{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:02:48Z","timestamp":1793505768552,"version":"4.5.0"},"reference-count":109,"publisher":"Springer Science and Business Media LLC","issue":"15","license":[{"start":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T00:00:00Z","timestamp":1363219200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s00216-013-6777-5","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T18:05:18Z","timestamp":1363370718000},"page":"5013-5030","source":"Crossref","is-referenced-by-count":49,"title":["Metabolomics of colorectal cancer: past and current analytical platforms"],"prefix":"10.1007","volume":"405","author":[{"given":"Michael D.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S.","family":"Resar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Herbert H.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,3,14]]},"reference":[{"key":"6777_CR1","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1085\/jgp.8.6.519","volume":"8","author":"O Warburg","year":"1927","unstructured":"Warburg O, Wind F, Negelein E (1927) The metabolism of tumors in the body. J Gen Physiol 8:519","journal-title":"J Gen Physiol"},{"key":"6777_CR2","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1126\/science.1160809","volume":"324","author":"MG Heiden Vander","year":"2012","unstructured":"Vander Heiden MG, Cantley LC, Thompson CB (2012) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029","journal-title":"Science"},{"key":"6777_CR3","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.ccr.2008.05.005","volume":"13","author":"G Kroemer","year":"2008","unstructured":"Kroemer G, Pouyssegur J (2008) Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 13:472","journal-title":"Cancer Cell"},{"key":"6777_CR4","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2012","unstructured":"Hanahan D, Weinberg RA (2012) Hallmarks of cancer: the next generation. Cell 144:646","journal-title":"Cell"},{"key":"6777_CR5","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/gm5","volume":"1","author":"QN Van","year":"2009","unstructured":"Van QN, Veenstra TD (2009) How close is the bench to the bedside? Metabolic profiling in cancer research. Genome Med 1:5","journal-title":"Genome Med"},{"key":"6777_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.critrevonc.2012.02.009","volume":"84","author":"WM Claudino","year":"2012","unstructured":"Claudino WM, Goncalves PH, di Leo A, Philip PA, Sarkar FH (2012) Metabolomics in cancer: a bench-to-bedside intersection. Crit Rev Oncol Hematol 84:1","journal-title":"Crit Rev Oncol Hematol"},{"key":"6777_CR7","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1098\/rstb.2003.1411","volume":"359","author":"JL Griffin","year":"2004","unstructured":"Griffin JL (2004) Metabolic profiles to define the genome: can we hear the phenotypes? Philos Trans R Soc B Biol Sci 359:857","journal-title":"Philos Trans R Soc B Biol Sci"},{"key":"6777_CR8","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1002\/cfg.82","volume":"2","author":"O Fiehn","year":"2001","unstructured":"Fiehn O (2001) Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks. Comp Funct Genom 2:155","journal-title":"Comp Funct Genom"},{"key":"6777_CR9","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1126\/science.1193494","volume":"330","author":"AJ Levine","year":"2010","unstructured":"Levine AJ, Puzio-Kuter AM (2010) The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 330:1340","journal-title":"Science"},{"key":"6777_CR10","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nrc3038","volume":"11","author":"WH Koppenol","year":"2011","unstructured":"Koppenol WH, Bounds PL, Dang CV (2011) Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer 11:325","journal-title":"Nat Rev Cancer"},{"key":"6777_CR11","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1097\/CCO.0b013e32834deb9e","volume":"24","author":"J-P Bayley","year":"2012","unstructured":"Bayley J-P, Devilee P (2012) The Warburg effect in 2012. Curr Opin Oncol 24:62","journal-title":"Curr Opin Oncol"},{"key":"6777_CR12","first-page":"1437","volume":"11","author":"A-FA Mentis","year":"2010","unstructured":"Mentis A-FA, Kararizou E (2010) Metabolism and cancer: an up-to-date review of a mutual connection. Asian Pacific J Cancer Prev 11:1437","journal-title":"Asian Pacific J Cancer Prev"},{"key":"6777_CR13","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.ceb.2006.10.005","volume":"18","author":"RJ Shaw","year":"2006","unstructured":"Shaw RJ (2006) Glucose metabolism and cancer. Curr Opin Cell Biol 18:598","journal-title":"Curr Opin Cell Biol"},{"key":"6777_CR14","unstructured":"ACS (2011) Colorectal cancer facts & figures 2011-2013. American Cancer Society, Atlanta, Georgia. \n                    http:\/\/www.cancer.org\/research\/cancerfactsfigures\/colorectalcancerfactsfigures\/colorectal-cancer-facts-figures-2011-2013-page"},{"key":"6777_CR15","unstructured":"ACS (2012) Cancer facts & figures 2012. American Cancer Society, Atlanta, Georgia. \n                    http:\/\/www.cancer.org\/acs\/groups\/content\/@epidemiologysurveilance\/documents\/document\/acspc-031941.pdf"},{"key":"6777_CR16","doi-asserted-by":"publisher","first-page":"4844","DOI":"10.1021\/pr9004162","volume":"8","author":"Y