{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:07:36Z","timestamp":1793383656620,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"15","license":[{"start":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T00:00:00Z","timestamp":1519344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Microalgae as a source of bioactive compounds: chromatographic fractionation of peptides and lipids and their mass spectrometric characterization","award":["RM11715C82118E74"],"award-info":[{"award-number":["RM11715C82118E74"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s00216-018-0925-x","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T05:13:59Z","timestamp":1519362839000},"page":"3573-3586","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["Peptidomic strategy for purification and identification of potential ACE-inhibitory and antioxidant peptides in Tetradesmus obliquus microalgae"],"prefix":"10.1007","volume":"410","author":[{"given":"Carmela Maria","family":"Montone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Laura","family":"Capriotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Cavaliere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"La Barbera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susy","family":"Piovesana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Zenezini Chiozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Lagan\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,23]]},"reference":[{"key":"925_CR1","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1007\/s00216-016-9303-8","volume":"408","author":"AL Capriotti","year":"2016","unstructured":"Capriotti AL, Cavaliere C, Piovesana S, Samperi R, Lagan\u00e0 A. Recent trends in the analysis of bioactive peptides in milk and dairy products. Anal Bioanal Chem. 2016;408:2677\u201385. https:\/\/doi.org\/10.1007\/s00216-016-9303-8 .","journal-title":"Anal Bioanal Chem"},{"key":"925_CR2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jprot.2015.01.020","volume":"119","author":"S Piovesana","year":"2015","unstructured":"Piovesana S, Capriotti ALAL, Cavaliere C, La Barbera G, Samperi R, Zenezini Chiozzi R, et al. Peptidome characterization and bioactivity analysis of donkey milk. J Proteome. 2015;119:21\u20139. https:\/\/doi.org\/10.1016\/j.jprot.2015.01.020 .","journal-title":"J Proteome"},{"key":"925_CR3","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1002\/jsfa.6670","volume":"94","author":"Z Yu","year":"2014","unstructured":"Yu Z, Yin Y, Zhao W, Chen F, Liu J. Application and bioactive properties of proteins and peptides derived from hen eggs: opportunities and challenges. J Sci Food Agric. 2014;94:2839\u201345. https:\/\/doi.org\/10.1002\/jsfa.6670 .","journal-title":"J Sci Food Agric"},{"key":"925_CR4","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.meatsci.2014.05.036","volume":"98","author":"T Lafarga","year":"2014","unstructured":"Lafarga T, Hayes M. Bioactive peptides from meat muscle and by-products: generation, functionality and application as functional ingredients. Meat Sci. 2014;98:227\u201339. https:\/\/doi.org\/10.1016\/j.meatsci.2014.05.036 .","journal-title":"Meat Sci"},{"key":"925_CR5","doi-asserted-by":"publisher","unstructured":"Capriotti AL, Cavaliere C, Foglia P, Piovesana S, Samperi R, Zenezini Chiozzi R, Lagan\u00e0 A. Development of an analytical strategy for the identification of potential bioactive peptides generated by in vitro tryptic digestion of fish muscle proteins. Anal Bioanal Chem 2015;407. doi: https:\/\/doi.org\/10.1007\/s00216-014-8094-z .","DOI":"10.1007\/s00216-014-8094-z"},{"key":"925_CR6","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.tifs.2016.02.007","volume":"51","author":"NRA Halim","year":"2016","unstructured":"Halim NRA, Yusof HM, Sarbon NM. Functional and bioactive properties of fish protein hydolysates and peptides: a comprehensive review. Trends Food Sci Technol. 