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All antemortem human blood donors were consented prior to participation and were screened and approved by Innovative Research Inc. (46,430 Peary Court Novi, MI 48377). Postmortem human blood samples were obtained and processed through Discovery Life Sciences Inc. (800 Hudson Way, Suite 1700 Huntsville, AL 35806). Postmortem sites are not required to obtain IRB approval as there is no increased risk to the subject. HHS defines a human subject as a \u201cliving individual.\u201d However, consent from either by the subject prior to passing or next of kin postmortem was obtained.All animals were cared for in compliance with the \u201cPrinciples of Laboratory Animal Care\u201d formulated by the National Society for Medical Research and the \u201cGuide for the Care and Use of Laboratory Animals\u201d prepared by the National Institutes of Health (National Academic Press, 1996). The University of Colorado\u2019s Institutional Animal Care and Use Committee (IACUC) approved the CN exposure study (ethics committee: Carter Severance, Genna Nault, Tara Hendry-Hofer, Nathan Wetmore). It complied with the regulations and guidelines of the Animal Welfare Act and the American Association for Accreditation of Laboratory Animal Care.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}