{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:57:50Z","timestamp":1783339070702,"version":"3.54.6"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271747"],"award-info":[{"award-number":["82271747"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00213-025-06862-3","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T10:57:39Z","timestamp":1754650659000},"page":"2619-2632","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Application of nanomaterials in central nervous system disorders"],"prefix":"10.1007","volume":"242","author":[{"given":"Yixuan","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yani","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangming","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuying","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congying","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7609-0944","authenticated-orcid":false,"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"issue":"8","key":"6862_CR1","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1111\/j.1528-1167.2008.01615.x","volume":"49","author":"M Akhtari","year":"2008","unstructured":"Akhtari M, Bragin A, Cohen M (2008) Functionalized magnetonanoparticles for MRI diagnosis and localization in epilepsy. Epilepsia 49(8):1419\u20131430","journal-title":"Epilepsia"},{"issue":"1","key":"6862_CR2","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3109\/17435390.2011.626538","volume":"7","author":"CE Albers","year":"2013","unstructured":"Albers CE, Hofstetter W, Siebenrock KA et al (2013) In vitro cytotoxicity of silver nanoparticles on osteoblasts and osteoclasts at antibacterial concentrations. Nanotoxicology 7(1):30\u201336","journal-title":"Nanotoxicology"},{"issue":"4","key":"6862_CR3","doi-asserted-by":"publisher","first-page":"3462","DOI":"10.3390\/cimb45040227","volume":"45","author":"N Alnaqbi","year":"2023","unstructured":"Alnaqbi N, Mohammad MG, Hamoudi R et al (2023) Molecular heterogeneity of the brain endothelium. Curr Issues Mol Biol 45(4):3462\u20133478","journal-title":"Curr Issues Mol Biol"},{"issue":"10","key":"6862_CR4","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1039\/D2NA00534D","volume":"5","author":"M Awashra","year":"2023","unstructured":"Awashra M, Mlynarz P (2023) The toxicity of nanoparticles and their interaction with cells: an in vitro metabolomic perspective. Nanoscale Adv 5(10):2674\u20132723","journal-title":"Nanoscale Adv"},{"key":"6862_CR5","doi-asserted-by":"crossref","unstructured":"Bakchine S (2019) Commentary: treating Alzheimer's disease: combine or fail?[J]. J Prev Alzheimer\u2019s Dis 6(3):174\u2013176","DOI":"10.14283\/jpad.2019.16"},{"issue":"10291","key":"6862_CR6","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","volume":"397","author":"BR Bloem","year":"2021","unstructured":"Bloem BR, Okun MS, Klein C (2021) Parkinson\u2019s disease. Lancet 397(10291):2284\u20132303","journal-title":"Lancet"},{"issue":"Pt A","key":"6862_CR7","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.mad.2016.06.008","volume":"161","author":"LM Buhlman","year":"2017","unstructured":"Buhlman LM (2017) Parkin loss-of-function pathology: premature neuronal senescence induced by high levels of reactive oxygen species? Mech Ageing Dev 161(Pt A):112\u2013120","journal-title":"Mech Ageing Dev"},{"issue":"3","key":"6862_CR8","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/j.1365-2141.2005.05444.x","volume":"129","author":"G Cesarman-Maus","year":"2005","unstructured":"Cesarman-Maus G, Hajjar KA (2005) Molecular mechanisms of fibrinolysis. Br J Haematol 129(3):307\u2013321","journal-title":"Br J Haematol"},{"issue":"12","key":"6862_CR9","doi-asserted-by":"publisher","first-page":"12224","DOI":"10.1021\/acsnano.8b06021","volume":"12","author":"M Colasuonno","year":"2018","unstructured":"Colasuonno M, Palange AL, Aid R et al (2018) Erythrocyte-inspired