Qiu","year":"2009","unstructured":"Qiu Y, Cai G, Su M, Chen T, Zheng X, Xu Y, Ni Y, Zhao A, Xu LX, Cai S, Jia W (2009) Serum metabolite profiling of human colorectal cancer using GC\u2212TOFMS and UPLC\u2212QTOFMS. J Proteome Res 8:4844","journal-title":"J Proteome Res"},{"key":"6777_CR17","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1021\/pr201001a","volume":"11","author":"Y Cheng","year":"2012","unstructured":"Cheng Y, Xie G, Chen T, Qiu Y, Zou X, Zheng M, Tan B, Feng B, Dong T, He P, Zhao L, Zhao A, Xu LX, Zhang Y, Jia W (2012) Distinct urinary metabolic profile of human colorectal cancer. J Proteome Res 11:1354","journal-title":"J Proteome Res"},{"key":"6777_CR18","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1021\/pr8006232","volume":"8","author":"EC Chan","year":"2009","unstructured":"Chan EC, Koh PK, Mal M, Cheah PY, Eu KW, Backshall A, Cavill R, Nicholson JK, Keun HC (2009) Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC\/MS). J Proteome Res 8:352","journal-title":"J Proteome Res"},{"key":"6777_CR19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1002\/mas.20108","volume":"26","author":"K Dettmer","year":"2007","unstructured":"Dettmer K, Aronov PA, Hammock BD (2007) Mass spectrometry-based metabolomics. Mass Spectrom Rev 26:51","journal-title":"Mass Spectrom Rev"},{"key":"6777_CR20","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.trac.2004.11.021","volume":"24","author":"WB Dunn","year":"2005","unstructured":"Dunn WB, Ellis DI (2005) Metabolomics: Current analytical platforms and methodologies. Trends Anal Chem 24:285","journal-title":"Trends Anal Chem"},{"key":"6777_CR21","doi-asserted-by":"crossref","unstructured":"Dunn WB, Bailey NJC, Johnson HE (2005) Measuring the metabolome: current analytical technologies. Analyst 130","DOI":"10.1039\/b418288j"},{"key":"6777_CR22","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.trac.2008.01.006","volume":"27","author":"M Bedair","year":"2008","unstructured":"Bedair M, Sumner LW (2008) Current and emerging mass-spectrometry technologies for metabolomics. Trends Anal Chem 27:238","journal-title":"Trends Anal Chem"},{"key":"6777_CR23","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.trac.2008.01.008","volume":"27","author":"G Theodoridis","year":"2008","unstructured":"Theodoridis G, Gika HG, Wilson ID (2008) LC-MS-based methodology for global metabolite profiling in metabonomics\/metabolomics. Trends Anal Chem 27:251","journal-title":"Trends Anal Chem"},{"key":"6777_CR24","first-page":"19","volume":"40","author":"A Okada","year":"1993","unstructured":"Okada A, Takehara H, Yoshida K, Nishi M, Miyake H, Kita Y, Komi N (1993) Increased aspartate and glutamate levels in both gastric and colon cancer tissues. Tokushima J Exp Med 40:19","journal-title":"Tokushima J Exp Med"},{"key":"6777_CR25","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1111\/j.1349-7006.1999.tb00764.x","volume":"90","author":"K Nakagami","year":"1999","unstructured":"Nakagami K, Uchida T, Ohwada S, Koibuchi Y, Suda Y, Sekine T, Morishita Y (1999) Increased choline kinase activity and elevated phosphocholine levels in human colon cancer. Jpn J Cancer Res 90:419","journal-title":"Jpn J Cancer Res"},{"key":"6777_CR26","doi-asserted-by":"publisher","unstructured":"Ong ES, Zou L, Li S, Cheah PY, Eu KW, Ong CN (2010) Metabolic profiling in colorectal cancer reveals signature metabolic shifts during tumorigenesis. Mol Cell Proteomics. doi:\n                    10.1074\/mcp.M900551-MCP200","DOI":"10.1074\/mcp.M900551-MCP200"},{"key":"6777_CR27","doi-asserted-by":"crossref","unstructured":"Denkert C, Budczies J, Weichert W, Wohlgemuth G, Scholz M, Kind T, Niesporek S, Noske A, Buckendahl A, Dietel M, Fiehn O (2008) Metabolite profiling of human colon carcinoma \u2013 deregulation of TCA cycle and amino acid turnover. Mol Cancer 7","DOI":"10.1186\/1476-4598-7-72"},{"key":"6777_CR28","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1002\/rcm.3898","volume":"23","author":"M Mal","year":"2009","unstructured":"Mal M, Koh PK, Cheah PY, Chan ECY (2009) Development and validation of a gas chromatography\/mass spectrometry method for the metabolic profiling of human colon tissue. Rapid Commun Mass Spectrom 23:487","journal-title":"Rapid Commun Mass Spectrom"},{"key":"6777_CR29","doi-asserted-by":"publisher","first-page":"4918","DOI":"10.1158\/0008-5472.CAN-08-4806","volume":"69","author":"A Hirayama","year":"2009","unstructured":"Hirayama A, Kami K, Sugimoto M, Sugawara M, Toki N, Onozuka H, Kinoshita T, Saito N, Ochiai A, Tomita M, Esumi H, Soga T (2009) Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res 69:4918","journal-title":"Cancer Res"},{"key":"6777_CR30","doi-asserted-by":"crossref","unstructured":"Seierstad T, R\u00f8e K, Sitter B, Halgunset J, Flatmark K, Ree AH, Olsen D, Gribbestad IS, Bathen TF (2008) Principal component analysis for the comparison of metabolic profiles from human rectal cancer biopsies and colorectal xenografts using high-resolution magic angle spinning 1H magnetic resonance spectroscopy. Mol Cancer 7","DOI":"10.1186\/1476-4598-7-33"},{"key":"6777_CR31","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1007\/s11306-008-0151-1","volume":"5","author":"M