{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:33:01Z","timestamp":1791045181961,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"30","license":[{"start":{"date-parts":[[2014,11,9]],"date-time":"2014-11-09T00:00:00Z","timestamp":1415491200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s00216-014-8255-0","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T20:28:57Z","timestamp":1415996937000},"page":"7937-7948","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":161,"title":["LC\/MS lipid profiling from human serum: a new method for global lipid extraction"],"prefix":"10.1007","volume":"406","author":[{"given":"Roberto Maria","family":"Pellegrino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Di Veroli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Valeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Goracci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Cruciani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,9]]},"reference":[{"key":"8255_CR1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.plipres.2007.09.001","volume":"47","author":"C Wolf","year":"2008","unstructured":"Wolf C, Quinn PJ (2008) Lipidomics: practical aspects and applications. Prog Lipid Res 47:15\u201336","journal-title":"Prog Lipid Res"},{"key":"8255_CR2","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nrd1776","volume":"4","author":"MR Wenk","year":"2005","unstructured":"Wenk MR (2005) The emerging field of lipidomics. Nat Rev Drug Discov 4:594\u2013610","journal-title":"Nat Rev Drug Discov"},{"key":"8255_CR3","doi-asserted-by":"crossref","unstructured":"Feng L, Prestwich GD (2005) Functional lipidomics. Dekker-CRC, New York 1\u2013329","DOI":"10.1201\/9781420027655"},{"key":"8255_CR4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/metabo1010021","volume":"1","author":"K Yang","year":"2011","unstructured":"Yang K, Han X (2011) Accurate quantification of lipid species by electrospray ionization mass spectrometry meets a key challenge in lipidomics. Metabolites 1:21\u201340","journal-title":"Metabolites"},{"key":"8255_CR5","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1046\/j.1471-4159.2002.00997.x","volume":"82","author":"X Han","year":"2002","unstructured":"Han X, Holtzman DM, McKeel DW Jr, Kelley J, Morris JC (2002) Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer\u2019s disease: potential role in disease pathogenesis. J Neurochem 82:809\u2013818","journal-title":"J Neurochem"},{"key":"8255_CR6","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nrc1143","volume":"3","author":"GB Mills","year":"2003","unstructured":"Mills GB, Moolenaar WH (2003) The emerging role of lysophosphatidic acid in cancer. Nat Rev Cancer 3:582\u2013591","journal-title":"Nat Rev Cancer"},{"key":"8255_CR7","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1200\/JCO.2006.08.5571","volume":"25","author":"Z Zhao","year":"2007","unstructured":"Zhao Z, Xiao Y, Elson P, Tan H, Plummer SJ, Berk M, Aung PP, Lavery IC, Achkar JP, Li L, Casey G, Xu Y (2007) Plasma lysophosphatidylcholine levels: potential biomarkers for colorectal cancer. J Clin Oncol 25:2696\u20132701","journal-title":"J Clin Oncol"},{"key":"8255_CR8","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.plipres.2007.04.001","volume":"46","author":"AD Postle","year":"2007","unstructured":"Postle AD, Wilton DC, Hunt AN, Attard GS (2007) Probing phospholipid dynamics by electrospray ionization mass spectrometry. Prog Lipid Res 46:200\u2013224","journal-title":"Prog Lipid Res"},{"key":"8255_CR9","doi-asserted-by":"crossref","first-page":"e6261","DOI":"10.1371\/journal.pone.0006261","volume":"4","author":"J Graessler","year":"2009","unstructured":"Graessler J, Schwudke D, Schwarz PEH, Herzog R, Shevchenko A, Bornstein SR (2009) Top-down lipidomics reveals ether lipid deficiency in blood plasma of hypertensive patients. PLoS ONE 4:e6261","journal-title":"PLoS ONE"},{"key":"8255_CR10","doi-asserted-by":"crossref","first-page":"e71846","DOI":"10.1371\/journal.pone.0071846","volume":"8","author":"C Fernandez","year":"2013","unstructured":"Fernandez C, Sandin