discoidal polymeric nanoconstructs carrying tissue plasminogen activator for the enhanced lysis of blood clots. ACS Nano 12(12):12224\u201312237","journal-title":"ACS Nano"},{"key":"6862_CR10","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.brainresbull.2019.11.017","volume":"155","author":"VA Cutinho","year":"2020","unstructured":"Cutinho VA, Mourya LI (2020) Approaches for encephalic drug delivery using nanomaterials: the current status[J]. Brain Res Bull 155:184\u2013190","journal-title":"Brain Res Bull"},{"issue":"3","key":"6862_CR11","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1002\/jbm.a.31298","volume":"84","author":"GC de Ruiter","year":"2008","unstructured":"de Ruiter GC, Onyeneho IA, Liang ET et al (2008) Methods for in vitro characterization of multichannel nerve tubes[J]. J Biomed Mater Res A 84(3):643\u2013651","journal-title":"J Biomed Mater Res A"},{"issue":"6","key":"6862_CR12","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.7150\/thno.21254","volume":"8","author":"X Dong","year":"2018","unstructured":"Dong X (2018) Current strategies for brain drug delivery. Theranostics 8(6):1481\u20131493","journal-title":"Theranostics"},{"issue":"2","key":"6862_CR13","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/jnr.23320","volume":"92","author":"YH Edrey","year":"2014","unstructured":"Edrey YH, Oddo S, Cornelius C et al (2014) Oxidative damage and amyloid-beta metabolism in brain regions of the longest-lived rodents[J]. J Neurosci Res 92(2):195\u2013205","journal-title":"J Neurosci Res"},{"issue":"2","key":"6862_CR14","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1002\/path.2089","volume":"211","author":"MM Esiri","year":"2007","unstructured":"Esiri MM (2007) Ageing and the brain. J Pathol 211(2):181\u2013187","journal-title":"J Pathol"},{"key":"6862_CR15","doi-asserted-by":"crossref","unstructured":"Fang X, Border JJ, Zhang H et al (2025) A soluble epoxide hydrolase inhibitor improves cerebrovascular dysfunction, neuroinflammation, amyloid burden, and cognitive impairments in the hAPP\/PS1 TgF344-AD rat model of Alzheimer\u2019s disease[J]. Int J Mol Sci 26(6):2433","DOI":"10.3390\/ijms26062433"},{"issue":"3","key":"6862_CR16","doi-asserted-by":"publisher","first-page":"246","DOI":"10.5607\/en.2014.23.3.246","volume":"23","author":"PY Gambaryan","year":"2014","unstructured":"Gambaryan PY, Kondrasheva IG, Severin ES et al (2014) Increasing the efficiency of Parkinson\u2019s disease treatment using a poly(lactic-co-glycolic acid) (PLGA) based L-DOPA delivery system. Exp Neurobiol 23(3):246\u2013252","journal-title":"Exp Neurobiol"},{"issue":"4","key":"6862_CR17","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1007\/s12274-016-1000-6","volume":"9","author":"N Gao","year":"2016","unstructured":"Gao N, Dong K, Zhao A et al (2016) Polyoxometalate-based nanozyme: design of a multifunctional enzyme for multi-faceted treatment of Alzheimer\u2019s disease. Nano Res 9(4):1079\u20131090","journal-title":"Nano Res"},{"issue":"23","key":"6862_CR18","doi-asserted-by":"publisher","first-page":"5077","DOI":"10.1039\/D2NA00353H","volume":"4","author":"A Grebinyk","year":"2022","unstructured":"Grebinyk A, Prylutska S, Grebinyk S et al (2022) Drug delivery with a pH-sensitive star-like dextran-graft polyacrylamide copolymer. Nanoscale Adv 4(23):5077\u20135088","journal-title":"Nanoscale Adv"},{"key":"6862_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.105795","volume":"97","author":"E Guler","year":"2024","unstructured":"Guler E, Kopuz A, Ertas B et al (2024) Anti-Alzheimer\u2019s effect of memantine\/donepezil\/metformin-loaded PVA\/PEO composite nanofibers produced by pressurized gyration: production, characterization, and in vitro evaluation. J Drug Deliv Sci Technol 97:105795","journal-title":"J Drug Deliv Sci Technol"},{"issue":"3","key":"6862_CR20","doi-asserted-by":"publisher","first-page":"537","DOI":"10.4103\/1673-5374.293155","volume":"16","author":"X