{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:59:48Z","timestamp":1790193588067,"version":"4.1.0"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32NS082145"],"award-info":[{"award-number":["T32NS082145"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG076030"],"award-info":[{"award-number":["R01AG076030"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX004693"],"award-info":[{"award-number":["BX004693"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"name":"San Antonio Nathan Shock Center of Excellence pilot grant"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"DOI":"10.1007\/s00213-026-07171-z","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:14:07Z","timestamp":1790147647000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting \u03b15-GABAA receptors to restore dopamine system function in a translationally relevant model of perimenopausal psychosis"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7651-5031","authenticated-orcid":false,"given":"Kayla","family":"Lilly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dishary","family":"Sharmin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Lodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"issue":"Suppl 1","key":"7171_CR1","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1017\/S1461145704004110","volume":"7","author":"A Abi-Dargham","year":"2004","unstructured":"Abi-Dargham A (2004) Do we still believe in the dopamine hypothesis? New data bring new evidence. Int J Neuropsychopharmacol 7(Suppl 1):S1-5","journal-title":"Int J Neuropsychopharmacol"},{"issue":"2","key":"7171_CR2","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/syn.890050211","volume":"5","author":"JB Becker","year":"1990","unstructured":"Becker JB (1990) Direct effect of 17 beta-estradiol on striatum: sex differences in dopamine release. Synapse 5(2):157\u2013164","journal-title":"Synapse"},{"issue":"1","key":"7171_CR3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0166-4328(86)90044-6","volume":"19","author":"JB Becker","year":"1986","unstructured":"Becker JB, Beer ME (1986) The influence of estrogen on nigrostriatal dopamine activity: behavioral and neurochemical evidence for both pre- and postsynaptic components. Behav Brain Res 19(1):27\u201333","journal-title":"Behav Brain Res"},{"key":"7171_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1348551","volume":"18","author":"PC Bendis","year":"2024","unstructured":"Bendis PC, Zimmerman S, Onisiforou A, Zanos P, Georgiou P (2024) The impact of estradiol on serotonin, glutamate, and dopamine systems. Front Neurosci 18:1348551","journal-title":"Front Neurosci"},{"issue":"1\u20133","key":"7171_CR5","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.schres.2014.05.005","volume":"157","author":"AM Boley","year":"2014","unstructured":"Boley AM, Perez SM, Lodge DJ (2014) A fundamental role for hippocampal parvalbumin in the dopamine hyperfunction associated with schizophrenia. Schizophr Res 157(1\u20133):238\u2013243","journal-title":"Schizophr Res"},{"issue":"4","key":"7171_CR6","first-page":"250","volume":"31","author":"HL Brooks","year":"2016","unstructured":"Brooks HL, Pollow DP, Hoyer PB (2016) The VCD mouse model of menopause and perimenopause for the study of sex differences in cardiovascular disease and the metabolic syndrome. Physiology (Bethesda) 31(4):250\u2013257","journal-title":"Physiology (Bethesda)"},{"issue":"1","key":"7171_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/schbul\/21.1.1","volume":"21","author":"DJ Castle","year":"1995","unstructured":"Castle DJ, Abel K, Takei N, Murray RM (1995) Gender differences in schizophrenia: hormonal effect or subtypes? Schizophr Bull 21(1):1\u201312","journal-title":"Schizophr Bull"},{"issue":"1","key":"7171_CR8","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0006-8993(93)91225-H","volume":"610","author":"SA Castner","year":"1993","unstructured":"Castner SA, Xiao L, Becker JB (1993) Sex differences in striatal dopamine: in