{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:05:54Z","timestamp":1783040754213,"version":"3.54.6"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"25","license":[{"start":{"date-parts":[[2018,7,21]],"date-time":"2018-07-21T00:00:00Z","timestamp":1532131200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000764","name":"King's College London","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000764","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s00216-018-1245-x","type":"journal-article","created":{"date-parts":[[2018,7,21]],"date-time":"2018-07-21T05:13:29Z","timestamp":1532150009000},"page":"6477-6487","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Subcellular mapping of living cells via synchrotron microFTIR and ZnS hemispheres"],"prefix":"10.1007","volume":"410","author":[{"given":"K. L. Andrew","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro L. V.","family":"Fale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Atharawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Wehbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfelice","family":"Cinque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,21]]},"reference":[{"issue":"11","key":"1245_CR1","doi-asserted-by":"publisher","first-page":"4768","DOI":"10.1021\/ac300313x","volume":"84","author":"L Vaccari","year":"2012","unstructured":"Vaccari L, Birarda G, Businaro L, Pacor S, Grenci G. Infrared microspectroscopy of live cells in microfluidic devices (MD-IRMS): toward a powerful label-free cell-based assay. Anal Chem. 2012;84(11):4768\u201375. \n                    https:\/\/doi.org\/10.1021\/ac300313x\n                    \n                  .","journal-title":"Anal Chem"},{"issue":"1","key":"1245_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1116\/1.2710336","volume":"2","author":"M Schmidt","year":"2007","unstructured":"Schmidt M, Wolfram T, Rumpler M, Tripp CP, Grunze M. Live cell adhesion assay with attenuated total reflection infrared spectroscopy. Biointerphases. 2007;2(1):1\u20135. \n                    https:\/\/doi.org\/10.1116\/1.2710336\n                    \n                  .","journal-title":"Biointerphases"},{"issue":"2","key":"1245_CR3","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1366\/000370209787391969","volume":"63","author":"MK Kuimova","year":"2009","unstructured":"Kuimova MK, Chan KLA, Kazarian SG. Chemical imaging of live cancer cells in the natural aqueous environment. Appl Spectrosc. 2009;63(2):164\u201371.","journal-title":"Appl Spectrosc"},{"issue":"1","key":"1245_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.vibspec.2003.07.002","volume":"34","author":"MK Alam","year":"2004","unstructured":"Alam MK, Timlin JA, Martin LE, Williams D, Lyons CR, Garrison K, et al. Spectroscopic evaluation of living murine macrophage cells before and after activation using attenuated total reflectance infrared spectroscopy. Vib Spectrosc. 2004;34(1):3\u201311. \n                    https:\/\/doi.org\/10.1016\/j.vibspec.2003.07.002\n                    \n                  .","journal-title":"Vib Spectrosc"},{"issue":"12","key":"1245_CR5","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1039\/c0an00548g","volume":"135","author":"EJ Marcsisin","year":"2010","unstructured":"Marcsisin EJ, Uttero CM, Miljkovic M, Diem M. Infrared microspectroscopy of live cells in aqueous media. Analyst. 2010;135(12):3227\u201332. \n                    https:\/\/doi.org\/10.1039\/c0an00548g\n                    \n                  .","journal-title":"Analyst"},{"issue":"23","key":"1245_CR6","doi-asserted-by":"publisher","first-page":"11673","DOI":"10.1021\/ac503915c","volume":"86","author":"KLA Chan","year":"2014","unstructured":"Chan KLA, Fale PLV. Label-free in situ quantification of drug in living cells at micromolar levels using infrared spectroscopy. Anal Chem. 2014;86(23):11673\u20139. \n                    https:\/\/doi.org\/10.1021\/ac503915c\n                    \n                  .","journal-title":"Anal Chem"},{"issue":"10 Part A","key":"1245_CR7","first-page":"2640","volume":"1853","author":"PLV Fale","year":"2015","unstructured":"Fale