{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T17:00:33Z","timestamp":1761930033118,"version":"3.37.3"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100006012","name":"Christian Doppler Forschungsgesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006012","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s00216-019-01980-2","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T05:02:21Z","timestamp":1563771741000},"page":"2081-2088","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Study of metabolism and identification of productive regions in filamentous fungi via spatially resolved time-of-flight secondary ion mass spectrometry"],"prefix":"10.1007","volume":"412","author":[{"given":"Lukas","family":"Veiter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Kubicek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Hutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst","family":"Pittenauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Herwig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Slouka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,22]]},"reference":[{"issue":"7","key":"1980_CR1","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1007\/s00253-018-8818-7","volume":"102","author":"L Veiter","year":"2018","unstructured":"Veiter L, Rajamanickam V, Herwig C. The filamentous fungal pellet-relationship between morphology and productivity. Appl Microbiol Biotechnol. 2018;102(7):2997\u20133006.","journal-title":"Appl Microbiol Biotechnol."},{"issue":"6","key":"1980_CR2","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1002\/bit.260460612","volume":"46","author":"J Nielsen","year":"1995","unstructured":"Nielsen J, Krabben P. Hyphal growth and fragmentation of Penicillium chrysogenum in submerged cultures. Biotechnol Bioeng. 1995;46(6):588\u201398.","journal-title":"Biotechnol Bioeng."},{"key":"1980_CR3","first-page":"1","volume":"149","author":"R Walisko","year":"2015","unstructured":"Walisko R, Moench-Tegeder J, Blotenberg J, Wucherpfennig T, Krull R. The taming of the shrew - controlling the morphology of filamentous eukaryotic and prokaryotic microorganisms. Adv Biochem Eng Biotechnol. 2015;149:1\u201327.","journal-title":"Adv Biochem Eng Biotechnol."},{"issue":"6","key":"1980_CR4","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.3109\/07388551.2015.1084262","volume":"36","author":"J Zhang","year":"2016","unstructured":"Zhang J, Zhang J. The filamentous fungal pellet and forces driving its formation. Crit Rev Biotechnol. 2016;36(6):1066\u201377.","journal-title":"Crit Rev Biotechnol."},{"key":"1980_CR5","first-page":"1","volume":"60","author":"GC Paul","year":"1998","unstructured":"Paul GC, Thomas CR. Characterisation of mycelial morphology using image analysis. Adv Biochem Eng Biotechnol. 1998;60:1\u201359.","journal-title":"Adv Biochem Eng Biotechnol."},{"issue":"6","key":"1980_CR6","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1002\/(SICI)1097-0290(19971220)56:6<593::AID-BIT1>3.0.CO;2-I","volume":"56","author":"TC Zangirolami","year":"1997","unstructured":"Zangirolami TC, Johansen CL, Nielsen J, Jorgensen SB. Simulation of penicillin production in fed-batch cultivations using a morphologically structured model. Biotechnol Bioeng. 1997;56(6):593\u2013604.","journal-title":"Biotechnol Bioeng."},{"issue":"7","key":"1980_CR7","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1002\/bit.260280713","volume":"28","author":"R Wittler","year":"1986","unstructured":"Wittler R, Baumgartl H, Lubbers DW, Schugerl K. Investigations of oxygen-transfer into Penicillium chrysogenum pellets by microprobe measurements. Biotechnol Bioeng. 1986;28(7):1024\u201336.","journal-title":"Biotechnol Bioeng."},{"key":"1980_CR8","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/978-1-4684-1188-1_72","volume":"169","author":"H Baumgartl","year":"1984","unstructured":"Baumgartl H, Wittler R, Lubbers DW, Schugerl K. Oxygen profiles and structure of Penicillium chrysogenum pellets. Adv Exp Med Biol. 1984;169:793\u20139.","journal-title":"Adv Exp Med Biol."},{"issue":"6","key":"1980_CR9","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1002\/bit.22351","volume":"103","author":"A Hille","year":"2009","unstructured":"Hille A, Neu TR, Hempel DC, Horn H. Effective diffusivities and mass fluxes in fungal biopellets. Biotechnol Bioeng. 2009;103(6):1202\u201313.","journal-title":"Biotechnol Bioeng."},{"issue":"5","key":"1980_CR10","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1002\/bit.20628","volume":"92","author":"A Hille","year":"2005","unstructured":"Hille A, Neu TR, Hempel DC, Horn H. Oxygen profiles and biomass distribution in biopellets of Aspergillus niger. Biotechnol Bioeng. 