vivo microdialysis and behavioral studies. Brain Res 610(1):127\u2013134","journal-title":"Brain Res"},{"key":"7171_CR9","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s44294-025-00061-3","volume":"3","author":"AC Cunningham","year":"2025","unstructured":"Cunningham AC, Hewings-Martin Y, Wickham AP, Prentice C, Payne JL, Zhaunova L (2025) Perimenopause symptoms, severity, and healthcare seeking in women in the US. Npj Women\u2019s Health 3:12","journal-title":"Npj Women's Health"},{"issue":"14","key":"7171_CR10","doi-asserted-by":"publisher","first-page":"11788","DOI":"10.3390\/ijms241411788","volume":"24","author":"NE Eassa","year":"2023","unstructured":"Eassa NE, Perez SM, Boley AM, Elam HB, Sharmin D, Cook JM, Lodge DJ (2023) alpha5-GABAA Receptor Modulation Reverses Behavioral and Neurophysiological Correlates of Psychosis in Rats with Ventral Hippocampal Alzheimer\u2019s Disease-like Pathology. Int J Mol Sci 24(14):11788","journal-title":"Int J Mol Sci"},{"issue":"8","key":"7171_CR11","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.tips.2018.04.003","volume":"39","author":"E Engin","year":"2018","unstructured":"Engin E, Benham RS, Rudolph U (2018) An emerging circuit pharmacology of GABA(A) receptors. Trends Pharmacol Sci 39(8):710\u2013732","journal-title":"Trends Pharmacol Sci"},{"issue":"13","key":"7171_CR12","doi-asserted-by":"publisher","first-page":"4915","DOI":"10.1523\/JNEUROSCI.21-13-04915.2001","volume":"21","author":"SB Floresco","year":"2001","unstructured":"Floresco SB, Todd CL, Grace AA (2001) Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons. J Neurosci 21(13):4915\u20134922","journal-title":"J Neurosci"},{"issue":"9","key":"7171_CR13","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1038\/nn1103","volume":"6","author":"SB Floresco","year":"2003","unstructured":"Floresco SB, West AR, Ash B, Moore H, Grace AA (2003) Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission. Nat Neurosci 6(9):968\u2013973","journal-title":"Nat Neurosci"},{"issue":"1","key":"7171_CR14","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1002\/cne.903590111","volume":"359","author":"JM Fritschy","year":"1995","unstructured":"Fritschy JM, Mohler H (1995) GABAA-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J Comp Neurol 359(1):154\u2013194","journal-title":"J Comp Neurol"},{"issue":"3","key":"7171_CR15","first-page":"193","volume":"62","author":"JB Frye","year":"2012","unstructured":"Frye JB, Lukefahr AL, Wright LE, Marion SL, Hoyer PB, Funk JL (2012) Modeling perimenopause in Sprague-Dawley rats by chemical manipulation of the transition to ovarian failure. Comp Med 62(3):193\u2013202","journal-title":"Comp Med"},{"issue":"9","key":"7171_CR16","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1038\/npp.2011.76","volume":"36","author":"KM Gill","year":"2011","unstructured":"Gill KM, Lodge DJ, Cook JM, Aras S, Grace AA (2011) A novel alpha5GABA(A)R-positive allosteric modulator reverses hyperactivation of the dopamine system in the MAM model of schizophrenia. Neuropsychopharmacology 36(9):1903\u20131911","journal-title":"Neuropsychopharmacology"},{"key":"7171_CR17","doi-asserted-by":"publisher","first-page":"789179","DOI":"10.3389\/fpsyt.2021.789179","volume":"12","author":"GM Giordano","year":"2021","unstructured":"Giordano GM, Bucci P, Mucci A, Pezzella P, Galderisi S (2021) Gender Differences in Clinical and Psychosocial Features Among Persons With Schizophrenia: A Mini Review. Front Psychiatry 12:789179","journal-title":"Front Psychiatry"},{"issue":"6","key":"7171_CR18","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1523\/JNEUROSCI.4751-07.2008","volume":"28","author":"J Glykys","year":"2008","unstructured":"Glykys J, Mann EO, Mody I (2008) Which GABA(A) receptor subunits are necessary for tonic inhibition in the hippocampus? J Neurosci 28(6):1421\u20131426","journal-title":"J Neurosci"},{"key":"7171_CR19","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/615356","author":"A