{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:58:46Z","timestamp":1781650726599,"version":"3.54.5"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005366","name":"University of Oslo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>As cannabis legalization and decriminalization have expanded, it is increasingly perceived as a low-risk substance. Concurrently, the potency of cannabis products and the number of young adults seeking treatment for cannabis use disorder have risen markedly. A growing body of research links early onset, frequent use, and high potency cannabis products to a range of adverse outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to examine whether frequent cannabis use during late adolescence affects cognitive functioning and increases the risk of developing anxiety in adulthood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male Sprague-Dawley rats were administered tetrahydrocannabinol (THC; 5 mg\/kg\/day) or vehicle from postnatal day (PND) 42 to 62. After a drug-free period, anxiety-like behavior was assessed in the elevated plus maze (EPM) and Light-Dark transition tests, while cognitive function was evaluated in the novel object recognition and Morris water maze (MWM) tests. THC concentrations in blood and brain tissue were quantified using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS\/MS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The rats displayed blood THC concentrations comparable to human cannabis users and reduced body weight during the exposure period \u2013 an effect that persisted for over two months following the final injection. Adolescent THC exposure impaired novelty preference in young adult animals, whereas effects on spatial memory were less definitive. THC-exposed rats showed anxiety-like behavior in the EPM test, but not in the Light-Dark transition test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that frequent cannabis exposure during adolescence may lead to long-term reductions in body weight, reduced novel object recognition, and increased vulnerability to certain aspects of anxiety-related behavior in adulthood.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00213-026-07067-y","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T08:19:49Z","timestamp":1776932389000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-term effects of adolescent THC exposure on anxiety-like behavior and cognitive function in male rats"],"prefix":"10.1007","author":[{"given":"Josephine Sena","family":"Lumor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette","family":"Nyberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Nerem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannike M\u00f8rch","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger Lise","family":"Bogen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"7067_CR1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.pbb.2014.02.014","volume":"120","author":"O Abboussi","year":"2014","unstructured":"Abboussi O, Tazi A, Paizanis E, El Ganouni S (2014) Chronic exposure to WIN55,212-2 affects more potently spatial learning and memory in adolescents than in adult rats via a negative action on dorsal hippocampal neurogenesis. Pharmacol Biochem Behav 120:95\u2013102. https:\/\/doi.org\/10.1016\/j.pbb.2014.02.014","journal-title":"Pharmacol Biochem Behav"},{"issue":"1","key":"7067_CR2","doi-asserted-by":"publisher","first-page":"23990","DOI":"10.1038\/s41598-021-03242-7","volume":"11","author":"SL Baglot","year":"2021","unstructured":"Baglot SL, Hume C, Petrie GN, Aukema RJ, Lightfoot SHM, Grace LM, Zhou R, Parker L, Rho JM, Borgland SL, McLaughlin RJ, Brechenmacher L, Hill MN (2021) Pharmacokinetics and central accumulation of delta-9-tetrahydrocannabinol (THC) and its bioactive metabolites are influenced by route of administration and sex in rats. Sci Rep 11(1):23990. https:\/\/doi.org\/10.1038\/s41598-021-03242-7","journal-title":"Sci Rep"},{"issue":"7","key":"7067_CR3","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/s41583-021-00465-5","volume":"22","author":"A Bara","year":"2021","unstructured":"Bara A, Ferland J-MN, Rompala G, Szutorisz H, Hurd YL (2021) Cannabis and synaptic reprogramming of the developing brain. Nat Rev Neurosci 22(7):423\u2013438. https:\/\/doi.org\/10.1038\/s41583-021-00465-5","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"7067_CR4","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1515\/intox-2017-0006","volume":"10","author":"K Belovicova","year":"2017","unstructured":"Belovicova K, Bogi E, Csatlosova K, Dubovicky M (2017) Animal tests for anxiety-like and depression-like behavior in rats. Interdiscip Toxicol 10(1):40\u201343. https:\/\/doi.org\/10.1515\/intox-2017-0006","journal-title":"Interdiscip Toxicol"},{"issue":"4","key":"7067_CR5","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1038\/npp.2010.229","volume":"36","author":"B Bingham","year":"2011","unstructured":"Bingham