":"Cardiovasc Drugs Ther"},{"key":"6840_CR102","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0006-8993(98)00291-1","volume":"795","author":"I Moroo","year":"1998","unstructured":"Moroo I, Tatsuno I, Uchida D, Tanaka T, Saito J, Saito Y, Hirai A (1998) Pituitary adenylate cyclase activating polypeptide (PACAP) stimulates mitogen-activated protein kinase (MAPK) in cultured rat astrocytes. Brain Res 795:191\u2013196","journal-title":"Brain Res"},{"key":"6840_CR103","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1152\/jn.1997.78.4.1997","volume":"78","author":"W M\u00fcller","year":"1997","unstructured":"M\u00fcller W, Heinemann U, Berlin K (1997) Cholecystokinin activates CCKB-receptor-mediated Ca-signaling in hippocampal astrocytes. J Neurophysiol 78:1997\u20132001","journal-title":"J Neurophysiol"},{"key":"6840_CR104","doi-asserted-by":"crossref","first-page":"973","DOI":"10.2174\/138161211795589346","volume":"17","author":"T Nakamachi","year":"2011","unstructured":"Nakamachi T, Farkas J, Watanabe J, Ohtaki H, Dohi K, Arata S, Shioda S (2011) Role of PACAP in neural stem\/progenitor cell and astrocyte\u2013from neural development to neural repair. Curr Pharm Des 17:973\u2013984","journal-title":"Curr Pharm Des"},{"key":"6840_CR105","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1038\/s41440-023-01260-8","volume":"46","author":"T Nakayama","year":"2023","unstructured":"Nakayama T, Mitsuno R, Azegami T, Sato Y, Hayashi K, Itoh H (2023) A systematic review and meta-analysis of the clinical impact of stopping renin-angiotensin system inhibitor in patients with chronic kidney disease. Hypertens Res 46:1525\u20131535","journal-title":"Hypertens Res"},{"key":"6840_CR106","doi-asserted-by":"crossref","first-page":"108052","DOI":"10.1016\/j.neuropharm.2020.108052","volume":"170","author":"V Neugebauer","year":"2020","unstructured":"Neugebauer V, Mazzitelli M, Cragg B, Ji G, Navratilova E, Porreca F (2020) Amygdala, neuropeptides, and chronic pain-related affective behaviors. Neuropharmacology 170:108052","journal-title":"Neuropharmacology"},{"key":"6840_CR107","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1038\/s41467-023-40968-6","volume":"14","author":"MM Novakovic","year":"2023","unstructured":"Novakovic MM, Korshunov KS, Grant RA, Martin ME, Valencia HA, Budinger GRS, Radulovic J, Prakriya M (2023) Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels. Nat Commun 14:5500","journal-title":"Nat Commun"},{"key":"6840_CR108","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1007\/s00535-008-2218-1","volume":"43","author":"T Okumura","year":"2008","unstructured":"Okumura T, Takakusaki K (2008) Role of orexin in central regulation of Gastrointestinal functions. J Gastroenterol 43:652\u2013660","journal-title":"J Gastroenterol"},{"key":"6840_CR109","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/s12864-016-2623-4","volume":"17","author":"S Paco","year":"2016","unstructured":"Paco S, Hummel M, Pl\u00e1 V, Sumoy L, Aguado F (2016) Cyclic AMP signaling restricts activation and promotes maturation and antioxidant defenses in astrocytes. BMC Genomics 17:304","journal-title":"BMC Genomics"},{"key":"6840_CR110","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.2174\/1570159X19666210906120302","volume":"20","author":"S Pain","year":"2022","unstructured":"Pain S, Brot S, Gaillard A (2022) Neuroprotective effects of neuropeptide Y against neurodegenerative disease. Curr Neuropharmacol 20:1717\u20131725","journal-title":"Curr Neuropharmacol"},{"key":"6840_CR111","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0196-9781(01)00396-5","volume":"22","author":"DG Parkes","year":"2001","unstructured":"Parkes DG, Weisinger RS, May CN (2001) Cardiovascular actions of CRH and urocortin: an update. Peptides 22:821\u2013827","journal-title":"Peptides"},{"key":"6840_CR112","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41569-019-0244-8","volume":"17","author":"M Paz Ocaranza","year":"2020","unstructured":"Paz Ocaranza M, Riquelme JA, Garc\u00eda L, Jalil JE, Chiong M, Santos RAS, Lavandero S (2020) Counter-regulatory renin-angiotensin system in cardiovascular disease. Nat Rev Cardiol 17:116\u2013129","journal-title":"Nat Rev Cardiol"},{"key":"6840_CR113","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00401-015-1513-1","volume":"131","author":"M Pekny","year":"2016","unstructured":"Pekny M, Pekna M, Messing A, Steinh\u00e4user C, Lee JM, Parpura V, Hol EM, Sofroniew MV, Verkhratsky A (2016) Astrocytes: a central element in neurological diseases. Acta Neuropathol 131:323\u2013345","journal-title":"Acta Neuropathol"},{"key":"6840_CR114","doi-asserted-by":"crossref","first-page":"G1117","DOI":"10.1152\/ajpgi.00035.2013","volume":"304","author":"A Plamboeck","year":"2013","unstructured":"Plamboeck A, Veedfald S, Deacon CF, Hartmann B, Wettergren A, Svendsen LB, Meisner S, Hovendal C, Vilsb\u00f8ll T, Knop FK, Holst JJ (2013) The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty. Am J Physiol Gastrointest Liver Physiol 304:G1117\u2013G1127","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"6840_CR115","doi-asserted-by":"crossref","first-page":"13815","DOI":"10.1523\/JNEUROSCI.5361-07.2008","volume":"28","author":"P Ramamoorthy","year":"2008","unstructured":"Ramamoorthy P, Whim MD (2008) Trafficking and fusion of neuropeptide Y-containing dense-core granules in astrocytes. J Neurosci 28:13815\u201313827","journal-title":"J Neurosci"},{"key":"6840_CR116","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/j.neurobiolaging.2005.09.022","volume":"27","author":"B Ramos","year":"2006","unstructured":"Ramos B, Baglietto-Vargas D, del Rio JC, Moreno-Gonzalez I, Santa-Maria C, Jimenez S, Caballero C, Lopez-Tellez JF, Khan ZU, Ruano D, Gutierrez A, Vitorica J (2006) Early neuropathology of somatostatin\/npy GABAergic cells in the hippocampus of a PS1xAPP Transgenic model of alzheimer\u2019s disease. Neurobiol Aging 27:1658\u20131672","journal-title":"Neurobiol Aging"},{"key":"6840_CR117","doi-asserted-by":"crossref","first-page":"110478","DOI":"10.1016\/j.pnpbp.2021.110478","volume":"114","author":"T Rana","year":"2022","unstructured":"Rana T, Behl T, Sehgal A, Singh S, Sharma N, Abdeen A, Ibrahim SF, Mani V, Iqbal MS, Bhatia S, Abdel Daim MM, Bungau S (2022) Exploring the role of neuropeptides in depression and anxiety. Prog Neuropsychopharmacol Biol Psychiatry 114:110478","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"6840_CR118","doi-asserted-by":"crossref","unstructured":"Rehfeld JF (2017) Cholecystokinin\u2014From local gut hormone to ubiquitous messenger. Front Endocrinol 8:47","DOI":"10.3389\/fendo.2017.00047"},{"key":"6840_CR119","doi-asserted-by":"crossref","first-page":"R139","DOI":"10.1530\/EC-21-0025","volume":"10","author":"JF Rehfeld","year":"2021","unstructured":"Rehfeld JF (2021) Cholecystokinin and the hormone concept. Endocr Connect 10:R139\u2013r150","journal-title":"Endocr Connect"},{"key":"6840_CR120","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.npep.2015.09.008","volume":"55","author":"F Reichmann","year":"2016","unstructured":"Reichmann F, Holzer P (2016) Neuropeptide Y: A stressful review. Neuropeptides 55:99\u2013109","journal-title":"Neuropeptides"},{"key":"6840_CR121","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1523\/JNEUROSCI.3579-15.2016","volume":"36","author":"DJ Reiner","year":"2016","unstructured":"Reiner DJ, Mietlicki-Baase EG, McGrath