{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:05:01Z","timestamp":1793070301341,"version":"4.5.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"23","license":[{"start":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T00:00:00Z","timestamp":1468540800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan.","doi-asserted-by":"crossref","award":["MOST104-2113-M-030-004"],"award-info":[{"award-number":["MOST104-2113-M-030-004"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s00216-016-9741-3","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T07:48:00Z","timestamp":1468568880000},"page":"6295-6306","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Simultaneous, rapid, and sensitive quantification of 8-hydroxy-2\u2032-deoxyguanosine and cotinine in human urine by on-line solid-phase extraction LC-MS\/MS: correlation with tobacco exposure biomarkers NNAL"],"prefix":"10.1007","volume":"408","author":[{"given":"Chao-Yu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ting","family":"Jhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ling","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Wen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,15]]},"reference":[{"key":"9741_CR1","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1080\/01926230290166724","volume":"30","author":"R Kohen","year":"2002","unstructured":"Kohen R, Nyska A. Invited review: oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol Pathol. 2002;30:620\u201350.","journal-title":"Toxicol Pathol"},{"key":"9741_CR2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","volume":"39","author":"M Valko","year":"2007","unstructured":"Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39:44\u201384.","journal-title":"Int J Biochem Cell Biol"},{"key":"9741_CR3","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1073\/pnas.87.12.4533","volume":"87","author":"CG Fraga","year":"1990","unstructured":"Fraga CG, Shigenaga MK, Park JW, Degan P, Ames BN. Oxidative damage to DNA during aging: 8-hydroxy-2\u2032-deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci U S A. 1990;87:4533\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9741_CR4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neulet.2009.11.065","volume":"469","author":"C Isobe","year":"2010","unstructured":"Isobe C, Abe T, Terayama Y. Levels of reduced and oxidized coenzyme Q-10 and 8-hydroxy-2\u2032-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinson\u2019s disease demonstrate that mitochondrial oxidative damage and\/or oxidative DNA damage contributes to the neurodegenerative process. Neurosci Lett. 2010;469:159\u201363.","journal-title":"Neurosci Lett"},{"key":"9741_CR5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.cardfail.2006.05.011","volume":"12","author":"E Watanabe","year":"2006","unstructured":"Watanabe E, Matsuda N, Shiga T, Kajimoto K, Ajiro Y, Kawarai H, et al. Significance of 8-hydroxy-2\u2032-deoxyguanosine levels in patients with idiopathic dilated cardiomyopathy. J Card Fail. 2006;12:527\u201332.","journal-title":"J Card Fail"},{"key":"9741_CR6","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S0959-8049(00)00095-2","volume":"36","author":"H Bartsch","year":"2000","unstructured":"Bartsch H, Nair J. New DNA-based biomarkers for oxidative stress and cancer chemoprevention studies. Eur J Cancer. 2000;36:1229\u201334.","journal-title":"Eur J Cancer"},{"key":"9741_CR7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s12017-011-8155-9","volume":"13","author":"Z Cai","year":"2011","unstructured":"Cai Z, Zhao B, Ratka A. Oxidative stress and \u03b2-amyloid protein in Alzheimer\u2019s disease. NeuroMolecular Med. 2011;13:223\u201350.","journal-title":"NeuroMolecular Med"},{"key":"9741_CR8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mrfmmm.2008.03.003","volume":"642","author":"P Rossner Jr","year":"2008","unstructured":"Rossner Jr P, Svecova V, Milcova A, Lnenickova Z, Solansky I, Sram RJ. Seasonal variability of oxidative stress markers in city bus drivers: part I. Oxidative damage to DNA. Mutat Res\/Fundam Mol Mech Mutagen. 2008;642:14\u201320.","journal-title":"Mutat Res\/Fundam Mol Mech Mutagen"},{"key":"9741_CR9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.mrfmmm.2005.01.022","volume":"574","author":"MS Cooke","year":"2005","unstructured":"Cooke MS, Evans MD, Dove R, Rozalski R, Gackowski D, Siomek A, et al. DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine. Mutat Res\/Fundam Mol Mech Mutagen. 