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One unified LC-MS method was used to analyse all analytes, which were split into three injection methods to ensure sufficient peak resolution. The unified method provided an average of 113% accuracy and 4.5% precision across the analyte range. Limits of detection were in the range of 35\u00a0pg\u00a0L<jats:sup>\u22121<\/jats:sup>\u20130.7\u00a0\u03bcg\u00a0L<jats:sup>\u22121<\/jats:sup>, in both river water and wastewater, with an average LOD of 33\u00a0ng\u00a0L<jats:sup>\u22121<\/jats:sup>. The method was combined with solid-phase extraction and applied in environmental samples, showing very good accuracy and precision, as well as excellent chromatographic resolution of a range of chiral enantiomers including beta-blockers, benzodiazepines and antidepressants. The method resulted in quantification of 75% of analytes in at least two matrices, and 56% in the trio of environmental matrices of river water, effluent wastewater and influent wastewater, enabling its use in monitoring compounds of environmental concern, from their sources of origin through to their discharge into the environment.<\/jats:p>","DOI":"10.1007\/s00216-020-02780-9","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T07:38:16Z","timestamp":1594280296000},"page":"5563-5581","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["A multi-residue method by supercritical fluid chromatography coupled with tandem mass spectrometry method for the analysis of chiral and non-chiral chemicals of emerging concern in environmental samples"],"prefix":"10.1007","volume":"412","author":[{"given":"Jack","family":"Rice","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneke","family":"Lubben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Kasprzyk-Hordern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"key":"2780_CR1","first-page":"1","volume":"327","author":"European Parliament & Council","year":"2000","unstructured":"European Parliament & Council. 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