{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:34:44Z","timestamp":1773747284764,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"21","license":[{"start":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T00:00:00Z","timestamp":1432684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1007\/s00216-015-8770-7","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T09:35:36Z","timestamp":1432632936000},"page":"6357-6368","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Metabolomic analysis of wild and transgenic Nicotiana langsdorffii plants exposed to abiotic stresses: unraveling metabolic responses"],"prefix":"10.1007","volume":"407","author":[{"given":"Elisa","family":"Scalabrin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Radaelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Rizzato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Bogani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Buiatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Gambaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Capodaglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,5,27]]},"reference":[{"key":"8770_CR1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00344-012-9272-x","volume":"32","author":"A Bartwal","year":"2013","unstructured":"Bartwal A, Mall R, Lohani P, Guru SK, Arora S (2013) Role of secondary metabolites and brassinosteroids in plant defense against environmental stresses. J Plant Growth Regul 32:216\u2013232. doi: 10.1007\/s00344-012-9272-x","journal-title":"J Plant Growth Regul"},{"key":"8770_CR2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0098-8472(03)00060-1","volume":"51","author":"J Larkindale","year":"2004","unstructured":"Larkindale J, Huang B (2004) Changes of lipid composition and saturation level in leaves and roots for heat-stressed and heat-acclimated creeping bentgrass (Agrostis stolonifera). Environ Exp Bot 51:57\u201367. doi: 10.1016\/S0098-8472(03)00060-1","journal-title":"Environ Exp Bot"},{"key":"8770_CR3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1023\/A:1007201411474","volume":"38","author":"I Yordanov","year":"2000","unstructured":"Yordanov I, Velikova V, Tsonev T (2000) Plant responses to drought, acclimation and stress tolerance. Photosynthetica 38:171\u2013186. doi: 10.1023\/A:1007201411474","journal-title":"Photosynthetica"},{"key":"8770_CR4","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1007\/s00018-012-1091-5","volume":"69","author":"T Obata","year":"2012","unstructured":"Obata T, Fernie AR (2012) The use of metabolomics to dissect plant responses to abiotic stresses. Cell Mol Life Sci 69:3225\u20133243. doi: 10.1007\/s00018-012-1091-5","journal-title":"Cell Mol Life Sci"},{"key":"8770_CR5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.colsurfb.2007.11.016","volume":"63","author":"KS Ganesh","year":"2008","unstructured":"Ganesh KS, Baskaran L, Rajasekaran S, Sumathi K, Chidambaram AL, Sundaramoorthy P (2008) Chromium stress induced alterations in biochemical and enzyme metabolism in aquatic and terrestrial plants. Colloids Surf B Biointerfaces 63:159\u2013163. doi: 10.1016\/j.colsurfb.2007.11.016","journal-title":"Colloids Surf B Biointerfaces"},{"key":"8770_CR6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2478\/intag-2013-0017","volume":"27","author":"J Lipiec","year":"2013","unstructured":"Lipiec J, Doussan C, Nosalewicz A, Kondracka K (2013) Effect of drought and heat stresses on plant growth and yield: a review. Int Agrophysics 27:463\u2013477. doi: 10.2478\/intag-2013-0017","journal-title":"Int Agrophysics"},{"key":"8770_CR7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ab.2009.10.038","volume":"398","author":"S Giannarelli","year":"2010","unstructured":"Giannarelli S, Muscatello B, Bogani P, Spiriti MM, Buiatti M, Fuoco R (2010) Comparative determination of some phytohormones in wild-type and genetically modified plants by gas chromatography\u2013mass spectrometry and high-performance liquid chromatography-tandem mass spectrometry. Anal Biochem 398:60\u201368. doi: 10.1016\/j.ab.2009.10.038","journal-title":"Anal Biochem"},{"key":"8770_CR8","first-page":"35","volume":"86","author":"T Irdani","year":"2003","unstructured":"Irdani T, Caroppo S, Ambrogioni L (2003) Response of Nicotiana tabacum plants overexpressing a glucocorticoid receptor to Meloidogyne incognita (Nematoda tylenchida) infestation. Redia 86:35\u201338","journal-title":"Redia"},{"key":"8770_CR9","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s00122-003-1322-0","volume":"107","author":"P Bettini","year":"2003","unstructured":"Bettini P, Michelotti S, Bindi D, Giannini