PLV, Altharawi A, Chan KLA. In situ Fourier transform infrared analysis of live cells\u2019 response to doxorubicin. BBA-Mol Cell Res. 2015;1853(10 Part A):2640\u20138.","journal-title":"BBA-Mol Cell Res"},{"key":"1245_CR8","doi-asserted-by":"crossref","unstructured":"Chan KLA, Fale PLV. Label-free optical imaging of live cells. In: Meglinski I, editor. Biophotonics for medical applications. Woodhead Publishing; 2015. p. 215\u201341.","DOI":"10.1016\/B978-0-85709-662-3.00008-7"},{"issue":"1","key":"1245_CR9","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.protis.2014.12.002","volume":"166","author":"J Vongsvivut","year":"2015","unstructured":"Vongsvivut J, Heraud P, Gupta A, Thyagarajan T, Puri M, McNaughton D, et al. Synchrotron-FTIR microspectroscopy enables the distinction of lipid accumulation in thraustochytrid strains through analysis of individual live cells. Protist. 2015;166(1):106\u201321. \n                    https:\/\/doi.org\/10.1016\/j.protis.2014.12.002\n                    \n                  .","journal-title":"Protist"},{"issue":"1","key":"1245_CR10","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.vibspec.2010.02.004","volume":"53","author":"KL Munro","year":"2010","unstructured":"Munro KL, Bambery KR, Carter EA, Puskar L, Tobin MJ, Wood BR, et al. Synchrotron radiation infrared microspectroscopy of arsenic-induced changes to intracellular biomolecules in live leukemia cells. Vib Spectrosc. 2010;53(1):39\u201344. \n                    https:\/\/doi.org\/10.1016\/j.vibspec.2010.02.004\n                    \n                  .","journal-title":"Vib Spectrosc"},{"issue":"6","key":"1245_CR11","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1080\/05704928.2016.1250214","volume":"52","author":"J Doherty","year":"2017","unstructured":"Doherty J, Cinque G, Gardner P. Single-cell analysis using Fourier transform infrared microspectroscopy. Appl Spectrosc Rev. 2017;52(6):560\u201387. \n                    https:\/\/doi.org\/10.1080\/05704928.2016.1250214\n                    \n                  .","journal-title":"Appl Spectrosc Rev"},{"key":"1245_CR12","doi-asserted-by":"publisher","first-page":"4040","DOI":"10.1039\/c3an00327b","volume":"138","author":"KLA Chan","year":"2013","unstructured":"Chan KLA, Kazarian SG. Aberration-free FTIR spectroscopic imaging of live cells in microfluidic devices. Analyst. 2013;138:4040\u20137. \n                    https:\/\/doi.org\/10.1039\/c3an00327b\n                    \n                  .","journal-title":"Analyst"},{"key":"1245_CR13","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.bpc.2014.03.002","volume":"189","author":"L Quaroni","year":"2014","unstructured":"Quaroni L, Zlateva T, Sarafimov B, Kreuzer HW, Wehbe K, Hegg EL, et al. Synchrotron based infrared imaging and spectroscopy via focal plane array on live fibroblasts in D2O enriched medium. Biophys Chem. 2014;189:40\u20138. \n                    https:\/\/doi.org\/10.1016\/j.bpc.2014.03.002\n                    \n                  .","journal-title":"Biophys Chem"},{"key":"1245_CR14","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1039\/c5fd00156k","volume":"187","author":"L Quaroni","year":"2016","unstructured":"Quaroni L, Zlateva T, Wehbe K, Cinque G. Infrared imaging of small molecules in living cells: from in vitro metabolic analysis to cytopathology. Faraday Discuss. 2016;187:259\u201371. \n                    https:\/\/doi.org\/10.1039\/c5fd00156k\n                    \n                  .","journal-title":"Faraday Discuss"},{"issue":"9","key":"1245_CR15","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1039\/c5lc01460c","volume":"16","author":"G Birarda","year":"2016","unstructured":"Birarda G, Ravasio A, Suryana M, Maniam S, Holman HYN, Grenci G. IR-Live: fabrication of a low-cost plastic microfluidic device for infrared spectromicroscopy of living cells. Lab Chip. 2016;16(9):1644\u201351. \n                    https:\/\/doi.org\/10.1039\/c5lc01460c\n                    \n                  .","journal-title":"Lab Chip"},{"issue":"1","key":"1245_CR16","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.vibspec.2010.01.016","volume":"53","author":"G Birarda","year":"2010","unstructured":"Birarda G, Grenci G, Businaro L, Marmiroli B, Pacor S, Piccirilli F, et al. Infrared microspectroscopy of biochemical response of living cells in microfabricated devices. Vib Spectrosc. 