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This study aimed to develop and evaluate a VAMS-based strategy for quantification of 13 frequently prescribed antipsychotics in finger prick blood within the scope of adherence monitoring to complement already-established qualitative urine analysis. The final workflow consisted of VAMS tip hydration and subsequent precipitation. Samples were analyzed by using reversed-phase ultra-high-performance liquid chromatography and Orbitrap mass spectrometry operated in parallel reaction monitoring mode. The analytical procedure was successfully validated based on international recommendations at three different HT values (20%, 40%, 60%) for most of the analytes. Selectivity and within\/between-run accuracy and precision were in accordance with the recommendations in most cases. Internal standard\u2013normalized matrix factor met recommended criteria for all analytes at HT 40%. For the HT values of 20% and 60%, only four substances did not meet the criteria. Dilution integrity was given for all substances, except for olanzapine, allowing a quantification over the whole therapeutic range of selected antipsychotics. Long-term stability in VAMS tips was tested and revealed degradation of five antipsychotic drugs after 1\u00a0week of storage at 24\u00a0\u00b0C. A proof of concept of the applicability of the method was obtained by quantification of a selection of the 13 antipsychotic drugs in VAMS tips and matched plasma samples. Results were coherent between matrices. Thus, VAMS was shown to be a promising alternative for adherence monitoring of at least the investigated antipsychotics.<\/jats:p>","DOI":"10.1007\/s00216-020-03143-0","type":"journal-article","created":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T23:02:30Z","timestamp":1612047750000},"page":"1729-1737","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Development, validation, and application of a quantitative volumetric absorptive microsampling\u2013based method in finger prick blood by means of LC-HRMS\/MS applicable for adherence monitoring of antipsychotics"],"prefix":"10.1007","volume":"413","author":[{"given":"Cathy M.","family":"Jacobs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Wagmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus R.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,30]]},"reference":[{"issue":"6","key":"3143_CR1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3238\/arztebl.2013.0092","volume":"110","author":"A Pfennig","year":"2013","unstructured":"Pfennig A, Bschor T, Falkai P, Bauer M. 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