M, Sampaio JL, Almgren P, Narkiewicz K, Hoffman M, Hedner T, Wahlstrand B, Simons K, Shevchenko A, James P, Melander O (2013) Plasma lipid composition and risk of developing cardiovascular disease. PLoS ONE 8:e71846","journal-title":"PLoS ONE"},{"key":"8255_CR11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0025-7125(16)30182-1","volume":"78","author":"JE Rossouw","year":"1994","unstructured":"Rossouw JE (1994) The effects of lowering serum cholesterol on coronary heart disease risk. Med Clin N Am 78:181\u2013195","journal-title":"Med Clin N Am"},{"key":"8255_CR12","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1194\/jlr.R300004-JLR200","volume":"44","author":"X Han","year":"2003","unstructured":"Han X, Gross RW (2003) Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics. J Lipid Res 44:1071\u20131079","journal-title":"J Lipid Res"},{"key":"8255_CR13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1185\/0300799039117028","volume":"17","author":"HW Breuer","year":"2001","unstructured":"Breuer HW (2001) Hypertriglyceridemia: a review of clinical relevance and treatment options: focus on cerivastatin. Curr Med Res Opin 17:60\u201373","journal-title":"Curr Med Res Opin"},{"key":"8255_CR14","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/mas.10061","volume":"22","author":"M Pulfer","year":"2003","unstructured":"Pulfer M, Murphy RC (2003) Electrospray mass spectrometry of phospholipids. Mass Spectrom Rev 22:332\u2013364","journal-title":"Mass Spectrom Rev"},{"key":"8255_CR15","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","author":"J Folch","year":"1957","unstructured":"Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497\u2013509","journal-title":"J Biol Chem"},{"key":"8255_CR16","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/o59-099","volume":"37","author":"EG Bligh","year":"1959","unstructured":"Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911\u2013917","journal-title":"Can J Biochem Physiol"},{"key":"8255_CR17","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1002\/rcm.3562","volume":"22","author":"K Retra","year":"2008","unstructured":"Retra K, Bleijerveld OB, van Gestel RA, Tielens AGM, van Hellemond JJ, Brouwers JF (2008) A simple and universal method for the separation and identification of phospholipid molecular species. Rapid Commun Mass Spectrom 22:1853\u20131862","journal-title":"Rapid Commun Mass Spectrom"},{"key":"8255_CR18","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1194\/jlr.M034330","volume":"54","author":"A Reis","year":"2013","unstructured":"Reis A, Rudnitskaya A, Blackburn GJ, Fauzi NM, Pitt AR, Spickett CM (2013) A comparison of five lipid extraction solvent systems for lipidomic studies of human LDL. J Lipid Res 54:1812\u20131824","journal-title":"J Lipid Res"},{"key":"8255_CR19","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1194\/jlr.D700041-JLR200","volume":"49","author":"V Matyash","year":"2008","unstructured":"Matyash V, Liebisch G, Kurzchalia TV, Shevchenko A, Schwudke D (2008) Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics. J Lipid Res 49:1137\u20131146","journal-title":"J Lipid Res"},{"key":"8255_CR20","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1194\/jlr.D023036","volume":"53","author":"L L\u00f6fgren","year":"2012","unstructured":"L\u00f6fgren L, St\u00e5hlman M, Forsberg GB, Saarinen S, Nilsson R, Hansson GI (2012) The BUME method: a novel automated chloroform-free 96-well total lipid extraction method for blood plasma. J Lipid Res 53:1690\u20131700","journal-title":"J Lipid Res"},{"key":"8255_CR21","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1194\/jlr.M009449","volume":"51","author":"O Quehenberger","year":"2010","unstructured":"Quehenberger O, Armando AM, Brown AH, Milne SB, Myers DS, Merrill AH, Bandyopadhyay S, Jones KN, Kelly S, Shaner RL, Sullards CM, Wang E, Murphy RC, Barkley RM, Leiker TJ, Raetz CRH, Guan Z, Laird GM, Six DA, Russell DW, McDonald JG, Subramaniam S, Fahy E, Dennis EA (2010) Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res 51:3299\u20133305","journal-title":"J Lipid