2005;574:58\u201366.","journal-title":"Mutat Res\/Fundam Mol Mech Mutagen"},{"key":"9741_CR10","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nrc1190","volume":"3","author":"SS Hecht","year":"2003","unstructured":"Hecht SS. Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat Rev Cancer. 2003;3:733\u201344.","journal-title":"Nat Rev Cancer"},{"key":"9741_CR11","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1093\/carcin\/13.12.2241","volume":"13","author":"S Loft","year":"1992","unstructured":"Loft S, Vistisen K, Ewertz M, Tj\u00f8nneland A, Overvad K, Poulsen HE. Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index. Carcinogenesis. 1992;13:2241\u20137.","journal-title":"Carcinogenesis"},{"key":"9741_CR12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/biof.5520220151","volume":"22","author":"S Kanaya","year":"2004","unstructured":"Kanaya S, Ikeya M, Yamamoto K, Moriya T, Furuhashi K, Sonoda M, et al. Comparison of an oxidative stress biomarker \u201curinary 8-hydroxy-2\u2032-deoxyguanosine,\u201d between smokers and non-smokers. BioFactors. 2004;22:255\u20138.","journal-title":"BioFactors"},{"key":"9741_CR13","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jchromb.2015.08.028","volume":"1019","author":"H Kataoka","year":"2016","unstructured":"Kataoka H, Mizuno K, Oda E, Saito A. Determination of the oxidative stress biomarker urinary 8-hydroxy-2\u2032-deoxyguanosine by automated on-line in-tube solid-phase microextraction coupled with liquid chromatography-tandem mass spectrometry. J Chromatogr B Anal Technol Biomed Life Sci. 2016;1019:140\u20136.","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"key":"9741_CR14","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3109\/08958378.2011.554460","volume":"23","author":"C Campos","year":"2011","unstructured":"Campos C, Guzm\u00e1n R, L\u00f3pez-Fern\u00e1ndez E, Casado \u00c1. Urinary biomarkers of oxidative\/nitrosative stress in healthy smokers. Inhal Toxicol. 2011;23:148\u201356.","journal-title":"Inhal Toxicol"},{"key":"9741_CR15","doi-asserted-by":"crossref","first-page":"5586","DOI":"10.3390\/ijerph110605586","volume":"11","author":"CY Lu","year":"2014","unstructured":"Lu CY, Ma YC, Chen PC, Wu CC, Chen YC. Oxidative stress of office workers relevant to tobacco smoking and inner air quality. Int J Environ Res Public Health. 2014;11:5586\u201397.","journal-title":"Int J Environ Res Public Health"},{"key":"9741_CR16","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/clpt.1994.169","volume":"56","author":"NL Benowitz","year":"1994","unstructured":"Benowitz NL, Jacob P. Metabolism of nicotine to cotinine studied by a dual stable isotope method. Clin Pharmacol Ther. 1994;56:483\u201393.","journal-title":"Clin Pharmacol Ther"},{"key":"9741_CR17","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1016\/j.jchromb.2009.08.033","volume":"877","author":"DM Shakleya","year":"2009","unstructured":"Shakleya DM, Huestis MA. Simultaneous and sensitive measurement of nicotine, cotinine, trans-3\u2032-hydroxycotinine and norcotinine in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B. 2009;877:3537\u201342.","journal-title":"J Chromatogr B"},{"key":"9741_CR18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jchromb.2009.11.032","volume":"878","author":"F Baumann","year":"2010","unstructured":"Baumann F, Regenthal R, Burgos-Guerrero IL, Hegerl U, Preiss R. Determination of nicotine and cotinine in human serum by means of LC\/MS. J Chromatogr B. 2010;878:107\u201311.","journal-title":"J Chromatogr B"},{"key":"9741_CR19","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1016\/j.jchromb.2010.08.041","volume":"878","author":"F Kardani","year":"2010","unstructured":"Kardani F, Daneshfar A, Sahrai R. Determination of nicotine, anabasine, and cotinine in urine and saliva samples using single-drop microextraction. J Chromatogr B. 2010;878:2857\u201362.","journal-title":"J Chromatogr B"},{"key":"9741_CR20","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1080\/1462220031000094213","volume":"5","author":"MJ Jarvis","year":"2003","unstructured":"Jarvis MJ, Primatesta P, Erens B, Feyerabend C, Bryant A. Measuring nicotine intake in population surveys: comparability of saliva cotinine and plasma cotinine estimates. Nicotine Tob Res. 2003;5:349\u201355.","journal-title":"Nicotine Tob Res"},{"key":"9741_CR21","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/jat\/24.5.333","volume":"24","author":"JT Bernert","year":"2000","unstructured":"Bernert JT, McGuffey JE, Morrison MA, Pirkle JL. Comparison of serum and salivary cotinine measurements by a sensitive high-performance liquid chromatography-tandem mass spectrometry method as an indicator of exposure to tobacco smoke among smokers and nonsmokers. J Anal Toxicol. 