{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:26:11Z","timestamp":1773415571898,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"29","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Key Projects of Natural Science Research in Colleges and Universities in Anhui Province","award":["2024AH051030"],"award-info":[{"award-number":["2024AH051030"]}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2408085QH284"],"award-info":[{"award-number":["2408085QH284"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074152"],"award-info":[{"award-number":["82074152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s00216-024-05591-4","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T17:02:53Z","timestamp":1730134973000},"page":"6931-6944","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Illustrate the metabolic regulatory mechanism of Taohong Siwu decoction in ischemic stroke by mass spectrometry imaging"],"prefix":"10.1007","volume":"416","author":[{"given":"Xiaoqun","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanxue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiyin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"5591_CR1","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/S0140-6736(16)30962-X","volume":"389","author":"GJ Hankey","year":"2017","unstructured":"Hankey GJ. Stroke. Lancet. 2017;389:641\u201354. https:\/\/doi.org\/10.1016\/S0140-6736(16)30962-X.","journal-title":"Lancet"},{"key":"5591_CR2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.neuron.2010.07.002","volume":"67","author":"MA Moskowitz","year":"2010","unstructured":"Moskowitz MA, Lo EH, Iadecola C. The science of stroke: mechanisms in search of treatments. Neuron. 2010;67:181\u201398. https:\/\/doi.org\/10.1016\/j.neuron.2010.07.002.","journal-title":"Neuron"},{"key":"5591_CR3","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3390\/vetsci8120321","volume":"8","author":"TK Lee","year":"2021","unstructured":"Lee TK, Hong J, Lee JW, Kim SS, Sim H, Lee JC, Kim DW, Lim SS, Kang I, Won MH. Ischemia-induced cognitive impairment is improved via remyelination and restoration of synaptic density in the hippocampus after treatment with COG-Up(R) in a gerbil model of ischemic stroke. Vet Sci. 2021;8:321. https:\/\/doi.org\/10.3390\/vetsci8120321.","journal-title":"Vet Sci"},{"key":"5591_CR4","doi-asserted-by":"publisher","first-page":"834329","DOI":"10.3389\/fneur.2022.834329","volume":"13","author":"L Yang","year":"2022","unstructured":"Yang L, Li MZ, Zhan Y, Feng XF, Lu Y, Li MC, Zhuang YM, Lei JF, Zhao H. The impact of ischemic stroke on gray and white matter injury correlated with motor and cognitive impairments in permanent MCAO rats: a multimodal MRI-based study. Front Neurol. 2022;13:834329. https:\/\/doi.org\/10.3389\/fneur.2022.834329.","journal-title":"Front Neurol"},{"key":"5591_CR5","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1021\/acs.jproteome.8b00339","volume":"18","author":"JL Geng","year":"2019","unstructured":"Geng JL, Zhang Y, Li SJ, Li SN, Wang JK, Wang H, Aa JY, Wang GJ. Metabolomic profiling reveals that reprogramming of cerebral glucose metabolism is involved in ischemic preconditioning-induced neuroprotection in a rodent model of ischemic stroke. J Proteome Res. 2019;18:57\u201368. https:\/\/doi.org\/10.1021\/acs.jproteome.8b00339.","journal-title":"J Proteome Res"},{"key":"5591_CR6","doi-asserted-by":"publisher","first-page":"125306","DOI":"10.1016\/j.talanta.2023.125306","volume":"268","author":"HH Liu","year":"2024","unstructured":"Liu HH, Xie T, Wang JY, Wang X, Han J, Huang ZH, Jiang LX, Nie ZX. In situ analysis of metabolic changes under hypoxic-ischemic encephalopathy via MALDI mass spectrometry imaging. Talanta. 