B, McFadden K, Zhang X, Bhatnagar S, Beck S, Valentino R (2011) Early adolescence as a critical window during which social stress distinctly alters behavior and brain norepinephrine activity. Neuropsychopharmacology 36(4):896\u2013909. https:\/\/doi.org\/10.1038\/npp.2010.229","journal-title":"Neuropsychopharmacology"},{"key":"7067_CR6","doi-asserted-by":"publisher","unstructured":"Blest-Hopley G, Colizzi M, Giampietro V, Bhattacharyya S (2020) Is the adolescent brain at greater vulnerability to the effects of cannabis? A narrative review of the evidence. Front Psychiatry 11\u20132020. https:\/\/doi.org\/10.3389\/fpsyt.2020.00859","DOI":"10.3389\/fpsyt.2020.00859"},{"issue":"8","key":"7067_CR7","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1007\/s00702-023-02607-8","volume":"130","author":"C Bouter","year":"2023","unstructured":"Bouter C, Ott FW, G\u00fcnther D, Weig L, Schmitz-Peiffer F, Rozyyeva M, Beindorff N, Bouter Y (2023) Chronic exposure to a synthetic cannabinoid alters cerebral brain metabolism and causes long-lasting behavioral deficits in adult mice. J Neural Transm 130(8):1013\u20131027. https:\/\/doi.org\/10.1007\/s00702-023-02607-8","journal-title":"J Neural Transm"},{"issue":"9","key":"7067_CR8","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1007\/s00213-019-05255-7","volume":"236","author":"AW Bruijnzeel","year":"2019","unstructured":"Bruijnzeel AW, Knight P, Panunzio S, Xue S, Bruner MM, Wall SC, Pompilus M, Febo M, Setlow B (2019) Effects in rats of adolescent exposure to cannabis smoke or THC on emotional behavior and cognitive function in adulthood. Psychopharmacology 236(9):2773\u20132784. https:\/\/doi.org\/10.1007\/s00213-019-05255-7","journal-title":"Psychopharmacology"},{"issue":"5","key":"7067_CR9","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/nrn3475","volume":"14","author":"KS Button","year":"2013","unstructured":"Button KS, Ioannidis JPA, Mokrysz C, Nosek BA, Flint J, Robinson ESJ, Munaf\u00f2 MR (2013) Power failure: why small sample size undermines the reliability of neuroscience. Nat Rev Neurosci 14(5):365\u2013376. https:\/\/doi.org\/10.1038\/nrn3475","journal-title":"Nat Rev Neurosci"},{"key":"7067_CR10","doi-asserted-by":"publisher","first-page":"109748","DOI":"10.1016\/j.jneumeth.2022.109748","volume":"384","author":"R Campos-Cardoso","year":"2023","unstructured":"Campos-Cardoso R, Godoy LD, Lazarini-Lopes W, Novaes LS, dos Santos NB, Perfetti JG, Garcia-Cairasco N, Munhoz CD, Padovan CM (2023) Exploring the light\/dark box test: Protocols and implications for neuroscience research. J Neurosci Methods 384:109748. https:\/\/doi.org\/10.1016\/j.jneumeth.2022.109748","journal-title":"J Neurosci Methods"},{"issue":"4","key":"7067_CR11","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1017\/S0954579416001280","volume":"29","author":"N Castellanos-Ryan","year":"2017","unstructured":"Castellanos-Ryan N, Pingault J-B, Parent S, Vitaro F, Tremblay RE, S\u00e9guin JR (2017) Adolescent cannabis use, change in neurocognitive function, and high-school graduation: A longitudinal study from early adolescence to young adulthood. Dev Psychopathol 29(4):1253\u20131266. https:\/\/doi.org\/10.1017\/S0954579416001280","journal-title":"Dev Psychopathol"},{"issue":"3","key":"7067_CR13","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.pbb.2006.03.006","volume":"83","author":"YM Cha","year":"2006","unstructured":"Cha YM, White AM, Kuhn CM, Wilson WA, Swartzwelder HS (2006) Differential effects of delta9-THC on learning in adolescent and adult rats. Pharmacol Biochem Behav 83(3):448\u2013455. https:\/\/doi.org\/10.1016\/j.pbb.2006.03.006","journal-title":"Pharmacol Biochem Behav"},{"issue":"5\u20136","key":"7067_CR12","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1097\/FBP.0b013e3282ee7b7e","volume":"18","author":"YM Cha","year":"2007","unstructured":"Cha YM, Jones KH, Kuhn CM, Wilson WA, Swartzwelder HS (2007) Sex differences in the effects of \u22069-tetrahydrocannabinol on spatial learning in adolescent and adult rats. Behav Pharmacol 18(5\u20136):563\u2013569. https:\/\/doi.org\/10.1097\/FBP.0b013e3282ee7b7e","journal-title":"Behav Pharmacol"},{"issue":"8","key":"7067_CR14","doi-asserted-by":"publisher","first-page":"e2328691","DOI":"10.1001\/jamanetworkopen.2023.28691","volume":"6","author":"J Chambers","year":"2023","unstructured":"Chambers J, Keyhani S, Ling PM, Hoggatt KJ, Hasin D, Nguyen N, Woods A, Ryder A, Cohen BE (2023) Perceptions of Safety of Daily Cannabis vs Tobacco Smoking and Secondhand Smoke Exposure, 2017\u20132021. JAMA Netw Open 6(8):e2328691\u2013e2328691. https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.28691","journal-title":"JAMA Netw Open"},{"issue":"1","key":"7067_CR15","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41572-021-00247-4","volume":"7","author":"JP Connor","year":"2021","unstructured":"Connor JP, Stjepanovi\u0107 D, Le Foll B, Hoch E, Budney AJ, Hall WD (2021) Cannabis use and