R, Capuana M, Buiatti M (2003) Pleiotropic effect of the insertion of the Agrobacterium rhizogenes rolD gene in tomato (Lycopersicon esculentum Mill.). Theor Appl Genet 107:831\u2013836. doi: 10.1007\/s00122-003-1322-0","journal-title":"Theor Appl Genet"},{"key":"8770_CR10","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s002990050411","volume":"17","author":"J Palaz\u00f3n","year":"1998","unstructured":"Palaz\u00f3n J, Cusid\u00f3 RM, Roig C, Pi\u00f1ol MT (1998) Expression of the rol C gene and nicotine production in transgenic roots and their regenerated plants. Plant Cell Rep 17:384\u2013390. doi: 10.1007\/s002990050411","journal-title":"Plant Cell Rep"},{"key":"8770_CR11","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jhazmat.2013.08.073","volume":"262","author":"M Bubba Del","year":"2013","unstructured":"Del Bubba M, Ancillotti C, Checchini L, Ciofi L, Fibbi D, Gonnelli C, Mosti S (2013) Chromium accumulation and changes in plant growth, selected phenolics and sugars of wild type and genetically modified Nicotiana langsdorffii. J Hazard Mater 262:394\u2013403. doi: 10.1016\/j.jhazmat.2013.08.073","journal-title":"J Hazard Mater"},{"key":"8770_CR12","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1006\/mpev.2001.0927","volume":"20","author":"MC Intrieri","year":"2001","unstructured":"Intrieri MC, Buiatti M (2001) The horizontal transfer of Agrobacterium rhizogenes genes and the evolution of the genus Nicotiana. Mol Phylogenet Evol 20:100\u2013110. doi: 10.1006\/mpev.2001.0927","journal-title":"Mol Phylogenet Evol"},{"key":"8770_CR13","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.jplph.2012.12.009","volume":"170","author":"R Fuoco","year":"2013","unstructured":"Fuoco R, Bogani P, Capodaglio G, Del Bubba M, Abollino O, Giannarelli S, Spiriti MM, Muscatello B, Doumett S, Turetta C, Zangrando R, Zelano V, Buiatti M (2013) Response to metal stress of Nicotiana langsdorffii plants wild-type and transgenic for the rat glucocorticoid receptor gene. J Plant Physiol 170:668\u2013675. doi: 10.1016\/j.jplph.2012.12.009","journal-title":"J Plant Physiol"},{"key":"8770_CR14","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11306-012-0434-4","volume":"9","author":"WB Dunn","year":"2013","unstructured":"Dunn WB, Erban A, Weber RJM, Creek DJ, Brown M, Breitling R, Hankemeier T, Goodacre R, Neumann S, Kopka J, Viant MR (2013) Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics. Metabolomics 9:44\u201366. doi: 10.1007\/s11306-012-0434-4","journal-title":"Metabolomics"},{"key":"8770_CR15","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nprot.2007.95","volume":"2","author":"RCH Vos De","year":"2007","unstructured":"De Vos RCH, Moco S, Lommen A, Keurentjes JJB, Bino RJ, Hall RD (2007) Untargeted large-scale plant metabolomics using liquid chromatography coupled to mass spectrometry. Nat Protoc 2:778\u2013791. doi: 10.1038\/nprot.2007.95","journal-title":"Nat Protoc"},{"key":"8770_CR16","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/pce.12002","volume":"36","author":"G Marti","year":"2013","unstructured":"Marti G, Erb M, Boccard J, Glauser G, Doyen GR, Villard N, Christelle RAM, Turlings TCJ, Rudaz S, Wolfender J-L (2013) Metabolomics reveals herbivore-induced metabolites of resistance and susceptibility in maize leaves and roots. Plant Cell Environ 36:621\u2013639. doi: 10.1111\/pce.12002","journal-title":"Plant Cell Environ"},{"key":"8770_CR17","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s11306-011-0369-1","volume":"8","author":"A Lommen","year":"2012","unstructured":"Lommen A, Kools HJ (2012) MetAlign 3.0: performance enhancement by efficient use of advances in computer hardware. Metabolomics 8:719\u2013726. doi: 10.1007\/s11306-011-0369-1","journal-title":"Metabolomics"},{"key":"8770_CR18","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1021\/ac900036d","volume":"81","author":"A Lommen","year":"2009","unstructured":"Lommen A (2009) MetAlign: interface-driven, versatile metabolomics tool for hyphenated full-scan mass spectrometry data preprocessing. Anal Chem 81:3079\u20133086. doi: 10.1021\/ac900036d","journal-title":"Anal Chem"},{"key":"8770_CR19","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1007\/s11306-011-0368-2","volume":"8","author":"YM Tikunov","year":"2012","unstructured":"Tikunov YM, Laptenok S, Hall RD, Bovy A, De Vos RCH (2012) MSClust: a tool for unsupervised mass spectra extraction of chromatography-mass spectrometry ion-wise aligned data. Metabolomics 8:714\u2013718. doi: 10.1007\/s11306-011-0368-2","journal-title":"Metabolomics"},{"key":"8770_CR20","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11306-007-0082-2","volume":"3","author":"LW