2024;268:125306. https:\/\/doi.org\/10.1016\/j.talanta.2023.125306.","journal-title":"Talanta"},{"key":"5591_CR7","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.3390\/molecules24091831","volume":"24","author":"L Luo","year":"2019","unstructured":"Luo L, Kang JZ, He Q, Qi Y, Chen XY, Wang SM, Liang SW. A NMR-based metabonomics approach to determine protective effect of a combination of multiple components derived from Naodesheng on ischemic stroke rats. Molecules. 2019;24:1831. https:\/\/doi.org\/10.3390\/molecules24091831.","journal-title":"Molecules"},{"key":"5591_CR8","doi-asserted-by":"publisher","first-page":"113641","DOI":"10.1016\/j.jep.2020.113641","volume":"268","author":"W Xia","year":"2021","unstructured":"Xia W, Hu S, Wang M, Xu F, Han L, Peng D. Exploration of the potential mechanism of the Tao Hong Si Wu Decoction for the treatment of postpartum blood stasis based on network pharmacology and in vivo experimental verification. J Ethnopharmacol. 2021;268:113641. https:\/\/doi.org\/10.1016\/j.jep.2020.113641.","journal-title":"J Ethnopharmacol"},{"key":"5591_CR9","doi-asserted-by":"publisher","first-page":"195835","DOI":"10.1155\/2015\/195835","volume":"2015","author":"L Han","year":"2015","unstructured":"Han L, Ji Z, Chen W, Yin D, Xu F, Li S, Chen F, Zhu G, Peng D. Protective effects of tao-Hong-si-wu decoction on memory impairment and hippocampal damage in animal model of vascular dementia. Evid Based Complement Alternat Med. 2015;2015:195835. https:\/\/doi.org\/10.1155\/2015\/195835.","journal-title":"Evid Based Complement Alternat Med"},{"key":"5591_CR10","doi-asserted-by":"publisher","first-page":"195158","DOI":"10.1155\/2013\/195158","volume":"2013","author":"D Yin","year":"2013","unstructured":"Yin D, Liu Z, Peng D, Yang Y, Gao X, Xu F, Han L. Serum containing TaoHong-Si-Wu decoction induces human endothelial cell VEGF production via PI3K\/Akt-eNOS signaling. Evid Based Complement Alternat Med. 2013;2013:195158. https:\/\/doi.org\/10.1155\/2013\/195158.","journal-title":"Evid Based Complement Alternat Med"},{"key":"5591_CR11","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.3390\/ph16101489","volume":"16","author":"AF Vujnovic","year":"2023","unstructured":"Vujnovic AF, Martinovic LS, Medija M, Waldowski RA. Distinct and dynamic changes in the temporal profiles of neurotransmitters in Drosophila melanogaster brain following volatilized cocaine or methamphetamine administrations. Pharmaceuticals. 2023;16:1489. https:\/\/doi.org\/10.3390\/ph16101489.","journal-title":"Pharmaceuticals"},{"key":"5591_CR12","doi-asserted-by":"publisher","first-page":"e202301309","DOI":"10.1002\/anie.202301309","volume":"62","author":"WW Tang","year":"2023","unstructured":"Tang WW, Shi JJ, Liu W, Lu X, Li B. MALDI imaging assisted discovery of a di-O-glycosyltransferase from Platycodon grandiflorum root. Angew Chem Int Ed. 2023;62:e202301309. https:\/\/doi.org\/10.1002\/anie.202301309.","journal-title":"Angew Chem Int Ed"},{"key":"5591_CR13","doi-asserted-by":"publisher","first-page":"3665","DOI":"10.1016\/j.apsb.2021.05.013","volume":"11","author":"Z Wang","year":"2021","unstructured":"Wang Z, Fu W, Huo M, He B, Liu Y, Tian L, Li W, Zhou Z, Wang B, Xia J, Chen Y, Wei J, Abliz Z. Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging. Acta Pharm Sin B. 2021;11:3665\u201377. https:\/\/doi.org\/10.1016\/j.apsb.2021.05.013.","journal-title":"Acta Pharm Sin B"},{"key":"5591_CR14","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1073\/pnas.1808950116","volume":"116","author":"C Sun","year":"2019","unstructured":"Sun C, Li T, Song X, Huang L, Zang Q, Xu J, Bi N, Jiao G, Hao Y, Chen Y, Zhang R, Luo Z, Li X, Wang L, Wang Z, Song Y, He J, Abliz Z. Spatially resolved metabolomics to discover tumor-associated metabolic alterations. Proc Natl Acad Sci USA. 2019;116:52\u20137. https:\/\/doi.org\/10.1073\/pnas.1808950116.