cannabis use disorder. Nat Reviews Disease Primers 7(1):16. https:\/\/doi.org\/10.1038\/s41572-021-00247-4","journal-title":"Nat Reviews Disease Primers"},{"issue":"4","key":"7067_CR17","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1523\/jneurosci.1050-20.2020","volume":"41","author":"M De Felice","year":"2021","unstructured":"De Felice M, Renard J, Hudson R, Szkudlarek HJ, Pereira BJ, Schmid S, Rushlow WJ, Laviolette SR (2021) L-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent \u2206-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry. J Neurosci 41(4):739\u2013750. https:\/\/doi.org\/10.1523\/jneurosci.1050-20.2020","journal-title":"J Neurosci"},{"issue":"3","key":"7067_CR16","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/s41386-022-01496-x","volume":"48","author":"M De Felice","year":"2023","unstructured":"De Felice M, Chen C, Rodr\u00edguez-Ruiz M, Szkudlarek HJ, Lam M, Sert S, Whitehead SN, Yeung KKC, Rushlow WJ, Laviolette SR (2023) Adolescent \u2206-9-tetrahydrocannabinol exposure induces differential acute and long-term neuronal and molecular disturbances in dorsal vs. ventral hippocampal subregions. Neuropsychopharmacology 48(3):540\u2013551. https:\/\/doi.org\/10.1038\/s41386-022-01496-x","journal-title":"Neuropsychopharmacology"},{"key":"7067_CR18","doi-asserted-by":"publisher","unstructured":"De Felice M, Szkudlarek HJ, Uzuneser TC, Rodr\u00edguez-Ruiz M, Sarikahya MH, Pusparajah M, Lazo G, Whitehead JP, Yeung SN, Rushlow KKC, WJ, Laviolette SR (2024) The impacts of adolescent cannabinoid exposure on striatal anxiety- and depressive-like pathophysiology are prevented by the antioxidant n-acetylcysteine. Biol Psychiatry: Global Open Sci 4(6). https:\/\/doi.org\/10.1016\/j.bpsgos.2024.100361","DOI":"10.1016\/j.bpsgos.2024.100361"},{"issue":"11","key":"7067_CR19","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1093\/ijnp\/pyaa058","volume":"23","author":"D De Gregorio","year":"2020","unstructured":"De Gregorio D, Dean Conway J, Canul M-L, Posa L, Bambico FR, Gobbi G (2020) Effects of Chronic Exposure to Low-Dose delta-9-Tetrahydrocannabinol in Adolescence and Adulthood on Serotonin\/Norepinephrine Neurotransmission and Emotional Behavior. Int J Neuropsychopharmacol 23(11):751\u2013761. https:\/\/doi.org\/10.1093\/ijnp\/pyaa058","journal-title":"Int J Neuropsychopharmacol"},{"key":"7067_CR20","unstructured":"European Union Drugs Agency (2024) European drug report 2024: Trends and Developments. https:\/\/www.euda.europa.eu\/publications\/european-drug-report\/2024_en"},{"issue":"5","key":"7067_CR23","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/s41593-020-0611-0","volume":"23","author":"J-MN Ferland","year":"2020","unstructured":"Ferland J-MN, Hurd YL (2020) Deconstructing the neurobiology of cannabis use disorder. Nat Neurosci 23(5):600\u2013610. https:\/\/doi.org\/10.1038\/s41593-020-0611-0","journal-title":"Nat Neurosci"},{"issue":"1","key":"7067_CR21","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1001\/jamapsychiatry.2022.3915","volume":"80","author":"J-MN Ferland","year":"2023","unstructured":"Ferland J-MN, Ellis RJ, Betts G, Silveira MM, de Firmino JB, Winstanley CA, Hurd YL (2023a) Long-Term Outcomes of Adolescent THC Exposure on Translational Cognitive Measures in Adulthood in an Animal Model and Computational Assessment of Human Data. JAMA Psychiatry 80(1):66\u201376. https:\/\/doi.org\/10.1001\/jamapsychiatry.2022.3915","journal-title":"JAMA Psychiatry"},{"issue":"6","key":"7067_CR22","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1038\/s41380-022-01467-0","volume":"28","author":"J-MN Ferland","year":"2023","unstructured":"Ferland J-MN, Ellis RJ, Rompala G, Landry JA, Callens JE, Ly A, Frier MD, Uzamere TO, Hurd YL (2023b) Dose mediates the protracted effects of adolescent THC exposure on reward and stress reactivity in males relevant to perturbation of the basolateral amygdala transcriptome. Mol Psychiatry 28(6):2583\u20132593. https:\/\/doi.org\/10.1038\/s41380-022-01467-0","journal-title":"Mol Psychiatry"},{"issue":"4","key":"7067_CR24","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1080\/17460441.2018.1418321","volume":"13","author":"F Freudenberg","year":"2018","unstructured":"Freudenberg F, O\u2019Leary A, Aguiar DC, Slattery DA (2018) Challenges with modelling anxiety disorders: a possible hindrance for drug discovery. Expert Opin Drug Discov 13(4):279\u2013281. https:\/\/doi.org\/10.1080\/17460441.2018.1418321","journal-title":"Expert Opin Drug Discov"},{"issue":"16","key":"7067_CR25","doi-asserted-by":"publisher","first-page":"8899","DOI":"10.3390\/ijms22168899","volume":"22","author":"M Gabaglio","year":"2021","unstructured":"Gabaglio M, Zamberletti E, Manenti C, Parolaro D, Rubino T (2021) Long-Term Consequences of Adolescent Exposure to THC-Rich\/CBD-Poor and CBD-Rich\/THC-Poor Combinations: A Comparison with Pure THC Treatment in Female Rats. Int J Mol Sci 22(16):8899. https:\/\/doi.org\/10.3390\/ijms22168899","journal-title":"Int