2010;53(1):6\u201311. \n                    https:\/\/doi.org\/10.1016\/j.vibspec.2010.01.016\n                    \n                  .","journal-title":"Vib Spectrosc"},{"issue":"5\u20138","key":"1245_CR17","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.mee.2009.11.081","volume":"87","author":"G Birarda","year":"2010","unstructured":"Birarda G, Grenci G, Businaro L, Marmiroli B, Pacor S, Vaccari L. Fabrication of a microfluidic platform for investigating dynamic biochemical processes in living samples by FTIR microspectroscopy. Microelectron Eng. 2010;87(5\u20138):806\u20139. \n                    https:\/\/doi.org\/10.1016\/j.mee.2009.11.081\n                    \n                  .","journal-title":"Microelectron Eng"},{"issue":"1","key":"1245_CR18","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.vibspec.2010.02.005","volume":"53","author":"MJ Tobin","year":"2010","unstructured":"Tobin MJ, Puskar L, Barber RL, Harvey EC, Heraud P, Wood BR, et al. FTIR spectroscopy of single live cells in aqueous media by synchrotron IR microscopy using microfabricated sample holders. Vib Spectrosc. 2010;53(1):34\u20138. \n                    https:\/\/doi.org\/10.1016\/j.vibspec.2010.02.005\n                    \n                  .","journal-title":"Vib Spectrosc"},{"issue":"16","key":"1245_CR19","doi-asserted-by":"publisher","first-page":"3219","DOI":"10.1039\/c1an15060j","volume":"136","author":"L Quaroni","year":"2011","unstructured":"Quaroni L, Zlateva T. Infrared spectromicroscopy of biochemistry in functional single cells. Analyst. 2011;136(16):3219\u201332. \n                    https:\/\/doi.org\/10.1039\/c1an15060j\n                    \n                  .","journal-title":"Analyst"},{"issue":"12","key":"1245_CR20","doi-asserted-by":"publisher","first-page":"6025","DOI":"10.1021\/acs.analchem.5b00371","volume":"87","author":"P Gelfand","year":"2015","unstructured":"Gelfand P, Smith RJ, Stavitski E, Borchelt DR, Miller LM. Characterization of protein structural changes in living cells using time-lapsed FTIR imaging. Anal Chem. 2015;87(12):6025\u201331. \n                    https:\/\/doi.org\/10.1021\/acs.analchem.5b00371\n                    \n                  .","journal-title":"Anal Chem"},{"issue":"11","key":"1245_CR21","doi-asserted-by":"publisher","first-page":"22753","DOI":"10.3390\/ijms141122753","volume":"14","author":"EC Mattson","year":"2013","unstructured":"Mattson EC, Aboualizadeh E, Barabas ME, Stucky CL, Hirschmugl CJ. Opportunities for live cell FT-infrared imaging: macromolecule identification with 2D and 3D localization. Int J Mol Sci. 2013;14(11):22753\u201381. \n                    https:\/\/doi.org\/10.3390\/ijms141122753\n                    \n                  .","journal-title":"Int J Mol Sci"},{"issue":"5","key":"1245_CR22","doi-asserted-by":"publisher","first-page":"135A","DOI":"10.1366\/000370210791211673","volume":"64","author":"SG Kazarian","year":"2010","unstructured":"Kazarian SG, Chan KLA. Micro- and macro-attenuated total reflection Fourier transform infrared spectroscopic imaging. Appl Spectrosc. 2010;64(5):135A\u201352A.","journal-title":"Appl Spectrosc"},{"key":"1245_CR23","doi-asserted-by":"crossref","unstructured":"Fale PLV, Chan KLA. Preventing damage of germanium optical material in attenuated total reflection-Fourier transform infrared (ATR-FTIR) studies of living cells. Vib Spectrosc 2016;in press.","DOI":"10.1016\/j.vibspec.2016.07.012"},{"issue":"19","key":"1245_CR24","doi-asserted-by":"publisher","first-page":"3377","DOI":"10.1021\/ac00115a003","volume":"67","author":"EN Lewis","year":"1995","unstructured":"Lewis EN, Treado PJ, Reeder RC, Story GM, Dowrey AE, Marcott C, et al. Fourier transform spectroscopic imaging using an infrared focal-plane array detector. Anal Chem. 1995;67(19):3377\u201381.","journal-title":"Anal Chem"},{"issue":"3","key":"1245_CR25","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1063\/1.1347965","volume":"72","author":"GL Carr","year":"2001","unstructured":"Carr GL. Resolution limits for infrared microspectroscopy explored with synchrotron radiation. Rev Sci Instrum. 