Piotto","year":"2008","unstructured":"Piotto M, Moussallieh FM, Dillmann B, Imperiale A, Neuville A, Brigand C, Bellocq JP, Elbayed K, Namer IJ (2008) Metabolic characterization of primary human colorectal cancers using high resolution magic angle spinning 1H magnetic resonance spectroscopy. Metabolomics 5:292","journal-title":"Metabolomics"},{"key":"6777_CR32","doi-asserted-by":"publisher","first-page":"3664","DOI":"10.1021\/pr100176g","volume":"9","author":"M-B Tessem","year":"2010","unstructured":"Tessem M-B, Seln\u00e6s KM, Sjursen W, Tran\u00f8 G, Giske\u00f8deg\u00e5rd GF, Bathen TF, Gribbestad IS, Hofsli E (2010) Discrimination of patients with microsatellite instability colon cancer using 1H HR MAS MR spectroscopy and chemometric analysis. J Proteome Res 9:3664","journal-title":"J Proteome Res"},{"key":"6777_CR33","doi-asserted-by":"publisher","first-page":"379","DOI":"10.5012\/bkcs.2010.31.02.379","volume":"31","author":"Y-K Chae","year":"2010","unstructured":"Chae Y-K, Kang W-Y, Kim S-H, Joo J-E, Han J-K, Hong B-W (2010) Combining information of common metabolites reveals global differences between colorectal cancerous and normal tissues. Bull Korean Chem Soc 31:379","journal-title":"Bull Korean Chem Soc"},{"key":"6777_CR34","doi-asserted-by":"publisher","first-page":"S68","DOI":"10.1002\/mrc.2519","volume":"47","author":"C Ludwig","year":"2009","unstructured":"Ludwig C, Ward DG, Martin A, Viant MR, Ismail T, Johnson PJ, Wakelam MJO, G\u00fcnther UL (2009) Fast targeted multidimensional NMR metabolomics of colorectal cancer. Magn Reson Chem 47:S68","journal-title":"Magn Reson Chem"},{"key":"6777_CR35","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1158\/0008-5472.CAN-11-1543","volume":"72","author":"I Bertini","year":"2012","unstructured":"Bertini I, Cacciatore S, Jensen BV, Schou JV, Johansen JS, Kruhoffer M, Luchinat C, Nielsen DL, Turano P (2012) Metabolomic NMR fingerprinting to identify and predict survival of patients with metastatic colorectal cancer. Cancer Res 72:356","journal-title":"Cancer Res"},{"key":"6777_CR36","doi-asserted-by":"crossref","unstructured":"Ritchie SA, Ahiahonu PWK, Jayasinghe D, Heath D, Liu J, Lu Y, Jin W, Kavianpour A, Yamazaki Y, Khan AM, Hossain M, Su-Myat KK, Wood PL, Krenitsky K, Takemasa I, Miyake M, Sekimoto M, Monden M, Matsubara H, Nomura F, Goodenowe DB (2010) Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection. BMC Med 8","DOI":"10.1186\/1741-7015-8-13"},{"key":"6777_CR37","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s11306-006-0043-1","volume":"3","author":"CY Lin","year":"2007","unstructured":"Lin CY, Wu H, Tjeerdema RS, Viant MR (2007) Evaluation of metabolite extraction strategies from tissue samples using NMR metabolomics. Metabolomics 3:55","journal-title":"Metabolomics"},{"key":"6777_CR38","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ab.2007.10.002","volume":"372","author":"H Wu","year":"2008","unstructured":"Wu H, Southam AD, Hines A, Viant MR (2008) High-throughput tissue extraction protocol for NMR- and MS-based metabolomics. Anal Biochem 372:204","journal-title":"Anal Biochem"},{"key":"6777_CR39","doi-asserted-by":"publisher","first-page":"4307","DOI":"10.1021\/ac051972y","volume":"78","author":"O Teahan","year":"2006","unstructured":"Teahan O, Gamble S, Holmes E, Waxman J, Nicholson JK, Bevan C, Keun HC (2006) Impact of analytical bias in metabonomic studies of human blood serum and plasma. Anal Chem 78:4307","journal-title":"Anal Chem"},{"key":"6777_CR40","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1021\/ac051312t","volume":"78","author":"EJ Want","year":"2006","unstructured":"Want EJ, O'Maille G, Smith CA, Brandon TR, Uritboonthai W, Qin C, Trauger SA, Siuzdak G (2006) Solvent-dependent metabolite distribution, clustering, and protein extraction for serum profiling with mass spectrometry. Anal Chem 78:743","journal-title":"Anal Chem"},{"key":"6777_CR41","doi-asserted-by":"publisher","first-page":"3285","DOI":"10.1021\/ac8024569","volume":"81","author":"SJ Bruce","year":"2009","unstructured":"Bruce SJ, Tavazzi I, Parisod V, Rezzi S, Kochhar S, Guy PA (2009) Investigation of human blood plasma sample preparation for performing metabolomics using ultrahigh performance liquid chromatography\/mass spectrometry. Anal Chem 81:3285","journal-title":"Anal Chem"},{"key":"6777_CR42","doi-asserted-by":"publisher","first-page":"7255","DOI":"10.1021\/ac0508604","volume":"77","author":"KO Boernsen","year":"2005","unstructured":"Boernsen KO, Gatzek S, Imbert G (2005) Controlled protein precipitation in combination with chip-based nanospray infusion mass spectrometry. An approach for metabolomics profiling of plasma. Anal Chem 77:7255","journal-title":"Anal Chem"},{"key":"6777_CR43","doi-asserted-by":"publisher","first-page":"4847","DOI":"10.1021\/ac9004875","volume":"81","author":"LM Smith","year":"2009","unstructured":"Smith LM, Maher AD, Want EJ, Elliott P, Stamler J, Hawkes GE, Holmes E, Lindon JC, Nicholson JK (2009) Large-scale human metabolic phenotyping and molecular epidemiological studies via 1H NMR spectroscopy of urine: investigation of borate preservation. Anal Chem 81:4847","journal-title":"Anal