Gogos","year":"2015","unstructured":"Gogos A, Sbisa AM, Sun J, Gibbons A, Udawela M, Dean B (2015) A role for estrogen in schizophrenia: clinical and preclinical findings. Int J Endocrinol. https:\/\/doi.org\/10.1155\/2015\/615356","journal-title":"Int J Endocrinol"},{"issue":"6","key":"7171_CR20","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1097\/JCP.0000000000000571","volume":"36","author":"A Gonzalez-Rodriguez","year":"2016","unstructured":"Gonzalez-Rodriguez A, Catalan R, Penades R, Ruiz Cortes V, Torra M, Seeman MV, Bernardo M (2016) Antipsychotic response worsens with postmenopausal duration in women with schizophrenia. J Clin Psychopharmacol 36(6):580\u2013587","journal-title":"J Clin Psychopharmacol"},{"key":"7171_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17155594","author":"A Gonzalez-Rodriguez","year":"2020","unstructured":"Gonzalez-Rodriguez A, Guardia A, Alvarez Pedrero A, Betriu M, Cobo J, Acebillo S, Monreal JA, Seeman MV, Palao D, Labad J (2020) Women with schizophrenia over the life span: health promotion, treatment and outcomes. Int J Environ Res Public Health. https:\/\/doi.org\/10.3390\/ijerph17155594","journal-title":"Int J Environ Res Public Health"},{"key":"7171_CR22","doi-asserted-by":"publisher","first-page":"204512531985997","DOI":"10.1177\/2045125319859973","volume":"9","author":"A Gonzalez-Rodriguez","year":"2019","unstructured":"Gonzalez-Rodriguez A, Seeman MV (2019) The association between hormones and antipsychotic use: a focus on postpartum and menopausal women. Ther Adv Psychopharmacol 9:2045125319859973","journal-title":"Ther Adv Psychopharmacol"},{"issue":"1","key":"7171_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0306-4522(91)90196-U","volume":"41","author":"AA Grace","year":"1991","unstructured":"Grace AA (1991) Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience 41(1):1\u201324","journal-title":"Neuroscience"},{"issue":"2\u20133","key":"7171_CR24","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/S0165-0173(99)00049-1","volume":"31","author":"AA Grace","year":"2000","unstructured":"Grace AA (2000) Gating of information flow within the limbic system and the pathophysiology of schizophrenia. Brain Res Brain Res Rev 31(2\u20133):330\u2013341","journal-title":"Brain Res Brain Res Rev"},{"issue":"3","key":"7171_CR25","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.neuropharm.2011.05.011","volume":"62","author":"AA Grace","year":"2012","unstructured":"Grace AA (2012) Dopamine system dysregulation by the hippocampus: implications for the pathophysiology and treatment of schizophrenia. Neuropharmacology 62(3):1342\u20131348","journal-title":"Neuropharmacology"},{"issue":"2","key":"7171_CR26","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/0306-4522(83)90135-5","volume":"10","author":"AA Grace","year":"1983","unstructured":"Grace AA, Bunney BS (1983) Intracellular and extracellular electrophysiology of nigral dopaminergic neurons\u20131. Identification and characterization. Neuroscience 10(2):301\u2013315","journal-title":"Neuroscience"},{"issue":"2","key":"7171_CR27","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0006-8993(85)91581-1","volume":"333","author":"AA Grace","year":"1985","unstructured":"Grace AA, Bunney BS (1985) Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity. Brain Res 333(2):271\u2013284","journal-title":"Brain Res"},{"issue":"5","key":"7171_CR28","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.tins.2007.03.003","volume":"30","author":"AA Grace","year":"2007","unstructured":"Grace AA, Floresco SB, Goto Y, Lodge DJ (2007) Regulation of firing of dopaminergic neurons and control of goal-directed behaviors. Trends Neurosci 30(5):220\u2013227","journal-title":"Trends Neurosci"},{"issue":"1\u20133","key":"7171_CR29","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.schres.2014.09.041","volume":"167","author":"S Heckers","year":"2015","unstructured":"Heckers S, Konradi C (2015) GABAergic mechanisms of hippocampal hyperactivity