{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T02:48:29Z","timestamp":1777085309272,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Shandong Provincial Medical and Health Science and Technology Project","award":["202423010194"],"award-info":[{"award-number":["202423010194"]}]},{"name":"Weifang City Science and Technology Development Plan Project","award":["2025YX067"],"award-info":[{"award-number":["2025YX067"]}]},{"name":"Weifang Medical University Scientific Research Innovation Project","award":["2023BSQD040"],"award-info":[{"award-number":["2023BSQD040"]}]},{"name":"Education and Teaching Reform and Research Project of Shandong Second Medical University","award":["2025YB012"],"award-info":[{"award-number":["2025YB012"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82101588"],"award-info":[{"award-number":["82101588"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"DOI":"10.1007\/s00213-026-07068-x","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T02:32:43Z","timestamp":1777084363000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["17\u03b2-Estradiol alleviates cognitive deficits by modulating fear memory reconsolidation in a PTSD rat model"],"prefix":"10.1007","author":[{"given":"Han","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zilong","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhao","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"Dou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,25]]},"reference":[{"key":"7068_CR1","doi-asserted-by":"publisher","DOI":"10.61373\/bm025l.0035","author":"N Acharya","year":"2025","unstructured":"Acharya N, Fabregat-Nab\u00e1s J, Andero R (2025) NK3R antagonism reduces fear expression in a PTSD-like model of female mice. Brain Med. https:\/\/doi.org\/10.61373\/bm025l.0035","journal-title":"Brain Med"},{"issue":"1","key":"7068_CR3","doi-asserted-by":"publisher","first-page":"17935","DOI":"10.1038\/s41598-019-54182-2","volume":"9","author":"MM Brockmann","year":"2019","unstructured":"Brockmann MM, D\u00f6ngi M, Einsfelder U, K\u00f6rber N, Refojo D, Stein V (2019) Neddylation regulates excitatory synaptic transmission and plasticity. Sci Rep 9(1):17935. https:\/\/doi.org\/10.1038\/s41598-019-54182-2","journal-title":"Sci Rep"},{"issue":"1","key":"7068_CR4","doi-asserted-by":"publisher","first-page":"12775","DOI":"10.1038\/s41598-018-30899-4","volume":"8","author":"C-Y Cai","year":"2018","unstructured":"Cai C-Y, Chen C, Zhou Y, Han Z, Qin C, Cao B, Tao Y, Bian X-L, Lin Y-H, Chang L, Wu H-Y, Luo C-X, Zhu D-Y (2018) PSD-95-nNOS Coupling Regulates Contextual Fear Extinction in the Dorsal CA3. Sci Rep 8(1):12775. https:\/\/doi.org\/10.1038\/s41598-018-30899-4","journal-title":"Sci Rep"},{"key":"7068_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-026-03513-7","author":"AA Grace","year":"2026","unstructured":"Grace AA, Uliana DL (2026) The ventral\/anterior hippocampus as a central hub for stress-related dopaminergic circuit dysfunction in psychiatric disorders. Mol Psychiatry. https:\/\/doi.org\/10.1038\/s41380-026-03513-7. Advance online publication","journal-title":"Mol Psychiatry"},{"issue":"16","key":"7068_CR6","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1016\/j.yexcr.2012.04.015","volume":"318","author":"Y Guo","year":"2012","unstructured":"Guo Y, Feng P (2012) OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res 318(16):2004\u20132013. https:\/\/doi.org\/10.1016\/j.yexcr.2012.04.015","journal-title":"Exp Cell Res"},{"issue":"10","key":"7068_CR7","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1038\/bjc.2017.89","volume":"116","author":"S Han","year":"2017","unstructured":"Han S, Meng L, Jiang Y, Cheng W, Tie X, Xia J, Wu A (2017) Lithium enhances the antitumour effect of temozolomide against TP53 wild-type glioblastoma cells via NFAT1\/FasL signalling. Br J Cancer 116(10):1302\u20131311. https:\/\/doi.org\/10.1038\/bjc.2017.89","journal-title":"Br