He","year":"2021","unstructured":"He X, Yang L, Wang Z et al (2021) Solid lipid nanoparticles loading with Curcumin and dexanabinol to treat major depressive disorder. Neural Regen Res 16(3):537\u2013542","journal-title":"Neural Regen Res"},{"issue":"6","key":"6862_CR21","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1080\/17425247.2024.2375400","volume":"21","author":"Y He","year":"2024","unstructured":"He Y, Wang Y, Wang L et al (2024) Understanding nanoparticle-liver interactions in nanomedicine[J]. Expert Opin Drug Deliv 21(6):829\u2013843","journal-title":"Expert Opin Drug Deliv"},{"issue":"10","key":"6862_CR22","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1007\/s11095-013-1005-8","volume":"30","author":"R Huang","year":"2013","unstructured":"Huang R, Ma H, Guo Y et al (2013) Angiopep-conjugated nanoparticles for targeted long-term gene therapy of Parkinson\u2019s disease. Pharm Res 30(10):2549\u20132559","journal-title":"Pharm Res"},{"key":"6862_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101556","volume":"46","author":"L Huang","year":"2022","unstructured":"Huang L, Zhang X, Ding Z et al (2022) PEGylated 2D-nanomaterials alleviate parkinson\u2019s disease by shielding PIP2 lipids to inhibit IP3 second messenger signaling. Nano Today 46:101556","journal-title":"Nano Today"},{"issue":"1","key":"6862_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-019-0965-z","volume":"18","author":"G Hussain","year":"2019","unstructured":"Hussain G, Wang J, Rasul A et al (2019) Role of cholesterol and sphingolipids in brain development and neurological diseases. Lipids Health Dis 18(1):26","journal-title":"Lipids Health Dis"},{"issue":"8","key":"6862_CR25","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1007\/s10571-019-00707-2","volume":"39","author":"J Jia","year":"2019","unstructured":"Jia J, Li C, Zhang T et al (2019) CeO(2)@PAA-LXW7 attenuates LPS-Induced inflammation in BV2 Microglia[J]. Cell Mol Neurobiol 39(8):1125\u20131137","journal-title":"Cell Mol Neurobiol"},{"key":"6862_CR26","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.biomaterials.2017.11.047","volume":"156","author":"M Juenet","year":"2018","unstructured":"Juenet M, Aid-Launais R, Li B et al (2018) Thrombolytic therapy based on fucoidan-functionalized polymer nanoparticles targeting P-selectin. Biomaterials 156:204\u2013216","journal-title":"Biomaterials"},{"issue":"4","key":"6862_CR27","doi-asserted-by":"publisher","first-page":"413","DOI":"10.3109\/17435390.2014.933903","volume":"9","author":"T Kasai","year":"2015","unstructured":"Kasai T, Umeda Y, Ohnishi M et al (2015) Thirteen-week study of toxicity of fiber-like multi-walled carbon nanotubes with whole-body inhalation exposure in rats. Nanotoxicology 9(4):413\u2013422","journal-title":"Nanotoxicology"},{"issue":"8","key":"6862_CR28","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1080\/03639045.2023.2244075","volume":"49","author":"S Kataria","year":"2023","unstructured":"Kataria S, Roy S, Chaurasia M et al (2023) Crisaborole loaded nanoemulgel for the mitigation of atopic dermatitis in mice model. Drug Dev Ind Pharm 49(8):521\u2013535","journal-title":"Drug Dev Ind Pharm"},{"key":"6862_CR29","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.2147\/IJN.S239608","volume":"15","author":"L Kong","year":"2020","unstructured":"Kong L, Li X, Ni Y et al (2020) Transferrin-Modified osthole pegylated liposomes travel the Blood-Brain barrier and mitigate alzheimer\u2019s Disease-Related pathology in APP\/PS-1 Mice[J]. Int J Nanomed 15:2841\u20132858","journal-title":"Int J Nanomed"},{"issue":"30","key":"6862_CR30","doi-asserted-by":"publisher","first-page":"9408","DOI":"10.1002\/anie.201805052","volume":"57","author":"HJ Kwon","year":"2018","unstructured":"Kwon HJ, Kim D, Seo K et al (2018) Ceria nanoparticle