J Mol Sci"},{"issue":"2","key":"7067_CR26","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3758\/s13415-024-01171-2","volume":"24","author":"S Gencturk","year":"2024","unstructured":"Gencturk S, Unal G (2024) Rodent tests of depression and anxiety: Construct validity and translational relevance. Cogn Affect Behav Neurosci 24(2):191\u2013224. https:\/\/doi.org\/10.3758\/s13415-024-01171-2","journal-title":"Cogn Affect Behav Neurosci"},{"key":"7067_CR27","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.17179\/excli2021-4072","volume":"20","author":"A Ghasemi","year":"2021","unstructured":"Ghasemi A, Jeddi S, Kashfi K (2021) The laboratory rat: Age and body weight matter. Excli j 20:1431\u20131445. https:\/\/doi.org\/10.17179\/excli2021-4072","journal-title":"Excli j"},{"issue":"4","key":"7067_CR28","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1001\/jamapsychiatry.2018.4500","volume":"76","author":"G Gobbi","year":"2019","unstructured":"Gobbi G, Atkin T, Zytynski T, Wang S, Askari S, Boruff J, Ware M, Marmorstein N, Cipriani A, Dendukuri N, Mayo N (2019) Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood: A Systematic Review and Meta-analysis. JAMA Psychiatry 76(4):426\u2013434. https:\/\/doi.org\/10.1001\/jamapsychiatry.2018.4500","journal-title":"JAMA Psychiatry"},{"key":"7067_CR29","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.bandc.2018.11.009","volume":"133","author":"EV Goldfarb","year":"2019","unstructured":"Goldfarb EV (2019) Enhancing memory with stress: Progress, challenges, and opportunities. Brain Cogn 133:94\u2013105. https:\/\/doi.org\/10.1016\/j.bandc.2018.11.009","journal-title":"Brain Cogn"},{"issue":"5","key":"7067_CR30","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1007\/s00213-023-06352-4","volume":"240","author":"B Halbout","year":"2023","unstructured":"Halbout B, Hutson C, Hua L, Inshishian V, Mahler SV, Ostlund SB (2023) Long-term effects of THC exposure on reward learning and motivated behavior in adolescent and adult male rats. Psychopharmacology 240(5):1151\u20131167. https:\/\/doi.org\/10.1007\/s00213-023-06352-4","journal-title":"Psychopharmacology"},{"issue":"7","key":"7067_CR31","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1177\/0269881120965931","volume":"35","author":"CM Hernandez","year":"2021","unstructured":"Hernandez CM, Orsini CA, Blaes SL, Bizon JL, Febo M, Bruijnzeel AW, Setlow B (2021) Effects of repeated adolescent exposure to cannabis smoke on cognitive outcomes in adulthood. J Psychopharmacol 35(7):848\u2013863. https:\/\/doi.org\/10.1177\/0269881120965931","journal-title":"J Psychopharmacol"},{"issue":"4","key":"7067_CR32","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.pbb.2009.06.013","volume":"93","author":"A Higuera-Matas","year":"2009","unstructured":"Higuera-Matas A, Botreau F, Migu\u00e9ns M, Del Olmo N, Borcel E, P\u00e9rez-\u00c1lvarez L, Garc\u00eda-Lecumberri C, Ambrosio E (2009) Chronic periadolescent cannabinoid treatment enhances adult hippocampal PSA-NCAM expression in male Wistar rats but only has marginal effects on anxiety, learning and memory. Pharmacol Biochem Behav 93(4):482\u2013490. https:\/\/doi.org\/10.1016\/j.pbb.2009.06.013","journal-title":"Pharmacol Biochem Behav"},{"issue":"5","key":"7067_CR33","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3390\/cells13050461","volume":"13","author":"K-M Jung","year":"2024","unstructured":"Jung K-M, Lin L, Piomelli D (2024) Overactivation of the Endocannabinoid System in Adolescence Disrupts Adult Adipose Organ Function in Mice. Cells 13(5):461. https:\/\/doi.org\/10.3390\/cells13050461","journal-title":"Cells"},{"issue":"2","key":"7067_CR34","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s00213-011-2342-0","volume":"218","author":"C Klein","year":"2011","unstructured":"Klein C, Karanges E, Spiro A, Wong A, Spencer J, Huynh T, Gunasekaran N, Karl T, Long LE, Huang X-F, Liu K, Arnold JC, McGregor IS (2011) Cannabidiol potentiates \u22069-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats. Psychopharmacology 218(2):443\u2013457. https:\/\/doi.org\/10.1007\/s00213-011-2342-0","journal-title":"Psychopharmacology"},{"key":"7067_CR35","doi-asserted-by":"publisher","first-page":"108008","DOI":"10.1016\/j.drugalcdep.2020.108008","volume":"212","author":"M Kongstorp","year":"2020","unstructured":"Kongstorp M, Bogen IL, Stiris T, Andersen JM (2020) Prenatal exposure to methadone or buprenorphine impairs cognitive performance in young adult rats. Drug Alcohol Depend 212:108008. https:\/\/doi.org\/10.1016\/j.drugalcdep.2020.108008","journal-title":"Drug Alcohol Depend"},{"issue":"7","key":"7067_CR36","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1002\/ejp.1377","volume":"23","author":"M-O Krebs","year":"2019","unstructured":"Krebs M-O, Kebir O, Jay TM (2019) Exposure to cannabinoids can lead to persistent cognitive and psychiatric disorders. Eur J Pain 