{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:18:04Z","timestamp":1776777484654,"version":"3.51.2"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ZIA ES103373"],"award-info":[{"award-number":["ZIA ES103373"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ZIC ES103362"],"award-info":[{"award-number":["ZIC ES103362"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ZIC EW103363"],"award-info":[{"award-number":["ZIC EW103363"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1007\/s00216-023-05004-y","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T07:02:22Z","timestamp":1698822142000},"page":"175-189","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Non-targeted chemical analysis of consumer botanical products labeled as blue cohosh (Caulophyllum thalictroides), goldenseal (Hydrastis canadensis), or yohimbe bark (Pausinystalia yohimbe) by NMR and MS"],"prefix":"10.1007","volume":"416","author":[{"given":"Giovanni O.","family":"Quiroz-Delfi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia V.","family":"Rider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4497-518X","authenticated-orcid":false,"given":"Stephen S.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2228-6308","authenticated-orcid":false,"given":"Alan K.","family":"Jarmusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey A.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,11,1]]},"reference":[{"key":"5004_CR1","unstructured":"Smith T. US sales of herbal supplements increase by 9.7% in 2021. HerbalGram. 2022;136:43\u201369."},{"key":"5004_CR2","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.fct.2018.04.007","volume":"118","author":"KA Shipkowski","year":"2018","unstructured":"Shipkowski KA, Betz JM, Birnbaum LS, Bucher JR, Coates PM, Hopp DC, et al. Naturally complex: perspectives and challenges associated with botanical dietary supplement safety assessment. Food Chem Toxicol. 2018;118:963\u201371.","journal-title":"Food Chem Toxicol"},{"issue":"2","key":"5004_CR3","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1093\/toxsci\/kfz189","volume":"172","author":"KR Ryan","year":"2019","unstructured":"Ryan KR, Huang MC, Ferguson SS, Waidyanatha S, Ramaiahgari S, Rice JR, et al. Evaluating sufficient similarity of botanical dietary supplements: combining chemical and in vitro biological data. Toxicol Sci. 2019;172(2):316\u201329.","journal-title":"Toxicol Sci"},{"key":"5004_CR4","doi-asserted-by":"crossref","unstructured":"Wishart DS, Cheng LL, Copie V, Edison AS, Eghbalnia HR, Hoch JC, et al. NMR and metabolomics-a roadmap for the future. Metabolites. 2022;12(8):678.","DOI":"10.3390\/metabo12080678"},{"issue":"12","key":"5004_CR5","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1007\/s13361-016-1469-y","volume":"27","author":"AC Schrimpe-Rutledge","year":"2016","unstructured":"Schrimpe-Rutledge AC, Codreanu SG, Sherrod SD, McLean JA. Untargeted metabolomics strategies-challenges and emerging directions. J Am Soc Mass Spectrom. 2016;27(12):1897\u2013905.","journal-title":"J Am Soc Mass Spectrom"},{"issue":"25","key":"5004_CR6","doi-asserted-by":"publisher","first-page":"6789","DOI":"10.1007\/s00216-020-02839-7","volume":"412","author":"BJ Collins","year":"2020","unstructured":"Collins BJ, Kerns SP, Aillon K, Mueller G, Rider CV, DeRose EF, et al. Comparison of phytochemical composition of Ginkgo biloba extracts using a combination of non-targeted and targeted analytical approaches. Anal Bioanal Chem. 2020;412(25):6789\u2013809.","journal-title":"Anal Bioanal Chem"},{"key":"5004_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.135232","volume":"408","author":"Y Le","year":"2023","unstructured":"Le Y, Lou X, Yu C, Guo C, He Y, Lu Y, et al. Integrated metabolomics analysis of Lactobacillus in fermented milk with fish gelatin hydrolysate in different degrees of hydrolysis. Food Chem. 2023;408: 135232.","journal-title":"Food Chem"},{"key":"5004_CR8","doi-asserted-by":"crossref","unstructured":"Marini F. Data handling in science and technology volume 28 chemometrics in food chemistry introduction. In: Marini F, editor. Chemometrics in food chemistry. Data handling in science and technology. 