systems for selective scavenging of mitochondrial, intracellular, and extracellular reactive oxygen species in parkinson\u2019s Disease[J]. Angew Chem Int Ed Engl 57(30):9408\u20139412","journal-title":"Angew Chem Int Ed Engl"},{"issue":"7","key":"6862_CR31","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/s41551-018-0252-8","volume":"2","author":"B Lee","year":"2018","unstructured":"Lee B, Lee K, Panda S et al (2018) Nanoparticle delivery of CRISPR into the brain rescues a mouse model of fragile X syndrome from exaggerated repetitive behaviours. Nat Biomed Eng 2(7):497\u2013507","journal-title":"Nat Biomed Eng"},{"key":"6862_CR32","doi-asserted-by":"publisher","first-page":"134356","DOI":"10.1016\/j.cej.2021.134356","volume":"432","author":"L Lei","year":"2022","unstructured":"Lei L, Tu Q, Jiao L et al (2022) Reactive oxygen species scavenging by hemin-based nanosheets reduces parkinson\u2019s disease symptoms in an animal model[J]. Chem Eng J 432:134356","journal-title":"Chem Eng J"},{"issue":"2","key":"6862_CR33","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S1474-4422(18)30405-8","volume":"18","author":"PA LeWitt","year":"2019","unstructured":"LeWitt PA, Hauser RA, Pahwa R et al (2019) Safety and efficacy of CVT-301 (levodopa inhalation powder) on motor function during off periods in patients with parkinson\u2019s disease: a randomised, double-blind, placebo-controlled phase 3 trial. Lancet Neurol 18(2):145\u2013154","journal-title":"Lancet Neurol"},{"issue":"39","key":"6862_CR34","doi-asserted-by":"publisher","first-page":"e2204976","DOI":"10.1002\/adma.202204976","volume":"34","author":"S Li","year":"2022","unstructured":"Li S, Wang Y, Wu M et al (2022) Spleen-Targeted Glabridin-Loaded nanoparticles regulate polarization of monocyte\/macrophage (M(o) \/M(phi)) for the treatment of cerebral Ischemia-Reperfusion Injury[J]. Adv Mater 34(39):e2204976","journal-title":"Adv Mater"},{"issue":"3","key":"6862_CR35","doi-asserted-by":"publisher","first-page":"3116","DOI":"10.1021\/acsami.3c15083","volume":"16","author":"S Li","year":"2024","unstructured":"Li S, Chen Z, Wang M et al (2024) Ultrasmall Cu(2)O@His nanozymes with RONS scavenging capability for anti-inflammatory therapy. ACS Appl Mater Interfaces 16(3):3116\u20133125","journal-title":"ACS Appl Mater Interfaces"},{"issue":"2","key":"6862_CR36","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/wnan.1304","volume":"7","author":"Z Lin","year":"2015","unstructured":"Lin Z, Monteiro-Riviere NA, Riviere JE (2015) Pharmacokinetics of metallic nanoparticles[J]. Wiley Interdiscip Rev Nanomed Nanobiotechnol 7(2):189\u2013217","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"issue":"2","key":"6862_CR37","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1148\/radiol.10090699","volume":"255","author":"H Liu","year":"2010","unstructured":"Liu H, Hua M, Chen P et al (2010) Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment. Radiology 255(2):415\u2013425","journal-title":"Radiology"},{"issue":"3","key":"6862_CR38","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.biomaterials.2012.10.017","volume":"34","author":"X Liu","year":"2013","unstructured":"Liu X, An C, Jin P et al (2013) Protective effects of cationic bovine serum albumin-conjugated pegylated Tanshinone IIA nanoparticles on cerebral ischemia. Biomaterials 34(3):817\u2013830","journal-title":"Biomaterials"},{"key":"6862_CR39","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00043","author":"J Liu","year":"2019","unstructured":"Liu J, Chang L, Song Y et al (2019) The role of NMDA receptors in Alzheimer\u2019s disease. Front Neurosci 8:13:43. https:\/\/doi.org\/10.3389\/fnins.2019.00043","journal-title":"Front Neurosci"},{"issue":"2","key":"6862_CR40","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","volume":"179","author":"JM Long","year":"2019","unstructured":"Long JM, Holtzman DM (2019) Alzheimer disease: an update on pathobiology and treatment strategies. Cell 179(2):312\u2013339","journal-title":"Cell"},{"key":"6862_CR41","doi-asserted-by":"publisher","unstructured":"Ma C, Hong F, Yang S (2022) Amyloidosis in Alzheimer\u2019s disease: pathogeny, etiology, and related therapeutic directions. Molecules 27(4):1210.