J Cancer"},{"issue":"11","key":"7068_CR9","doi-asserted-by":"publisher","first-page":"5106","DOI":"10.1210\/en.2009-0305","volume":"150","author":"Y Hojo","year":"2009","unstructured":"Hojo Y, Higo S, Ishii H, Ooishi Y, Mukai H, Murakami G, Kominami T, Kimoto T, Honma S, Poirier D, Kawato S (2009) Comparison between Hippocampus-Synthesized and Circulation-Derived Sex Steroids in the Hippocampus. Endocrinology 150(11):5106\u20135112. https:\/\/doi.org\/10.1210\/en.2009-0305","journal-title":"Endocrinology"},{"issue":"3","key":"7068_CR10","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1212\/01.CON.0000466667.20403.b1","volume":"21","author":"RE Jorge","year":"2015","unstructured":"Jorge RE (2015) Posttraumatic stress disorder. Continuum: Lifelong Learn Neurol 21(3):789\u2013805","journal-title":"Continuum: Lifelong Learn Neurol"},{"issue":"9","key":"7068_CR11","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1093\/hmg\/ddab052","volume":"30","author":"LC Kandasamy","year":"2021","unstructured":"Kandasamy LC, Tsukamoto M, Banov V, Tsetsegee S, Nagasawa Y, Kato M, Matsumoto N, Takeda J, Itohara S, Ogawa S, Young LJ, Zhang Q (2021) Limb-clasping, cognitive deficit, and increased vulnerability to kainic acid-induced seizures in neuronal glycosylphosphatidylinositol deficiency mouse models. Hum Mol Genet 30(9):758\u2013770. https:\/\/doi.org\/10.1093\/hmg\/ddab052","journal-title":"Hum Mol Genet"},{"key":"7068_CR12","doi-asserted-by":"publisher","unstructured":"Kar N (2011) Cognitive behavioral therapy for the treatment of post-traumatic stress disorder: A review. Neuropsychiatr Dis Treat 167. https:\/\/doi.org\/10.2147\/NDT.S10389","DOI":"10.2147\/NDT.S10389"},{"key":"7068_CR13","doi-asserted-by":"publisher","unstructured":"Kato A, Hojo Y, Higo S, Komatsuzaki Y, Murakami G, Yoshino H, Uebayashi M, Kawato S (2013) Female hippocampal estrogens have a significant correlation with cyclic fluctuation of hippocampal spines. Front Neural Circuits 7. https:\/\/doi.org\/10.3389\/fncir.2013.00149","DOI":"10.3389\/fncir.2013.00149"},{"issue":"2","key":"7068_CR14","doi-asserted-by":"publisher","first-page":"eadq8336","DOI":"10.1126\/sciadv.adq8336","volume":"11","author":"G Leone","year":"2025","unstructured":"Leone G, Casanave H, Postel C, Fraisse F, Vall\u00e9e T, de La Sayette V, Dayan J, Peschanski D, Eustache F, Gagnepain P (2025) Plasticity of human resilience mechanisms. Sci Adv 11(2):eadq8336. https:\/\/doi.org\/10.1126\/sciadv.adq8336","journal-title":"Sci Adv"},{"issue":"3","key":"7068_CR15","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.biopsych.2017.09.006","volume":"83","author":"MW Logue","year":"2018","unstructured":"Logue MW, van Rooij SJH, Dennis EL, Davis SL, Hayes JP, Stevens JS, Densmore M, Haswell CC, Ipser J, Koch SBJ, Korgaonkar M, Lebois LAM, Peverill M, Baker JT, Boedhoe PSW, Frijling JL, Gruber SA, Harpaz-Rotem I, Jahanshad N, Koopowitz S, Morey RA (2018) Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia. Biol Psychiatry 83(3):244\u2013253. https:\/\/doi.org\/10.1016\/j.biopsych.2017.09.006","journal-title":"Biol Psychiatry"},{"issue":"1","key":"7068_CR16","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1038\/srep01103","volume":"3","author":"C Maharana","year":"2013","unstructured":"Maharana C, Sharma KP, Sharma SK (2013) Feedback Mechanism in Depolarization-Induced Sustained Activation of Extracellular Signal-Regulated Kinase in the Hippocampus. Sci Rep 3(1):1103. https:\/\/doi.org\/10.1038\/srep01103","journal-title":"Sci Rep"},{"issue":"5929","key":"7068_CR18","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1126\/science.1167975","volume":"324","author":"M-H Monfils","year":"2009","unstructured":"Monfils M-H, Cowansage KK, Klann E, LeDoux JE (2009) Extinction-reconsolidation boundaries: Key to persistent attenuation of fear memories. Science 