2005;92(5):614\u201323.","journal-title":"Biotechnol Bioeng."},{"issue":"23","key":"1980_CR11","doi-asserted-by":"publisher","first-page":"8865","DOI":"10.1021\/ac8013687","volume":"80","author":"AV Walker","year":"2008","unstructured":"Walker AV. Why is SIMS underused in chemical and biological analysis? Challenges and opportunities. Anal Chem. 2008;80(23):8865\u201370.","journal-title":"Anal Chem."},{"issue":"2","key":"1980_CR12","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1179\/1743284714Y.0000000668","volume":"31","author":"S Fearn","year":"2015","unstructured":"Fearn S. Characterisation of biological material with ToF-SIMS: a review. Mater Sci Technol. 2015;31(2):148\u201361.","journal-title":"Mater Sci Technol."},{"issue":"1","key":"1980_CR13","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/sia.4932","volume":"45","author":"S Kayser","year":"2013","unstructured":"Kayser S, Rading D, Moellers R, Kollmer F, Niehuis E. Surface spectrometry using large argon clusters. Surf Interface Anal. 2013;45(1):131\u20133.","journal-title":"Surf Interface Anal."},{"issue":"3","key":"1980_CR14","doi-asserted-by":"publisher","first-page":"03B301","DOI":"10.1116\/1.4993628","volume":"13","author":"J Nunez","year":"2017","unstructured":"Nunez J, Renslow R, Cliff JB 3rd, Anderton CR. NanoSIMS for biological applications: current practices and analyses. Biointerphases. 2017;13(3):03B301.","journal-title":"Biointerphases."},{"issue":"8","key":"1980_CR15","doi-asserted-by":"publisher","first-page":"4067","DOI":"10.1128\/AEM.68.8.4067-4073.2002","volume":"68","author":"JB Cliff","year":"2002","unstructured":"Cliff JB, Gaspar DJ, Bottomley PJ, Myrold DD. Exploration of inorganic C and N assimilation by soil microbes with time-of-flight secondary ion mass spectrometry. Appl Environ Microbiol. 2002;68(8):4067\u201373.","journal-title":"Appl Environ Microbiol."},{"key":"1980_CR16","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s13068-015-0407-8","volume":"8","author":"M Couturier","year":"2015","unstructured":"Couturier M, Navarro D, Chevret D, Henrissat B, Piumi F, Ruiz-Duenas FJ, et al. Enhanced degradation of softwood versus hardwood by the white-rot fungus Pycnoporus coccineus. Biotechnol Biofuels. 2015;8:216.","journal-title":"Biotechnol Biofuels."},{"key":"1980_CR17","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.apsusc.2013.10.177","volume":"289","author":"M Kubicek","year":"2014","unstructured":"Kubicek M, Holzlechner G, Opitz AK, Larisegger S, Hutter H, Fleig J. A novel ToF-SIMS operation mode for sub 100 nm lateral resolution: application and performance. Appl Surf Sci. 2014;289:407\u201316.","journal-title":"Appl Surf Sci."},{"issue":"3","key":"1980_CR18","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1002\/btpr.1901","volume":"30","author":"AE Posch","year":"2014","unstructured":"Posch AE, Herwig C. Physiological description of multivariate interdependencies between process parameters, morphology and physiology during fed-batch penicillin production. Biotechnol Prog. 2014;30(3):689\u201399.","journal-title":"Biotechnol Prog."},{"issue":"20","key":"1980_CR19","doi-asserted-by":"publisher","first-page":"8923","DOI":"10.1007\/s00253-016-7787-y","volume":"100","author":"D Ehgartner","year":"2016","unstructured":"Ehgartner D, Fricke J, Schroder A, Herwig C. At-line determining spore germination of Penicillium chrysogenum bioprocesses in complex media. Appl Microbiol Biotechnol. 2016;100(20):8923\u201330.","journal-title":"Appl Microbiol Biotechnol."},{"issue":"7","key":"1980_CR20","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1039\/c3ja50059d","volume":"28","author":"G Holzlechner","year":"2013","unstructured":"Holzlechner G, Kubicek M, Hutter H, Fleig J. A novel ToF-SIMS operation mode for improved accuracy and lateral resolution of oxygen isotope measurements on oxides. J Anal Atom Spectrom. 2013;28(7):1080\u20139.","journal-title":"J Anal Atom Spectrom."}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-019-01980-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00216-019-01980-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-019-01980-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T23:13:34Z","timestamp":1595286814000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00216-019-01980-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,22]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["1980"],"URL":"https:\/\/doi.org\/10.1007\/s00216-019-01980-2","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"type":"print","value":"1618-2642"},{"type":"electronic","value":"1618-2650"}],"subject":[],"published":{"date-parts":[[2019,7,22]]},"assertion":[{"value":"3 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}