LE, Zimmer DJ, Bence KK, Sousa GL, Konanur VR, Krawczyk J, Burk DH, Kanoski SE, Hermann GE, Rogers RC, Hayes MR (2016) Astrocytes regulate GLP-1 Receptor-Mediated effects on energy balance. J Neurosci 36:3531\u20133540","journal-title":"J Neurosci"},{"key":"6840_CR122","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/med.22012","volume":"44","author":"K Saleki","year":"2024","unstructured":"Saleki K, Alijanizadeh P, Javanmehr N, Rezaei N (2024) The role of Toll-like receptors in neuropsychiatric disorders: immunopathology, treatment, and management. Med Res Rev 44:1267\u20131325","journal-title":"Med Res Rev"},{"key":"6840_CR123","doi-asserted-by":"crossref","first-page":"173878","DOI":"10.1016\/j.pbb.2024.173878","volume":"245","author":"KS Satao","year":"2024","unstructured":"Satao KS, Doshi GM (2024) Anxiety and the brain: neuropeptides as emerging factors. Pharmacol Biochem Behav 245:173878","journal-title":"Pharmacol Biochem Behav"},{"key":"6840_CR124","first-page":"251","volume":"2","author":"JP Schwartz","year":"1994","unstructured":"Schwartz JP, Taniwaki T (1994) Heterogeneity of expression of neuropeptide genes by astrocytes: functional implications. Perspect Dev Neurobiol 2:251\u2013257","journal-title":"Perspect Dev Neurobiol"},{"key":"6840_CR125","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1172\/JCI75276","volume":"124","author":"A Secher","year":"2014","unstructured":"Secher A, Jelsing J, Baquero AF, Hecksher-S\u00f8rensen J, Cowley MA, Dalb\u00f8ge LS, Hansen G, Grove KL, Pyke C, Raun K, Sch\u00e4ffer L, Tang-Christensen M, Verma S, Witgen BM, Vrang N, Bjerre Knudsen L (2014) The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss. J Clin Invest 124:4473\u20134488","journal-title":"J Clin Invest"},{"key":"6840_CR126","doi-asserted-by":"crossref","first-page":"106545","DOI":"10.1016\/j.isci.2023.106545","volume":"26","author":"MC Selles","year":"2023","unstructured":"Selles MC, Fortuna JTS, de Faria YPR, Siqueira LD, Lima-Filho R, Longo BM, Froemke RC, Chao MV, Ferreira ST (2023) Oxytocin attenuates microglial activation and restores social and non-social memory in APP\/PS1 alzheimer model mice. iScience 26:106545","journal-title":"iScience"},{"key":"6840_CR127","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s12974-019-1638-6","volume":"16","author":"Y Shan","year":"2019","unstructured":"Shan Y, Tan S, Lin Y, Liao S, Zhang B, Chen X, Wang J, Deng Z, Zeng Q, Zhang L, Wang Y, Hu X, Qiu W, Peng L, Lu Z (2019) The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke. J Neuroinflamm 16:242","journal-title":"J Neuroinflamm"},{"key":"6840_CR128","doi-asserted-by":"crossref","unstructured":"Shen YC, Sun X, Li L, Zhang HY, Huang ZL, Wang YQ (2022) Roles of neuropeptides in Sleep-Wake regulation. Int J Mol Sci 23:4599","DOI":"10.3390\/ijms23094599"},{"key":"6840_CR129","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bbr.2017.03.032","volume":"327","author":"L Shi","year":"2017","unstructured":"Shi L, Zhang Z, Li L, H\u00f6lscher C (2017) A novel dual GLP-1\/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the alzheimer icv. STZ rat model. Behav Brain Res 327:65\u201374","journal-title":"Behav Brain Res"},{"key":"6840_CR130","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3233\/JAD-190958","volume":"73","author":"S Shimizu","year":"2020","unstructured":"Shimizu S, Takenoshita N, Inagawa Y, Tsugawa A, Hirose D, Kaneko Y, Ogawa Y, Serisawa S, Sakurai S, Hirao K, Kanetaka H, Kanbayashi T, Imanishi A, Sakurai H, Hanyu H (2020) Positive association between cognitive function and cerebrospinal fluid orexin A levels in alzheimer\u2019s disease. J Alzheimers Dis 73:117\u2013123","journal-title":"J Alzheimers