\u00a0https:\/\/doi.org\/10.3390\/molecules27041210","DOI":"10.3390\/molecules27041210"},{"issue":"12","key":"6862_CR42","doi-asserted-by":"publisher","first-page":"5110","DOI":"10.1039\/c1nr10797f","volume":"3","author":"MA Malvindi","year":"2011","unstructured":"Malvindi MA, Di Corato R, Curcio A et al (2011) Multiple functionalization of fluorescent nanoparticles for specific biolabeling and drug delivery of dopamine. Nanoscale 3(12):5110\u20135119","journal-title":"Nanoscale"},{"key":"6862_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111354","volume":"137","author":"PK Mante","year":"2021","unstructured":"Mante PK, Adomako NO, Antwi P et al (2021) Solid-lipid nanoparticle formulation improves antiseizure action of cryptolepine. Biomed Pharmacother 137:111354","journal-title":"Biomed Pharmacother"},{"key":"6862_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108352","volume":"190","author":"G Marucci","year":"2021","unstructured":"Marucci G, Buccioni M, Ben DD et al (2021) Efficacy of acetylcholinesterase inhibitors in Alzheimer\u2019s disease. Neuropharmacology 190:108352","journal-title":"Neuropharmacology"},{"issue":"11","key":"6862_CR45","doi-asserted-by":"publisher","first-page":"4375","DOI":"10.7150\/thno.95614","volume":"14","author":"C Miao","year":"2024","unstructured":"Miao C, Shen Y, Lang Y et al (2024) Biomimetic nanoparticles with enhanced Rapamycin delivery for autism spectrum disorder treatment via autophagy activation and oxidative stress modulation. Theranostics 14(11):4375\u20134392","journal-title":"Theranostics"},{"key":"6862_CR46","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.neuroscience.2014.05.019","volume":"274","author":"MM Migliore","year":"2014","unstructured":"Migliore MM, Ortiz R, Dye S et al (2014) Neurotrophic and neuroprotective efficacy of intranasal GDNF in a rat model of parkinson\u2019s disease. Neuroscience 274:11\u201323","journal-title":"Neuroscience"},{"key":"6862_CR47","doi-asserted-by":"publisher","first-page":"7643280","DOI":"10.1155\/2023\/7643280","volume":"2023","author":"F Mozafari","year":"2023","unstructured":"Mozafari F, Rashidzadeh H, Bijani S et al (2023) Enhancing the neuroprotection potential of Edaravone in transient global ischemia treatment with Glutathione- (GSH-) conjugated Poly(methacrylic acid) Nanogel as a Promising Carrier for Targeted Brain Drug Delivery[J]. Oxid Med Cell Longev 2023:7643280","journal-title":"Oxid Med Cell Longev"},{"key":"6862_CR48","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.ejpb.2018.11.002","volume":"133","author":"T Musumeci","year":"2018","unstructured":"Musumeci T, Serapide MF, Pellitteri R et al (2018) Oxcarbazepine free or loaded PLGA nanoparticles as effective intranasal approach to control epileptic seizures in rodents. Eur J Pharm Biopharm 133:309\u2013320","journal-title":"Eur J Pharm Biopharm"},{"issue":"12","key":"6862_CR49","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1038\/nm.3407","volume":"19","author":"B Obermeier","year":"2013","unstructured":"Obermeier B, Daneman R, Ransohoff RM (2013) Development, maintenance and disruption of the blood-brain barrier. Nat Med 19(12):1584\u20131596","journal-title":"Nat Med"},{"issue":"12","key":"6862_CR50","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1038\/s41563-020-0755-z","volume":"19","author":"B Ouyang","year":"2020","unstructured":"Ouyang B, Poon W, Zhang Y et al (2020) The dose threshold for nanoparticle tumour delivery. Nat Mater 19(12):1362\u20131371","journal-title":"Nat