in schizophrenia. Schizophr Res 167(1\u20133):4\u201311","journal-title":"Schizophr Res"},{"issue":"8","key":"7171_CR30","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1001\/archgenpsychiatry.2012.169","volume":"69","author":"OD Howes","year":"2012","unstructured":"Howes OD, Kambeitz J, Kim E, Stahl D, Slifstein M, Abi-Dargham A, Kapur S (2012) The nature of dopamine dysfunction in schizophrenia and what this means for treatment: meta-analysisof imaging studies. Arch Gen Psychiatry 69(8):776\u2013786","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"7171_CR31","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/bdrb.20103","volume":"80","author":"PB Hoyer","year":"2007","unstructured":"Hoyer PB, Sipes IG (2007) Development of an animal model for ovotoxicity using 4-vinylcyclohexene: a case study. Birth Defects Res B Dev Reprod Toxicol 80(2):113\u2013125","journal-title":"Birth Defects Res B Dev Reprod Toxicol"},{"issue":"6","key":"7171_CR32","doi-asserted-by":"publisher","first-page":"e2800","DOI":"10.1097\/MD.0000000000002800","volume":"95","author":"LY Hu","year":"2016","unstructured":"Hu LY, Shen CC, Hung JH, Chen PM, Wen CH, Chiang YY, Lu T (2016) Risk of Psychiatric Disorders Following Symptomatic Menopausal Transition: A Nationwide Population-Based Retrospective Cohort Study. Medicine 95(6):e2800","journal-title":"Medicine"},{"key":"7171_CR33","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3389\/fnmol.2019.00179","volume":"12","author":"TC Jacob","year":"2019","unstructured":"Jacob TC (2019) Neurobiology and therapeutic potential of alpha5-GABA type A receptors. Front Mol Neurosci 12:179","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"7171_CR34","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3109\/19396368.2011.648820","volume":"58","author":"CJ Kappeler","year":"2012","unstructured":"Kappeler CJ, Hoyer PB (2012) 4-vinylcyclohexene diepoxide: a model chemical for ovotoxicity. Syst Biol Reprod Med 58(1):57\u201362","journal-title":"Syst Biol Reprod Med"},{"issue":"7","key":"7171_CR35","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.pnpbp.2003.09.004","volume":"27","author":"S Kapur","year":"2003","unstructured":"Kapur S, Mamo D (2003) Half a century of antipsychotics and still a central role for dopamine D2 receptors. Prog Neuropsychopharmacol Biol Psychiatry 27(7):1081\u20131090","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"Suppl 1","key":"7171_CR36","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.genm.2009.02.001","volume":"6","author":"NG Kase","year":"2009","unstructured":"Kase NG (2009) Impact of hormone therapy for women aged 35 to 65 years, from contraception to hormone replacement. Gend Med 6(Suppl 1):37\u201359","journal-title":"Gend Med"},{"issue":"1","key":"7171_CR37","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/s41398-022-02115-5","volume":"12","author":"S Knight","year":"2022","unstructured":"Knight S, McCutcheon R, Dwir D, Grace AA, O\u2019Daly O, McGuire P, Modinos G (2022) Hippocampal circuit dysfunction in psychosis. Transl Psychiatry 12(1):344","journal-title":"Transl Psychiatry"},{"issue":"1\u20133","key":"7171_CR38","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.schres.2011.06.007","volume":"131","author":"C Konradi","year":"2011","unstructured":"Konradi C, Yang CK, Zimmerman EI, Lohmann KM, Gresch P, Pantazopoulos H, Berretta S, Heckers S (2011) Hippocampal interneurons are abnormal in schizophrenia. Schizophr Res 131(1\u20133):165\u2013173","journal-title":"Schizophr Res"},{"issue":"4","key":"7171_CR39","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1177\/026988119901300405","volume":"13","author":"M Laruelle","year":"1999","unstructured":"Laruelle M, Abi-Dargham A (1999) Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies. J Psychopharmacol 13(4):358\u2013371","journal-title":"J Psychopharmacol"},{"issue":"4","key":"7171_CR40","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/(SICI)1098-2396(19990315)31:4<241::AID-SYN1>3.0.CO;2-#","volume":"31","author":"M