23(7):1225\u20131233. https:\/\/doi.org\/10.1002\/ejp.1377","journal-title":"Eur J Pain"},{"key":"7067_CR37","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.copsyc.2020.07.005","volume":"38","author":"E Kroon","year":"2021","unstructured":"Kroon E, Kuhns L, Cousijn J (2021) The short-term and long-term effects of cannabis on cognition: recent advances in the field. Curr Opin Psychol 38:49\u201355. https:\/\/doi.org\/10.1016\/j.copsyc.2020.07.005","journal-title":"Curr Opin Psychol"},{"issue":"3","key":"7067_CR38","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1037\/neu0000615","volume":"34","author":"DJ Krzyzanowski","year":"2020","unstructured":"Krzyzanowski DJ, Purdon SE (2020) Duration of abstinence from cannabis is positively associated with verbal learning performance: A systematic review and meta-analysis. Neuropsychology 34(3):359\u2013372. https:\/\/doi.org\/10.1037\/neu0000615","journal-title":"Neuropsychology"},{"issue":"8","key":"7067_CR39","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1093\/jat\/bkv082","volume":"39","author":"D Lee","year":"2015","unstructured":"Lee D, Bergamaschi MM, Milman G, Barnes AJ, Queiroz RHC, Vandrey R, Huestis MA (2015) Plasma Cannabinoid Pharmacokinetics After Controlled Smoking and Ad libitum Cannabis Smoking in Chronic Frequent Users. J Anal Toxicol 39(8):580\u2013587. https:\/\/doi.org\/10.1093\/jat\/bkv082","journal-title":"J Anal Toxicol"},{"issue":"3","key":"7067_CR40","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.jaac.2016.12.014","volume":"56","author":"A Levine","year":"2017","unstructured":"Levine A, Clemenza K, Rynn M, Lieberman J (2017) Evidence for the Risks and Consequences of Adolescent Cannabis Exposure. J Am Acad Child Adolesc Psychiatry 56(3):214\u2013225. https:\/\/doi.org\/10.1016\/j.jaac.2016.12.014","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"1","key":"7067_CR41","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/s41380-024-02668-5","volume":"30","author":"Z Li","year":"2025","unstructured":"Li Z, Mukherjee D, Duric B, Austin-Zimmerman I, Trotta G, Spinazzola E, Quattrone D, Murray RM, Di Forti M (2025) Systematic review and meta-analysis on the effects of chronic peri-adolescent cannabinoid exposure on schizophrenia-like behaviour in rodents. Mol Psychiatry 30(1):285\u2013295. https:\/\/doi.org\/10.1038\/s41380-024-02668-5","journal-title":"Mol Psychiatry"},{"issue":"7","key":"7067_CR42","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/j.cmet.2023.05.002","volume":"35","author":"L Lin","year":"2023","unstructured":"Lin L, Jung K-M, Lee H-L, Le J, Colleluori G, Wood C, Palese F, Squire E, Ramirez J, Su S, Torrens A, Fotio Y, Tang L, Yu C, Yang Q, Huang L, DiPatrizio N, Jang C, Cinti S, Piomelli D (2023) Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood. Cell Metabol 35(7):1227\u20131241e1227. https:\/\/doi.org\/10.1016\/j.cmet.2023.05.002","journal-title":"Cell Metabol"},{"issue":"11","key":"7067_CR43","doi-asserted-by":"publisher","first-page":"e78386","DOI":"10.1371\/journal.pone.0078386","volume":"8","author":"A Llorente-Berzal","year":"2013","unstructured":"Llorente-Berzal A, Puighermanal E, Burokas A, Ozaita A, Maldonado R, Marco EM, Viveros M-P (2013) Sex-Dependent Psychoneuroendocrine Effects of THC and MDMA in an Animal Model of Adolescent Drug Consumption. PLOS ONE 8(11):e78386. https:\/\/doi.org\/10.1371\/journal.pone.0078386","journal-title":"PLOS ONE"},{"issue":"2","key":"7067_CR44","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1080\/00952990.2023.2299922","volume":"50","author":"DJE Lowe","year":"2024","unstructured":"Lowe DJE, Sorkhou M, George TP (2024) Cannabis use in adolescents and anxiety symptoms and disorders: a systematic review and meta-analysis. Am J Drug Alcohol Abus 50(2):150\u2013161. https:\/\/doi.org\/10.1080\/00952990.2023.2299922","journal-title":"Am J Drug Alcohol Abus"},{"issue":"7","key":"7067_CR45","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.biopsych.2015.07.028","volume":"79","author":"H-C Lu","year":"2016","unstructured":"Lu H-C, Mackie K (2016) An Introduction to the Endogenous Cannabinoid System. Biol Psychiatry 79(7):516\u2013525. https:\/\/doi.org\/10.1016\/j.biopsych.2015.07.028","journal-title":"Biol Psychiatry"},{"issue":"5","key":"7067_CR46","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1111\/j.1460-9568.2009.06648.x","volume":"29","author":"JE McCutcheon","year":"2009","unstructured":"McCutcheon JE, Marinelli M (2009) Age matters. Eur J Neurosci 29(5):997\u20131014. https:\/\/doi.org\/10.1111\/j.1460-9568.2009.06648.x","journal-title":"Eur J Neurosci"},{"issue":"40","key":"7067_CR47","doi-asserted-by":"publisher","first-page":"E2657","DOI":"10.1073\/pnas.1206820109","volume":"109","author":"MH Meier","year":"2012","unstructured":"Meier MH, Caspi A, Ambler A, Harrington H, Houts R, Keefe RSE, McDonald K, Ward A, Poulton R, Moffitt TE (2012) Persistent cannabis users show neuropsychological decline from childhood to midlife. Proc