2000;24:333\u20139.","journal-title":"J Anal Toxicol"},{"key":"9741_CR22","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.2105\/AJPH.77.11.1435","volume":"77","author":"MJ Jarvis","year":"1987","unstructured":"Jarvis MJ, Tunstall-Pedoe H, Feyerabend C, Vesey C, Saloojee Y. Comparison of tests used to distinguish smokers from nonsmokers. Am J Public Health. 1987;77:1435\u20138.","journal-title":"Am J Public Health"},{"key":"9741_CR23","first-page":"767","volume":"11","author":"K Shimoi","year":"2002","unstructured":"Shimoi K, Kasai H, Yokota N, Toyokuni S, Kinae N. Comparison between high-performance liquid chromatography and enzyme-linked immunosorbent assay for the determination of 8-hydroxy-2\u2032-deoxyguanosine in human urine. Cancer Epidemiol Biomark Prev. 2002;11:767\u201370.","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"9741_CR24","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.cca.2010.04.027","volume":"411","author":"S Park","year":"2010","unstructured":"Park S, Lee DH, Park JG, Lee YT, Chung J. A sensitive enzyme immunoassay for measuring cotinine in passive smokers. Clin Chim Acta. 2010;411:1238\u201342.","journal-title":"Clin Chim Acta"},{"key":"9741_CR25","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/0959-8049(94)00490-0","volume":"31A","author":"C Tagesson","year":"1995","unstructured":"Tagesson C, Kallberg M, Klintenberg C, Starkhammar H. Determination of urinary 8-hydroxydeoxyguanosine by automated coupled-column high performance liquid chromatography: a powerful technique for assaying in vivo oxidative DNA damage in cancer patients. Eur J Cancer. 1995;31A:934\u201340.","journal-title":"Eur J Cancer"},{"key":"9741_CR26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.aca.2004.04.018","volume":"516","author":"E Samcov\u00e1","year":"2004","unstructured":"Samcov\u00e1 E, Marhol P, Opekar F, Langmaier J. Determination of urinary 8-hydroxy-2\u2032-deoxyguanosine in obese patients by HPLC with electrochemical detection. Anal Chim Acta. 2004;516:107\u201310.","journal-title":"Anal Chim Acta"},{"key":"9741_CR27","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1042\/bj20040004","volume":"380","author":"HS Lin","year":"2004","unstructured":"Lin HS, Jenner AM, Ong CN, Huang SH, Whiteman M, Halliwell B. A high-throughput and sensitive methodology for the quantification of urinary 8-hydroxy-2\u2032-deoxyguanosine: measurement with gas chromatography\u2013mass spectrometry after single solid-phase extraction. Biochem J. 2004;380:541\u20138.","journal-title":"Biochem J"},{"key":"9741_CR28","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jchromb.2006.07.029","volume":"844","author":"CN Man","year":"2006","unstructured":"Man CN, Gam LH, Ismail S, Lajis R, Awang R. Simple, rapid and sensitive assay method for simultaneous quantification of urinary nicotine and cotinine using gas chromatography\u2013mass spectrometry. J Chromatogr B. 2006;844:322\u20137.","journal-title":"J Chromatogr B"},{"key":"9741_CR29","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1016\/j.jchromb.2011.10.026","volume":"879","author":"MJ Li","year":"2011","unstructured":"Li MJ, Zhang JB, Li WL, Chu QC, Ye JN. Capillary electrophoretic determination of DNA damage markers: content of 8-hydroxy-2\u2032-deoxyguanosine and 8-nitroguanine in urine. J Chromatogr B. 2011;879:3818\u201322.","journal-title":"J Chromatogr B"},{"key":"9741_CR30","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1016\/j.jchromb.2011.09.038","volume":"879","author":"CJ Wang","year":"2011","unstructured":"Wang CJ, Yang NH, Chang CC, Liou SH, Lee HL. Rapid and simple one-step membrane extraction for the determination of 8-hydroxy-2\u2032-deoxyguanosine in human plasma by a combination of on-line solid phase extraction and LC\u2013MS\/MS. J Chromatogr B. 2011;879:3538\u201343.","journal-title":"J Chromatogr B"},{"key":"9741_CR31","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jchromb.2012.02.043","volume":"893\u2013894","author":"C