324(5929):951\u2013955","journal-title":"Science"},{"issue":"1","key":"7068_CR19","doi-asserted-by":"publisher","first-page":"e707","DOI":"10.1038\/tp.2015.194","volume":"6","author":"S Monteiro","year":"2016","unstructured":"Monteiro S, Ferreira FM, Pinto V, Roque S, Morais M, De S\u00e1-Cal\u00e7ada D, Mota C, Correia-Neves M, Cerqueira JJ (2016) Absence of IFN\u03b3 promotes hippocampal plasticity and enhances cognitive performance. Translational Psychiatry 6(1):e707\u2013e707. https:\/\/doi.org\/10.1038\/tp.2015.194","journal-title":"Translational Psychiatry"},{"issue":"15","key":"7068_CR20","doi-asserted-by":"publisher","first-page":"2105336","DOI":"10.1002\/advs.202105336","volume":"9","author":"M Morr","year":"2022","unstructured":"Morr M, Noell J, Sassin D, Daniels J, Philipsen A, Becker B, Stoffel-Wagner B, Hurlemann R, Scheele D (2022) Lonely in the Dark: Trauma Memory and Sex\u2010Specific Dysregulation of Amygdala Reactivity to Fear Signals. Adv Sci 9(15):2105336","journal-title":"Adv Sci"},{"issue":"1","key":"7068_CR21","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s13195-019-0554-4","volume":"11","author":"L Poppe","year":"2019","unstructured":"Poppe L, Ru\u00e9 L, Timmers M, Lenaerts A, Storm A, Callaerts-Vegh Z, Courtand G, De Boer A, Smolders S, Van Damme P, Van Den Bosch L, Hooge D, De Strooper R, Robberecht B, W., Lemmens R (2019) EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer\u2019s disease. Alzheimer\u2019s Research & Therapy 11(1):102. https:\/\/doi.org\/10.1186\/s13195-019-0554-4","journal-title":"Alzheimer\u2019s Research & Therapy"},{"issue":"12","key":"7068_CR23","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1016\/j.bpsc.2020.04.012","volume":"5","author":"A Sartin-Tarm","year":"2020","unstructured":"Sartin-Tarm A, Ross MC, Privatsky AA, Cisler JM (2020) Estradiol Modulates Neural and Behavioral Arousal in Women With Posttraumatic Stress Disorder During a Fear Learning and Extinction Task. Biol Psychiatry: Cogn Neurosci Neuroimaging 5(12):1114\u20131122. https:\/\/doi.org\/10.1016\/j.bpsc.2020.04.012","journal-title":"Biol Psychiatry: Cogn Neurosci Neuroimaging"},{"issue":"1","key":"7068_CR24","doi-asserted-by":"publisher","first-page":"6730","DOI":"10.1038\/s41598-019-43159-w","volume":"9","author":"MJ Scarlata","year":"2019","unstructured":"Scarlata MJ, Lee SH, Lee D, Kandigian SE, Hiller AJ, Dishart JG, Mintz GE, Wang Z, Coste GI, Mousley AL, Soler I, Lawson K, Ng AJ, Bezek JL, Bergstrom HC (2019) Chemogenetic stimulation of the infralimbic cortex reverses alcohol-induced fear memory overgeneralization. Sci Rep 9(1):6730. https:\/\/doi.org\/10.1038\/s41598-019-43159-w","journal-title":"Sci Rep"},{"issue":"48","key":"7068_CR25","doi-asserted-by":"publisher","first-page":"16137","DOI":"10.1523\/JNEUROSCI.4161-10.2010","volume":"30","author":"T Smejkalova","year":"2010","unstructured":"Smejkalova T, Woolley CS (2010) Estradiol acutely potentiates hippocampal excitatory synaptic transmission through a presynaptic mechanism. J Neurosci 30(48):16137\u201316148","journal-title":"J Neurosci"},{"issue":"4","key":"7068_CR26","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1016\/j.neuroscience.2009.09.058","volume":"164","author":"A Tashiro","year":"2009","unstructured":"Tashiro A, Okamoto K, Bereiter DA (2009) Chronic inflammation and estradiol interact through MAPK activation to affect TMJ nociceptive processing by trigeminal caudalis neurons. Neuroscience 164(4):1813\u20131820. https:\/\/doi.org\/10.1016\/j.neuroscience.2009.09.058","journal-title":"Neuroscience"},{"issue":"10","key":"7068_CR27","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/s41583-020-0362-7","volume":"21","author":"LR Taxier","year":"2020","unstructured":"Taxier LR, Gross KS, Frick KM (2020) Oestradiol as a neuromodulator of learning and memory. Nat Rev Neurosci 21(10):535\u2013550","journal-title":"Nat Rev Neurosci"},{"key":"7068_CR28","doi-asserted-by":"publisher","first-page":"108072","DOI":"10.1016\/j.phrs.2025.108072","volume":"223","author":"SA