2016;51:24\u201333. https:\/\/doi.org\/10.1016\/j.tifs.2016.02.007 .","journal-title":"Trends Food Sci Technol"},{"key":"925_CR7","doi-asserted-by":"publisher","first-page":"5657","DOI":"10.1007\/s00216-016-9672-z","volume":"408","author":"R Zenezini Chiozzi","year":"2016","unstructured":"Zenezini Chiozzi R, Capriotti AL, Cavaliere C, La Barbera G, Piovesana S, Samperi R, et al. Purification and identification of endogenous antioxidant and ACE-inhibitory peptides from donkey milk by multidimensional liquid chromatography and nanoHPLC-high resolution mass spectrometry. Anal Bioanal Chem. 2016;408:5657\u201366. https:\/\/doi.org\/10.1007\/s00216-016-9672-z .","journal-title":"Anal Bioanal Chem"},{"key":"925_CR8","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.jfca.2015.08.007","volume":"44","author":"AL Capriotti","year":"2015","unstructured":"Capriotti AL, Caruso G, Cavaliere C, Samperi R, Ventura S, Zenezini Chiozzi R, et al. Identification of potential bioactive peptides generated by simulated gastrointestinal digestion of soybean seeds and soy milk proteins. J Food Compos Anal. 2015;44:205\u201313. https:\/\/doi.org\/10.1016\/j.jfca.2015.08.007 .","journal-title":"J Food Compos Anal"},{"key":"925_CR9","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.algal.2013.01.004","volume":"2","author":"AP Batista","year":"2013","unstructured":"Batista AP, Gouveia L, Bandarra NM, Franco JM, Raymundo A. Comparison of microalgal biomass profiles as novel functional ingredient for food products. Algal Res. 2013;2:164\u201373. https:\/\/doi.org\/10.1016\/j.algal.2013.01.004 .","journal-title":"Algal Res"},{"key":"925_CR10","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.tifs.2016.10.026","volume":"59","author":"CECC Ejike","year":"2017","unstructured":"Ejike CECC, Collins SA, Balasuriya N, Swanson AK, Mason B, Udenigwe CC. Prospects of microalgae proteins in producing peptide-based functional foods for promoting cardiovascular health. Trends Food Sci Technol. 2017;59:30\u20136. https:\/\/doi.org\/10.1016\/j.tifs.2016.10.026 .","journal-title":"Trends Food Sci Technol"},{"key":"925_CR11","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.apenergy.2016.06.024","volume":"179","author":"PC Hallenbeck","year":"2016","unstructured":"Hallenbeck PC, Grogger M, Mraz M, Veverka D. Solar biofuels production with microalgae. Appl Energy. 2016;179:136\u201345. https:\/\/doi.org\/10.1016\/J.APENERGY.2016.06.024 .","journal-title":"Appl Energy"},{"key":"925_CR12","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.rser.2017.05.199","volume":"79","author":"M Faried","year":"2017","unstructured":"Faried M, Samer M, Abdelsalam E, Yousef RS, Attia YA, Ali AS. Biodiesel production from microalgae: processes, technologies and recent advancements. Renew Sust Energ Rev. 2017;79:893\u2013913. https:\/\/doi.org\/10.1016\/J.RSER.2017.05.199 .","journal-title":"Renew Sust Energ Rev"},{"key":"925_CR13","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.biortech.2016.04.078","volume":"214","author":"JH Duarte","year":"2016","unstructured":"Duarte JH, Fanka LS, Costa JAV. Utilization of simulated flue gas containing CO2, SO2, NO and ash for Chlorella fusca cultivation. Bioresour Technol. 2016;214:159\u201365. https:\/\/doi.org\/10.1016\/J.BIORTECH.2016.04.078 .","journal-title":"Bioresour Technol"},{"key":"925_CR14","doi-asserted-by":"publisher","DOI":"10.1002\/9783527679577","volume-title":"Marine algae extracts","author":"S-K Kim","year":"2015","unstructured":"Kim S-K, Chojnacka K. Marine algae extracts. Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA; 2015."