Res"},{"key":"8255_CR22","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1194\/jlr.D001503","volume":"51","author":"Z Zhao","year":"2010","unstructured":"Zhao Z, Xu Y (2010) An extremely simple method for extraction of lysophospholipids and phospholipids from blood samples. J Lipid Res 51:652\u2013659","journal-title":"J Lipid Res"},{"key":"8255_CR23","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1351\/pac200274050835","volume":"74","author":"M Thompson","year":"2002","unstructured":"Thompson M, Ellison SLR, Wood R (2002) Harmonized guidelines for single laboratory validation of methods of analysis. (IUPAC Technical Report). Pure Appl Chem 74:835\u2013855","journal-title":"Pure Appl Chem"},{"key":"8255_CR24","doi-asserted-by":"crossref","first-page":"6648","DOI":"10.1021\/ac201195d","volume":"83","author":"SS Bird","year":"2011","unstructured":"Bird SS, Marur VR, Sniatynski MJ, Greenberg HK, Kristal BS (2011) Serum lipidomics profiling using LC-MS and high-energy collisional dissociation fragmentation: focus on triglyceride detection and characterization. Anal Chem 83:6648\u20136657","journal-title":"Anal Chem"},{"key":"8255_CR25","doi-asserted-by":"crossref","first-page":"D527","DOI":"10.1093\/nar\/gkl838","volume":"35","author":"M Sud","year":"2007","unstructured":"Sud M, Fahy E, Cotter D, Brown A, Dennis EA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Subramaniam S (2007) LMSD: LIPID MAPS structure database. Nucleic Acids Res 35:D527\u2013D532","journal-title":"Nucleic Acids Res"},{"key":"8255_CR26","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jchromb.2005.06.005","volume":"823","author":"R Taguchi","year":"2005","unstructured":"Taguchi R, Houjou T, Nakanishi H, Yamazaki T, Ishida M, Imagawa M, Shimizu T (2005) Focused lipidomics by tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 823:26\u201336","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"8255_CR27","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1194\/jlr.D008391","volume":"51","author":"E Camera","year":"2010","unstructured":"Camera E, Ludovici M, Galante M, Sinagra J, Picardo M (2010) Comprehensive analysis of the major lipid classes in sebum by rapid resolution high-performance liquid chromatography and electrospray mass spectrometry. J Lipid Res 51:3377\u20133388","journal-title":"J Lipid Res"},{"key":"8255_CR28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0166-1280(99)00360-7","volume":"503","author":"G Cruciani","year":"2000","unstructured":"Cruciani G, Crivori P, Carrupt PA, Testa B (2000) Molecular fields in quantitative structure-permeation relationships: the VolSurf approach. J Mol Struct THEOCHEM 503:17\u201330","journal-title":"J Mol Struct THEOCHEM"},{"key":"8255_CR29","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ymeth.2006.05.014","volume":"39","author":"S Milne","year":"2006","unstructured":"Milne S, Ivanova P, Forrester J, Brown HA (2006) Lipidomics: an analysis of cellular lipids by ESI-MS. Methods 39:92\u2013103","journal-title":"Methods"},{"key":"8255_CR30","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.bbalip.2004.09.003","volume":"1686","author":"G Liebisch","year":"2004","unstructured":"Liebisch G, Lieser B, Rathenberg J, Drobnik W, Schmitz G (2004) High-throughput quantification of phosphatidylcholine and sphingomyelin by electrospray ionization tandem mass spectrometry coupled with isotope correction algorithm. Biochim Biophys Acta 1686:108\u2013117","journal-title":"Biochim Biophys Acta"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-014-8255-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00216-014-8255-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-014-8255-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T10:50:48Z","timestamp":1650624648000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00216-014-8255-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,9]]},"references-count":30,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["8255"],"URL":"https:\/\/doi.org\/10.1007\/s00216-014-8255-0","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,9]]}}}