{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:16:29Z","timestamp":1786979789721,"version":"build-2736575974"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"B&W Tek","award":["Borrowing the i-QCRx"],"award-info":[{"award-number":["Borrowing the i-QCRx"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s00216-021-03223-9","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T17:03:58Z","timestamp":1614099838000},"page":"2587-2596","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Quality control of cytostatic drug preparations\u2014comparison of workflow and performance of Raman\/UV and high-performance liquid chromatography coupled with diode array detection (HPLC-DAD)"],"prefix":"10.1007","volume":"413","author":[{"given":"Lars M. H.","family":"Reinders","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin D.","family":"Klassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"vom Eyser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2477-6167","authenticated-orcid":false,"given":"Thorsten","family":"Teutenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Jaeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten C.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Tuerk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"issue":"6","key":"3223_CR1","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1159\/000074148","volume":"26","author":"T Muller","year":"2003","unstructured":"Muller T. Typical medication errors in oncology: analysis and prevention strategies. Onkologie. 2003;26(6):539\u201344. https:\/\/doi.org\/10.1159\/000074148.","journal-title":"Onkologie."},{"issue":"5","key":"3223_CR2","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1177\/1078155219834999","volume":"25","author":"A Sendra-Garcia","year":"2019","unstructured":"Sendra-Garcia A, Martinez-Gomez MA, Albert-Mari A, Jimenez-Torres NV, Climente-Marti M. Quantitative and qualitative control of antineoplastic preparations: Gravimetry versus HPLC. J Oncol Pharm Pract. 2019;25(5):1204\u201316. https:\/\/doi.org\/10.1177\/1078155219834999.","journal-title":"J Oncol Pharm Pract"},{"issue":"1\u20132","key":"3223_CR3","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.ijpharm.2016.02.028","volume":"502","author":"F Benizri","year":"2016","unstructured":"Benizri F, Dalifard B, Zemmour C, Henriquet M, Fougereau E, Le Franc B. DrugCam (R)-an intelligent video camera system to make safe cytotoxic drug preparations. Int J Pharm. 2016;502(1\u20132):198\u2013207. https:\/\/doi.org\/10.1016\/j.ijpharm.2016.02.028.","journal-title":"Int J Pharm"},{"issue":"1","key":"3223_CR4","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.ijpharm.2015.08.041","volume":"494","author":"C Bazin","year":"2015","unstructured":"Bazin C, Cassard B, Caudron E, Prognon P, Havard L. Comparative analysis of methods for real-time analytical control of chemotherapies preparations. Int J Pharm. 2015;494(1):329\u201336. https:\/\/doi.org\/10.1016\/j.ijpharm.2015.08.041.","journal-title":"Int J Pharm"},{"issue":"1","key":"3223_CR5","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1515\/pthp-2017-0006","volume":"2","author":"F Lagarce","year":"2017","unstructured":"Lagarce F. Centrally prepared cytotoxic drugs: what is the purpose of their quality control? Pharm Technol Hosp Pharm. 2017;2(1):29\u201333. https:\/\/doi.org\/10.1515\/pthp-2017-0006.","journal-title":"Pharm Technol Hosp Pharm."},{"issue":"3","key":"3223_CR6","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S0731-7085(03)00630-7","volume":"34","author":"J Bouligand","year":"2004","unstructured":"Bouligand J, Paci A, Mercier L, Vassal G, Bourget P. High-performance thin-layer chromatography with a derivatization procedure, a suitable method for the identification and the quantitation of busulfan in various pharmaceutical products. J Pharmaceut Biomed. 2004;34(3):525\u201330. https:\/\/doi.org\/10.1016\/S0731-7085(03)00630-7.","journal-title":"J Pharmaceut Biomed."},{"issue":"5","key":"3223_CR7","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1016\/S0731-7085(02)00541-1","volume":"30","author":"A Paci","year":"2003","unstructured":"Paci A, Mercier L, Bourget P. Identification and quantitation of antineoplastic compounds in chemotherapeutic infusion bags by use of HPTLC: application to the vinca-alkaloids. J Pharmaceut Biomed. 2003;30(5):1603\u201310. https:\/\/doi.org\/10.1016\/S0731-7085(02)00541-1.","journal-title":"J Pharmaceut Biomed"},{"issue":"5","key":"3223_CR8","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1016\/j.jpba.2009.03.007","volume":"49","author":"A Delmas","year":"2009","unstructured":"Delmas A, Gordien JB, Bernadou JM, Roudaut M, Gresser A, Malki L, et al. Quantitative and qualitative control of cytotoxic preparations by HPLC-UV in a centralized parenteral preparations unit. J Pharmaceut Biomed. 2009;49(5):1213\u201320. https:\/\/doi.org\/10.1016\/j.jpba.2009.03.007.","journal-title":"J Pharmaceut Biomed."},{"key":"3223_CR9","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.talanta.2018.05.042","volume":"187","author":"E Jaccoulet","year":"2018","unstructured":"Jaccoulet E, Schweitzer-Chaput A, Toussaint B, Prognon P, Caudron E. Simple and ultra-fast recognition and quantitation of compounded monoclonal antibodies: application to flow injection analysis combined to UV spectroscopy and matching method. Talanta. 2018;187:279\u201386. https:\/\/doi.org\/10.1016\/j.talanta.2018.05.042.","journal-title":"Talanta."