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5591_CR15","doi-asserted-by":"publisher","first-page":"3218","DOI":"10.1021\/acs.analchem.2c03767","volume":"95","author":"WW Tang","year":"2023","unstructured":"Tang WW, Zhang YJ, Li P, Li B. Evaluation of intestinal drug absorption and interaction using quadruple single-pass intestinal perfusion coupled with mass spectrometry imaging. Anal Chem. 2023;95:3218\u201327. https:\/\/doi.org\/10.1021\/acs.analchem.2c03767.","journal-title":"Anal Chem"},{"key":"5591_CR16","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.apsb.2019.12.004","volume":"10","author":"Z Wang","year":"2020","unstructured":"Wang Z, He B, Liu Y, Huo M, Fu W, Yang C, Wei J, Abliz Z. In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging. Acta Pharm Sin B. 2020;10:1083\u201393. https:\/\/doi.org\/10.1016\/j.apsb.2019.12.004.","journal-title":"Acta Pharm Sin B"},{"key":"5591_CR17","doi-asserted-by":"publisher","first-page":"124046","DOI":"10.1016\/j.talanta.2022.124046","volume":"253","author":"X Wang","year":"2023","unstructured":"Wang X, Yang X, Hou Z, Tian S, Xu G, Li G, Wen L, Bi D, Gao F, Shen Y, Huang G. Whole-brain mapping of metabolic alterations in a mouse model of Alzheimer\u2019s disease by desorption electrospray ionization mass spectrometry imaging. Talanta. 2023;253:124046. https:\/\/doi.org\/10.1016\/j.talanta.2022.124046.","journal-title":"Talanta"},{"key":"5591_CR18","doi-asserted-by":"publisher","first-page":"125060","DOI":"10.1016\/j.talanta.2023.125060","volume":"266","author":"WK Ban","year":"2024","unstructured":"Ban WK, Jiang XY, Lv LJ, Jiao Y, Huang JP, Yang ZH, You YY. Illustrate the distribution and metabolic regulatory effects of pterostilbene in cerebral ischemia-reperfusion rat brain by mass spectrometry imaging and spatial metabolomics. Talanta. 2024;266:125060. https:\/\/doi.org\/10.1016\/j.talanta.2023.125060.","journal-title":"Talanta"},{"key":"5591_CR19","doi-asserted-by":"publisher","first-page":"590453","DOI":"10.3389\/fphar.2020.590453","volume":"8","author":"M Wang","year":"2020","unstructured":"Wang M, Liu Z, Hu S, Duan X, Zhang Y, Peng C, Peng D, Han L. Taohong Siwu decoction ameliorates ischemic stroke injury via suppressing pyroptosis. Front Pharmacol. 2020;8:590453. https:\/\/doi.org\/10.3389\/fphar.2020.590453.","journal-title":"Front Pharmacol"},{"issue":"8","key":"5591_CR20","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/S1875-5364(20)30074-1","volume":"18","author":"FF Chen","year":"2020","unstructured":"Chen FF, Wang MM, Xia WW, Peng DY, Han L. Tao-Hong-Si-Wu decoction promotes angiogenesis after cerebral ischaemia in rats via platelet microparticles. Chin J Nat Med. 2020;18(8):620\u20137. https:\/\/doi.org\/10.1016\/S1875-5364(20)30074-1.","journal-title":"Chin J Nat Med."},{"issue":"1","key":"5591_CR21","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1161\/01.str.20.1.84","volume":"20","author":"EZ Longa","year":"1989","unstructured":"Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20(1):84\u201391. https:\/\/doi.org\/10.1161\/01.str.20.1.84.","journal-title":"Stroke"},{"key":"5591_CR22","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/s1385-299x(00)00059-3","volume":"7","author":"IV Victorov","year":"2001","unstructured":"Victorov IV, Lyjin AA, Aleksandrova OP. A modified roller method for organotypic brain cultures: free-floating slices of postnatal rat hippocampus. Brain Res Protoc. 2001;7:30\u20137. https:\/\/doi.org\/10.1016\/s1385-299x(00)00059-3.","journal-title":"Brain Res Protoc"},{"key":"5591_CR23","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1007\/s00216-023-05091-x","volume":"416","author":"XQ Wang","year":"2024","unstructured":"Wang XQ, Hu YY, Zhu WT, Wang DL. Investigation of metabolite alterations in the kidneys of methionine-choline-deficient mouse by mass spectrometry imaging. Anal Bioanal Chem. 2024;416:1011\u201322. https:\/\/doi.org\/10.1007\/s00216-023-05091-x.","journal-title":"Anal Bioanal Chem"},{"issue":"6","key":"5591_CR24","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.cmet.2011.08.016","volume":"14","author":"M B\u00e9langer","year":"2011","unstructured":"B\u00e9langer M, Allaman I, Magistretti PJ. Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. Cell Metab. 2011;14(6):724\u201338. https:\/\/doi.org\/10.1016\/j.cmet.2011.08.016.","journal-title":"Cell Metab."},{"key":"5591_CR25","doi-asserted-by":"publisher","first-page":"e4144","DOI":"10.1002\/bmc.4144","volume":"32","author":"Q Ma","year":"2018","unstructured":"Ma Q, Li PL, Hua YL, Ji P, Yao WL, Zhang XS, Zhong LJ, Wei YM. Effects of Tao-Hong-Si-Wu decoction on acute blood stasis in rats based on a LC-Q\/TOF-MS metabolomics and network approach. Biomed Chromatogr. 2018;32:e4144. https:\/\/doi.org\/10.1002\/bmc.4144.","journal-title":"Biomed Chromatogr"},{"key":"5591_CR26","doi-asserted-by":"publisher","first-page":"5590","DOI":"10.3390\/ijms21155590","volume":"21","author":"D Spari","year":"2020","unstructured":"Spari D, Beldi G. Extracellular ATP as an inter-kingdom signaling molecule: release mechanisms by bacteria and its implication on the host. Int J Mol Sci. 2020;21:5590. https:\/\/doi.org\/10.3390\/ijms21155590.","journal-title":"Int J Mol Sci"},{"key":"5591_CR27","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.cbpc.2004.04.019","volume":"138","author":"MS Zietara","year":"2004","unstructured":"Zietara MS, S\u0142omi\u0144ska E, Rurangwa E, Ollevier F, Swierczy\u0144ski J, Skorkowski EF. In vitro adenine nucleotide catabolism in African catfish spermatozoa. Comp Biochem Physiol B Biochem Mol Biol. 2004;138:385\u20139. https:\/\/doi.org\/10.1016\/j.cbpc.2004.04.019.","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"5591_CR28","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0009-8981(88)90096-4","volume":"175","author":"NJ Fuller","year":"1988","unstructured":"Fuller NJ, Elia M. Factors influencing the production of creatinine: implications for the determination and interpretation of urinary creatinine and creatine in man. Clin Chim Acta. 1988;175:199\u2013210. https:\/\/doi.org\/10.1016\/0009-8981(88)90096-4.","journal-title":"Clin Chim Acta"},{"key":"5591_CR29","doi-asserted-by":"publisher","first-page":"490","DOI":"10.3390\/nu13020490","volume":"13","author":"AM Muccini","year":"2021","unstructured":"Muccini AM, Tran NT, de Guingand DL, Philip M, Della Gatta PA, Galinsky R, Sherman LS, Kelleher MA, Palmer KR, Berry MJ, Walker DW, Snow RJ, Ellery SJ. Creatine metabolism in female reproduction, pregnancy and newborn health. Nutrients. 2021;13:490. https:\/\/doi.org\/10.3390\/nu13020490.","journal-title":"Nutrients"},{"key":"5591_CR30","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/jnc.15811","volume":"166","author":"JV Andersen","year":"2023","unstructured":"Andersen JV, Schousboe A. Milestone review: metabolic dynamics of glutamate and GABA mediated neurotransmission-the essential roles of astrocytes. J Neurochem. 2023;166:109\u201337. https:\/\/doi.org\/10.1111\/jnc.15811.","journal-title":"J Neurochem"},{"key":"5591_CR31","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s41586-021-04230-7","volume":"601","author":"RN Delgado","year":"2022","unstructured":"Delgado RN, Allen DE, Keefe MG, Mancia Leon WR, Ziffra RS, Crouch EE, Alvarez-Buylla A, Nowakowsk TJ. Individual human cortical progenitors can produce excitatory and inhibitory neurons. Nature. 2022;601:397\u2013403. https:\/\/doi.org\/10.1038\/s41586-021-04230-7.","journal-title":"Nature"},{"key":"5591_CR32","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1111\/j.1471-4159.2009.06187.x","volume":"110","author":"A Cavallero","year":"2009","unstructured":"Cavallero A, Marte A, Fedele E. L-aspartate as an amino acid neurotransmitter: mechanisms of the depolarization-induced release from cerebrocortical synaptosomes. J Neurochem. 