Dis"},{"key":"6840_CR131","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.it.2020.07.004","volume":"41","author":"MV Sofroniew","year":"2020","unstructured":"Sofroniew MV (2020) Astrocyte reactivity: subtypes, states, and functions in CNS innate immunity. Trends Immunol 41:758\u2013770","journal-title":"Trends Immunol"},{"key":"6840_CR132","doi-asserted-by":"crossref","first-page":"e29790","DOI":"10.1371\/journal.pone.0029790","volume":"7","author":"M Song","year":"2012","unstructured":"Song M, Xiong JX, Wang YY, Tang J, Zhang B, Bai Y (2012) VIP enhances phagocytosis of fibrillar beta-amyloid by microglia and attenuates amyloid deposition in the brain of APP\/PS1 mice. PLoS ONE 7:e29790","journal-title":"PLoS ONE"},{"key":"6840_CR133","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1161\/HYPERTENSIONAHA.114.04691","volume":"65","author":"S Sriramula","year":"2015","unstructured":"Sriramula S, Xia H, Xu P, Lazartigues E (2015) Brain-Targeted Angiotensin-Converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting Cyclooxygenase-Mediated inflammation. Hypertension 65:577\u2013586","journal-title":"Hypertension"},{"key":"6840_CR134","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1073\/pnas.0712303105","volume":"105","author":"D Stanic","year":"2008","unstructured":"Stanic D, Paratcha G, Ledda F, Herzog H, Kopin AS, H\u00f6kfelt T (2008) Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain. Proc Natl Acad Sci U S A 105:3610\u20133615","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6840_CR135","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s13311-018-00694-0","volume":"16","author":"V Sudhakar","year":"2019","unstructured":"Sudhakar V, Richardson RM (2019) Gene therapy for neurodegenerative diseases. Neurotherapeutics 16:166\u2013175","journal-title":"Neurotherapeutics"},{"key":"6840_CR136","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.bbi.2020.10.014","volume":"91","author":"J Sun","year":"2021","unstructured":"Sun J, Li H, Jin Y, Yu J, Mao S, Su KP, Ling Z, Liu J (2021a) Probiotic Clostridium butyricum ameliorated motor deficits in a mouse model of parkinson\u2019s disease via gut microbiota-GLP-1 pathway. Brain Behav Immun 91:703\u2013715","journal-title":"Brain Behav Immun"},{"key":"6840_CR137","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000514963","volume":"45","author":"Y Sun","year":"2021","unstructured":"Sun Y, Tisdale RK, Kilduff TS (2021b) Hypocretin\/Orexin receptor Pharmacology and sleep phases. Front Neurol Neurosci 45:22\u201337","journal-title":"Front Neurol Neurosci"},{"key":"6840_CR138","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fnins.2013.00029","volume":"7","author":"G Sundstr\u00f6m","year":"2013","unstructured":"Sundstr\u00f6m G, Larsson TA, Xu B, Heldin J, Larhammar D (2013) Interactions of zebrafish peptide YYb with the neuropeptide Y-family receptors Y4, Y7, Y8a, and Y8b. Front Neurosci 7:29","journal-title":"Front Neurosci"},{"key":"6840_CR139","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1253\/circj.CJ-18-0428","volume":"83","author":"M Takefuji","year":"2019","unstructured":"Takefuji M, Murohara T (2019) Corticotropin-Releasing hormone family and their receptors in the cardiovascular system. Circ J 83:261\u2013266","journal-title":"Circ J"},{"key":"6840_CR140","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11010-020-03834-3","volume":"474","author":"R Tang","year":"2020","unstructured":"Tang R, Xu Z (2020) Gene therapy: a double-edged sword with great powers. Mol Cell Biochem 474:73\u201381","journal-title":"Mol Cell Biochem"},{"key":"6840_CR141","doi-asserted-by":"crossref","first-page":"11908","DOI":"10.3390\/ijms252211908","volume":"25","author":"A