Hosozumi","year":"2012","unstructured":"Hosozumi C, Toriba A, Chuesaard T, Kameda T, Tang N, Hayakawa K. Analysis of 8-hydroxy-2\u2032-deoxyguanosine in human urine using hydrophilic interaction chromatography with tandem mass spectrometry. J Chromatogr B. 2012;893\u2013894:173\u20136.","journal-title":"J Chromatogr B"},{"key":"9741_CR32","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jchromb.2007.03.016","volume":"853","author":"M Harri","year":"2007","unstructured":"Harri M, Kasai H, Mori T, Tornaeus J, Savela K, Peltonen K. Analysis of 8-hydroxy-2\u2032-deoxyguanosine in urine using high-performance liquid chromatography\u2013electrospray tandem mass spectrometry. J Chromatogr B. 2007;853:242\u20136.","journal-title":"J Chromatogr B"},{"key":"9741_CR33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jchromb.2012.09.018","volume":"907","author":"P Li","year":"2012","unstructured":"Li P, Beck WD, Callahan PM, Terry Jr AV, Bartlett MG. Quantitation of cotinine and its metabolites in rat plasma and brain tissue by hydrophilic interaction chromatography tandem mass spectrometry (HILIC\u2013MS\/MS). J Chromatogr B. 2012;907:117\u201325.","journal-title":"J Chromatogr B"},{"key":"9741_CR34","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jchromb.2010.12.012","volume":"879","author":"P Jacob Iii","year":"2011","unstructured":"Jacob Iii P, Yu L, Duan M, Ramos L, Yturralde O, Benowitz NL. Determination of the nicotine metabolites cotinine and trans-3\u2032-hydroxycotinine in biologic fluids of smokers and non-smokers using liquid chromatography\u2013tandem mass spectrometry: biomarkers for tobacco smoke exposure and for phenotyping cytochrome P450 2A6 activity. J Chromatogr B. 2011;879:267\u201376.","journal-title":"J Chromatogr B"},{"key":"9741_CR35","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/rcm.1763","volume":"19","author":"L Sabatini","year":"2005","unstructured":"Sabatini L, Barbieri A, Tosi M, Roda A, Violante FS. A method for routine quantitation of urinary 8-hydroxy-2\u2032-deoxyguanosine based on solid-phase extraction and micro-high-performance liquid chromatography\/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2005;19:147\u201352.","journal-title":"Rapid Commun Mass Spectrom"},{"key":"9741_CR36","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.aca.2005.04.051","volume":"545","author":"L Song","year":"2005","unstructured":"Song L, Davis W, Abrams SM, Hemiup J, Latif Kazim A, Michael Cummings K, et al. Sensitive and rapid method for the determination of urinary cotinine in non-smokers: an application for studies assessing exposures to second hand smoke (SHS). Anal Chim Acta. 2005;545:200\u20138.","journal-title":"Anal Chim Acta"},{"key":"9741_CR37","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.cca.2012.02.017","volume":"413","author":"KB Scheidweiler","year":"2012","unstructured":"Scheidweiler KB, Shakleya DM, Huestis MA. Simultaneous quantification of nicotine, cotinine, trans-3\u2032-hydroxycotinine, norcotinine and mecamylamine in human urine by liquid chromatography\u2013tandem mass spectrometry. Clin Chim Acta. 2012;413:978\u201384.","journal-title":"Clin Chim Acta"},{"key":"9741_CR38","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0378-4347(01)00451-0","volume":"778","author":"M Meger","year":"2002","unstructured":"Meger M, Meger-Kossien I, Schuler-Metz A, Janket D, Scherer G. Simultaneous determination of nicotine and eight nicotine metabolites in urine of smokers using liquid chromatography\u2013tandem mass spectrometry. J Chromatogr B. 2002;778:251\u201361.","journal-title":"J Chromatogr B"},{"key":"9741_CR39","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0378-4347(00)00306-6","volume":"746","author":"F Ceppa","year":"2000","unstructured":"Ceppa F, El Jahiri Y, Mayaudon H, Dupuy O, Burnat P. High-performance liquid chromatographic determination of cotinine in urine in isocratic mode. J Chromatogr B. 2000;746:115\u201322.","journal-title":"J Chromatogr B"},{"key":"9741_CR40","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.scitotenv.2013.02.025","volume":"450\u2013451","author":"S Zhang","year":"2013","unstructured":"Zhang S, Song X, Zhang W, Luo N, Cai L. Determination of low urinary 8-hydroxy-2\u2032-deoxyguanosine excretion with capillary electrophoresis and molecularly imprinted monolith solid phase microextraction. Sci Total Environ. 