Chem"},{"key":"6777_CR44","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/S0731-7085(03)00410-2","volume":"33","author":"EM Lenz","year":"2003","unstructured":"Lenz EM, Bright J, Wilson ID, Morgan SR, Nash AFP (2003) A 1H NMR-based metabonomic study of urine and plasma samples obtained from healthy human subjects. J Pharm Biomed Anal 33:1103","journal-title":"J Pharm Biomed Anal"},{"key":"6777_CR45","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0378-4347(01)00138-4","volume":"758","author":"T Kuhara","year":"2001","unstructured":"Kuhara T (2001) Diagnosis of inborn errors of metabolism using filter paper urine, urease treatment, isotope dilution and gas chromatography\u2013mass spectrometry. J Chromatogr B: Biomed Sci Appl 758:3","journal-title":"J Chromatogr B: Biomed Sci Appl"},{"key":"6777_CR46","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1021\/ac8022857","volume":"81","author":"M B\u00fcscher Jr","year":"2009","unstructured":"B\u00fcscher M Jr, Czernik D, Ewald JC, Sauer U, Zamboni N (2009) Cross-platform comparison of methods for quantitative metabolomics of primary metabolism. Anal Chem 81:2135","journal-title":"Anal Chem"},{"key":"6777_CR47","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1038\/nbt0705-833","volume":"23","author":"JC Lindon","year":"2005","unstructured":"Lindon JC, Nicholson JK, Holmes E, Keun HC, Craig A, Pearce JTM, Bruce SJ, Hardy N, Sansone S-A, Antti H, Jonsson P, Daykin C, Navarange M, Beger RD, Verheij ER, Amberg A, Baunsgaard D, Cantor GH, Lehman-McKeeman L, Earll M, Wold S, Johansson E, Haselden JN, Kramer K, Thomas C, Lindberg J, Schuppe-Koistinen I, Wilson ID, Reily MD, Robertson DG, Senn H, Krotzky A, Kochhar S, Powell J, van der Ouderaa F, Plumb R, Schaefer H, Spraul M (2005) Summary recommendations for standardization and reporting of metabolic analyses. Nat Biotechnol 23:833","journal-title":"Nat Biotechnol"},{"key":"6777_CR48","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jchromb.2007.10.022","volume":"866","author":"X Lu","year":"2008","unstructured":"Lu X, Zhao X, Bai C, Zhao C, Lu G, Xu G (2008) LC\u2013MS-based metabonomics analysis. J Chromatogr B 866:64","journal-title":"J Chromatogr B"},{"key":"6777_CR49","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1146\/annurev.anchem.1.031207.113026","volume":"1","author":"JC Lindon","year":"2008","unstructured":"Lindon JC, Nicholson JK (2008) Spectroscopic and statistical techniques for information recovery in metabonomics and metabolomics. Annu Rev Anal Chem 1:45","journal-title":"Annu Rev Anal Chem"},{"key":"6777_CR50","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1021\/pr101161u","volume":"10","author":"L Lin","year":"2011","unstructured":"Lin L, Huang Z, Gao Y, Yan X, Xing J, Hang W (2011) LC-MS based serum metabonomic analysis for renal cell carcinoma diagnosis, staging, and biomarker discovery. J Proteome Res 10:1396","journal-title":"J Proteome Res"},{"key":"6777_CR51","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1007\/DCR.0b013e31819c9a2c","volume":"52","author":"KW Jordan","year":"2009","unstructured":"Jordan KW, Nordenstam J, Lauwers GY, Rothenberger DA, Alavi K, Garwood M, Cheng LL (2009) Metabolomic characterization of human rectal adenocarcinoma with intact tissue magnetic resonance spectroscopy. Dis Colon Rectum 52:520","journal-title":"Dis Colon Rectum"},{"key":"6777_CR52","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1021\/pr801094b","volume":"8","author":"V Righi","year":"2009","unstructured":"Righi V, Durante C, Cocchi M, Calabrese C, Di Febo G, Lecce F, Pisi A, Tugnoli V, Mucci A, Schenetti L (2009) Discrimination of healthy and neoplastic human colon tissues by ex vivo HR-MAS NMR spectroscopy and chemometric analyses. J Proteome Res 8:1859","journal-title":"J Proteome Res"},{"key":"6777_CR53","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1002\/(SICI)1099-1492(199602)9:1<33::AID-NBM391>3.0.CO;2-G","volume":"9","author":"A Moreno","year":"1996","unstructured":"Moreno A, Ar\u00fas C (1996) Quantitative and qualitative characterization of 1H NMR spectra of colon tumors, normal mucosa and their perchloric acid extracts: decreased levels of myo-inositol in tumours can be detected in intact biopsies. NMR Biomed 9:33","journal-title":"NMR Biomed"},{"key":"6777_CR54","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1021\/pr901081y","volume":"9","author":"Y Qiu","year":"2010","unstructured":"Qiu Y, Cai G, Su M, Chen T, Liu Y, Xu Y, Ni Y, Zhao A, Cai S, Xu LX, Jia W (2010) Urinary metabonomic study on colorectal cancer. J Proteome Res 9:1627","journal-title":"J Proteome Res"},{"key":"6777_CR55","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1021\/ac001147b","volume":"73","author":"LM Matz","year":"2001","unstructured":"Matz LM, Hill HH (2001) Evaluation of opiate separation by high-resolution electrospray ionization-ion mobility spectrometry\/mass spectrometry. Anal Chem 73:1664","journal-title":"Anal Chem"},{"key":"6777_CR56","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.ijms.2010.02.007","volume":"298","author":"P Dwivedi","year":"2010","unstructured":"Dwivedi P, Schultz AJ Jr, Hill HH (2010) Metabolic profiling of human blood by high-resolution ion mobility