Tillinger","year":"2024","unstructured":"Tillinger A, Zvozilov\u00e1 A, Mach M, Horv\u00e1thov\u00e1 \u013d, Dziewiczov\u00e1 L, Osack\u00e1 J (2024) Single intranasal administration of Ucn3 affects the development of PTSD symptoms in an animal model. Int J Mol Sci 25:11908","journal-title":"Int J Mol Sci"},{"key":"6840_CR142","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s12035-022-03061-5","volume":"60","author":"P Tiwari","year":"2023","unstructured":"Tiwari P, Tiwari V, Gupta S, Shukla S, Hanif K (2023) Activation of Angiotensin-converting enzyme 2 protects against Lipopolysaccharide-induced glial activation by modulating Angiotensin-converting enzyme 2\/angiotensin (1\u20137)\/Mas receptor Axis. Mol Neurobiol 60:203\u2013227","journal-title":"Mol Neurobiol"},{"key":"6840_CR143","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000514960","volume":"45","author":"B Toor","year":"2021","unstructured":"Toor B, Ray LB, Pozzobon A, Fogel SM (2021) Sleep, orexin and cognition. Front Neurol Neurosci 45:38\u201351","journal-title":"Front Neurol Neurosci"},{"key":"6840_CR144","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12031-011-9618-z","volume":"46","author":"N Tun\u00e7el","year":"2012","unstructured":"Tun\u00e7el N, Korkmaz OT, Tekin N, \u015eener E, Aky\u00fcz F, \u0130nal M (2012) Antioxidant and Anti-Apoptotic activity of vasoactive intestinal peptide (VIP) against 6-Hydroxy dopamine toxicity in the rat Corpus striatum. J Mol Neurosci 46:51\u201357","journal-title":"J Mol Neurosci"},{"key":"6840_CR145","doi-asserted-by":"crossref","first-page":"12199","DOI":"10.1038\/ncomms12199","volume":"7","author":"LW Tung","year":"2016","unstructured":"Tung LW, Lu GL, Lee YH, Yu L, Lee HJ, Leishman E, Bradshaw H, Hwang LL, Hung MS, Mackie K, Zimmer A, Chiou LC (2016) Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons. Nat Commun 7:12199","journal-title":"Nat Commun"},{"key":"6840_CR146","first-page":"245","volume":"39","author":"W Vale","year":"1983","unstructured":"Vale W, Rivier C, Brown MR, Spiess J, Koob G, Swanson L, Bilezikjian L, Bloom F, Rivier J (1983) Chemical and biological characterization of Corticotropin releasing factor. Recent Prog Horm Res 39:245\u2013270","journal-title":"Recent Prog Horm Res"},{"issue":"Suppl 3","key":"6840_CR147","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1097\/01.ASN.0000032549.36050.78","volume":"13","author":"M Volpe","year":"2002","unstructured":"Volpe M, Savoia C, De Paolis P, Ostrowska B, Tarasi D, Rubattu S (2002) The renin-angiotensin system as a risk factor and therapeutic target for cardiovascular and renal disease. J Am Soc Nephrol 13(Suppl 3):S173\u2013S178","journal-title":"J Am Soc Nephrol"},{"key":"6840_CR148","doi-asserted-by":"crossref","unstructured":"Vuppaladhadiam L, Ehsan C, Akkati M, Bhargava A (2020) Corticotropin-releasing factor family: a stress hormone-receptor system\u2019s emerging role in mediating sex-specific signaling. Cells 9","DOI":"10.3390\/cells9040839"},{"key":"6840_CR149","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/s41593-021-00800-0","volume":"24","author":"J Wahis","year":"2021","unstructured":"Wahis J, Baudon A, Althammer F, Kerspern D, Goyon S, Hagiwara D, Lefevre A, Barteczko L, Boury-Jamot B, Bellanger B, Abatis M, Da Silva Gouveia M, Benusiglio D, Eliava M, Rozov A, Weinsanto I, Knobloch-Bollmann HS, Kirchner MK, Roy RK, Wang H, Pertin M, Inquimbert P, Pitzer C, Siemens J, Goumon Y, Boutrel B, Lamy CM, Decosterd I, Chatton JY, Rouach N, Young WS, Stern JE, Poisbeau P, Stoop R, Darbon P, Grinevich V, Charlet A (2021) Astrocytes mediate the effect of Oxytocin in the central amygdala on neuronal activity and affective States in rodents. Nat Neurosci 