Natl Acad Sci 109(40):E2657\u2013E2664. https:\/\/doi.org\/10.1073\/pnas.1206820109","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"7067_CR49","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1097\/psy.0000000000000665","volume":"81","author":"MH Meier","year":"2019","unstructured":"Meier MH, Pardini D, Beardslee J, Matthews KA (2019) Associations Between Cannabis Use and Cardiometabolic Risk Factors: A Longitudinal Study of Men. Biopsychosoc Sci Med 81(3):281\u2013288. https:\/\/doi.org\/10.1097\/psy.0000000000000665","journal-title":"Biopsychosoc Sci Med"},{"issue":"3","key":"7067_CR48","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1007\/s40429-024-00571-1","volume":"11","author":"MH Meier","year":"2024","unstructured":"Meier MH, Olive MF, Jenks OA, Wernik SR (2024) Cannabis Use and Cognitive Functioning Across the Lifespan. Curr Addict Rep 11(3):384\u2013395. https:\/\/doi.org\/10.1007\/s40429-024-00571-1","journal-title":"Curr Addict Rep"},{"key":"7067_CR50","doi-asserted-by":"publisher","first-page":"100303","DOI":"10.1016\/j.forc.2020.100303","volume":"23","author":"V Meneses","year":"2021","unstructured":"Meneses V, Hernandez M (2021) Cannabinoid distribution in postmortem samples. Forensic Chem 23:100303. https:\/\/doi.org\/10.1016\/j.forc.2020.100303","journal-title":"Forensic Chem"},{"key":"7067_CR51","doi-asserted-by":"publisher","first-page":"111367","DOI":"10.1016\/j.drugalcdep.2024.111367","volume":"262","author":"H Nyberg","year":"2024","unstructured":"Nyberg H, Bogen IL, Nygaard E, Andersen JM (2024) Effects of prenatal exposure to methadone or buprenorphine and maternal separation on anxiety-like behavior in rats. Drug Alcohol Depend 262:111367. https:\/\/doi.org\/10.1016\/j.drugalcdep.2024.111367","journal-title":"Drug Alcohol Depend"},{"issue":"1","key":"7067_CR52","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.1111\/ejn.14598","volume":"52","author":"N Poulia","year":"2020","unstructured":"Poulia N, Delis F, Brakatselos C, Lekkas P, Kokras N, Dalla C, Antoniou K (2020) Escalating low-dose \u22069-tetrahydrocannabinol exposure during adolescence induces differential behavioral and neurochemical effects in male and female adult rats. Eur J Neurosci 52(1):2681\u20132693. https:\/\/doi.org\/10.1111\/ejn.14598","journal-title":"Eur J Neurosci"},{"issue":"7","key":"7067_CR53","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1111\/bph.15394","volume":"178","author":"N Poulia","year":"2021","unstructured":"Poulia N, Delis F, Brakatselos C, Polissidis A, Koutmani Y, Kokras N, Dalla C, Politis PK, Antoniou K (2021) Detrimental effects of adolescent escalating low-dose \u22069-tetrahydrocannabinol leads to a specific bio-behavioural profile in adult male rats. Br J Pharmacol 178(7):1722\u20131736. https:\/\/doi.org\/10.1111\/bph.15394","journal-title":"Br J Pharmacol"},{"issue":"7","key":"7067_CR54","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3390\/neurolint17070107","volume":"17","author":"APdS Queiroz","year":"2025","unstructured":"Queiroz APdS, Pedro P, Waisman Campos MO, Torales M, Ventriglio J, A., Castaldelli-Maia JM (2025) Cognitive Effects of Cannabis Use: A Comprehensive Review Across Domains. Neurol Int 17(7):107. https:\/\/doi.org\/10.3390\/neurolint17070107","journal-title":"Neurol Int"},{"issue":"2","key":"7067_CR55","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.bbr.2008.06.007","volume":"193","author":"A Ramos","year":"2008","unstructured":"Ramos A, Pereira E, Martins GC, Wehrmeister TD, Iz\u00eddio GS (2008) Integrating the open field, elevated plus maze and light\/dark box to assess different types of emotional behaviors in one single trial. Behav Brain Res 193(2):277\u2013288. https:\/\/doi.org\/10.1016\/j.bbr.2008.06.007","journal-title":"Behav Brain Res"},{"issue":"2","key":"7067_CR56","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1093\/cercor\/bhv335","volume":"27","author":"J Renard","year":"2016","unstructured":"Renard J, Rosen LG, Loureiro M, De Oliveira C, Schmid S, Rushlow WJ, Laviolette SR (2016) Adolescent Cannabinoid Exposure Induces a Persistent Sub-Cortical Hyper-Dopaminergic State and Associated Molecular Adaptations in the Prefrontal Cortex. Cereb Cortex 27(2):1297\u20131310. https:\/\/doi.org\/10.1093\/cercor\/bhv335","journal-title":"Cereb Cortex"},{"issue":"1","key":"7067_CR57","doi-asserted-by":"publisher","first-page":"11420","DOI":"10.1038\/s41598-017-11645-8","volume":"7","author":"J Renard","year":"2017","unstructured":"Renard J, Szkudlarek HJ, Kramar CP, Jobson CEL, Moura K, Rushlow WJ, Laviolette SR (2017) Adolescent THC Exposure Causes Enduring Prefrontal Cortical Disruption of GABAergic Inhibition and Dysregulation of Sub-Cortical Dopamine Function. Sci Rep 7(1):11420. https:\/\/doi.org\/10.1038\/s41598-017-11645-8","journal-title":"Sci Rep"},{"issue":"22","key":"7067_CR58","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.3390\/cells13221875","volume":"13","author":"RJ Rodrigues","year":"2024","unstructured":"Rodrigues RJ, Marques JM, K\u00f6falvi A (2024) Cannabis, Endocannabinoids and Brain Development: From Embryogenesis to Adolescence. Cells 13(22):1875. https:\/\/doi.org\/10.3390\/cells13221875","journal-title":"Cells"},{"issue":"11","key":"7067_CR60","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.1038\/sj.npp.1301664","volume":"33","author":"T Rubino","year":"2008","unstructured":"Rubino T, Vigano D, Realini N, Guidali C, Braida D, Capurro V, Castiglioni C, Cherubino F, Romualdi P, Candeletti S, Sala M, Parolaro D (2008) Chronic \u22069-Tetrahydrocannabinol During Adolescence Provokes Sex-Dependent Changes in the Emotional Profile in Adult Rats: Behavioral and Biochemical Correlates. Neuropsychopharmacology 33(11):2760\u20132771. https:\/\/doi.org\/10.1038\/sj.npp.1301664","journal-title":"Neuropsychopharmacology"},{"issue":"8","key":"7067_CR59","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1002\/hipo.20554","volume":"19","author":"T Rubino","year":"2009","unstructured":"Rubino T, Realini N, Braida D, Guidi S, Capurro V, Vigan\u00f2 D, Guidali C, Pinter M, Sala M, Bartesaghi R, Parolaro D (2009) Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood. Hippocampus 19(8):763\u2013772. https:\/\/doi.org\/10.1002\/hipo.20554","journal-title":"Hippocampus"},{"issue":"1","key":"7067_CR61","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1177\/0269881111405362","volume":"26","author":"T Rubino","year":"2012","unstructured":"Rubino T, Zamberletti E, Parolaro D (2012) Adolescent exposure to cannabis as a risk factor for psychiatric disorders. J Psychopharmacol 26(1):177\u2013188. https:\/\/doi.org\/10.1177\/0269881111405362","journal-title":"J Psychopharmacol"},{"issue":"5","key":"7067_CR62","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1038\/s41386-020-00839-w","volume":"46","author":"CM Ruiz","year":"2021","unstructured":"Ruiz CM, Torrens A, Castillo E, Perrone CR, Cevallos J, Inshishian VC, Harder EV, Justeson DN, Huestis MA, Swarup V, Piomelli D, Mahler SV (2021) Pharmacokinetic, behavioral, and brain activity effects of \u22069-tetrahydrocannabinol in adolescent male and female rats. Neuropsychopharmacology 46(5):959\u2013969. https:\/\/doi.org\/10.1038\/s41386-020-00839-w","journal-title":"Neuropsychopharmacology"},{"issue":"5","key":"7067_CR63","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1038\/npp.2015.295","volume":"41","author":"M Scherma","year":"2016","unstructured":"Scherma M, Dess\u00ec C, Muntoni AL, Lecca S, Satta V, Luchicchi A, Pistis M, Panlilio LV, Fattore L, Goldberg SR, Fratta W, Fadda P (2016) Adolescent \u22069-Tetrahydrocannabinol Exposure Alters WIN55,212-2 Self-Administration in Adult Rats. Neuropsychopharmacology 41(5):1416\u20131426. https:\/\/doi.org\/10.1038\/npp.2015.295","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"7067_CR64","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1089\/can.2022.0183","volume":"8","author":"AF Scheyer","year":"2023","unstructured":"Scheyer AF, Laviolette SR, Pelissier AL, Manzoni OJJ (2023) Cannabis in Adolescence: Lasting Cognitive Alterations and Underlying Mechanisms. Cannabis Cannabinoid Res 8(1):12\u201323. https:\/\/doi.org\/10.1089\/can.2022.0183","journal-title":"Cannabis Cannabinoid Res"},{"issue":"1","key":"7067_CR65","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00441-013-1581-2","volume":"354","author":"M Schneider","year":"2013","unstructured":"Schneider M (2013) Adolescence as a vulnerable period to alter rodent behavior. Cell Tissue Res 354(1):99\u2013106. https:\/\/doi.org\/10.1007\/s00441-013-1581-2","journal-title":"Cell Tissue Res"},{"issue":"6","key":"7067_CR66","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1001\/jamapsychiatry.2018.0335","volume":"75","author":"JC Scott","year":"2018","unstructured":"Scott JC, Slomiak ST, Jones JD, Rosen AFG, Moore TM, Gur RC (2018) Association of Cannabis With Cognitive Functioning in Adolescents and Young Adults: A Systematic Review and Meta-analysis. JAMA Psychiatry 75(6):585\u2013595. https:\/\/doi.org\/10.1001\/jamapsychiatry.2018.0335","journal-title":"JAMA Psychiatry"},{"issue":"8","key":"7067_CR67","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1016\/j.neuropharm.2011.07.002","volume":"61","author":"EY Shen","year":"2011","unstructured":"Shen EY, Ali SF, Meyer JS (2011) Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats. Neuropharmacology 61(8):1183\u20131192. https:\/\/doi.org\/10.1016\/j.neuropharm.2011.07.002","journal-title":"Neuropharmacology"},{"issue":"9","key":"7067_CR68","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1002\/hipo.22427","volume":"25","author":"MJ Smith","year":"2015","unstructured":"Smith MJ, Cobia DJ, Reilly JL, Gilman JM, Roberts AG, Alpert KI, Wang L, Breiter HC, Csernansky JG (2015) Cannabis-related episodic memory deficits and hippocampal morphological differences in healthy individuals and schizophrenia subjects. Hippocampus 