2009;110:924\u201334. https:\/\/doi.org\/10.1111\/j.1471-4159.2009.06187.x.","journal-title":"J Neurochem"},{"key":"5591_CR33","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.3390\/biom11111666","volume":"11","author":"IT Helenius","year":"2021","unstructured":"Helenius IT, Madala HR, Yeh JJ. An Asp to strike out cancer? Therapeutic possibilities arising from aspartate\u2019s emerging roles in cell proliferation and survival. Biomolecules. 2021;11:1666. https:\/\/doi.org\/10.3390\/biom11111666.","journal-title":"Biomolecules"},{"key":"5591_CR34","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1186\/s12964-023-01373-0","volume":"21","author":"M Xuan","year":"2023","unstructured":"Xuan M, Gu X, Li J, Huang D, Xue C, He Y. Polyamines: their significance for maintaining health and contributing to diseases. Cell Commun Signal. 2023;21:348. https:\/\/doi.org\/10.1186\/s12964-023-01373-0.","journal-title":"Cell Commun Signal"},{"key":"5591_CR35","doi-asserted-by":"publisher","first-page":"e17833","DOI":"10.15252\/emmm.202317833","volume":"15","author":"TM Stewart","year":"2023","unstructured":"Stewart TM, Foley JR, Holbert CE, Khomutov M, Rastkari N, Tao X, Khomutov AR, Zhai RG, Casero RA Jr. Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome. Embo Mol Med. 2023;15:e17833. https:\/\/doi.org\/10.15252\/emmm.202317833.","journal-title":"Embo Mol Med"},{"key":"5591_CR36","doi-asserted-by":"publisher","first-page":"154889","DOI":"10.1016\/j.phymed.2023.154889","volume":"116","author":"MH Ri","year":"2023","unstructured":"Ri MH, Xing Y, Zuo HY, Li MY, Jin HL, Ma J, Jin X. Regulatory mechanisms of natural compounds from traditional Chinese herbal medicines on the microglial response in ischemic stroke. Phytomedicine. 2023;116:154889. https:\/\/doi.org\/10.1016\/j.phymed.2023.154889.","journal-title":"Phytomedicine"},{"key":"5591_CR37","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/aps.2014.124","volume":"36","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Wang S, Zhu W, Ma Y, Zhang F, Liang R, Xu H, Yang H. Deciphering the pharmacological mechanism of the Chinese formula huanglian-jie-du decoction in the treatment of ischemic stroke using a systems biology-based strategy. Acta Pharmacol Sin. 2015;36:724\u201333. https:\/\/doi.org\/10.1038\/aps.2014.124.","journal-title":"Acta Pharmacol Sin"},{"key":"5591_CR38","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.smrv.2010.06.005","volume":"15","author":"T Porkka-Heiskanen","year":"2011","unstructured":"Porkka-Heiskanen T, Kalinchuk AV. Adenosine, energy metabolism and sleep homeostasis. Sleep Med Rev. 2011;15:123\u201335. https:\/\/doi.org\/10.1016\/j.smrv.2010.06.005.","journal-title":"Sleep Med Rev"},{"key":"5591_CR39","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1161\/01.str.6.6.678","volume":"6","author":"FM Yatsu","year":"1975","unstructured":"Yatsu FM, Lee LW, Liao CL. Energy metabolism during brain ischemia. Stability during reversible and irreversible damage. Stroke. 1975;6:678\u201383. https:\/\/doi.org\/10.1161\/01.str.6.6.678.","journal-title":"Stroke"},{"key":"5591_CR40","doi-asserted-by":"publisher","first-page":"721428","DOI":"10.3389\/fnagi.2021.721428","volume":"13","author":"X Zhou","year":"2021","unstructured":"Zhou X, Chen H, Wang L, Lenahan C, Lian L, Ou Y, He Y. Mitochondrial dynamics: a potential therapeutic target for ischemic stroke. Front Aging Neurosci. 2021;13:721428. https:\/\/doi.org\/10.3389\/fnagi.2021.721428.","journal-title":"Front Aging Neurosci"},{"key":"5591_CR41","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/978-1-4020-6486-9_11","volume":"46","author":"AM Klein","year":"2007","unstructured":"Klein AM, Ferrante RJ. The neuroprotective role of creatine. Subcell Biochem. 