},{"issue":"17","key":"3223_CR10","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1002\/elps.201400603","volume":"36","author":"E Jaccoulet","year":"2015","unstructured":"Jaccoulet E, Smadja C, Prognon P, Taverna M. Capillary electrophoresis for rapid identification of monoclonal antibodies for routine application in hospital. Electrophoresis. 2015;36(17):2050\u20136. https:\/\/doi.org\/10.1002\/elps.201400603.","journal-title":"Electrophoresis."},{"issue":"1\u20132","key":"3223_CR11","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.ijpharm.2016.01.002","volume":"499","author":"F Nardella","year":"2016","unstructured":"Nardella F, Beck M, Collart-Dutilleul P, Becker G, Boulanger C, Perello L, et al. A UV-Raman spectrometry method for quality control of anticancer preparations: results after 18 months of implementation in hospital pharmacy. Int J Pharm. 2016;499(1\u20132):343\u201350. https:\/\/doi.org\/10.1016\/j.ijpharm.2016.01.002.","journal-title":"Int J Pharm"},{"issue":"3","key":"3223_CR12","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1515\/pthp-2017-0021","volume":"2","author":"T Chouquet","year":"2017","unstructured":"Chouquet T, Benoit G, Morand K. Analytical control of pediatric chemotherapy preparations with a UV-Raman automaton: results after 18 months of implementation and development of a suitable method for low volume preparations. Pharm Technol Hosp Pharm. 2017;2(3):117\u201329. https:\/\/doi.org\/10.1515\/pthp-2017-0021.","journal-title":"Pharm Technol Hosp Pharm"},{"key":"3223_CR13","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.talanta.2013.10.060","volume":"119","author":"LMM Le","year":"2014","unstructured":"Le LMM, Caudron E, Baillet-Guffroy A, Eyeleigh L. Non-invasive quantification of 5-fluorouracil and gemcitabine in aqueous matrix by direct measurement through glass vials using near-infrared spectroscopy. Talanta. 2014;119:361\u20136. https:\/\/doi.org\/10.1016\/j.talanta.2013.10.060.","journal-title":"Talanta."},{"key":"3223_CR14","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.talanta.2018.11.062","volume":"196","author":"L Le","year":"2019","unstructured":"Le L, Berge M, Tfayli A, Guffroy AB, Prognon P, Dowek A, et al. Quantification of gemcitabine intravenous drugs by direct measurement in chemotherapy plastic bags using a handheld Raman spectrometer. Talanta. 2019;196:376\u201380. https:\/\/doi.org\/10.1016\/j.talanta.2018.11.062.","journal-title":"Talanta."},{"key":"3223_CR15","unstructured":"Deutscher Apotheker Verlag. European Pharmacopoeia, 9th Ed.; 2018."},{"key":"3223_CR16","unstructured":"Schmiedel. DA-VDR. USP 42 - NF 37 The United States Pharmacopeia and National Formulary 2019: Main Edition Plus Supplements 1 and 2; 2018."},{"key":"3223_CR17","unstructured":"Swissmedic. Pharmacopoea Helvetica, 11th Ed.; 2019."},{"key":"3223_CR18","unstructured":"Busch A. Ergebnisse von Apothekenkontrollen Aktenzeichen IV B 5 - G.0611; 2019."},{"key":"3223_CR19","unstructured":"Council Directive. Council Directive 90\/394\/EEC of 28 June 1990 on the protection of workers from the risks related to exposure to carcinogens at work (Sixth individual Directive within the meaning of Article 16 (1) of Directive 89\/391\/EEC); 1990."},{"key":"3223_CR20","unstructured":"Working Group 1 of the Joint Committee for Guides in Metrology. Evaluation of measurement data \u2014 Guide to the expression of uncertainty in measurement; 2008."},{"key":"3223_CR21","volume-title":"The statistical analysis of experimental data","author":"J Mandel","year":"1964","unstructured":"Mandel J. The statistical analysis of experimental data. Washington: Wiley; 1964."},{"key":"3223_CR22","unstructured":"Pharmacopoea Europaea. Test for extractable volume of parenteral preparations; 2018."},{"issue":"3","key":"3223_CR23","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1310\/hpj4903-221","volume":"49","author":"MR Cohen","year":"2014","unstructured":"Cohen MR, Smetzer JL. Understanding and managing intravenous container overfill; potential dose confusion. Hosp Pharm. 2014;49(3):221\u20136. https:\/\/doi.org\/10.1310\/hpj4903-221.","journal-title":"Hosp Pharm"},{"key":"3223_CR24","unstructured":"Thiessen JJ. A review of the oncology under-dosing incident. 2013. URL: http:\/\/www.health.gov.on.ca\/en\/public\/programs\/cancer\/drugsupply\/docs\/report_thiessen_oncology_under-dosing.pdf Last accessed: 07.09.2020."},{"key":"3223_CR25","unstructured":"DIN EN ISO\/IEC 17025:2018 General requirements for the competence of testing and calibration laboratories. 2017."},{"issue":"2","key":"3223_CR26","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1177\/1078155212457963","volume":"19","author":"F Dziopa","year":"2013","unstructured":"Dziopa F, Galy G, Bauler S, Vincent B, Crochon S, Tall ML, et al. A quantitative and qualitative method to control chemotherapeutic preparations by Fourier transform infrared\u2013ultraviolet spectrophotometry. J Oncol Pharm Pract. 2013;19(2):121\u20139. https:\/\/doi.org\/10.1177\/1078155212457963.","journal-title":"J Oncol Pharm Pract"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-021-03223-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00216-021-03223-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-021-03223-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T21:19:59Z","timestamp":1616534399000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00216-021-03223-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,23]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["3223"],"URL":"https:\/\/doi.org\/10.1007\/s00216-021-03223-9","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,23]]},"assertion":[{"value":"20 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}