},{"key":"925_CR15","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/1750-3841.14011","volume":"83","author":"H Admassu","year":"2018","unstructured":"Admassu H, Gasmalla MAA, Yang R, Zhao W. Bioactive peptides derived from seaweed protein and their health benefits: antihypertensive, antioxidant, and antidiabetic properties. J Food Sci. 2018;83:6\u201316. https:\/\/doi.org\/10.1111\/1750-3841.14011 .","journal-title":"J Food Sci"},{"key":"925_CR16","doi-asserted-by":"publisher","unstructured":"Alzahrani MAJ, Perera CO, Hemar Y. Production of bioactive proteins and peptides from the diatom Nitzschia laevis and comparison of their in vitro antioxidant activities with those from Spirulina platensis and Chlorella vulgaris. Int J Food Sci Technol. 2017; https:\/\/doi.org\/10.1111\/ijfs.13642 .","DOI":"10.1111\/ijfs.13642"},{"key":"925_CR17","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jbiotec.2016.11.001","volume":"240","author":"CE Ochoa-M\u00e9ndez","year":"2016","unstructured":"Ochoa-M\u00e9ndez CE, Lara-Hern\u00e1ndez I, Gonz\u00e1lez LM, Aguirre-Ba\u00f1uelos P, Ibarra-Barajas M, Castro-Moreno P, et al. Bioactivity of an antihypertensive peptide expressed in Chlamydomonas reinhardtii. J Biotechnol. 2016;240:76\u201384. https:\/\/doi.org\/10.1016\/j.jbiotec.2016.11.001 .","journal-title":"J Biotechnol"},{"key":"925_CR18","doi-asserted-by":"publisher","unstructured":"Piovesana S, Capriotti AL, Cavaliere C, La Barbera G, Montone CM, Zenezini Chiozzi R, Lagan\u00e0 A. Recent trends and analytical challenges in plant bioactive peptide separation, identification and validation. Anal Bioanal Chem 2018; 852. https:\/\/doi.org\/10.1007\/s00216-018-0852-x .","DOI":"10.1007\/s00216-018-0852-x"},{"key":"925_CR19","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.foodres.2017.07.037","volume":"100","author":"PA Harnedy","year":"2017","unstructured":"Harnedy PA, O\u2019Keeffe MB, FitzGerald RJ. Fractionation and identification of antioxidant peptides from an enzymatically hydrolysed Palmaria palmata protein isolate. Food Res Int. 2017;100:416\u201322. https:\/\/doi.org\/10.1016\/J.FOODRES.2017.07.037 .","journal-title":"Food Res Int"},{"key":"925_CR20","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.foodchem.2016.09.053","volume":"218","author":"AC Neves","year":"2017","unstructured":"Neves AC, Harnedy PA, O\u2019Keeffe MB, FitzGerald RJ. Bioactive peptides from Atlantic salmon (Salmo salar) with angiotensin converting enzyme and dipeptidyl peptidase IV inhibitory, and antioxidant activities. Food Chem. 2017;218:396\u2013405. https:\/\/doi.org\/10.1016\/j.foodchem.2016.09.053 .","journal-title":"Food Chem"},{"key":"925_CR21","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.jff.2016.09.010","volume":"27","author":"R Zenezini Chiozzi","year":"2016","unstructured":"Zenezini Chiozzi R, Capriotti AL, Cavaliere C, La Barbera G, Piovesana S, Lagan\u00e0 A. Identification of three novel angiotensin-converting enzyme inhibitory peptides derived from cauliflower by-products by multidimensional liquid chromatography and bioinformatics. J Funct Foods. 2016;27:262\u201373. https:\/\/doi.org\/10.1016\/j.jff.2016.09.010 .","journal-title":"J Funct Foods"},{"key":"925_CR22","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/1751-7915.12167","volume":"8","author":"SP Cuellar-Bermudez","year":"2015","unstructured":"Cuellar-Bermudez SP, Aguilar-Hernandez I, Cardenas-Chavez DL, Ornelas-Soto N, Romero-Ogawa MA, Parra-Saldivar R. Extraction and purification of high-value metabolites from microalgae: essential lipids, astaxanthin and phycobiliproteins. Microb Biotechnol. 2015;8:190\u2013209. https:\/\/doi.org\/10.1111\/1751-7915.12167 .","journal-title":"Microb Biotechnol"},{"key":"925_CR23","doi-asserted-by":"publisher","first-page":"415","DOI":"10.3303\/CET1649070","volume":"49","author":"F Caprio Di","year":"2016","unstructured":"Di Caprio F, Visca A, Altimari P, Toro L, Iaquaniello G, Pagnanelli F. Two stage process of microalgae cultivation for starch and carotenoid production. Chem Eng Trans. 