Sumner","year":"2007","unstructured":"Sumner LW, Amberg A, Barrett D, Beale MH, Beger R, Daykin CA, Fan TW-M, Fiehn O, Goodacre R, Griffin JL, Hankemeier T, Hardy N, Harnly J, Higashi R, Kopka J, Lane AN, Lindon JC, Marriott P, Nicholls AW, Reily MD, Thaden JJ, Viant MR (2007) Proposed minimum reporting standards for chemical analysis. Metabolomics 3:211\u2013221. doi: 10.1007\/s11306-007-0082-2","journal-title":"Metabolomics"},{"key":"8770_CR21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00425-003-0992-9","volume":"217","author":"N Sato","year":"2003","unstructured":"Sato N, Aoki M, Maru Y, Sonoike K, Minoda A, Tsuzuki M (2003) Involvement of sulfoquinovosyl diacylglycerol in the structural integrity and heat-tolerance of photosystem II. Planta 217:245\u2013251. doi: 10.1007\/s00425-003-0992-9","journal-title":"Planta"},{"key":"8770_CR22","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1111\/j.1365-3040.2006.01527.x","volume":"29","author":"J Chen","year":"2006","unstructured":"Chen J, Burke JJ, Xin Z, Xu C, Velten J (2006) Characterization of the Arabidopsis thermosensitive mutant atts02 reveals an important role for galactolipids in thermotolerance. Plant Cell Environ 29:1437\u20131448. doi: 10.1111\/j.1365-3040.2006.01527.x","journal-title":"Plant Cell Environ"},{"key":"8770_CR23","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1365-313X.2011.04531.x","volume":"66","author":"A Burgos","year":"2011","unstructured":"Burgos A, Szymanski J, Seiwert B, Degenkolbe T, Hannah MA, Giavalisco P, Willmitzer L (2011) Analysis of short-term changes in the Arabidopsis thaliana glycerolipidome in response to temperature and light. Plant J 66:656\u2013668. doi: 10.1111\/j.1365-313X.2011.04531.x","journal-title":"Plant J"},{"key":"8770_CR24","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1093\/pcp\/pct104","volume":"54","author":"M Otsuru","year":"2013","unstructured":"Otsuru M, Yu Y, Mizoi J, Kawamoto-Fujioka M, Wang J, Fujiki Y, Nishida I (2013) Mitochondrial phosphatidylethanolamine level modulates Cyt c oxidase activity to maintain respiration capacity in Arabidopsis thaliana rosette leaves. Plant Cell Physiol 54:1612\u20131619. doi: 10.1093\/pcp\/pct104","journal-title":"Plant Cell Physiol"},{"key":"8770_CR25","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1104\/pp.112.204735","volume":"160","author":"J Kim","year":"2012","unstructured":"Kim J, Kang K, Gonzales-Vigil E, Shi F, Jones AD, Barry CS, Last RL (2012) Striking natural diversity in glandular trichome acylsugar composition is shaped by variation at the acyltransferase2 Locus in the wild tomato Solanum habrochaites. Plant Physiol 160:1854\u20131870. doi: 10.1104\/pp. 112.204735","journal-title":"Plant Physiol"},{"key":"8770_CR26","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s11306-013-0585-y","volume":"10","author":"B Ghosh","year":"2013","unstructured":"Ghosh B, Westbrook TC, Jones AD (2013) Comparative structural profiling of trichome specialized metabolites in tomato (Solanum lycopersicum) and S. habrochaites: acylsugar profiles revealed by UHPLC \/ MS and NMR. Metabolomics 10:496\u2013507. doi: 10.1007\/s11306-013-0585-y","journal-title":"Metabolomics"},{"key":"8770_CR27","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1365-313X.2010.04154.x","volume":"62","author":"A Schilmiller","year":"2010","unstructured":"Schilmiller A, Shi F, Kim J, Charbonneau AL, Holmes D, Jones AD, Last RL (2010) Mass spectrometry screening reveals widespread diversity in trichome specialized metabolites of tomato chromosomal substitution lines. Plant J 62:391\u2013403. doi: 10.1111\/j.1365-313X.2010.04154.x","journal-title":"Plant J"},{"key":"8770_CR28","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/treephys\/20.9.629","volume":"20","author":"LB P\u00e9rez-estrada","year":"2000","unstructured":"P\u00e9rez-estrada LB, Cano-santana Z, Oyama K (2000) Variation in leaf trichomes of Wigandia urens: environmental factors and physiological consequences. Tree Physiol 20:629\u2013632. doi: 10.1093\/treephys\/20.9.629","journal-title":"Tree Physiol"},{"key":"8770_CR29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF02854034","volume":"61","author":"J Kuc","year":"1984","unstructured":"Kuc J (1984) Steroid glykoalkaloids and related compounds as potato quality factors. Am Potato J 61:123\u2013139. doi: 10.1007\/BF02854034","journal-title":"Am Potato J"},{"key":"8770_CR30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1023\/B:ABIM.0000010362.79928.77","volume":"40","author":"ZV Udalova","year":"2004","unstructured":"Udalova ZV, Zinov