25(9):1042\u20131051. https:\/\/doi.org\/10.1002\/hipo.22427","journal-title":"Hippocampus"},{"key":"7067_CR69","doi-asserted-by":"publisher","unstructured":"Sorkhou M, Bedder RH, George TP (2021) The behavioral sequelae of cannabis use in healthy people: a systematic review . Front Psychiatr 12. https:\/\/doi.org\/10.3389\/fpsyt.2021.630247","DOI":"10.3389\/fpsyt.2021.630247"},{"issue":"7","key":"7067_CR70","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.euroneuro.2013.12.012","volume":"24","author":"S Stopponi","year":"2014","unstructured":"Stopponi S, Soverchia L, Ubaldi M, Cippitelli A, Serpelloni G, Ciccocioppo R (2014) Chronic THC during adolescence increases the vulnerability to stress-induced relapse to heroin seeking in adult rats. Eur Neuropsychopharmacol 24(7):1037\u20131045. https:\/\/doi.org\/10.1016\/j.euroneuro.2013.12.012","journal-title":"Eur Neuropsychopharmacol"},{"key":"7067_CR71","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.bbr.2012.12.014","volume":"241","author":"T Timi\u0107","year":"2013","unstructured":"Timi\u0107 T, Joksimovi\u0107 S, Mili\u0107 M, Divljakovi\u0107 J, Batini\u0107 B, Savi\u0107 MM (2013) Midazolam impairs acquisition and retrieval, but not consolidation of reference memory in the Morris water maze. Behav Brain Res 241:198\u2013205. https:\/\/doi.org\/10.1016\/j.bbr.2012.12.014","journal-title":"Behav Brain Res"},{"issue":"6","key":"7067_CR72","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1089\/can.2021.0205","volume":"7","author":"A Torrens","year":"2022","unstructured":"Torrens A, Roy P, Lin L, Vu C, Grimes D, Inshishian VC, Montesinos JS, Ahmed F, Mahler SV, Huestis MA, Das A, Piomelli D (2022) Comparative Pharmacokinetics of \u22069-Tetrahydrocannabinol in Adolescent and Adult Male and Female Rats. Cannabis Cannabinoid Res 7(6):814\u2013826. https:\/\/doi.org\/10.1089\/can.2021.0205","journal-title":"Cannabis Cannabinoid Res"},{"key":"7067_CR73","doi-asserted-by":"publisher","unstructured":"Trezza V, Campolongo P, Manduca A, Morena M, Palmery M, Vanderschuren L, Cuomo V (2012) Altering endocannabinoid neurotransmission at critical developmental ages: impact on rodent emotionality and cognitive performance. Front Behav Neurosci 6\u20132012. https:\/\/doi.org\/10.3389\/fnbeh.2012.00002","DOI":"10.3389\/fnbeh.2012.00002"},{"key":"7067_CR74","unstructured":"United Nations Office on Drugs and Crime (2024) World drug report 2024: Key findings and conclusions. United Nations. https:\/\/www.unodc.org\/documents\/data-and-analysis\/WDR_2024\/WDR24_Key_findings_and_conclusions.pdf"},{"key":"7067_CR75","doi-asserted-by":"crossref","unstructured":"United Nations Office on Drugs and Crime (2025) World drug report 2025: Key findings. United Nations. https:\/\/www.unodc.org\/documents\/data-and-analysis\/WDR_2025\/WDR25_B1_Key_findings.pdf","DOI":"10.18356\/9789211546859c005"},{"issue":"1","key":"7067_CR76","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1124\/jpet.115.227181","volume":"356","author":"PF Weed","year":"2016","unstructured":"Weed PF, Filipeanu CM, Ketchum MJ, Winsauer PJ (2016) Chronic \u22069-Tetrahydrocannabinol during Adolescence Differentially Modulates Striatal CB1 Receptor Expression and the Acute and Chronic Effects on Learning in Adult Rats. J Pharmacol Exp Ther 356(1):20\u201331. https:\/\/doi.org\/10.1124\/jpet.115.227181","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"7067_CR77","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S2352-4642(18)30342-0","volume":"3","author":"J Wilson","year":"2019","unstructured":"Wilson J, Freeman TP, Mackie CJ (2019) Effects of increasing cannabis potency on adolescent health. Lancet Child Adolesc Health 3(2):121\u2013128. https:\/\/doi.org\/10.1016\/S2352-4642(18)30342-0","journal-title":"Lancet Child Adolesc Health"},{"key":"7067_CR78","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.nbd.2013.10.028","volume":"63","author":"E Zamberletti","year":"2014","unstructured":"Zamberletti E, Beggiato S, Steardo L, Prini P, Antonelli T, Ferraro L, Rubino T, Parolaro D (2014) Alterations of prefrontal cortex GABAergic transmission in the complex psychotic-like phenotype induced by adolescent delta-9-tetrahydrocannabinol exposure in rats. Neurobiol Dis 63:35\u201347. https:\/\/doi.org\/10.1016\/j.nbd.2013.10.028","journal-title":"Neurobiol Dis"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-026-07067-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-026-07067-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-026-07067-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:37:07Z","timestamp":1781649427000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-026-07067-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":78,"alternative-id":["7067"],"URL":"https:\/\/doi.org\/10.1007\/s00213-026-07067-y","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]},"assertion":[{"value":"10 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}