24:529\u2013541","journal-title":"Nat Neurosci"},{"key":"6840_CR150","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.biopha.2018.07.148","volume":"107","author":"Y Wang","year":"2018","unstructured":"Wang Y, Zhao S, Liu X, Zheng Y, Li L, Meng S (2018) Oxytocin improves animal behaviors and ameliorates oxidative stress and inflammation in autistic mice. Biomed Pharmacother 107:262\u2013269","journal-title":"Biomed Pharmacother"},{"key":"6840_CR151","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1007\/s12035-020-02171-2","volume":"58","author":"J Wang","year":"2021","unstructured":"Wang J, Hou Y, Zhang L, Liu M, Zhao J, Zhang Z, Ma Y, Hou W (2021) Estrogen attenuates traumatic brain injury by inhibiting the activation of microglia and Astrocyte-Mediated neuroinflammatory responses. Mol Neurobiol 58:1052\u20131061","journal-title":"Mol Neurobiol"},{"key":"6840_CR152","doi-asserted-by":"crossref","first-page":"104762","DOI":"10.1016\/j.neubiorev.2022.104762","volume":"139","author":"X Wang","year":"2022","unstructured":"Wang X, Yang J, Hashimoto K (2022) (R)-ketamine as prophylactic and therapeutic drug for neurological disorders: beyond depression. Neurosci Biobehavioral Reviews 139:104762","journal-title":"Neurosci Biobehavioral Reviews"},{"key":"6840_CR153","doi-asserted-by":"crossref","first-page":"e0041523","DOI":"10.1128\/msystems.00415-23","volume":"8","author":"X Wang","year":"2023","unstructured":"Wang X, Sun Z, Yang T, Lin F, Ye S, Yan J, Li T, Chen J (2023a) Sodium butyrate facilitates CRHR2 expression to alleviate HPA axis hyperactivity in autism-like rats induced by prenatal lipopolysaccharides through histone deacetylase Inhibition. mSystems 8:e0041523","journal-title":"mSystems"},{"key":"6840_CR154","doi-asserted-by":"crossref","first-page":"109716","DOI":"10.1016\/j.neuropharm.2023.109716","volume":"240","author":"Z-J Wang","year":"2023","unstructured":"Wang Z-J, Li X-R, Chai S-F, Li W-R, Li S, Hou M, Li J-L, Ye Y-C, Cai H-Y, H\u00f6lscher C, Wu M-N (2023b) Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of alzheimer\u2019s disease via the GLP-1R\/SIRT1\/GLUT4 pathway. Neuropharmacology 240:109716","journal-title":"Neuropharmacology"},{"key":"6840_CR155","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S1734-1140(11)70583-7","volume":"63","author":"A Woldan-Tambor","year":"2011","unstructured":"Woldan-Tambor A, Biega\u0144ska K, Wiktorowska-Owczarek A, Zawilska JB (2011) Activation of orexin\/hypocretin type 1 receptors stimulates cAMP synthesis in primary cultures of rat astrocytes. Pharmacol Rep 63:717\u2013723","journal-title":"Pharmacol Rep"},{"key":"6840_CR156","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0006-8993(00)02922-X","volume":"887","author":"C-K Won","year":"2000","unstructured":"Won C-K, Oh YS (2000) cAMP-induced stellation in primary astrocyte cultures with regional heterogeneity. Brain Res 887:250\u2013258","journal-title":"Brain Res"},{"key":"6840_CR157","doi-asserted-by":"crossref","unstructured":"Wright JW, Kawas LH, Harding JW (2013) A role for the brain RAS in alzheimer\u2019s and parkinson\u2019s diseases. Front Endocrinol 4:158","DOI":"10.3389\/fendo.2013.00158"},{"key":"6840_CR158","doi-asserted-by":"crossref","first-page":"166230","DOI":"10.1016\/j.bbadis.2021.166230","volume":"1867","author":"D Xu","year":"2021","unstructured":"Xu D, Kong T, Shao Z, Liu M, Zhang R, Zhang S, Kong Q, Chen J, Cheng B, Wang C (2021a) Orexin-A alleviates astrocytic apoptosis and inflammation via inhibiting OX1R-mediated NF-\u03baB and MAPK signaling pathways in cerebral ischemia\/reperfusion injury. Biochim Biophys Acta Mol Basis Dis 1867:166230","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"6840_CR159","doi-asserted-by":"crossref","first-page":"109839","DOI":"10.1016\/j.cellsig.2020.109839","volume":"79","author":"D