Legault","year":"1999","unstructured":"Legault M, Wise RA (1999) Injections of N-methyl-D-aspartate into the ventral hippocampus increase extracellular dopamine in the ventral tegmental area and nucleus accumbens. Synapse 31(4):241\u2013249","journal-title":"Synapse"},{"issue":"4","key":"7171_CR41","doi-asserted-by":"publisher","DOI":"10.1136\/gpsych-2022-100823","volume":"35","author":"X Li","year":"2022","unstructured":"Li X, Zhou W, Yi Z (2022) A glimpse of gender differences in schizophrenia. Gen Psychiatr 35(4):e100823","journal-title":"Gen Psychiatr"},{"issue":"2","key":"7171_CR42","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.0207e04","volume":"68","author":"JA Lieberman","year":"2007","unstructured":"Lieberman JA (2007) Effectiveness of antipsychotic drugs in patients with chronic schizophrenia: efficacy, safety and cost outcomes of CATIE and other trials. J Clin Psychiatry 68(2):e04","journal-title":"J Clin Psychiatry"},{"issue":"8","key":"7171_CR43","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1038\/mp.2017.249","volume":"23","author":"JA Lieberman","year":"2018","unstructured":"Lieberman JA, Girgis RR, Brucato G, Moore H, Provenzano F, Kegeles L, Javitt D, Kantrowitz J, Wall MM, Corcoran CM, Schobel SA, Small SA (2018) Hippocampal dysfunction in the pathophysiology of schizophrenia: a selective review and hypothesis for early detection and intervention. Mol Psychiatry 23(8):1764\u20131772","journal-title":"Mol Psychiatry"},{"issue":"12","key":"7171_CR44","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1056\/NEJMoa051688","volume":"353","author":"JA Lieberman","year":"2005","unstructured":"Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Keefe RSE, Davis SM, Davis CE, Lebowitz BD, Severe J, Hsiao JK (2005) Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 353(12):1209\u20131223","journal-title":"N Engl J Med"},{"key":"7171_CR45","doi-asserted-by":"crossref","unstructured":"Lilly K, Mondal P, Cook JM, Perez SM, Lodge DJ. (2026). Enantiomer-specific modulation of GABAA receptors differentially regulates stress-induced dopamine dysregulation.","DOI":"10.1007\/s00213-026-07164-y"},{"issue":"7","key":"7171_CR46","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1038\/sj.npp.1300963","volume":"31","author":"DJ Lodge","year":"2006","unstructured":"Lodge DJ, Grace AA (2006) The hippocampus modulates dopamine neuron responsivity by regulating the intensity of phasic neuron activation. Neuropsychopharmacology 31(7):1356\u20131361","journal-title":"Neuropsychopharmacology"},{"issue":"42","key":"7171_CR47","doi-asserted-by":"publisher","first-page":"11424","DOI":"10.1523\/JNEUROSCI.2847-07.2007","volume":"27","author":"DJ Lodge","year":"2007","unstructured":"Lodge DJ, Grace AA (2007) Aberrant hippocampal activity underlies the dopamine dysregulation in an animal model of schizophrenia. J Neurosci 27(42):11424\u201311430","journal-title":"J Neurosci"},{"issue":"9","key":"7171_CR48","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.tips.2011.05.001","volume":"32","author":"DJ Lodge","year":"2011","unstructured":"Lodge DJ, Grace AA (2011) Hippocampal dysregulation of dopamine system function and the pathophysiology of schizophrenia. Trends Pharmacol Sci 32(9):507\u2013513","journal-title":"Trends Pharmacol Sci"},{"issue":"1","key":"7171_CR49","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s00429-021-02375-9","volume":"227","author":"E Luquin","year":"2022","unstructured":"Luquin E, Paternain B, Zugasti I, Santoma C, Mengual E (2022) Stereological estimations and neurochemical characterization of neurons expressing GABAA and GABAB receptors in the rat pedunculopontine and laterodorsal tegmental nuclei. Brain Struct Funct 227(1):89\u2013110","journal-title":"Brain Struct Funct"},{"issue":"9","key":"7171_CR50","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.tips.2023.06.009","volume":"44","author":"B Luscher","year":"2023","unstructured":"Luscher