2001;72(3):1613\u20139. \n                    https:\/\/doi.org\/10.1063\/1.1347965\n                    \n                  .","journal-title":"Rev Sci Instrum"},{"issue":"1\u20132","key":"1245_CR26","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S0924-2031(01)00192-8","volume":"29","author":"DL Wetzel","year":"2002","unstructured":"Wetzel DL. A new approach to the problem of dispersive windows in infrared microspectroscopy. Vib Spectrosc. 2002;29(1\u20132):291\u20137.","journal-title":"Vib Spectrosc"},{"issue":"2","key":"1245_CR27","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1021\/ac302846d","volume":"85","author":"KLA Chan","year":"2013","unstructured":"Chan KLA, Kazarian SG. Correcting the effect of refraction and dispersion of light in FT-IR spectroscopic imaging in transmission through thick infrared windows. Anal Chem. 2013;85(2):1029\u201336. \n                    https:\/\/doi.org\/10.1021\/ac302846d\n                    \n                  .","journal-title":"Anal Chem"},{"issue":"4","key":"1245_CR28","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1007\/s00216-012-6521-6","volume":"405","author":"K Wehbe","year":"2013","unstructured":"Wehbe K, Filik J, Frogley MD, Cinque G. The effect of optical substrates on micro-FTIR analysis of single mammalian cells. Anal Bioanal Chem. 2013;405(4):1311\u201324. \n                    https:\/\/doi.org\/10.1007\/s00216-012-6521-6\n                    \n                  .","journal-title":"Anal Bioanal Chem"},{"issue":"2","key":"1245_CR29","doi-asserted-by":"publisher","first-page":"250","DOI":"10.12693\/APhysPolA.129.250","volume":"129","author":"S Yao","year":"2016","unstructured":"Yao S, Guidi MC, Delugin M, Della-Ventura G, Marcelli A, Petibois C. Methodology for FTIR imaging of individual cells. Acta Phys Pol A. 2016;129(2):250\u20134.","journal-title":"Acta Phys Pol A"},{"issue":"5","key":"1245_CR30","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/nmeth.1585","volume":"8","author":"MJ Nasse","year":"2011","unstructured":"Nasse MJ, Walsh MJ, Mattson EC, Reininger R, Kajdacsy-Balla A, Macias V, et al. High-resolution Fourier-transform infrared chemical imaging with multiple synchrotron beams. Nat Methods. 2011;8(5):413\u20136. \n                    https:\/\/doi.org\/10.1038\/nmeth.1585\n                    \n                  .","journal-title":"Nat Methods"},{"issue":"7","key":"1245_CR31","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1039\/c4an01982b","volume":"140","author":"CR Findlay","year":"2015","unstructured":"Findlay CR, Wiens R, Rak M, Sedlmair J, Hirschmugl CJ, Morrison J, et al. Rapid biodiagnostic ex vivo imaging at 1 mu m pixel resolution with thermal source FTIR FPA. Analyst. 2015;140(7):2493\u2013503. \n                    https:\/\/doi.org\/10.1039\/c4an01982b\n                    \n                  .","journal-title":"Analyst"},{"key":"1245_CR32","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1039\/c5fd00158g","volume":"187","author":"JA Kimber","year":"2016","unstructured":"Kimber JA, Foreman L, Turner B, Rich P, Kazarian SG. FTIR spectroscopic imaging and mapping with correcting lenses for studies of biological cells and tissues. Faraday Discuss. 2016;187:69\u201385. \n                    https:\/\/doi.org\/10.1039\/c5fd00158g\n                    \n                  .","journal-title":"Faraday Discuss"},{"issue":"4","key":"1245_CR33","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1366\/00037020360625907","volume":"57","author":"KLA Chan","year":"2003","unstructured":"Chan KLA, Kazarian SG. New opportunities in micro- and macro-attenuated total reflection infrared spectroscopic imaging: spatial resolution and sampling versatility. Appl Spectrosc. 