Xu","year":"2021","unstructured":"Xu D, Kong T, Zhang S, Cheng B, Chen J, Wang C (2021b) Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated mapk\/erk\/mtor pathway. Cell Signal 79:109839","journal-title":"Cell Signal"},{"key":"6840_CR160","first-page":"493","volume":"47","author":"J Ye","year":"2018","unstructured":"Ye J, Sun Z, Hu W (2018) [Roles of astrocytes in cerebral infarction and related therapeutic strategies]. Zhejiang Da Xue Xue Bao Yi Xue Ban 47:493\u2013498","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"key":"6840_CR161","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s12031-016-0757-0","volume":"59","author":"\u0130H Yelkenli","year":"2016","unstructured":"Yelkenli \u0130H, Ulupinar E, Korkmaz OT, \u015eener E, Ku\u015f G, Filiz Z, Tun\u00e7el N (2016) Modulation of Corpus striatal neurochemistry by astrocytes and vasoactive intestinal peptide (VIP) in parkinsonian rats. J Mol Neurosci 59:280\u2013289","journal-title":"J Mol Neurosci"},{"key":"6840_CR162","doi-asserted-by":"crossref","first-page":"7037","DOI":"10.1007\/s12035-024-04025-7","volume":"61","author":"L Zhai","year":"2024","unstructured":"Zhai L, Sheng Y, Wang J, Zhou X, Li W, Wu S, Yang Y (2024) Atractylenolide I suppresses A1 astrocyte activation to improve depression in mice. Mol Neurobiol 61:7037\u20137045","journal-title":"Mol Neurobiol"},{"key":"6840_CR163","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1210\/en.2017-00336","volume":"159","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Zheng Y, Xu Y, Sheng H, Ni X (2018) Corticotropin-Releasing hormone suppresses synapse formation in the Hippocampus of male rats via Inhibition of CXCL5 secretion by glia. Endocrinology 159:622\u2013638","journal-title":"Endocrinology"},{"key":"6840_CR164","doi-asserted-by":"crossref","first-page":"111529","DOI":"10.1016\/j.mce.2021.111529","volume":"542","author":"M Zhang","year":"2022","unstructured":"Zhang M, Wu Y, Gao R, Chen X, Chen R, Chen Z (2022a) Glucagon-like peptide-1 analogs mitigate neuroinflammation in alzheimer\u2019s disease by suppressing NLRP2 activation in astrocytes. Mol Cell Endocrinol 542:111529","journal-title":"Mol Cell Endocrinol"},{"key":"6840_CR165","doi-asserted-by":"crossref","first-page":"943","DOI":"10.14336\/AD.2021.1029","volume":"13","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Liu C, Shi R, Zhou S, Shan H, Deng L, Chen T, Guo Y, Zhang Z, Yang G-Y, Wang Y, Tang Y (2022b) Blocking C3d+\/GFAP+ A1 astrocyte conversion with semaglutide attenuates blood-brain barrier disruption in mice after ischemic stroke. Aging Disease 13:943\u2013959","journal-title":"Aging Disease"},{"key":"6840_CR166","doi-asserted-by":"crossref","unstructured":"Zhang Z, Li H, Su Y, Ma J, Yuan Y, Yu Z, Shi M, Shao S, Zhang Z, H\u00f6lscher C (2022c) Neuroprotective effects of a cholecystokinin analogue in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine parkinson\u2019s disease mouse model. Frontiers in Neuroscience 16:814430","DOI":"10.3389\/fnins.2022.814430"},{"key":"6840_CR167","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1038\/s41380-023-02127-7","volume":"28","author":"X Zhang","year":"2023","unstructured":"Zhang X, Asim M, Fang W, Md Monir H, Wang H, Kim K, Feng H, Wang S, Gao Q, Lai Y, He J (2023) Cholecystokinin B receptor antagonists for the treatment of depression via blocking long-term potentiation in the basolateral amygdala. Mol Psychiatry 28:3459\u20133474","journal-title":"Mol Psychiatry"},{"key":"6840_CR168","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13195-024-01472-1","volume":"16","author":"N Zhang","year":"2024","unstructured":"Zhang