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Intermittent access (IntA) to cocaine produces even more robust addiction-like behavior than LgA, but it is not known if this produces comparable incubation of craving and effects on CP-AMPARs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rats underwent 5 days of short access training followed by 10 days of LgA or IntA cocaine self-administration; drug na\u00efve rats served as controls. Some rats were used for within-subject incubation testing at withdrawal days 1, 30 and 45, while others were used to measure the effects of LgA and IntA experience on CP-AMPAR-mediated transmission at withdrawal day 30\u201335.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IntA and LgA self-administration followed by withdrawal resulted in similar patterns of incubation across both sexes. Additionally, CP-AMPAR-mediated transmission was similarly enhanced in LgA and IntA groups compared to drug na\u00efve animals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite much less total cocaine consumption IntA resulted in incubation of craving and enhancements in NAc CP-AMPAR plasticity similar to LgA. This adds to a growing literature demonstrating that the intermittency of cocaine consumption can produce robust neurobehavioral plasticity comparable to LgA, in the absence of high levels of cocaine consumption.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00213-026-07152-2","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:17:58Z","timestamp":1787732278000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of withdrawal from intermittent vs. long access cocaine self-administration on nucleus accumbens calcium permeable AMPA receptor transmission and incubation of craving in female and male rats"],"prefix":"10.1007","author":[{"given":"Amanda M.","family":"Catalfio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy L.","family":"Fetterly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Wickens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry E.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie R.","family":"Ferrario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"7152_CR1","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1093\/ilar.52.3.309","volume":"52","author":"SH Ahmed","year":"2011","unstructured":"Ahmed SH, Kenny PJ (2011) Cracking the molecular code of cocaine addiction. 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