Mater"},{"issue":"19","key":"6862_CR51","doi-asserted-by":"publisher","first-page":"10565","DOI":"10.1073\/pnas.1913956117","volume":"117","author":"CS Petit","year":"2020","unstructured":"Petit CS, Lee JJ, Boland S et al (2020) Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration[J]. Proc Natl Acad Sci U S A 117(19):10565\u201310574","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"6862_CR52","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1177\/23969873221099477","volume":"7","author":"AA Polymeris","year":"2022","unstructured":"Polymeris AA, Zietz A, Schaub F et al (2022) Once versus twice daily direct oral anticoagulants in patients with recent stroke and atrial fibrillation[J]. Eur Stroke J 7(3):221\u2013229","journal-title":"Eur Stroke J"},{"issue":"3","key":"6862_CR53","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.ejpb.2013.06.005","volume":"85","author":"M Popov","year":"2013","unstructured":"Popov M, Abu Hammad I, Bachar T et al (2013) Delivery of analgesic peptides to the brain by nano-sized bolaamphiphilic vesicles made of monolayer membranes. Eur J Pharm Biopharm 85(3):381\u2013389","journal-title":"Eur J Pharm Biopharm"},{"key":"6862_CR54","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190062","author":"CP Profaci","year":"2020","unstructured":"Profaci CP, Munji RN, Pulido RS et al (2020) The blood-brain barrier in health and disease: important unanswered questions. J Exp Med 217(4):e20190062.\u00a0https:\/\/doi.org\/10.1084\/jem.20190062","journal-title":"J Exp Med"},{"issue":"12","key":"6862_CR55","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1111\/epi.12412","volume":"54","author":"S Rubi","year":"2013","unstructured":"Rubi S, Costes N, Heckemann RA et al (2013) Positron emission tomography with alpha-[11\u00a0C]methyl-L-tryptophan in tuberous sclerosis complex-related epilepsy[J]. Epilepsia 54(12):2143\u20132150","journal-title":"Epilepsia"},{"issue":"10","key":"6862_CR56","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1002\/jat.3193","volume":"35","author":"B Sha","year":"2015","unstructured":"Sha B, Gao W, Cui X et al (2015) The potential health challenges of TiO2 nanomaterials. J Appl Toxicol 35(10):1086\u20131101","journal-title":"J Appl Toxicol"},{"issue":"7","key":"6862_CR57","doi-asserted-by":"publisher","first-page":"3028","DOI":"10.1016\/j.apsb.2022.02.025","volume":"12","author":"X Shan","year":"2022","unstructured":"Shan X, Gong X, Li J et al (2022) Current approaches of nanomedicines in the market and various stage of clinical translation. Acta Pharm Sin B 12(7):3028\u20133048","journal-title":"Acta Pharm Sin B"},{"key":"6862_CR58","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.2147\/IJN.S361377","volume":"17","author":"HJ Shin","year":"2022","unstructured":"Shin HJ, Lee KY, Kang JW et al (2022) Perampanel reduces brain damage via induction of M2 microglia in a neonatal rat stroke Model[J]. Int J Nanomed 17:2791\u20132804","journal-title":"Int J Nanomed"},{"key":"6862_CR59","doi-asserted-by":"publisher","first-page":"4727","DOI":"10.2147\/IJN.S419369","volume":"18","author":"H Singh","year":"2023","unstructured":"Singh H, Desimone MF, Pandya S et al (2023) Revisiting the green synthesis of nanoparticles: Uncovering influences of plant extracts as reducing agents for enhanced synthesis efficiency and its biomedical Applications[J]. Int J Nanomed 18:4727\u20134750","journal-title":"Int J Nanomed"},{"issue":"1","key":"6862_CR60","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/imr.13121","volume":"311","author":"BC Smith","year":"2022","unstructured":"Smith BC, Tinkey RA, Shaw BC et al (2022) Targetability of the neurovascular unit in inflammatory diseases of the central nervous system. Immunol Rev 311(1):39\u201349","journal-title":"Immunol Rev"},{"issue":"21","key":"6862_CR61","doi-asserted-by":"publisher","first-page":"5928","DOI":"10.1073\/pnas.1522071113","volume":"113","author":"SD