{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:42:44Z","timestamp":1790768564679,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2013,2,10]],"date-time":"2013-02-10T00:00:00Z","timestamp":1360454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1007\/s00216-013-6784-6","type":"journal-article","created":{"date-parts":[[2013,2,9]],"date-time":"2013-02-09T04:39:28Z","timestamp":1360384768000},"page":"4295-4305","source":"Crossref","is-referenced-by-count":29,"title":["Simultaneous determination of opiates, methadone, amphetamines, cocaine, and metabolites in human placenta and umbilical cord by LC-MS\/MS"],"prefix":"10.1007","volume":"405","author":[{"given":"Ana","family":"de Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Pi\u00f1eiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Lendoiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelines","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"L\u00f3pez-Rivadulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Concheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,2,10]]},"reference":[{"key":"6784_CR1","unstructured":"Substance Abuse and Mental Health Services Administration (SAMHSA) (2012) Results from the 2011 National Survey on Drug Use and Health: summary of national findings. NSDUH Series H-44, HHS Publication No (SMA) 12\u20134713"},{"key":"6784_CR2","first-page":"2314","volume":"44","author":"LP Finnegan","year":"1985","unstructured":"Finnegan LP (1985) Effects of maternal opiate abuse on the newborn. Fed Proc 44:2314\u20132317","journal-title":"Fed Proc"},{"key":"6784_CR3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/09595230802245261","volume":"27","author":"S Mayet","year":"2008","unstructured":"Mayet S, Groshkova T, Morgan L, MacCormack T, Strang J (2008) Drugs and pregnancy\u2014outcomes of women engaged with a specialist perinatal outreach addictions service. Drug Alcohol Rev 27:497\u2013503","journal-title":"Drug Alcohol Rev"},{"key":"6784_CR4","first-page":"16","volume":"149","author":"B Zuckerman","year":"1995","unstructured":"Zuckerman B, Frank D, Brown E (1995) Overview of the effects of abuse and drugs on pregnancy and offspring. NIDA Res Monogr 149:16\u201338","journal-title":"NIDA Res Monogr"},{"key":"6784_CR5","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1007\/s00216-007-1228-9","volume":"388","author":"T Gray","year":"2007","unstructured":"Gray T, Huestis M (2007) Bioanalytical procedures for monitoring in utero drug exposure. Anal Bioanal Chem 388:1455\u20131465","journal-title":"Anal Bioanal Chem"},{"key":"6784_CR6","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/FTD.0b013e31815c14ce","volume":"29","author":"J Lozano","year":"2007","unstructured":"Lozano J, Garcia-Algar O, Vall O, de la Torre R, Scaravelli G, Pichini S (2007) Biological matrices for the evaluation of in utero exposure to drugs of abuse. Ther Drug Monit 29:711\u2013734","journal-title":"Ther Drug Monit"},{"key":"6784_CR7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.addbeh.2009.10.007","volume":"35","author":"MA Bessa","year":"2010","unstructured":"Bessa MA, Mitsuhiro SS, Chalem E, Barros MM, Guinsburg R, Laranjeira R (2010) Underreporting of use of cocaine and marijuana during the third trimester of gestation among pregnant adolescents. Addict Behav 35:266\u2013269","journal-title":"Addict Behav"},{"key":"6784_CR8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0379-0738(02)00160-3","volume":"128","author":"MA Huestis","year":"2002","unstructured":"Huestis MA, Choo RE (2002) Drug abuse\u2019s smallest victims: in utero drug exposure. Forensic Sci Int 128:20\u201330","journal-title":"Forensic Sci Int"},{"key":"6784_CR9","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/clpt.2008.156","volume":"84","author":"SL Kacinko","year":"2008","unstructured":"Kacinko SL, Jones HE, Johnson RE, Choo RE, Huestis MA (2008) Correlations of maternal buprenorphine dose, buprenorphine, and metabolite concentrations in meconium with neonatal outcomes. Clin Pharmacol Ther 84:604\u2013612","journal-title":"Clin Pharmacol Ther"},{"key":"6784_CR10","first-page":"988","volume":"118","author":"OQ Casanova","year":"1994","unstructured":"Casanova OQ, Lombardero N, Behnke M, Eyler FD, Conlon M, Bertholf RL (1994) Detection of cocaine exposure in the neonate. Analyses of urine, meconium, and amniotic fluid from mothers and infants exposed to cocaine. Arch Pathol Lab Med 118:988\u2013993","journal-title":"Arch Pathol Lab Med"},{"key":"6784_CR11","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/sj.clpt.6100506","volume":"83","author":"G