B, Maguire JL, Rudolph U, Sibille E (2023) GABA(A) receptors as targets for treating affective and cognitive symptoms of depression. Trends Pharmacol Sci 44(9):586\u2013600","journal-title":"Trends Pharmacol Sci"},{"issue":"5","key":"7171_CR51","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1523\/JNEUROSCI.0567-18.2018","volume":"39","author":"E Magnin","year":"2019","unstructured":"Magnin E, Francavilla R, Amalyan S, Gervais E, David LS, Luo X, Topolnik L (2019) Input-specific synaptic location and function of the alpha5 GABA(A) receptor subunit in the mouse CA1 hippocampal neurons. J Neurosci 39(5):788\u2013801","journal-title":"J Neurosci"},{"issue":"6","key":"7171_CR52","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.1038\/s41380-020-0711-y","volume":"26","author":"TR Marques","year":"2021","unstructured":"Marques TR, Ashok AH, Angelescu I, Borgan F, Myers J, Lingford-Hughes A, Nutt DJ, Veronese M, Turkheimer FE, Howes OD (2021) GABA-A receptor differences in schizophrenia: a positron emission tomography study using [(11)C]Ro154513. Mol Psychiatry 26(6):2616\u20132625","journal-title":"Mol Psychiatry"},{"issue":"1","key":"7171_CR53","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1095\/biolreprod.103.016113","volume":"71","author":"LP Mayer","year":"2004","unstructured":"Mayer LP, Devine PJ, Dyer CA, Hoyer PB (2004) The follicle-deplete mouse ovary produces androgen. Biol Reprod 71(1):130\u2013138","journal-title":"Biol Reprod"},{"issue":"6","key":"7171_CR54","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/S0890-6238(02)00048-5","volume":"16","author":"LP Mayer","year":"2002","unstructured":"Mayer LP, Pearsall NA, Christian PJ, Devine PJ, Payne CM, McCuskey MK, Marion SL, Sipes IG, Hoyer PB (2002) Long-term effects of ovarian follicular depletion in rats by 4-vinylcyclohexene diepoxide. Reprod Toxicol 16(6):775\u2013781","journal-title":"Reprod Toxicol"},{"issue":"8","key":"7171_CR55","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1093\/ijnp\/pyac035","volume":"25","author":"AM McCoy","year":"2022","unstructured":"McCoy AM, Prevot TD, Mian MY, Cook JM, Frazer A, Sibille EL, Carreno FR, Lodge DJ (2022) Positive Allosteric Modulation of alpha5-GABAA Receptors Reverses Stress-Induced Alterations in Dopamine System Function and Prepulse Inhibition of Startle. Int J Neuropsychopharmacol 25(8):688\u2013698","journal-title":"Int J Neuropsychopharmacol"},{"key":"7171_CR56","doi-asserted-by":"crossref","unstructured":"McCoy AM, Prevot TD, Mian MY, Sharmin D, Ahmad AN, Cook JM, Sibille EL, Lodge DJ (2024). \"Extrasynaptic localization is essential for alpha5GABA(A) receptor modulation of dopamine system function.\" eNeuro 11(3).","DOI":"10.1523\/ENEURO.0344-23.2023"},{"issue":"4","key":"7171_CR57","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0166-2236(96)80023-3","volume":"19","author":"RM McKernan","year":"1996","unstructured":"McKernan RM, Whiting PJ (1996) Which GABAA-receptor subtypes really occur in the brain? Trends Neurosci 19(4):139\u2013143","journal-title":"Trends Neurosci"},{"issue":"1","key":"7171_CR58","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/ajhb.1310040107","volume":"4","author":"SM McKinlay","year":"1992","unstructured":"McKinlay SM, Brambilla DJ, Posner JG (1992) The normal menopause transition. Am J Hum Biol 4(1):37\u201346","journal-title":"Am J Hum Biol"},{"issue":"1","key":"7171_CR59","first-page":"46","volume":"59","author":"FS Muhammad","year":"2009","unstructured":"Muhammad FS, Goode AK, Kock ND, Arifin EA, Cline JM, Adams MR, Hoyer PB, Christian PJ, Isom S, Kaplan JR, Appt SE (2009) Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes. Comp Med 59(1):46\u201359","journal-title":"Comp Med"},{"issue":"1","key":"7171_CR60","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/s41398-019-0603-6","volume":"9","author":"SM Perez","year":"2019","unstructured":"Perez SM, Boley A, Lodge DJ (2019) Region specific knockdown of Parvalbumin or Somatostatin produces neuronal and behavioral deficits consistent with those observed in schizophrenia. Transl Psychiatry 9(1):264","journal-title":"Transl Psychiatry"},{"key":"7171_CR61","unstructured":"Perez SM, Boley AM, Elam HB, Yang OJ, Lilly K, Lodge DJ (2026). A circuit mechanism for psychosis vulnerability during perimenopause. PNAS, In revision."