N, Sui Y, Jendrichovsky P, Feng H, Shi H, Zhang X, Xu S, Sun W, Zhang H, Chen X, Tortorella MD, He J (2024) Cholecystokinin B receptor agonists alleviates anterograde amnesia in cholecystokinin-deficient and aged alzheimer\u2019s disease mice. Alzheimers Res Ther 16:109","journal-title":"Alzheimers Res Ther"},{"key":"6840_CR169","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1210\/en.2015-1812","volume":"157","author":"Y Zheng","year":"2016","unstructured":"Zheng Y, Zhang YM, Ni X (2016) Urocortin 2 but not urocortin 3 promotes the synaptic formation in Hipppocampal neurons via induction of NGF production by astrocytes. Endocrinology 157:1200\u20131210","journal-title":"Endocrinology"},{"key":"6840_CR170","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41392-024-01931-z","volume":"9","author":"Z Zheng","year":"2024","unstructured":"Zheng Z, Zong Y, Ma Y, Tian Y, Pang Y, Zhang C, Gao J (2024) Glucagon-like peptide-1 receptor: mechanisms and advances in therapy. Signal Transduct Target Ther 9:234","journal-title":"Signal Transduct Target Ther"},{"key":"6840_CR171","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/cns.13123","volume":"25","author":"B Zhou","year":"2019","unstructured":"Zhou B, Zuo YX, Jiang RT (2019) Astrocyte morphology: diversity, plasticity, and role in neurological diseases. CNS Neurosci Ther 25:665\u2013673","journal-title":"CNS Neurosci Ther"},{"key":"6840_CR172","doi-asserted-by":"crossref","unstructured":"Zhu J, Tang J (2020) LncRNA Gm14205 induces astrocytic NLRP3 inflammasome activation via inhibiting Oxytocin receptor in postpartum depression. Biosci Rep 40:BSR20200672","DOI":"10.1042\/BSR20200672"},{"key":"6840_CR173","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.psychres.2014.11.048","volume":"226","author":"JB Zik","year":"2015","unstructured":"Zik JB, Roberts DL (2015) The many faces of oxytocin: implications for psychiatry. Psychiatry Res 226:31\u201337","journal-title":"Psychiatry Res"},{"key":"6840_CR174","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1046\/j.1471-4159.1998.70052165.x","volume":"70","author":"V Zupan","year":"1998","unstructured":"Zupan V, Hill JM, Brenneman DE, Gozes I, Fridkin M, Robberecht P, Evrard P, Gressens P (1998) Involvement of pituitary adenylate cyclase-activating polypeptide II vasoactive intestinal peptide 2 receptor in mouse neocortical astrocytogenesis. J Neurochem 70:2165\u20132173","journal-title":"J Neurochem"},{"key":"6840_CR175","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.regpep.2004.05.021","volume":"123","author":"M Zusev","year":"2004","unstructured":"Zusev M, Gozes I (2004) Differential regulation of activity-dependent neuroprotective protein in rat astrocytes by VIP and PACAP. Regul Pept 123:33\u201341","journal-title":"Regul Pept"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-025-06840-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-025-06840-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-025-06840-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:47:34Z","timestamp":1761907654000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-025-06840-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,19]]},"references-count":175,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["6840"],"URL":"https:\/\/doi.org\/10.1007\/s00213-025-06840-9","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,19]]},"assertion":[{"value":"8 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Neither generative AI nor AI-assisted technologies were used throughout the entire writing process.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors do not have any competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}