2013;450\u2013451:266\u201370.","journal-title":"Sci Total Environ"},{"key":"9741_CR41","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.talanta.2014.09.029","volume":"132","author":"WC Chiang","year":"2015","unstructured":"Chiang WC, Chen CY, Lee TC, Lee HL, Lin YW. Fast and simple screening for the simultaneous analysis of seven metabolites derived from five volatile organic compounds in human urine using on-line solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry. Talanta. 2015;132:469\u201378.","journal-title":"Talanta"},{"key":"9741_CR42","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jchromb.2011.11.024","volume":"881\u2013882","author":"X Zhou","year":"2012","unstructured":"Zhou X, Ye X, Calafat AM. Automated on-line column-switching HPLC\u2013MS\/MS method for the quantification of triclocarban and its oxidative metabolites in human urine and serum. J Chromatogr B. 2012;881\u2013882:27\u201333.","journal-title":"J Chromatogr B"},{"key":"9741_CR43","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.talanta.2007.03.001","volume":"73","author":"HL Lee","year":"2007","unstructured":"Lee HL, Wang C, Lin S, Hsieh DPH. Liquid chromatography\/tandem mass spectrometric method for the simultaneous determination of tobacco-specific nitrosamine NNK and its five metabolites. Talanta. 2007;73:76\u201380.","journal-title":"Talanta"},{"key":"9741_CR44","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1021\/tx980005y","volume":"11","author":"SS Hecht","year":"1998","unstructured":"Hecht SS. Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Chem Res Toxicol. 1998;11:559\u2013603.","journal-title":"Chem Res Toxicol"},{"key":"9741_CR45","first-page":"6912","volume":"48","author":"A Rivenson","year":"1988","unstructured":"Rivenson A, Hoffmann D, Prokopczyk B, Amin S, Hecht SS. Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and areca-derived N-nitrosamines. Cancer Res. 1988;48:6912\u20137.","journal-title":"Cancer Res"},{"key":"9741_CR46","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1093\/carcin\/21.6.1233","volume":"21","author":"P Upadhyaya","year":"2000","unstructured":"Upadhyaya P, Carmella SG, Guengerich FP, Hecht SS. Formation and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers in vitro in mouse, rat and human tissues. Carcinogenesis. 2000;21:1233\u20138.","journal-title":"Carcinogenesis"},{"key":"9741_CR47","first-page":"1257","volume":"12","author":"SG Carmella","year":"2003","unstructured":"Carmella SG, Han S, Fristad A, Yang Y, Hecht SS. Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine. Cancer Epidemiol Biomarkers Prev. 2003;12:1257\u201361.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"9741_CR48","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1021\/tx5001915","volume":"27","author":"M Jing","year":"2014","unstructured":"Jing M, Wang Y, Upadhyaya P, Jain V, Yuan JM, Hatsukami DK, et al. Liquid chromatography\u2013electrospray ionization\u2013tandem mass spectrometry quantitation of urinary [pyridine-d4]4-hydroxy-4-(3-pyridyl)butanoic acid, a biomarker of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolic activation in smokers. Chem Res Toxicol. 2014;27:1547\u201355.","journal-title":"Chem Res Toxicol"},{"key":"9741_CR49","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.toxlet.2012.11.002","volume":"216","author":"CJ Chung","year":"2013","unstructured":"Chung CJ, Pu YS, Shiue HS, Lee HL, Lin P, Yang HY, et al. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism-related enzymes gene polymorphisms, NNK metabolites levels and urothelial carcinoma. Toxicol Lett. 2013;216:16\u201322.","journal-title":"Toxicol Lett"},{"key":"9741_CR50","first-page":"1249","volume":"53","author":"JY Yang","year":"2015","unstructured":"Yang JY, Ahn HK, Lee SW, Han YJ, Oh YJ, Vel\u00e1zquez-Armenta EY, et al. Simple high-throughput analytical method using ultra-performance liquid chromatography coupled with tandem mass spectrometry to quantify total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in urine. Clin Chem Lab Med. 2015;53:1249\u201357.","journal-title":"Clin Chem Lab Med"},{"key":"9741_CR51","first-page":"635","volume":"4","author":"SG Carmella","year":"1995","unstructured":"Carmella SG, Akerkar SA, Richie JP, Hecht SS. Intraindividual and interindividual differences in metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers\u2019 urine. Cancer Epidemiol Biomark Prev. 1995;4:635\u201342.","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"9741_CR52","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2105\/AJPH.78.6.699","volume":"78","author":"MA Wall","year":"1988","unstructured":"Wall MA, Johnson J, Jacob P, Benowitz NL. Cotinine in the serum, saliva, and urine of nonsmokers, passive smokers, and active smokers. Am J Public Health. 