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The complex functionality and high reactivity of TCs complicate the creation of immunogens which is currently the bottleneck for developing sensitive immunoassays. In this case, competitive bioreceptor assays for the analysis of small organic molecules are preferable and, moreover, flow-based regenerable bioassays are optimally suited for automated analysis applications. Therefore, the solution for rapid and sensitive analysis of TCs is the regenerable CL receptor assay with a covalently immobilized DNA oligonucleotide containing the specific operator sequence <jats:italic>tetO<\/jats:italic> to which the repressor protein TetR binds only in the absence of TCs. The TC measurements are performed on the CL microarray analysis platform MCR 3 within 30\u00a0min per sample. The LoD in spiked tap water was determined to be 0.1\u00a0\u03bcg\u00a0L<jats:sup>\u22121<\/jats:sup>, and for 1\u00a0\u03bcg\u00a0L<jats:sup>\u22121<\/jats:sup> TET, recoveries of 77%\u2009\u00b1\u200916% were obtained. Due to the stability of the immobilized DNA oligonucleotide and the resulting regenerability of the assay for various measurements, the new method is highly cost- and resource-efficient and ideally suited for the monitoring of environmental samples in the field.<\/jats:p>","DOI":"10.1007\/s00216-019-02368-y","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T19:06:41Z","timestamp":1579201601000},"page":"3467-3476","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Flow-based regenerable chemiluminescence receptor assay for the detection of tetracyclines"],"prefix":"10.1007","volume":"412","author":[{"given":"Verena K.","family":"Meyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire V.","family":"Chatelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Niessner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Seidel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,16]]},"reference":[{"issue":"1","key":"2368_CR1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.2174\/138955712798868977","volume":"12","author":"F Bahrami","year":"2012","unstructured":"Bahrami F, Morris DL, Pourgholami MH. 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