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Extraction conditions such as type of sorbent, sample pH, number of charge\/discharge cycles, and elution volume were studied. Hallucinogenic compounds were extracted from oral fluid samples using C18 MEPS, loading with 100 \u03bcL sample (adjusted to pH 7) in 3 cycles, washing with 100 \u03bcL deionized water, and eluting with 50 \u03bcL methanol in 1 cycle, giving quantitative recoveries and no significant matrix effects. Limits of detection from 0.09 to 1.22\u00a0\u03bcg L<jats:sup>\u22121<\/jats:sup>; recoveries from 80 to 129% performed in spiked oral fluid samples at 20, 50, and 100\u00a0\u03bcg L<jats:sup>\u22121<\/jats:sup>; and high precision with relative standard deviations lower than 9% were obtained. The proposed methodology was demonstrated to be appropriate for the simple and sensitive determination of NBOMe derivates and other synthetic hallucinogenic substances in oral fluid samples.<\/jats:p>\n                <jats:p><jats:bold>Graphical Abstract<\/jats:bold><\/jats:p>","DOI":"10.1007\/s00216-023-04751-2","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T15:03:02Z","timestamp":1684854182000},"page":"3607-3617","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Determination of synthetic hallucinogens in oral fluids by microextraction by packed sorbent and liquid chromatography\u2013tandem mass spectrometry"],"prefix":"10.1007","volume":"415","author":[{"given":"Evan","family":"Lesne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Mu\u00f1oz-Bartual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1543-1877","authenticated-orcid":false,"given":"Francesc A.","family":"Esteve-Turrillas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"4751_CR1","unstructured":"United Nations Office on Drugs and Crime. 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