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Informed consent was obtained from all individual participants included in the study.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"KMG has provided consultation to Achieve Life Sciences, Indivior, and Jazz Pharmaceuticals, and he has received research support from Aelis Farma. ALM-C has provided consultation to Indivior and has received research support from PleoPharma. The other authors report no conflicts of interest.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}