Koren","year":"2008","unstructured":"Koren G, Hutson J, Gareri J (2008) Novel methods for the detection of drug and alcohol exposure during pregnancy: implications for maternal and child health. Clin Pharmacol Ther 83:631\u2013634","journal-title":"Clin Pharmacol Ther"},{"key":"6784_CR12","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0379-0738(99)00171-1","volume":"107","author":"J Klein","year":"2000","unstructured":"Klein J, Karaskov T, Koren G (2000) Clinical applications of hair testing for drugs of abuse\u2014the Canadian experience. Forensic Sci Int 107:281\u2013288","journal-title":"Forensic Sci Int"},{"key":"6784_CR13","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00216-009-2706-z","volume":"394","author":"M Concheiro-Guisan","year":"2009","unstructured":"Concheiro-Guisan M, Shakleya DM, Huestis MA (2009) Simultaneous quantification of buprenorphine, norbuprenorphine, buprenorphine glucuronide, and norbuprenorphine glucuronide in human placenta by liquid chromatography mass spectrometry. Anal Bioanal Chem 394:513\u2013522","journal-title":"Anal Bioanal Chem"},{"key":"6784_CR14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/jat\/33.5.243","volume":"33","author":"A Castro de","year":"2009","unstructured":"de Castro A, Concheiro M, Shakleya DM, Huestis M (2009) Simultaneous quantification of methadone, cocaine, opiates, and metabolites in human placenta by liquid chromatography-mass spectrometry. J Anal Toxicol 33:243\u2013252","journal-title":"J Anal Toxicol"},{"key":"6784_CR15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.forsciint.2009.12.044","volume":"196","author":"X Joya","year":"2010","unstructured":"Joya X, Pujadas M, Falcon M, Civit E, Garcia-Algar O, Vall O, Pichini S, Luna A, de la Torre R et al (2010) Gas chromatography\u2013mass spectrometry assay for the simultaneous quantification of drugs of abuse in human placenta at 12th week of gestation. Forensic Sci Int 196:38\u201342","journal-title":"Forensic Sci Int"},{"key":"6784_CR16","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/FTD.0b013e3182055f14","volume":"33","author":"SJ Marin","year":"2010","unstructured":"Marin SJ, Christensen RD, Baer VL, Clark CJ, McMillin GA (2010) Nicotine and metabolites in paired umbilical cord tissue and meconium specimens. Ther Drug Monit 33:80\u201385","journal-title":"Ther Drug Monit"},{"key":"6784_CR17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/jat\/21.2.97","volume":"21","author":"RE Winecker","year":"1997","unstructured":"Winecker RE, Goldberger BA, Tebbett I, Behnke M, Eyler FD, Conlon M, Wobie K, Karlix J, Bertholf RL (1997) Detection of cocaine and its metabolites in amniotic fluid and umbilical cord tissue. J Anal Toxicol 21:97\u2013104","journal-title":"J Anal Toxicol"},{"key":"6784_CR18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1093\/jat\/17.1.62","volume":"17","author":"CM Moore","year":"1993","unstructured":"Moore CM, Brown S, Negrusz A, Tebbett I, Meyer W, Jain L (1993) Determination of cocaine and its major metabolite, benzoylecgonine, in amniotic fluid, umbilical cord blood, umbilical cord tissue, and neonatal urine: a case study. J Anal Toxicol 17:62","journal-title":"J Anal Toxicol"},{"key":"6784_CR19","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1016\/j.jchromb.2009.09.021","volume":"877","author":"J Jones","year":"2009","unstructured":"Jones J, Rios R, Jones M, Lewis D, Plate C (2009) Determination of amphetamine and methamphetamine in umbilical cord using liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 877:3701\u20133706","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"6784_CR20","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.forsciint.2009.04.005","volume":"188","author":"M Concheiro","year":"2009","unstructured":"Concheiro M, Shakleya DM, Huestis MA (2009) Simultaneous quantification of buprenorphine, norbuprenorphine, buprenorphine-glucuronide and norbuprenorphine-glucuronide in human umbilical cord by liquid chromatography tandem mass spectrometry. Forensic Sci Int 188:144\u2013151","journal-title":"Forensic Sci Int"},{"key":"6784_CR21","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/FTD.0b013e31822724f0","volume":"33","author":"A Castro de","year":"2011","unstructured":"de Castro A, Jones HE, Johnson RE, Gray TR, Shakleya DM, Huestis MA (2011) Methadone, cocaine, opiates, and metabolite disposition in umbilical cord and correlations to maternal methadone dose and neonatal outcomes. Ther Drug Monit 33:443\u2013452","journal-title":"Ther Drug