mass spectrometry (IM-MS). Int J Mass Spectrom 298:78","journal-title":"Int J Mass Spectrom"},{"key":"6777_CR57","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s12127-008-0006-5","volume":"11","author":"P Dwivedi","year":"2008","unstructured":"Dwivedi P, Hill HH (2008) A rapid analytical method for hair analysis using ambient pressure ion mobility mass spectrometry with electrospray ionization (ESI-IMMS). Int J Ion Mobil Spectrom 11:61","journal-title":"Int J Ion Mobil Spectrom"},{"key":"6777_CR58","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s11306-007-0093-z","volume":"4","author":"P Dwivedi","year":"2008","unstructured":"Dwivedi P, Wu P, Klopsch SJ, Puzon GJ, Xun L, Hill HH (2008) Metabolic profiling by ion mobility mass spectrometry (IMMS). Metabolomics 4:63","journal-title":"Metabolomics"},{"key":"6777_CR59","doi-asserted-by":"publisher","first-page":"7944","DOI":"10.1021\/ac901030k","volume":"81","author":"K Kaplan","year":"2009","unstructured":"Kaplan K, Dwivedi P, Davidson S, Yang Q, Tso P, Siems W, Hill HH (2009) Monitoring dynamic changes in lymph metabolome of fasting and fed rats by electrospray ionization-ion mobility mass spectrometry (ESI-IMMS). Anal Chem 81:7944","journal-title":"Anal Chem"},{"key":"6777_CR60","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s12127-011-0066-9","volume":"14","author":"K Kaplan","year":"2011","unstructured":"Kaplan K, Liu X, Fu Y-M, Lin H, Meadows GG, Siems W, Hill HH (2011) Metabolic differences among melanoma and two prostate cancer cell lines by electrospray ion mobility mass spectrometry. Int J Ion Mobil Spectrom 14:151","journal-title":"Int J Ion Mobil Spectrom"},{"key":"6777_CR61","doi-asserted-by":"publisher","first-page":"25435","DOI":"10.1074\/jbc.R111.238691","volume":"286","author":"Z Lei","year":"2011","unstructured":"Lei Z, Huhman DV, Sumner LW (2011) Mass spectrometry strategies in metabolomics. J Biol Chem 286:25435","journal-title":"J Biol Chem"},{"key":"6777_CR62","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.trac.2007.12.001","volume":"27","author":"DS Wishart","year":"2008","unstructured":"Wishart DS (2008) Quantitative metabolomics using NMR. Trends Anal Chem 27:228","journal-title":"Trends Anal Chem"},{"key":"6777_CR63","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1002\/mrm.10108","volume":"47","author":"ASK Dzik-Jurasz","year":"2002","unstructured":"Dzik-Jurasz ASK, Murphy PS, George M, Prock T, Collins DJ, Swift I, Leach MO, Rowland IJ (2002) Human rectal adenocarcinoma: demonstration of1H-MR spectra in vivo at 1.5\u00a0T. Magn Reson Med 47:809","journal-title":"Magn Reson Med"},{"key":"6777_CR64","doi-asserted-by":"publisher","first-page":"3944","DOI":"10.1021\/pr0702565","volume":"6","author":"Y Wang","year":"2007","unstructured":"Wang Y, Holmes E, Comelli EM, Fotopoulos G, Dorta G, Tang H, Rantalainen MJ, Lindon JC, Corth\u00e9sy-Theulaz IE, Fay LB, Kochhar S, Nicholson JK (2007) Topographical variation in metabolic signatures of human gastrointestinal biopsies revealed by high-resolution magic-angle spinning 1H NMR spectroscopy. J Proteome Res 6:3944","journal-title":"J Proteome Res"},{"key":"6777_CR65","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/nbm.1940060202","volume":"6","author":"A Moreno","year":"1993","unstructured":"Moreno A, Rey M, Montane JM, Alonso J, Ar\u00fas C (1993) 1H NMR spectroscopy of colon tumors and normal mucosal biopsies; elevated taurine levels and reduced polyethyleneglycol absorption in tumors may have diagnostic significance. NMR Biomed 6:111","journal-title":"NMR Biomed"},{"key":"6777_CR66","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/BF00300208","volume":"6","author":"TE Merchant","year":"1991","unstructured":"Merchant TE, Kasimos JN, de Graaf PW, Minsky BD, Gierke LW, Glonek T (1991) Phospholipid profiles of human colon cancer using 31P magnetic resonance spectroscopy. Int J Colorectal Dis 6:121","journal-title":"Int J Colorectal Dis"},{"key":"6777_CR67","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1002\/mrm.1910260114","volume":"26","author":"TE Merchant","year":"1992","unstructured":"Merchant TE, Characiejus D, Kasimos JN, Den Otter W, Gierke LW, Glonek T (1992) Phosphodiesters in saponified extracts of human breast and colon tumors using 31P magnetic resonance spectroscopy. Magn Reson Med 26:132","journal-title":"Magn Reson Med"},{"key":"6777_CR68","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/mrm.1910200213","volume":"20","author":"CL Lean","year":"1991","unstructured":"Lean CL, Mackinnon WB, Mountford CE (1991) Fucose in 1H COSY spectra of plasma membrane fragments shed from human malignant colorectal cells. Magn Reson Med 20:306","journal-title":"Magn Reson Med"},{"key":"6777_CR69","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/0300-9084(89)90077-1","volume":"71","author":"JP Galons","year":"1989","unstructured":"Galons JP, Fantini J, Vion-Dury J, Cozzone PJ, Canioni P (1989) Metabolic changes in undifferentiated and differentiated human colon adenocarcinoma cells studied by multinuclear magnetic resonance spectroscopy. Biochimie 71:949","journal-title":"Biochimie"},{"key":"6777_CR70","first-page":"527","volume":"50","author":"JN Kasimos","year":"1990","unstructured":"Kasimos