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Additionally, while older age was associated with better working memory in the CBD group before use, that relationship was progressively attenuated over the subsequent timepoints. There were no significant effects of cannabis use on cognition in the domains of executive function, episodic memory, or processing speed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Given the ubiquity of cannabis use for chronic pain and the ongoing call for more data, this study is relevant for informing clinical guidance on whether, and how, cannabis could be used in this context. In particular, understanding the acute impact on cognition from cannabis is critical, as cognitive functioning directly affects patients\u2019 daily lives and quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00213-026-07157-x","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:53:37Z","timestamp":1788270817000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of delta-9 tetrahydrocannabinol and cannabidiol on cognitive outcomes following acute use of cannabis for chronic pain"],"prefix":"10.1007","author":[{"given":"Ren\u00e9e","family":"Martin-Willett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha N.","family":"Melendez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent E.","family":"Hutchison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela D.","family":"Bryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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Importantly, the study design was conceptualized to be in compliance with all FDA, NIH, and federal regulations concerning the study of legal market cannabis at the time the study was conducted, including pre-registration on clinicaltrials.org (NCT03522324; record created 5\/9\/2018). Patients or the general public were not involved in the design, conduct, or reporting of the trial. We used the CONSORT reporting guidelines (Hopewell et al.\n                      \n                      ) to draft this manuscript, and the CONSORT reporting checklist (Hopewell et al.\n                      \n                      ) when editing.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"NCT03522324","order":2,"name":"Ethics","label":"Clinical trial registration","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Dr. Bryan receives personal fees for service on the scientific advisory board for Charlotte\u2019s Web, Inc.","order":3,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}