28. Amsterdam: Elsevier Science Bv; 2013. p. 1\u20135.","DOI":"10.1016\/B978-0-444-59528-7.00001-6"},{"issue":"1","key":"5004_CR9","first-page":"E66","volume":"15","author":"JJ Dugoua","year":"2008","unstructured":"Dugoua JJ, Perri D, Seely D, Mills E, Koren G. Safety and efficacy of blue cohosh (Caulophyllum thalictroides) during pregnancy and lactation. J Popul Ther Clin Pharmacol. 2008;15(1):E66\u201373.","journal-title":"J Popul Ther Clin Pharmacol"},{"key":"5004_CR10","doi-asserted-by":"crossref","unstructured":"Xu T, Kuang TT, Du H, Li Q, Feng T, Zhang Y, et al. Magnoflorine: a review of its pharmacology, pharmacokinetics and toxicity. Pharmacol Res. 2020;152:104632.","DOI":"10.1016\/j.phrs.2020.104632"},{"issue":"1","key":"5004_CR11","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1021\/np400758t","volume":"77","author":"S Datta","year":"2014","unstructured":"Datta S, Mahdi F, Ali Z, Jekabsons MB, Khan IA, Nagle DG, et al. Toxins in botanical dietary supplements: blue cohosh components disrupt cellular respiration and mitochondrial membrane potential. J Nat Prod. 2014;77(1):111\u20137.","journal-title":"J Nat Prod"},{"key":"5004_CR12","doi-asserted-by":"crossref","unstructured":"Mandal SK, Maji AK, Mishra SK, Ishfaq PM, Devkota HP, Silva AS, et al. Goldenseal (Hydrastis canadensis L.) and its active constituents: a critical review of their efficacy and toxicological issues. Pharmacol Res. 2020;160:21.","DOI":"10.1016\/j.phrs.2020.105085"},{"issue":"2","key":"5004_CR13","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1002\/ptr.3554","volume":"26","author":"Y Zhao","year":"2012","unstructured":"Zhao Y, Hellum BH, Liang A, Nilsen OG. The in vitro inhibition of human CYP1A2, CYP2D6 and CYP3A4 by tetrahydropalmatine, neferine and berberine. Phytother Res. 2012;26(2):277\u201383.","journal-title":"Phytother Res"},{"issue":"1","key":"5004_CR14","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.toxlet.2013.05.641","volume":"221","author":"S Chen","year":"2013","unstructured":"Chen S, Wan L, Couch L, Lin H, Li Y, Dobrovolsky VN, et al. Mechanism study of goldenseal-associated DNA damage. Toxicol Lett. 2013;221(1):64\u201372.","journal-title":"Toxicol Lett"},{"issue":"7","key":"5004_CR15","doi-asserted-by":"publisher","first-page":"3641","DOI":"10.1016\/j.bmc.2008.02.015","volume":"16","author":"ER Correche","year":"2008","unstructured":"Correche ER, Andujar SA, Kurdelas RR, Lechon MJG, Freile ML, Enriz RD. Antioxidant and cytotoxic activities of canadine: biological effects and structural aspects. Bioorgan Med Chem. 2008;16(7):3641\u201351.","journal-title":"Bioorgan Med Chem"},{"key":"5004_CR16","doi-asserted-by":"crossref","unstructured":"Fernando Aguilar RC, Birgit Dusemund, Pierre Galtier, David Gott, Ursula Gundert-Remy, J\u00fcrgen K\u00f6nig, Claude Lambr\u00e9, Jean-Charles Leblanc, Pasquale Mosesso, Alicja Mortensen, Agneta Oskarsson, Dominique Parent-Massin, Martin Rose, Ivan Stankovic, Paul Tobback, Ine Waalkens-Berendsen, Ruud Woutersen and Matthew Wright. Scientific opinion on the evaluation of the safety in use of yohimbe (Pausinystalia yohimbe (K. Schum.) Pierre ex Beille). EFSA J. 2013;11(7):3302.","DOI":"10.2903\/j.efsa.2013.3302"},{"issue":"18","key":"5004_CR17","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.1002\/rcm.5158","volume":"25","author":"JH Sun","year":"2011","unstructured":"Sun JH, Baker A, Chen P. Profiling the indole alkaloids in yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry. Rapid Commun Mass Sp. 2011;25(18):2591\u2013602.","journal-title":"Rapid Commun Mass Sp"},{"key":"5004_CR18","doi-asserted-by":"crossref","unstructured":"Pang ZQ, Chong J, Zhou GY, Morais DAD, Chang L, Barrette M, et al. MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights. Nucleic Acids Res. 2021;49(W1):W388-W96.","DOI":"10.1093\/nar\/gkab382"},{"key":"5004_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.aca.2018.05.031","volume":"1030","author":"N Karu","year":"2018","unstructured":"Karu N, Deng L, Slae M, Guo AC, Sajed T, Huynh H, et al. A review on human fecal metabolomics: methods, applications and the human fecal metabolome database. Anal Chim Acta. 2018;1030:1\u201324.","journal-title":"Anal Chim Acta"},{"key":"5004_CR20","doi-asserted-by":"crossref","unstructured":"West EE, Merle NS, Kaminski MM, Palacios G, Kumar D, Wang L, et al. Loss of CD4(+) T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection. Immunity. 