{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:19:43Z","timestamp":1778757583569,"version":"3.51.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Swinburne University of Technology"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale<\/jats:title>\n                    <jats:p>Acute alcohol intoxication impairs cognitive and motor control, elevating risk in safety\u2013critical contexts. While blood alcohol concentration (BAC) quantifies exposure, it does not reflect real-time functional impairment. Mobile, performance-based assessments may offer scalable detection tools, but their sensitivity under controlled alcohol challenge requires further validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the sensitivity of a mobile cognitive assessment (DRUID\u00ae) to alcohol-induced impairment across low and moderate intoxication levels and examined objective cognitive performance and subjective intoxication within a unified framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a randomised, double-blind, placebo-controlled, within-subjects trial, 30 healthy adults (33% female; aged 23\u201349\u00a0years) completed neurocognitive testing following placebo, low-dose alcohol (mean peak BAC 0.04%), and moderate-dose alcohol (mean peak BAC 0.07%). Cognitive performance was measured using the Cambridge Neuropsychological Test Automated Battery (CANTAB) and DRUID\u00ae, while subjective effects were assessed via the Brief Biphasic Alcohol Effects Scale and a single-item intoxication rating.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Moderate alcohol intoxication significantly impaired spatial working memory, sustained attention, and psychomotor control (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), and elevated DRUID\u00ae impairment scores at 130\u00a0min post-dose relative to placebo (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Low-dose alcohol increased subjective intoxication and sedation (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) without measurable cognitive impairment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Moderate alcohol produced persistent neurocognitive deficits despite dissociation between subjective and objective measures. Findings support performance-based impairment models and highlight mobile cognitive tools such as DRUID\u00ae as practical candidates for real-time functional assessment in applied safety settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>ACTRN12623000528651, 19\/05\/2023.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00213-026-07090-z","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:34:05Z","timestamp":1778754845000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A randomised, double-blind, placebo-controlled trial examining the dose-dependent effects of acute alcohol intoxication on neurocognitive performance"],"prefix":"10.1007","author":[{"given":"Blair","family":"Aitken","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brook","family":"Shiferaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke A.","family":"Downey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke","family":"Manning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Arkell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Lenn\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonny","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amie C.","family":"Hayley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"issue":"6","key":"7090_CR1","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/j.neuron.2017.10.032","volume":"96","author":"KP Abrahao","year":"2017","unstructured":"Abrahao KP, Salinas AG, Lovinger DM (2017) Alcohol and the brain: neuronal molecular targets, synapses, and circuits. 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Brook Shiferaw, Jonny Kuo and Michael Lenn\u00e9 are employees of Seeing Machines. Blair Aitken, Luke Downey, Brooke Manning and Thomas Arkell have nothing to declare. Additionally, this work was supported by an industry research grant from Seeing Machines awarded to Amie Hayley. Seeing Machines contributed to aspects of study design and interpretation of findings but had no role in data collection, data management or statistical analysis. During the conduct of this work, Amie Hayley was also supported by a Rebecca L. Cooper Al and Val Rosenstrauss Fellowship [grant number F2021894].","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}