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Animals were randomly assigned to four groups: control\u2009+\u2009saline, CUS\u2009+\u2009saline, control\u2009+\u2009AVE0991, and CUS\u2009+\u2009AVE0991 (3\u00a0mg\/kg,\n                      <jats:italic>i.p<\/jats:italic>\n                      .). AVE was administered daily during the last two weeks of the stress protocol. Behavioral tests were performed to evaluate anxiety- and depressive-like behaviors, and plasma corticosterone, blood glucose levels, and brain-derived neurotrophic factor (BDNF) levels in the prefrontal cortex, hippocampus, and hypothalamus were measured.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CUS exposure significantly increased plasma corticosterone and glucose levels and induced anxiety- and depressive-like behaviors. Stressed animals also showed reduced BDNF levels in the prefrontal cortex, hippocampus, and hypothalamus. Treatment with AVE0991 attenuated the increase in corticosterone and prevented stress-induced hyperglycemia. Moreover, AVE0991 reduced depressive-like behavior, increased latency to immobility, and improved anxiety-related parameters in the elevated plus maze and open field tests without affecting locomotor activity. AVE0991 also prevented the reduction of BDNF levels in stress-exposed animals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings validate the CUS model and demonstrate that activation of the Mas receptor by AVE0991 exerts anxiolytic, antidepressant, and neuroprotective effects, supporting its potential as a therapeutic strategy for stress-related neuropsychiatric disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00213-026-07126-4","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:34:40Z","timestamp":1783931680000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The nonpeptide angiotensin-(1\u20137) mimic AVE0991 attenuates neuroendocrine and behavioral responses to chronic unpredictable stress"],"prefix":"10.1007","author":[{"given":"Maria Luiza Antunes","family":"Fonseca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Beatriz","family":"de Oliveira Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sth\u00e9fanie C. 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