Spassieva","year":"2016","unstructured":"Spassieva SD, Ji X, Liu Y et al (2016) Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency. Proc Natl Acad Sci U S A 113(21):5928\u20135933","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6862_CR62","doi-asserted-by":"crossref","unstructured":"Sun H, Ge S, Jiang B et al (2025) Incidence of first-ever stroke, stroke events, and early case fatality rate in China: results from a national population-based survey[J]. Neuroepidemiology 1\u201313","DOI":"10.1159\/000543474"},{"key":"6862_CR63","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3762\/bjnano.6.23","volume":"6","author":"JM Tan","year":"2015","unstructured":"Tan JM, Foo JB, Fakurazi S et al (2015) Release behaviour and toxicity evaluation of Levodopa from carboxylated single-walled carbon nanotubes. Beilstein J Nanotechnol 6:243\u2013253","journal-title":"Beilstein J Nanotechnol"},{"key":"6862_CR64","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jconrel.2023.06.021","volume":"360","author":"BD Tri","year":"2023","unstructured":"Tri BD, Shashni B, Matsui H et al (2023) Designing poly(gamma-aminobutyric acid)-based nanoparticles for the treatment of major depressive disorders. J Control Release 360:110\u2013121","journal-title":"J Control Release"},{"issue":"1","key":"6862_CR65","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/med.21817","volume":"42","author":"QZ Tuo","year":"2022","unstructured":"Tuo QZ, Zhang ST, Lei P (2022) Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications. Med Res Rev 42(1):259\u2013305","journal-title":"Med Res Rev"},{"issue":"13","key":"6862_CR66","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1016\/j.celrep.2017.06.012","volume":"19","author":"J Wei","year":"2017","unstructured":"Wei J, Zhang YY, Luo J et al (2017) The GARP complex is involved in intracellular cholesterol transport via targeting NPC2 to lysosomes. Cell Rep 19(13):2823\u20132835","journal-title":"Cell Rep"},{"key":"6862_CR67","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.brainres.2008.01.039","volume":"1200","author":"B Wilson","year":"2008","unstructured":"Wilson B, Samanta MK, Santhi K et al (2008) Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of Rivastigmine into the brain to treat alzheimer\u2019s disease. Brain Res 1200:159\u2013168","journal-title":"Brain Res"},{"issue":"22","key":"6862_CR68","doi-asserted-by":"publisher","first-page":"1901844","DOI":"10.1002\/advs.201901844","volume":"6","author":"H Yang","year":"2019","unstructured":"Yang H, Li X, Zhu L et al (2019) Heat shock protein inspired nanochaperones restore Amyloid-beta homeostasis for preventative therapy of alzheimer\u2019s Disease[J]. Adv Sci (Weinh) 6(22):1901844","journal-title":"Adv Sci (Weinh)"},{"key":"6862_CR69","doi-asserted-by":"publisher","first-page":"4449","DOI":"10.2147\/IJN.S208332","volume":"14","author":"H Yavarpour-Bali","year":"2019","unstructured":"Yavarpour-Bali H, Ghasemi-Kasman M, Pirzadeh M (2019) Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders. Int J Nanomed 14:4449\u20134460","journal-title":"Int J Nanomed"},{"issue":"3","key":"6862_CR70","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s13311-013-0187-4","volume":"10","author":"YJ Yu","year":"2013","unstructured":"Yu YJ, Watts RJ (2013) Developing therapeutic antibodies for neurodegenerative disease. Neurotherapeutics 10(3):459\u2013472","journal-title":"Neurotherapeutics"},{"key":"6862_CR71","doi-asserted-by":"publisher","DOI":"10.3390\/nano11041057","author":"A Zarinwall","year":"2021","unstructured":"Zarinwall A, Asadian-Birjand M, Seleci DA et al (2021) Magnetic nanoparticle-based dianthin targeting for controlled drug release using the endosomal escape enhancer SO1861. Nanomaterials 11(4):1057.