},{"key":"7171_CR62","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.psyneuen.2014.05.005","volume":"47","author":"SM Perez","year":"2014","unstructured":"Perez SM, Chen L, Lodge DJ (2014) Alterations in dopamine system function across the estrous cycle of the MAM rodent model of schizophrenia. Psychoneuroendocrinology 47:88\u201397","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"7171_CR63","doi-asserted-by":"publisher","first-page":"067","DOI":"10.1093\/schizbullopen\/sgac067","volume":"3","author":"SM Perez","year":"2022","unstructured":"Perez SM, Elam HB, Lodge DJ (2022) Increased Presynaptic Dopamine Synthesis Capacity Is Associated With Aberrant Dopamine Neuron Activity in the Methylazoxymethanol Acetate Rodent Model Used to Study Schizophrenia-Related Pathologies. Schizophr Bull Open 3(1):067","journal-title":"Schizophr Bull Open"},{"issue":"50","key":"7171_CR64","doi-asserted-by":"publisher","first-page":"10607","DOI":"10.1523\/JNEUROSCI.2629-16.2018","volume":"38","author":"SM Perez","year":"2018","unstructured":"Perez SM, Lodge DJ (2018) Convergent inputs from the hippocampus and thalamus to the nucleus accumbens regulate dopamine neuron activity. J Neurosci 38(50):10607\u201310618","journal-title":"J Neurosci"},{"issue":"1","key":"7171_CR65","first-page":"78","volume":"3","author":"SM Perez","year":"2022","unstructured":"Perez SM, McCoy AM, Prevot TD, Milan MY, Carreno FR, Frazer A, Cook JM, Sibille E, Lodge DJ (2022) Hippocampal \u03b15-GABAA receptors modulate dopamine neuron activity in the rat ventral tegmental area. Biological Psychiatry: Global Open Access 3(1):78\u201386","journal-title":"Biological Psychiatry: Global Open Access"},{"issue":"2","key":"7171_CR66","first-page":"84","volume":"5","author":"TD Prevot","year":"2019","unstructured":"Prevot TD, Li G, Vidojevic A, Misquitta KA, Fee C, Santrac A, Knutson DE, Stephen MR, Kodali R, Zahn NM, Arnold LA, Scholze P, Fisher JL, Markovic BD, Banasr M, Cook JM, Savic M, Sibille E (2019) Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles. Mol Neuropsychiatry 5(2):84\u201397","journal-title":"Mol Neuropsychiatry"},{"issue":"6","key":"7171_CR67","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/BF02190244","volume":"242","author":"A Riecher-Rossler","year":"1993","unstructured":"Riecher-Rossler A, Hafner H (1993) Schizophrenia and oestrogens\u2013is there an association? Eur Arch Psychiatry Clin Neurosci 242(6):323\u2013328","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"2","key":"7171_CR68","first-page":"215","volume":"8","author":"MV Seeman","year":"2012","unstructured":"Seeman MV (2012) Women and psychosis. Womens Health 8(2):215\u2013224","journal-title":"Womens Health"},{"issue":"4","key":"7171_CR69","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1517\/14728222.10.4.515","volume":"10","author":"P Seeman","year":"2006","unstructured":"Seeman P (2006) Targeting the dopamine D2 receptor in schizophrenia. Expert Opin Ther Targets 10(4):515\u2013531","journal-title":"Expert Opin Ther Targets"},{"issue":"5","key":"7171_CR70","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.tins.2004.03.005","volume":"27","author":"A Semyanov","year":"2004","unstructured":"Semyanov A, Walker MC, Kullmann DM, Silver RA (2004) Tonically active GABA A receptors: modulating gain and maintaining the tone. Trends Neurosci 27(5):262\u2013269","journal-title":"Trends Neurosci"},{"key":"7171_CR71","doi-asserted-by":"crossref","unstructured":"Sharmin D, Mian MY, Marcotte M, Prevot TD, Sibille E, Witkin JM, Cook JM (2023). Synthesis and Receptor Binding Studies of alpha5 GABA(A)R Selective Novel Imidazodiazepines Targeted