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All mouse procedures were carried out according to the regulations of the University of Notre Dame Animal Care and Use Committee (IACUC 14-02-1577) and with approval of the Notre Dame Institutional Review Board.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}