2023;56(9):2036\u201353 e12.","DOI":"10.1016\/j.immuni.2023.07.014"},{"issue":"5","key":"5004_CR21","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1093\/jn\/133.5.1302","volume":"133","author":"SH Zeisel","year":"2003","unstructured":"Zeisel SH, Mar MH, Howe JC, Holden JM. Concentrations of choline-containing compounds and betaine in common foods. J Nutr. 2003;133(5):1302\u20137.","journal-title":"J Nutr"},{"key":"5004_CR22","doi-asserted-by":"crossref","unstructured":"Nikolic D, Lankin DC, Cisowska T, Chen SN, Pauli GF, van Breemen RB, editors. Nitrogen-containing constituents of black cohosh: chemistry, structure elucidation, and biological activities. 52nd Annual Meeting of the Phytochemical-Society-of-North-America; 2013 Aug 03\u201307; Oregon State Univ, Corvallis, OR. NEW YORK: Springer; 2015.","DOI":"10.1007\/978-3-319-20397-3_2"},{"key":"5004_CR23","unstructured":"Supplements NIoHOoD. Dietary Supplement Label Database 2023 [Available from: https:\/\/dsld.od.nih.gov\/."},{"issue":"2","key":"5004_CR24","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1080\/10408398.2018.1524364","volume":"60","author":"RL Bailey","year":"2020","unstructured":"Bailey RL. Current regulatory guidelines and resources to support research of dietary supplements in the United States. Crit Rev Food Sci Nutr. 2020;60(2):298\u2013309.","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"8","key":"5004_CR25","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.26040","volume":"5","author":"C Crawford","year":"2022","unstructured":"Crawford C, Avula B, Lindsey AT, Walter A, Katragunta K, Khan IA, et al. Analysis of select dietary supplement products marketed to support or boost the immune system. JAMA Netw Open. 2022;5(8): e2226040.","journal-title":"JAMA Netw Open"},{"issue":"2","key":"5004_CR26","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1021\/acs.jnatprod.2c00929","volume":"86","author":"S Gafner","year":"2023","unstructured":"Gafner S, Blumenthal M, Foster S, Cardellina JH 2nd, Khan IA, Upton R. Botanical ingredient forensics: detection of attempts to deceive commonly used analytical methods for authenticating herbal dietary and food ingredients and supplements. J Nat Prod. 2023;86(2):460\u201372.","journal-title":"J Nat Prod"},{"issue":"3","key":"5004_CR27","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1055\/s-0041-1732306","volume":"111","author":"S Shahabi","year":"2022","unstructured":"Shahabi S, Borneman JP. The electrostatic model of homeopathy: the mechanism of physicochemical activities of homeopathic medicines. Homeopathy. 2022;111(3):210\u20136.","journal-title":"Homeopathy"},{"key":"5004_CR28","doi-asserted-by":"crossref","unstructured":"Zuiderveen GH. Benzylisoquinoline alkaloid content in goldenseal (Hydrastis canadensis L.) is influenced by phenological stage, reproductive status, and time-of-day. Phytochem Lett. 2021;42(April 2021):61\u20137.","DOI":"10.1016\/j.phytol.2021.02.006"},{"issue":"18","key":"5004_CR29","doi-asserted-by":"publisher","first-page":"4273","DOI":"10.1007\/s00216-020-02678-6","volume":"412","author":"ED Wallace","year":"2020","unstructured":"Wallace ED, Todd DA, Harnly JM, Cech NB, Kellogg JJ. Identification of adulteration in botanical samples with untargeted metabolomics. Anal Bioanal Chem. 2020;412(18):4273\u201386.","journal-title":"Anal Bioanal Chem"},{"key":"5004_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.780228","volume":"8","author":"EJ Abraham","year":"2021","unstructured":"Abraham EJ, Kellogg JJ. Chemometric-guided approaches for profiling and authenticating botanical materials. Front Nutr. 2021;8: 780228.","journal-title":"Front Nutr"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-023-05004-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00216-023-05004-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-023-05004-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T03:14:08Z","timestamp":1704165248000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00216-023-05004-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["5004"],"URL":"https:\/\/doi.org\/10.1007\/s00216-023-05004-y","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,1]]},"assertion":[{"value":"28 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}