2016;49:415\u201320. https:\/\/doi.org\/10.3303\/CET1649070 .","journal-title":"Chem Eng Trans"},{"key":"925_CR24","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1002\/jssc.201401319","volume":"38","author":"AL Capriotti","year":"2015","unstructured":"Capriotti AL, Cavaliere C, Piovesana S, Stampachiacchiere S, Ventura S, Zenezini Chiozzi R, et al. Characterization of quinoa seed proteome combining different protein precipitation techniques: improvement of knowledge of nonmodel plant proteomics. J Sep Sci. 2015;38:1017\u201325. https:\/\/doi.org\/10.1002\/jssc.201401319 .","journal-title":"J Sep Sci"},{"key":"925_CR25","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.talanta.2017.09.010","volume":"178","author":"AL Capriotti","year":"2018","unstructured":"Capriotti AL, Cavaliere C, Ferraris F, Gianotti V, Laus M, Piovesana S, et al. New Ti-IMAC magnetic polymeric nanoparticles for phosphopeptide enrichment from complex real samples. Talanta. 2018;178:274\u201381. https:\/\/doi.org\/10.1016\/j.talanta.2017.09.010 .","journal-title":"Talanta"},{"key":"925_CR26","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.fuel.2015.02.004","volume":"150","author":"R Mu\u00f1oz","year":"2015","unstructured":"Mu\u00f1oz R, Navia R, Ciudad G, Tessini C, Jeison D, Mella R, et al. Preliminary biorefinery process proposal for protein and biofuels recovery from microalgae. Fuel. 2015;150:425\u201333. https:\/\/doi.org\/10.1016\/J.FUEL.2015.02.004 .","journal-title":"Fuel"},{"key":"925_CR27","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1002\/lite.200800074","volume":"20","author":"SK Jensen","year":"2008","unstructured":"Jensen SK. Improved Bligh and Dyer extraction procedure. Lipid Technol. 2008;20:280\u20131. https:\/\/doi.org\/10.1002\/lite.200800074 .","journal-title":"Lipid Technol"},{"key":"925_CR28","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1039\/C4RA11914B","volume":"5","author":"H Abedini Najafabadi","year":"2015","unstructured":"Abedini Najafabadi H, Pazuki G, Vossoughi M. Experimental study and thermodynamic modeling for purification of extracted algal lipids using an organic\/aqueous two-phase system. RSC Adv. 2015;5:1153\u201360. https:\/\/doi.org\/10.1039\/C4RA11914B .","journal-title":"RSC Adv"},{"key":"925_CR29","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1194\/jlr.D700041-JLR200","volume":"49","author":"V Matyash","year":"2008","unstructured":"Matyash V, Liebisch G, Kurzchalia TV, Shevchenko A, Schwudke D. Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics. J Lipid Res. 2008;49:1137\u201346. https:\/\/doi.org\/10.1194\/jlr.D700041-JLR200 .","journal-title":"J Lipid Res"},{"key":"925_CR30","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.biortech.2012.07.102","volume":"123","author":"G Yoo","year":"2012","unstructured":"Yoo G, Park W-K, Kim CW, Choi Y-E, Yang J-W. Direct lipid extraction from wet Chlamydomonas reinhardtii biomass using osmotic shock. Bioresour Technol. 2012;123:717\u201322. https:\/\/doi.org\/10.1016\/J.BIORTECH.2012.07.102 .","journal-title":"Bioresour Technol"},{"key":"925_CR31","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","volume":"26","author":"R Re","year":"1999","unstructured":"Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 1999;26:1231\u20137. https:\/\/doi.org\/10.1016\/S0891-5849(98)00315-3 .","journal-title":"Free Radic Biol Med"},{"key":"925_CR32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045012","volume":"7","author":"C Mooney","year":"2012","unstructured":"Mooney C, Haslam NJ, Pollastri G, Shields DC. Towards the improved discovery and design of functional peptides: common features of diverse classes permit generalized prediction of bioactivity. PLoS One. 2012;7:e45012. https:\/\/doi.org\/10.1371\/journal.pone.0045012 .","journal-title":"PLoS One"},{"key":"925_CR33","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s12223-011-0069-2","volume":"56","author":"M Klimek-Ochab","year":"2011","unstructured":"Klimek-Ochab M, Brzezi\u0144ska-Rodak M, Zyma\u0144czyk-Duda E, Lejczak B, Kafarski P. Comparative study of fungal cell disruption\u2014scope and limitations of the methods. Folia Microbiol (Praha). 