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I have carefully read and understood the submission guidelines and requirements of the journal.I certify that the data, figures, and images presented in this manuscript are original or have been\u00a0authorized and licensed legally. I guarantee that ethical standards have been followed in animal\u00a0experiments.I hereby declare that I have made every effort to avoid errors and misconduct in this research and that the results presented in this manuscript are truthful and reliable. I also declare that I will not be held responsible for any negative consequences resulting from the publication of this manuscript.I hereby declare that I have made every effort to avoid errors and misconduct in this research and that the results presented in this manuscript are truthful and reliable. I also declare that I will not be held responsible for any negative consequences resulting from the publication of this manuscript.Please feel free to contact me at renyan_sxpph@sxmu.edu.cn for further information or clarification.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}