JN, Merchant TE, Gierke LW, Glonek T (1990) 31P magnetic resonance spectroscopy of human colon cancer. Cancer Res 50:527","journal-title":"Cancer Res"},{"key":"6777_CR71","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1016\/0024-3205(92)90260-V","volume":"50","author":"Y Elitsur","year":"1992","unstructured":"Elitsur Y, Moshier JA, Murthy R, Barbish A, Luk GD (1992) Polyamine levels, ornithine decarboxylase (ODC) activity, and ODC-mRNA expression in normal and cancerous human colonocytes. Life Sci 50:1417","journal-title":"Life Sci"},{"key":"6777_CR72","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1002\/bjs.1800711019","volume":"71","author":"AN Kingsnorth","year":"1984","unstructured":"Kingsnorth AN, Lumsden AB, Wallace HM (1984) Polyamines in colorectal cancer. Br J Surg 71:791","journal-title":"Br J Surg"},{"key":"6777_CR73","doi-asserted-by":"publisher","first-page":"4784","DOI":"10.1021\/ac0341618","volume":"75","author":"H Idborg-Bj\u00f6rkman","year":"2003","unstructured":"Idborg-Bj\u00f6rkman H, Edlund P-O, Kvalheim OM, Schuppe-Koistinen I, Jacobsson SP (2003) Screening of biomarkers in rat urine using LC\/electrospray ionization-MS and two-way data analysis. Anal Chem 75:4784","journal-title":"Anal Chem"},{"key":"6777_CR74","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.jchromb.2003.08.026","volume":"796","author":"W Naidong","year":"2003","unstructured":"Naidong W (2003) Bioanalytical liquid chromatography tandem mass spectrometry methods on underivatized silica columns with aqueous\/organic mobile phases. J Chromatogr B 796:209","journal-title":"J Chromatogr B"},{"key":"6777_CR75","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1021\/pr049769r","volume":"4","author":"ID Wilson","year":"2005","unstructured":"Wilson ID, Nicholson JK, Castro-Perez J, Granger JH, Johnson KA, Smith BW, Plumb RS (2005) High resolution \u201cultra performance\u201d liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies. J Proteome Res 4:591","journal-title":"J Proteome Res"},{"key":"6777_CR76","doi-asserted-by":"publisher","first-page":"3289","DOI":"10.1021\/ac060245f","volume":"78","author":"A Nordstr\u00f6m","year":"2006","unstructured":"Nordstr\u00f6m A, O'Maille G, Qin C, Siuzdak G (2006) Nonlinear data alignment for UPLC\u2212MS and HPLC\u2212MS based metabolomics: quantitative analysis of endogenous and exogenous metabolites in human serum. Anal Chem 78:3289","journal-title":"Anal Chem"},{"key":"6777_CR77","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.trac.2006.02.004","volume":"25","author":"R Ramautar","year":"2006","unstructured":"Ramautar R, Demirci A, Jong GJD (2006) Capillary electrophoresis in metabolomics. Trends Anal Chem 25:455","journal-title":"Trends Anal Chem"},{"key":"6777_CR78","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.chroma.2007.02.065","volume":"1168","author":"MRN Monton","year":"2007","unstructured":"Monton MRN, Soga T (2007) Metabolome analysis by capillary electrophoresis\u2013mass spectrometry. J Chromatogr A 1168:237","journal-title":"J Chromatogr A"},{"key":"6777_CR79","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1002\/rcm.2928","volume":"21","author":"X Tang","year":"2007","unstructured":"Tang X, Bruce JE, Hill HH (2007) Design and performance of an atmospheric pressure ion mobility Fourier transform ion cyclotron resonance mass spectrometer. Rapid Commun Mass Spectrom 21:1115","journal-title":"Rapid Commun Mass Spectrom"},{"key":"6777_CR80","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1016\/j.jasms.2005.04.007","volume":"16","author":"EW Robinson","year":"2005","unstructured":"Robinson EW, Williams ER (2005) Multidimensional separations of ubiquitin conformers in the gas phase: relating ion cross sections to H\/D exchange measurements. J Am Soc Mass Spectrom 16:1427","journal-title":"J Am Soc Mass Spectrom"},{"key":"6777_CR81","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1021\/ac9809175","volume":"71","author":"SC Henderson","year":"1999","unstructured":"Henderson SC, Valentine SJ, Counterman AE, Clemmer DE (1999) ESI\/ion trap\/ion mobility\/time-of-flight mass spectrometry for rapid and sensitive analysis of biomolecular mixtures. Anal Chem 71:291","journal-title":"Anal Chem"},{"key":"6777_CR82","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1021\/ac035376k","volume":"76","author":"AS Woods","year":"2004","unstructured":"Woods AS, Ugarov M, Egan T, Koomen J, Gillig KJ, Fuhrer K, Gonin M, Schultz JA (2004) Lipid\/peptide\/nucleotide separation with MALDI-ion mobility-TOF MS. Anal Chem 76:2187","journal-title":"Anal Chem"},{"key":"6777_CR83","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1021\/pr060055l","volume":"5","author":"AS Woods","year":"2006","unstructured":"Woods AS, Ugarov M, Jackson SN, Egan T, Wang H-YJ, Murray KK, Schultz JA (2006) IR\u2212MALDI\u2212LDI combined with ion mobility orthogonal time-of-flight mass spectrometry. J Proteome Res 5:1484","journal-title":"J Proteome Res"},{"key":"6777_CR84","doi-asserted-by":"crossref","unstructured":"Dwivedi P, Wu P, Klopsch S, Puzon G, Xun L, Hill H (2008) Metabolic profiling by ion mobility mass spectrometry (IMMS) 