2003;57(4):381\u20139.","journal-title":"Appl Spectrosc"},{"issue":"21","key":"1245_CR34","doi-asserted-by":"publisher","first-page":"24377","DOI":"10.1364\/oe.24.024377","volume":"24","author":"M Kumbham","year":"2016","unstructured":"Kumbham M, Daly S, O'Dwyer K, Mouras R, Liu N, Mani A, et al. Doubling the far-field resolution in mid-infrared microscopy. Opt Express. 2016;24(21):24377\u201389. \n                    https:\/\/doi.org\/10.1364\/oe.24.024377\n                    \n                  .","journal-title":"Opt Express"},{"issue":"1\u20132","key":"1245_CR35","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.infrared.2006.01.026","volume":"49","author":"E Levenson","year":"2006","unstructured":"Levenson E, Lerch P, Martin MC. Infrared imaging: synchrotrons vs. arrays, resolution vs. speed. Infrared Phys Technol. 2006;49(1\u20132):45\u201352. \n                    https:\/\/doi.org\/10.1016\/j.infrared.2006.01.026\n                    \n                  .","journal-title":"Infrared Phys Technol"},{"issue":"7","key":"1245_CR36","doi-asserted-by":"publisher","first-page":"3670","DOI":"10.1021\/ac5040659","volume":"87","author":"E Mitri","year":"2015","unstructured":"Mitri E, Kenig S, Coceano G, Bedolla DE, Tormen M, Grenci G, et al. Time-resolved FT-IR microspectroscopy of protein aggregation induced by heat-shock in live cells. Anal Chem. 2015;87(7):3670\u20137. \n                    https:\/\/doi.org\/10.1021\/ac5040659\n                    \n                  .","journal-title":"Anal Chem"},{"issue":"7","key":"1245_CR37","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1039\/c4an02053g","volume":"140","author":"C Hughes","year":"2015","unstructured":"Hughes C, Henderson A, Kansiz M, Dorling KM, Jimenez-Hernandez M, Brown MD, et al. Enhanced FTIR bench-top imaging of single biological cells. Analyst. 2015;140(7):2080\u20135. \n                    https:\/\/doi.org\/10.1039\/c4an02053g\n                    \n                  .","journal-title":"Analyst"},{"issue":"12","key":"1245_CR38","doi-asserted-by":"publisher","first-page":"4212","DOI":"10.1039\/c5an00256g","volume":"140","author":"Z Farhane","year":"2015","unstructured":"Farhane Z, Bonnier F, Casey A, Byrne HJ. Raman micro spectroscopy for in vitro drug screening: subcellular localisation and interactions of doxorubicin. Analyst. 2015;140(12):4212\u201323. \n                    https:\/\/doi.org\/10.1039\/c5an00256g\n                    \n                  .","journal-title":"Analyst"},{"issue":"1","key":"1245_CR39","doi-asserted-by":"publisher","first-page":"e201700060","DOI":"10.1002\/jbio.201700060","volume":"11","author":"Zeineb Farhane","year":"2017","unstructured":"Farhane Z, Bonnier F, Howe O, Casey A, Byrne HJ. Doxorubicin kinetics and effects on lung cancer cell lines using in vitro Raman micro-spectroscopy: binding signatures, drug resistance and DNA repair. J Biophotonics. 2018;11(1) \n                    https:\/\/doi.org\/10.1002\/jbio.201700060\n                    \n                  .","journal-title":"Journal of Biophotonics"},{"key":"1245_CR40","doi-asserted-by":"publisher","first-page":"294","DOI":"10.3390\/cells2020294","volume":"2","author":"MG Bottone","year":"2013","unstructured":"Bottone MG, Santin G, Aredia F, Bernocchi G, Pellicciari C, Scovassi AI. Morphological features of organelles during apoptosis: an overview. Cell. 2013;2:294\u2013305.","journal-title":"Cell"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00216-018-1245-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-018-1245-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-018-1245-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T21:28:30Z","timestamp":1589923710000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00216-018-1245-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,21]]},"references-count":40,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["1245"],"URL":"https:\/\/doi.org\/10.1007\/s00216-018-1245-x","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,21]]},"assertion":[{"value":"16 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"There is no potential conflict of interest from this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}