\u00a0https:\/\/doi.org\/10.3390\/nano11041057","journal-title":"Nanomaterials"},{"issue":"6","key":"6862_CR72","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/j.nano.2016.02.019","volume":"12","author":"K Zarschler","year":"2016","unstructured":"Zarschler K, Rocks L, Licciardello N et al (2016) Ultrasmall inorganic nanoparticles: state-of-the-art and perspectives for biomedical applications. Nanomedicine 12(6):1663\u20131701","journal-title":"Nanomedicine"},{"issue":"9459","key":"6862_CR73","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/S0140-6736(05)70801-1","volume":"365","author":"Z Zhang","year":"2005","unstructured":"Zhang Z, Roman GC, Hong Z (2005) Parkinson\u2019s disease in China: prevalence in Beijing, Xian, and Shanghai. Lancet 365(9459):595\u2013597","journal-title":"Lancet"},{"key":"6862_CR74","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.954470","volume":"10","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Zou Z, Liu S et al (2022) Nanogels as novel nanocarrier systems for efficient delivery of CNS therapeutics. Front Bioeng Biotechnol 10:954470","journal-title":"Front Bioeng Biotechnol"},{"key":"6862_CR75","doi-asserted-by":"crossref","unstructured":"Zhao Y, Zhang X, Chen X et al (2022) Neuronal injuries in cerebral infarction and ischemic stroke: from mechanisms to treatment (Review)[J]. Int J Mol Med 49(2):15","DOI":"10.3892\/ijmm.2021.5070"},{"issue":"11","key":"6862_CR76","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1038\/s41565-024-01765-4","volume":"19","author":"S Zhao","year":"2024","unstructured":"Zhao S, Gao K, Han H et al (2024) Acid-degradable lipid nanoparticles enhance the delivery of mRNA. Nat Nanotechnol 19(11):1702\u20131711","journal-title":"Nat Nanotechnol"},{"issue":"7","key":"6862_CR77","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1177\/0271678X20911331","volume":"40","author":"Z Zheng","year":"2020","unstructured":"Zheng Z, Chopp M, Chen J (2020) Multifaceted roles of pericytes in central nervous system homeostasis and disease. J Cereb Blood Flow Metab 40(7):1381\u20131401","journal-title":"J Cereb Blood Flow Metab"},{"issue":"9","key":"6862_CR78","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1038\/s41588-022-01148-2","volume":"54","author":"X Zhou","year":"2022","unstructured":"Zhou X, Feliciano P, Shu C et al (2022) Integrating de Novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes[J]. Nat Genet 54(9):1305\u20131319","journal-title":"Nat Genet"},{"key":"6862_CR79","doi-asserted-by":"crossref","unstructured":"Zielinska A, Carreiro F, Oliveira AM et al (2020) Polymeric nanoparticles: production, characterization, toxicology and ecotoxicology[J]. Molecules 25(16):3731","DOI":"10.3390\/molecules25163731"},{"issue":"1","key":"6862_CR80","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.ajhg.2011.06.008","volume":"89","author":"A Zimprich","year":"2011","unstructured":"Zimprich A, Benet-Pages A, Struhal W et al (2011) A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. Am J Hum Genet 89(1):168\u2013175","journal-title":"Am J Hum Genet"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-025-06862-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-025-06862-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-025-06862-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T05:02:58Z","timestamp":1764824578000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-025-06862-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,8]]},"references-count":80,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["6862"],"URL":"https:\/\/doi.org\/10.1007\/s00213-025-06862-3","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,8]]},"assertion":[{"value":"2 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All the authors read the manuscript carefully and gave their consent for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to public"}},{"value":"The authors report no conflicts of interest in this work.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}