4:63","DOI":"10.1007\/s11306-007-0093-z"},{"key":"6777_CR85","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1002\/jms.994","volume":"41","author":"BH Clowers","year":"2006","unstructured":"Clowers BH, Hill HH (2006) Influence of cation adduction on the separation characteristics of flavonoid diglycoside isomers using dual gate-ion mobility-quadrupole ion trap mass spectrometry. J Mass Spectrom 41:339","journal-title":"J Mass Spectrom"},{"key":"6777_CR86","doi-asserted-by":"publisher","first-page":"6381","DOI":"10.1021\/ac050871x","volume":"77","author":"K Tang","year":"2005","unstructured":"Tang K, Li F, Shvartsburg AA, Strittmatter EF, Smith RD (2005) Two-dimensional gas-phase separations coupled to mass spectrometry for analysis of complex mixtures. Anal Chem 77:6381","journal-title":"Anal Chem"},{"key":"6777_CR87","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1126\/science.1120177","volume":"310","author":"BT Ruotolo","year":"2005","unstructured":"Ruotolo BT (2005) Evidence for macromolecular protein rings in the absence of bulk water. Science 310:1658","journal-title":"Science"},{"key":"6777_CR88","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1021\/ac061567m","volume":"79","author":"SI Merenbloom","year":"2007","unstructured":"Merenbloom SI, Bohrer BC, Koeniger SL, Clemmer DE (2007) Assessing the peak capacity of IMS\u2212IMS separations of tryptic peptide ions in He at 300\u00a0K. Anal Chem 79:515","journal-title":"Anal Chem"},{"key":"6777_CR89","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/(SICI)1520-6521(1996)1:1<49::AID-FACT7>3.0.CO;2-9","volume":"1","author":"AP Snyder","year":"1996","unstructured":"Snyder AP, Thornton SN, Dworzanski JP, Meuzelaar HLC (1996) Detection of the picolinic acid biomarker in Bacillus spores using a potentially field-portable pyrolysis\u2014gas chromatography\u2014ion mobility spectrometry system. Field Anal Chem Technol 1:49","journal-title":"Field Anal Chem Technol"},{"key":"6777_CR90","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S1387-3806(01)00511-5","volume":"212","author":"SJ Valentine","year":"2001","unstructured":"Valentine SJ, Kulchania M, Barnes CAS, Clemmer DE (2001) Multidimensional separations of complex peptide mixtures: a combined high-performance liquid chromatography\/ion mobility\/time-of-flight mass spectrometry approach. Int J Mass Spectrom 212:97","journal-title":"Int J Mass Spectrom"},{"key":"6777_CR91","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz-Pinedo C, El Mjiyad N, Ricci JE (2012) Cancer metabolism: current perspectives and future directions. Cell Death Dis 3","DOI":"10.1038\/cddis.2011.123"},{"key":"6777_CR92","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1002\/rcm.1641","volume":"18","author":"K Giles","year":"2004","unstructured":"Giles K, Pringle SD, Worthington KR, Little D, Wildgoose JL, Bateman RH (2004) Applications of a travelling wave-based radio-frequency-only stacked ring ion guide. Rapid Commun Mass Spectrom 18:2401","journal-title":"Rapid Commun Mass Spectrom"},{"issue":"7","key":"6777_CR93","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1021\/ac203116a","volume":"84","author":"H Li","year":"2012","unstructured":"Li H, Giles K, Bendiak B, Kaplan K, Siems WF, Hill HH (2012) Resolving structural isomers of monosaccharide methyl glycosides using drift tube and traveling wave ion mobility mass spectrometry. Anal Chem 84(7):3231\u20133239","journal-title":"Anal Chem"},{"key":"6777_CR94","doi-asserted-by":"publisher","first-page":"3763","DOI":"10.1002\/rcm.4328","volume":"23","author":"WPK Chong","year":"2009","unstructured":"Chong WPK, Goh LT, Reddy SG, Yusufi FNK, Lee DY, Wong NSC, Heng CK, Yap MGS, Ho YS (2009) Metabolomics profiling of extracellular metabolites in recombinant Chinese hamster ovary fed-batch culture. Rapid Commun Mass Spectrom 23:3763","journal-title":"Rapid Commun Mass Spectrom"},{"key":"6777_CR95","doi-asserted-by":"publisher","first-page":"4825","DOI":"10.1021\/pr200629p","volume":"10","author":"JC Garc\u00eda-Ca\u00f1averas","year":"2011","unstructured":"Garc\u00eda-Ca\u00f1averas JC, Donato MT, Castell JV, Lahoz A (2011) A comprehensive untargeted metabonomic analysis of human steatotic liver tissue by RP and HILIC chromatography coupled to mass spectrometry reveals important metabolic alterations. J Proteome Res 10:4825","journal-title":"J Proteome Res"},{"key":"6777_CR96","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1007\/s00216-011-5556-4","volume":"402","author":"G Paglia","year":"2011","unstructured":"Paglia G, Hrafnsd\u00f3ttir S, Magn\u00fasd\u00f3ttir M, Fleming RMT, Thorlacius S, Palsson B\u00d8, Thiele I (2011) Monitoring metabolites consumption and secretion in cultured cells using ultra-performance liquid chromatography quadrupole\u2013time of flight mass spectrometry (UPLC\u2013Q\u2013ToF-MS). Anal Bioanal Chem 402:1183","journal-title":"Anal Bioanal Chem"},{"key":"6777_CR97","doi-asserted-by":"crossref","unstructured":"Dong H, Zhang A, Sun H, Wang H, Lu X, Wang M, Ni B, Wang X (2012) Ingenuity pathways analysis of urine metabolomics phenotypes toxicity of Chuanwu in Wistar rats by UPLC-Q-TOF-HDMS coupled with pattern recognition methods. Mol Biosyst 