Torrisi","year":"2026","unstructured":"Torrisi SA, Tropea MR, Rizzo S, Giovenzana M, Magri C, Barbon A, Mingardi J, Chinello C, Pagani L, Piga I, Leggio L, Iraci N, Gulisano W, Drago F, Puzzo D, Musazzi L, Leggio GM (2026) Functional, synaptoproteomic and structural adaptations underlying sex-dependent traumatic stress susceptibility\/resilience in the hippocampus. Pharmacol Res 223:108072. https:\/\/doi.org\/10.1016\/j.phrs.2025.108072","journal-title":"Pharmacol Res"},{"issue":"2","key":"7068_CR29","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.neures.2012.03.003","volume":"73","author":"H Wang","year":"2012","unstructured":"Wang H, Zuo D, He B, Qiao F, Zhao M, Wu Y (2012) Conditioned fear stress combined with single-prolonged stress: A new PTSD mouse model. Neurosci Res 73(2):142\u2013152. https:\/\/doi.org\/10.1016\/j.neures.2012.03.003","journal-title":"Neurosci Res"},{"key":"7068_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/2580837","volume":"2016","author":"S Wi","year":"2016","unstructured":"Wi S, Yu JH, Kim M, Cho S-R (2016) In vivo expression of reprogramming factors increases hippocampal neurogenesis and synaptic plasticity in chronic hypoxic-ischemic brain injury. Neural Plast 2016:1\u201311. https:\/\/doi.org\/10.1155\/2016\/2580837","journal-title":"Neural Plast"},{"key":"7068_CR32","doi-asserted-by":"publisher","unstructured":"Yu YH, Lim YS, Ou CY, Chang KC, Tsai AC, Chang FC, Huang ACW (2022) The medial prefrontal cortex, nucleus accumbens, basolateral amygdala, and hippocampus regulate the amelioration of environmental enrichment and cue in fear behavior in the animal model of PTSD. Behavioural Neurology, 2022:1\u201314. https:\/\/doi.org\/10.1155\/2022\/7331714","DOI":"10.1155\/2022\/7331714"},{"issue":"6","key":"7068_CR33","doi-asserted-by":"publisher","first-page":"e3018","DOI":"10.1002\/brb3.3018","volume":"13","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Wei R, Ni M, Wu Q, Li Y, Ge Y, Kong X, Li X, Chen G (2023) An enriched environment improves maternal sleep deprivation-induced cognitive deficits and synaptic plasticity via hippocampal histone acetylation. Brain Behav 13(6):e3018. https:\/\/doi.org\/10.1002\/brb3.3018","journal-title":"Brain Behav"},{"key":"7068_CR34","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3389\/fncel.2019.00275","volume":"13","author":"C Zhou","year":"2019","unstructured":"Zhou C, Xue F, Xue S, Sang H, Liu L, Wang Y, Cai M, Zhang Z-J, Tan Q, Wang H, Peng Z (2019) Electroacupuncture Pretreatment Ameliorates PTSD-Like Behaviors in Rats by Enhancing Hippocampal Neurogenesis via the Keap1\/Nrf2 Antioxidant Signaling Pathway. Front Cell Neurosci 13:275. https:\/\/doi.org\/10.3389\/fncel.2019.00275","journal-title":"Front Cell Neurosci"},{"key":"7068_CR36","doi-asserted-by":"publisher","first-page":"113801","DOI":"10.1016\/j.psychres.2021.113801","volume":"298","author":"ZD Zuschlag","year":"2021","unstructured":"Zuschlag ZD, Compean E, Nietert P, Lauzon S, Hamner M, Wang Z (2021) Dopamine transporter (DAT1) gene in combat veterans with PTSD: A case-control study. Psychiatry Res 298:113801. https:\/\/doi.org\/10.1016\/j.psychres.2021.113801","journal-title":"Psychiatry Res"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-026-07068-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-026-07068-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-026-07068-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T02:32:45Z","timestamp":1777084365000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-026-07068-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,25]]},"references-count":30,"alternative-id":["7068"],"URL":"https:\/\/doi.org\/10.1007\/s00213-026-07068-x","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,25]]},"assertion":[{"value":"30 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}