2011;56:469\u201375. https:\/\/doi.org\/10.1007\/s12223-011-0069-2 .","journal-title":"Folia Microbiol (Praha)"},{"key":"925_CR34","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1002\/elps.200700461","volume":"29","author":"K Nagai","year":"2008","unstructured":"Nagai K, Yotsukura N, Ikegami H, Kimura H, Morimoto K. Protein extraction for 2-DE from the lamina ofEcklonia kurome (laminariales): recalcitrant tissue containing high levels of viscous polysaccharides. Electrophoresis. 2008;29:672\u201381. https:\/\/doi.org\/10.1002\/elps.200700461 .","journal-title":"Electrophoresis"},{"key":"925_CR35","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein dye binding. Anal Biochem. 1976;72:248\u201354. https:\/\/doi.org\/10.1016\/0003-2697(76)90527-3 .","journal-title":"Anal Biochem"},{"key":"925_CR36","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0003-2697(79)90222-7","volume":"100","author":"GL Peterson","year":"1979","unstructured":"Peterson GL. Review of the Folin phenol protein quantitation method of Lowry, Rosebrough, Farr and Randall. Anal Biochem. 1979;100:201\u201320. https:\/\/doi.org\/10.1016\/0003-2697(79)90222-7 .","journal-title":"Anal Biochem"},{"key":"925_CR37","doi-asserted-by":"publisher","first-page":"7587","DOI":"10.1016\/j.biortech.2010.04.077","volume":"101","author":"CV Gonz\u00e1lez L\u00f3pez","year":"2010","unstructured":"Gonz\u00e1lez L\u00f3pez CV, del Carmen Cer\u00f3n Garc\u00eda M, Fern\u00e1ndez FGA, Bustos CS, Chisti Y, Sevilla JMF. Protein measurements of microalgal and cyanobacterial biomass. Bioresour Technol. 2010;101:7587\u201391. https:\/\/doi.org\/10.1016\/j.biortech.2010.04.077 .","journal-title":"Bioresour Technol"},{"key":"925_CR38","doi-asserted-by":"crossref","first-page":"427","DOI":"10.25518\/1780-4507.13132","volume":"20","author":"A Barka","year":"2016","unstructured":"Barka A, Blecker C. Microalgae as a potential source of single-cell proteins. A review. Biotechnol Agron Soc Environ. 2016;20:427\u201336.","journal-title":"Biotechnol Agron Soc Environ"},{"key":"925_CR39","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.jff.2014.10.020","volume":"11","author":"E Gonz\u00e1lez-Garc\u00eda","year":"2014","unstructured":"Gonz\u00e1lez-Garc\u00eda E, Marina ML, Garc\u00eda MC. Plum (Prunus domestica L.) by-product as a new and cheap source of bioactive peptides: extraction method and peptides characterization. J Funct Foods. 2014;11:428\u201337. https:\/\/doi.org\/10.1016\/J.JFF.2014.10.020 .","journal-title":"J Funct Foods"},{"key":"925_CR40","doi-asserted-by":"publisher","unstructured":"Awuor OL, Edward Kirwa M, Betty M, Jackim MF (2017) Optimization of Alcalase hydrolysis conditions for production of Dagaa (Rastrineobola argentea) protein hydrolysate with antioxidative properties. Ind Chem; 3. https:\/\/doi.org\/10.4172\/2469-9764.1000122 .","DOI":"10.4172\/2469-9764.1000122"},{"key":"925_CR41","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.foodchem.2014.02.040","volume":"157","author":"H-S Jeong","year":"2014","unstructured":"Jeong H-S, Kim H-Y, Ahn SH, Oh SC, Yang I, Choi I-G. Optimization of enzymatic hydrolysis conditions for extraction of pectin from rapeseed cake (Brassica napus L.) using commercial enzymes. Food Chem. 2014;157:332\u20138. https:\/\/doi.org\/10.1016\/j.foodchem.2014.02.040 .","journal-title":"Food Chem"},{"key":"925_CR42","doi-asserted-by":"publisher","first-page":"3071","DOI":"10.1021\/pr3011588","volume":"12","author":"A Kalli","year":"2013","unstructured":"Kalli A, Smith GT, Sweredoski MJ, Hess S. Evaluation and optimization of mass spectrometric settings during data-dependent acquisition mode: focus on LTQ-Orbitrap mass analyzers. J Proteome Res. 2013;12:3071\u201386. https:\/\/doi.org\/10.1021\/pr3011588 .","journal-title":"J Proteome Res"},{"key":"925_CR43","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1002\/jssc.200500116","volume":"28","author":"M Gilar","year":"2005","unstructured":"Gilar M, Olivova P, Daly AE, Gebler JC. Two-dimensional separation of peptides using RP-RP-HPLC system with different pH in first and second separation dimensions. J Sep Sci. 2005;28:1694\u2013703. https:\/\/doi.org\/10.1002\/jssc.200500116 .","journal-title":"J Sep Sci"},{"key":"925_CR44","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3390\/md14020032","volume":"14","author":"T Furuta","year":"2016","unstructured":"Furuta T, Miyabe Y, Yasui H, Kinoshita Y, Kishimura H. Angiotensin I converting enzyme inhibitory peptides derived from phycobiliproteins of dulse Palmaria palmata. Mar Drugs. 2016;14:32. https:\/\/doi.org\/10.3390\/md14020032 .","journal-title":"Mar Drugs"},{"key":"925_CR45","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.foodchem.2014.12.027","volume":"176","author":"A Connolly","year":"2015","unstructured":"Connolly A, O\u2019Keeffe MB, Piggott CO, Nongonierma AB, FitzGerald RJ. Generation and identification of angiotensin converting enzyme (ACE) inhibitory peptides from a brewers\u2019 spent grain protein isolate. Food Chem. 2015;176:64\u201371. https:\/\/doi.org\/10.1016\/j.foodchem.2014.12.027 .","journal-title":"Food Chem"},{"key":"925_CR46","doi-asserted-by":"publisher","first-page":"3419","DOI":"10.1016\/j.biortech.2009.02.014","volume":"100","author":"I-CC Sheih","year":"2009","unstructured":"Sheih I-CC, Wu T-KK, Fang TJ. Antioxidant properties of a new antioxidative peptide from algae protein waste hydrolysate in different oxidation systems. Bioresour Technol. 2009;100:3419\u201325. https:\/\/doi.org\/10.1016\/j.biortech.2009.02.014 .","journal-title":"Bioresour Technol"},{"key":"925_CR47","first-page":"505","volume":"4","author":"OS Nimmi","year":"2012","unstructured":"Nimmi OS, George P. Evaluation of the antioxidant potential of a newly developed polyherbal formulation for antiobesity. Int J Pharm Pharm Sci. 2012;4:505\u201310.","journal-title":"Int J Pharm Pharm Sci"},{"key":"925_CR48","doi-asserted-by":"crossref","unstructured":"Brahmachari G. Chemistry and pharmacology of naturally occurring bioactive compounds. 1st ed. Boca Raton: CRC Press; 2013.","DOI":"10.1201\/b13867"},{"key":"925_CR49","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/978-981-10-6175-2_9","volume-title":"Peanut processing characteristics and quality evaluation","author":"Q Wang","year":"2018","unstructured":"Wang Q. Preparation of functional peanut oligopeptide and its biological activity. In: Peanut processing characteristics and quality evaluation. Singapore: Springer Singapore; 2018. p. 461\u2013537."},{"key":"925_CR50","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.foodchem.2007.06.039","volume":"106","author":"J-S Tsai","year":"2008","unstructured":"Tsai J-S, Chen T-J, Pan BS, Gong S-D, Chung M-Y. Antihypertensive effect of bioactive peptides produced by protease-facilitated lactic acid fermentation of milk. Food Chem. 2008;106:552\u20138. https:\/\/doi.org\/10.1016\/J.FOODCHEM.2007.06.039 .","journal-title":"Food Chem"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00216-018-0925-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-018-0925-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-018-0925-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T20:01:01Z","timestamp":1660507261000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00216-018-0925-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,23]]},"references-count":50,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["925"],"URL":"https:\/\/doi.org\/10.1007\/s00216-018-0925-x","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,23]]},"assertion":[{"value":"4 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}