SV, Vasil IS, Paseshnichenko VA (2004) Correlation between the structure of plant steroids and their effects on phytoparasitic nematodes. Appl Biochem Microbiol 40:109\u2013113. doi: 10.1023\/B:ABIM.0000010362.79928.77","journal-title":"Appl Biochem Microbiol"},{"key":"8770_CR31","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1021\/jf980151+","volume":"46","author":"NA Coria","year":"1998","unstructured":"Coria NA, Sarqu\u0131 JI, Penalosa I, Urzua M (1998) Heat-induced damage in potato (Solanum tuberosum) tubers: membrane stability, tissue viability, and accumulation of glycoalkaloids. J Agric Food Chem 46:4524\u20134528. doi: 10.1021\/jf980151+","journal-title":"J Agric Food Chem"},{"key":"8770_CR32","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1006\/pmpp.1997.0098","volume":"50","author":"L Dimenstein","year":"1997","unstructured":"Dimenstein L, Lisker N, Kedar N, Levy D (1997) Changes in the content of steroidal glycoalkaloids in potato tubers grown in the field and in the greenhouse under different conditions of light, temperature and daylength. Physiol Mol Plant Pathol 50:391\u2013402. doi: 10.1006\/pmpp.1997.0098","journal-title":"Physiol Mol Plant Pathol"},{"key":"8770_CR33","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/BF02910006","volume":"76","author":"A Nitithamyong","year":"1999","unstructured":"Nitithamyong A, Vonelbe JH, Wheeler RM, Tibbitts TW (1999) Glycoalkaloids in potato tubers grown under controlled environments. Am J Potato Res 76:337\u2013343. doi: 10.1007\/BF02910006","journal-title":"Am J Potato Res"},{"key":"8770_CR34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.plantsci.2011.02.009","volume":"182","author":"L Torras-Claveria","year":"2012","unstructured":"Torras-Claveria L, J\u00e1uregui O, Codina C, Tiburcio AF, Bastida J, Viladomat F (2012) Analysis of phenolic compounds by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry in senescent and water-stressed tobacco. Plant Sci 182:71\u201378. doi: 10.1016\/j.plantsci.2011.02.009","journal-title":"Plant Sci"},{"key":"8770_CR35","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1365-3040.2007.01764.x","volume":"31","author":"J Mortel Van de","year":"2008","unstructured":"Van de Mortel J, Schat H, Moerland PD, Van Themaat VEL, Van der Ent S, Blankestijn H, Ghandilyan A, Tsiatsiani S, Aarts MGM (2008) Expression differences for genes involved in lignin, glutathione and sulphate metabolism in response to cadmium in Arabidopsis thaliana and the related Zn \/ Cd-hyperaccumulator Thlaspi caerulescens. Plant Cell Environ 31:301\u2013324. doi: 10.1111\/j.1365-3040.2007.01764.x","journal-title":"Plant Cell Environ"},{"key":"8770_CR36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.febslet.2004.04.011","volume":"566","author":"A Mith\u00f6fer","year":"2004","unstructured":"Mith\u00f6fer A, Schulze B, Boland W (2004) Biotic and heavy metal stress response in plants: evidence for common signals. FEBS Lett 566:1\u20135. doi: 10.1016\/j.febslet.2004.04.011","journal-title":"FEBS Lett"},{"key":"8770_CR37","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0005-2760(98)00048-4","volume":"1393","author":"SB Ryu","year":"1998","unstructured":"Ryu SB, Wang X (1998) Increase in free linolenic and linoleic acids associated with phospholipase D-mediated hydrolysis of phospholipids in wounded castor bean leaves. Biochim Biophys Acta Lipids Lipid Metab 1393:193\u2013202. doi: 10.1016\/S0005-2760(98)00048-4","journal-title":"Biochim Biophys Acta Lipids Lipid Metab"},{"key":"8770_CR38","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1094\/MPMI-21-12-1561","volume":"21","author":"VP Bulgakov","year":"2008","unstructured":"Bulgakov VP, Aminin DL, Shkryl YN, Gorpenchenko TY, Veremeichik GN, Dmitrenok PS, Zhuravlev YN (2008) Suppression of reactive oxygen species and enhanced stress tolerance in Rubia cordifolia cells expressing the rolC oncogene. Mol Plant Microbe Interact 21:1561\u20131570. doi: 10.1094\/MPMI-21-12-1561","journal-title":"Mol Plant Microbe Interact"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-015-8770-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00216-015-8770-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-015-8770-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T16:31:51Z","timestamp":1599064311000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00216-015-8770-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,27]]},"references-count":38,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["8770"],"URL":"https:\/\/doi.org\/10.1007\/s00216-015-8770-7","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,27]]}}}