8","DOI":"10.1039\/c1mb05366c"},{"key":"6777_CR98","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0378-1119(01)00689-8","volume":"277","author":"R Reeves","year":"2001","unstructured":"Reeves R (2001) Molecular biology of HMGA proteins: hubs of nuclear function. Gene 277:63","journal-title":"Gene"},{"key":"6777_CR99","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1158\/0008-5472.CAN-09-1212","volume":"70","author":"LMS Resar","year":"2010","unstructured":"Resar LMS (2010) The high mobility group A1 gene: transforming inflammatory signals into cancer? Cancer Res 70:436","journal-title":"Cancer Res"},{"key":"6777_CR100","doi-asserted-by":"crossref","unstructured":"Belton A, Gabrovsky A, Bae YK, Reeves R, Iacobuzio-Donahue C, Huso DL, Resar LMS (2012) HMGA1 induces intestinal polyposis in transgenic mice and drives tumor progression and stem cell properties in colon cancer cells. PLoS ONE 7","DOI":"10.1371\/journal.pone.0030034"},{"key":"6777_CR101","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1002\/ijc.2910470404","volume":"47","author":"NK Berdinskikh","year":"1991","unstructured":"Berdinskikh NK, Ignatenko NA, Zaletok SP, Ganina KP, Chorniy VA (1991) Ornithine decarboxylase activity and polyamine content in adenocarcinomas of human stomach and large intestine. J Int Cancer 47:496","journal-title":"J Int Cancer"},{"key":"6777_CR102","first-page":"1571","volume":"51","author":"SC Phan","year":"1991","unstructured":"Phan SC, Morotomi M, Guillem JG, LoGerfo P, Weinstein IB (1991) Decreased levels of 1,2-sn-diacylglycerol in human colon tumors. Cancer Res 51:1571","journal-title":"Cancer Res"},{"key":"6777_CR103","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1097\/GIM.0b013e31818b0d9b","volume":"10","author":"RJ Deberardinis","year":"2008","unstructured":"Deberardinis RJ (2008) Is cancer a disease of abnormal cellular metabolism? New angles on an old idea. Genet Med 10:767","journal-title":"Genet Med"},{"key":"6777_CR104","doi-asserted-by":"publisher","first-page":"9063","DOI":"10.1073\/pnas.94.17.9063","volume":"94","author":"MA Turner","year":"1997","unstructured":"Turner MA, Simpson A, McInnes RR, Howell PL (1997) Human argininosuccinate lyase: a structural basis for intragenic complementation. Proc Natl Acad Sci USA 94:9063","journal-title":"Proc Natl Acad Sci USA"},{"key":"6777_CR105","doi-asserted-by":"publisher","first-page":"3270","DOI":"10.1073\/pnas.1019393108","volume":"108","author":"ZJ Reitman","year":"2011","unstructured":"Reitman ZJ, Jin G, Karoly ED, Spasojevic I, Yang J, Kinzler KW, He Y, Bigner DD, Vogelstein B, Yan H (2011) Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome. Proc Natl Acad Sci USA 108:3270","journal-title":"Proc Natl Acad Sci USA"},{"key":"6777_CR106","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/nature08617","volume":"462","author":"L Dang","year":"2009","unstructured":"Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM (2009) Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462:739","journal-title":"Nature"},{"key":"6777_CR107","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ccr.2010.12.014","volume":"19","author":"W Xu","year":"2011","unstructured":"Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim S-H, Ito S, Yang C, Wang P, Xiao M-T (2011) Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of \u03b1-ketoglutarate-dependent dioxygenases. Cancer Cell 19:17","journal-title":"Cancer Cell"},{"key":"6777_CR108","doi-asserted-by":"publisher","first-page":"3236","DOI":"10.1158\/0008-5472.CAN-10-3894","volume":"71","author":"M Hilvo","year":"2011","unstructured":"Hilvo M, Denkert C, Lehtinen L, Muller B, Brockmoller S, Seppanen-Laakso T, Budczies J, Bucher E, Yetukuri L, Castillo S, Berg E, Nygren H, Sysi-Aho M, Griffin JL, Fiehn O, Loibl S, Richter-Ehrenstein C, Radke C, Hyotylainen T, Kallioniemi O, Iljin K, Oresic M (2011) Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression. Cancer Res 71:3236","journal-title":"Cancer Res"},{"key":"6777_CR109","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1021\/pr200685r","volume":"11","author":"SF Brockm\u00f6ller","year":"2012","unstructured":"Brockm\u00f6ller SF, Bucher E, M\u00fcller BM, Budczies J, Hilvo M, Griffin JL, Ore\u0161i\u010d M, Kallioniemi O, Iljin K, Loibl S, Darb-Esfahani S, Sinn BV, Klauschen F, Prinzler J, Bangemann N, Ismaeel F, Fiehn O, Dietel M, Denkert C (2012) Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase (GPAM) in breast cancer\u2014link to patient survival, hormone receptor status, and metabolic profiling. J Proteome Res 11:850","journal-title":"J Proteome Res"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-013-6777-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00216-013-6777-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-013-6777-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-013-6777-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T21:26:35Z","timestamp":1581974795000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00216-013-6777-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,14]]},"references-count":109,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["6777"],"URL":"https:\/\/doi.org\/10.1007\/s00216-013-6777-5","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,14]]}}}