Monit"},{"key":"6784_CR22","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1016\/j.jchromb.2009.07.028","volume":"877","author":"A Castro de","year":"2009","unstructured":"de Castro A, Concheiro M, Shakleya DM, Huestis MA (2009) Development and validation of a liquid chromatography mass spectrometry assay for the simultaneous quantification of methadone, cocaine, opiates and metabolites in human umbilical cord. J Chromatogr B Analyt Technol Biomed Life Sci 877:3065\u20133071","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"6784_CR23","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1373\/clinchem.2010.154864","volume":"57","author":"A Castro de","year":"2011","unstructured":"de Castro A, Jones HE, Johnson RE, Gray TR, Shakleya DM, Huestis MA (2011) Maternal methadone dose, placental methadone concentrations, and neonatal outcomes. Clin Chem 57:449\u2013458","journal-title":"Clin Chem"},{"key":"6784_CR24","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/FTD.0b013e3181d0bd68","volume":"32","author":"M Concheiro","year":"2010","unstructured":"Concheiro M, Jones HE, Johnson RE, Choo R, Shakleya DM, Huestis MA (2010) Maternal buprenorphine dose, placenta buprenorphine, and metabolite concentrations and neonatal outcomes. Ther Drug Monit 32:206\u2013215","journal-title":"Ther Drug Monit"},{"key":"6784_CR25","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/jat\/34.8.498","volume":"34","author":"M Concheiro","year":"2010","unstructured":"Concheiro M, Jones HE, Johnson RE, Choo R, Shakleya DM, Huestis MA (2010) Umbilical cord monitoring of in utero drug exposure to buprenorphine and correlation with maternal dose and neonatal outcomes. J Anal Toxicol 34:498\u2013505","journal-title":"J Anal Toxicol"},{"key":"6784_CR26","unstructured":"The Commission of the European Communities (2002) Commision decision of 12 August 2002 implementing Council Directive 96\/23\/EC concerning the performance of analytical methods and the interpretation of results. Off J Eur Commun L 221:8\u201336"},{"key":"6784_CR27","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/clinchem\/30.2.290","volume":"30","author":"JS Krouwer","year":"1984","unstructured":"Krouwer JS, Rabinowitz R (1984) How to improve estimates of imprecision. Clin Chem 30:290\u2013292","journal-title":"Clin Chem"},{"key":"6784_CR28","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1021\/ac020361s","volume":"75","author":"BK Matuszewski","year":"2003","unstructured":"Matuszewski BK, Constanzer ML, Chavez-Eng CM (2003) Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS\/MS. Anal Chem 75:3019\u20133030","journal-title":"Anal Chem"},{"key":"6784_CR29","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1093\/jat\/23.6.446","volume":"23","author":"MA ElSohly","year":"1999","unstructured":"ElSohly MA, Kopycki W, Feng S, Murphy TP (1999) Identification and analysis of the major metabolites of cocaine in meconium. J Anal Toxicol 23:446\u2013451","journal-title":"J Anal Toxicol"},{"key":"6784_CR30","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1111\/j.1360-0443.2010.03097.x","volume":"105","author":"TR Gray","year":"2010","unstructured":"Gray TR, Choo RE, Concheiro M, Williams E, Elko A, Jansson LM, Jones HE, Huestis MA (2010) Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome. Addiction 105:2151\u20132159","journal-title":"Addiction"},{"key":"6784_CR31","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.bcp.2004.04.011","volume":"68","author":"TN Nanovskaya","year":"2004","unstructured":"Nanovskaya TN, Deshmukh SV, Nekhayeva IA, Zharikova OL, Hankins GD, Ahmed MS (2004) Methadone metabolism by human placenta. Biochem Pharmacol 68:583\u2013591","journal-title":"Biochem Pharmacol"},{"key":"6784_CR32","doi-asserted-by":"crossref","unstructured":"Gray TR, Choo RE, Concheiro M, Williams E, Elko A, Jansson LM, Huestis MA (2010) Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome. Addiction 105:2151\u20132159","DOI":"10.1111\/j.1360-0443.2010.03097.x"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-013-6784-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00216-013-6784-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-013-6784-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T01:51:07Z","timestamp":1644285067000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00216-013-6784-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,10]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["6784"],"URL":"https:\/\/doi.org\/10.1007\/s00216-013-6784-6","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,10]]}}}