for Psychiatric and Cognitive Disorders. Molecules 28(12)","DOI":"10.3390\/molecules28124771"},{"issue":"1","key":"7171_CR72","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1093\/schbul\/sbac139","volume":"49","author":"IE Sommer","year":"2023","unstructured":"Sommer IE, Brand BA, Gangadin S, Tanskanen A, Tiihonen J, Taipale H (2023) Women with schizophrenia-spectrum disorders after menopause: a vulnerable group for relapse. Schizophr Bull 49(1):136\u2013143","journal-title":"Schizophr Bull"},{"key":"7171_CR73","unstructured":"Speroff L, Fritz M (2005) Menpause and the perimenopausal transition. Clinical gynecology endocrinology and infertility, 7th ed. Lippincott Williams and Wilkins, Philadelphia,PA, pp 621\u2013688"},{"key":"7171_CR74","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.ejphar.2016.09.016","volume":"791","author":"TT Stamenic","year":"2016","unstructured":"Stamenic TT, Poe MM, Rehman S, Santrac A, Divovic B, Scholze P, Ernst M, Cook JM, Savic MM (2016) Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABAA receptors containing the alpha5 subunit. Eur J Pharmacol 791:433\u2013443","journal-title":"Eur J Pharmacol"},{"issue":"1\u20132","key":"7171_CR75","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0006-8993(99)01152-X","volume":"822","author":"C Sur","year":"1999","unstructured":"Sur C, Fresu L, Howell O, McKernan RM, Atack JR (1999) Autoradiographic localization of alpha5 subunit-containing GABAA receptors in rat brain. Brain Res 822(1\u20132):265\u2013270","journal-title":"Brain Res"},{"key":"7171_CR76","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.maturitas.2021.07.003","volume":"152","author":"A Szeliga","year":"2021","unstructured":"Szeliga A, Stefanowski B, Meczekalski B, Snopek M, Kostrzak A, Smolarczyk R, Bala G, Duszewska A, Smolarczyk K, Maciejewska-Jeske M (2021) Menopause in women with schizophrenia, schizoaffective disorder and bipolar disorder. Maturitas 152:57\u201362","journal-title":"Maturitas"},{"issue":"7","key":"7171_CR77","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.tins.2012.02.003","volume":"35","author":"MA Ungless","year":"2012","unstructured":"Ungless MA, Grace AA (2012) Are you or aren\u2019t you? Challenges associated with physiologically identifying dopamine neurons. Trends Neurosci 35(7):422\u2013430","journal-title":"Trends Neurosci"},{"key":"7171_CR78","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-026-03791-1","author":"OJ Yang","year":"2026","unstructured":"Yang OJ, Reiley HB, Boley AM, Perez SM, Lodge DJ (2026) A cortical insula-orbitofrontal circuit drives stress-induced dopamine system dysfunction. Mol Psychiatry. https:\/\/doi.org\/10.1038\/s41380-026-03791-1","journal-title":"Mol Psychiatry"},{"key":"7171_CR79","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.yhbeh.2018.04.002","volume":"104","author":"KE Yoest","year":"2018","unstructured":"Yoest KE, Quigley JA, Becker JB (2018) Rapid effects of ovarian hormones in dorsal striatum and nucleus accumbens. Horm Behav 104:119\u2013129","journal-title":"Horm Behav"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-026-07171-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-026-07171-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-026-07171-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:03:48Z","timestamp":1790190228000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-026-07171-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":79,"alternative-id":["7171"],"URL":"https:\/\/doi.org\/10.1007\/s00213-026-07171-z","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"assertion":[{"value":"8 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"DJL has received research funding from Heptares Therapeutics Ltd., consulting fees from Alkermes Inc., and is a patent co-inventor (US 2019\/0117637), all of which are unrelated to the work described in this manuscript. All other authors declare that they have no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}