1988;78:699\u2013701.","journal-title":"Am J Public Health"},{"key":"9741_CR53","first-page":"129","volume":"118","author":"D Behera","year":"2003","unstructured":"Behera D, Uppal R, Majumdar S. Urinary levels of nicotine & cotinine in tobacco users. Indian J Med Res. 2003;118:129\u201333.","journal-title":"Indian J Med Res"},{"key":"9741_CR54","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1080\/13547500701421341","volume":"12","author":"W Zielinska-Danch","year":"2007","unstructured":"Zielinska-Danch W, Wardas W, Sobczak A, Szoltysek-Boldys I. Estimation of urinary cotinine cut-off points distinguishing non-smokers, passive and active smokers. Biomarkers. 2007;12:484\u201396.","journal-title":"Biomarkers"},{"key":"9741_CR55","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0378-4347(98)00259-X","volume":"715","author":"JL Ravanat","year":"1998","unstructured":"Ravanat JL, Duretz B, Guiller A, Douki T, Cadet J. Isotope dilution high-performance liquid chromatography-electrospray tandem mass spectrometry assay for the measurement of 8-oxo-7,8-dihydro-2\u2032-deoxyguanosine in biological samples. J Chromatogr B. 1998;715:349\u201356.","journal-title":"J Chromatogr B"},{"key":"9741_CR56","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3390\/ijerph6020445","volume":"6","author":"A Valavanidis","year":"2009","unstructured":"Valavanidis A, Vlachogianni T, Fiotakis K. Tobacco smoke: involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles. Int J Environ Res Public Health. 2009;6:445\u201362.","journal-title":"Int J Environ Res Public Health"},{"key":"9741_CR57","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/03067318608077117","volume":"26","author":"IK O\u2019Neill","year":"1986","unstructured":"O\u2019Neill IK, Fishbein L. An IARC manual series aimed at assisting cancer epidemiology and prevention. \u201cEnvironmental carcinogens: selected methods of analysis\u201d. Int J Environ Anal Chem. 1986;26:229\u201340.","journal-title":"Int J Environ Anal Chem"},{"key":"9741_CR58","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/ntr\/ntq237","volume":"13","author":"ML Goniewicz","year":"2011","unstructured":"Goniewicz ML, Eisner MD, Lazcano-Ponce E, Zielinska-Danch W, Koszowski B, Sobczak A, et al. Comparison of urine cotinine and the tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and their ratio to discriminate active from passive smoking. Nicotine Tob Res. 2011;13:202\u20138.","journal-title":"Nicotine Tob Res"},{"key":"9741_CR59","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.chroma.2014.02.017","volume":"1336","author":"P Zhang","year":"2014","unstructured":"Zhang P, Lian K, Wu X, Yao M, Lu X, Kang W, et al. Evaluation of the oxidative deoxyribonucleic acid damage biomarker 8-hydroxy-2\u2032-deoxyguanosine in the urine of leukemic children by micellar electrokinetic capillary chromatography. J Chromatogr A. 2014;1336:112\u20139.","journal-title":"J Chromatogr A"},{"key":"9741_CR60","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.scitotenv.2011.11.039","volume":"414","author":"HC Chiang","year":"2012","unstructured":"Chiang HC, Huang YK, Chen PF, Chang CC, Wang CJ, Lin P, et al. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone is correlated with 8-hydroxy-2\u2032-deoxyguanosine in humans after exposure to environmental tobacco smoke. Sci Total Environ. 2012;414:134\u20139.","journal-title":"Sci Total Environ"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-016-9741-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00216-016-9741-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-016-9741-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T14:28:53Z","timestamp":1498314533000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00216-016-9741-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,15]]},"references-count":60,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["9741"],"URL":"https:\/\/doi.org\/10.1007\/s00216-016-9741-3","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,15]]}}}