2007;46:205\u201343. https:\/\/doi.org\/10.1007\/978-1-4020-6486-9_11.","journal-title":"Subcell Biochem"},{"key":"5591_CR42","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s12017-008-8053-y","volume":"10","author":"PJ Adhihetty","year":"2008","unstructured":"Adhihetty PJ, Beal MF. Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases. Neuromolecular Med. 2008;10:275\u201390. https:\/\/doi.org\/10.1007\/s12017-008-8053-y.","journal-title":"Neuromolecular Med"},{"key":"5591_CR43","doi-asserted-by":"publisher","first-page":"5909","DOI":"10.1523\/JNEUROSCI.1278-04.2004","volume":"24","author":"S Zhu","year":"2004","unstructured":"Zhu S, Li M, Figueroa BE, Liu A, Stavrovskaya IG, Pasinelli P, Beal MF, Brown RH Jr, Kristal BS, Ferrante RJ, Friedlander RM. Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice. J Neurosci. 2004;24:5909\u201312. https:\/\/doi.org\/10.1523\/JNEUROSCI.1278-04.2004.","journal-title":"J Neurosci"},{"key":"5591_CR44","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3390\/metabo10010027","volume":"10","author":"F Tian","year":"2020","unstructured":"Tian F, Liu RZ, Fan CX, Sun Y, Huang X, Nie ZX, Zhao PuXP. Effects of thymoquinone on small-molecule metabolites in a rat model of cerebral ischemia reperfusion injury assessed using MALDI-MSI. Metabolites. 2020;10:27. https:\/\/doi.org\/10.3390\/metabo10010027.","journal-title":"Metabolites"},{"key":"5591_CR45","doi-asserted-by":"publisher","first-page":"102331","DOI":"10.1016\/j.pneurobio.2022.102331","volume":"217","author":"JV Andersen","year":"2022","unstructured":"Andersen JV, Schousboe A, Verkhratsky A. Astrocyte energy and neurotransmitter metabolism in Alzheimer\u2019s disease: integration of the glutamate\/GABA-glutamine cycle. Prog Neurobiol. 2022;217:102331. https:\/\/doi.org\/10.1016\/j.pneurobio.2022.102331.","journal-title":"Prog Neurobiol"},{"key":"5591_CR46","doi-asserted-by":"publisher","first-page":"110470","DOI":"10.1016\/j.biopha.2020.110470","volume":"129","author":"T Zhu","year":"2020","unstructured":"Zhu T, Wang L, Tian F, Zhao X, Pu XP, Sun GB, Sun XB. Anti-ischemia\/reperfusion injury effects of notoginsenoside R1 on small molecule metabolism in rat brain after ischemic stroke as visualized by MALDI\u2013MS imaging. Biomed Pharmacother. 2020;129:110470. https:\/\/doi.org\/10.1016\/j.biopha.2020.110470.","journal-title":"Biomed Pharmacother"},{"key":"5591_CR47","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1097\/01.WCB.0000050066.57184.60","volume":"23","author":"C Demougeot","year":"2003","unstructured":"Demougeot C, Bertrand N, Prigent-Tessier A, Garnier P, Mossiat C, Giroud M, Marie C, Beley A. Reversible loss of N-acetyl-aspartate in rats subjected to long-term focal cerebral ischemia. J Cereb Blood Flow Metab. 2003;23:482\u20139. https:\/\/doi.org\/10.1097\/01.WCB.0000050066.57184.60.","journal-title":"J Cereb Blood Flow Metab"},{"key":"5591_CR48","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1017\/s0317167100006247","volume":"36","author":"GH Kim","year":"2009","unstructured":"Kim GH, Komotar RJ, McCullough-Hicks ME, Otten ML, Starke RM, Kellner CP, Garrett MC, Merkow MB, Rynkowski M, Dash KA, Connolly ES. The role of polyamine metabolism in neuronal injury following cerebral ischemia. Can J Neurol Sci. 2009;36:14\u20139. https:\/\/doi.org\/10.1017\/s0317167100006247.","journal-title":"Can J Neurol Sci"},{"key":"5591_CR49","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.2174\/092986707781058841","volume":"14","author":"J Li","year":"2007","unstructured":"Li J, Doyle KM, Tatlisumak T. Polyamines in the brain: distribution, biological interactions, and their potential therapeutic role in brain ischaemia. Curr Med Chem. 2007;14:1807\u201313. https:\/\/doi.org\/10.2174\/092986707781058841.","journal-title":"Curr Med Chem"},{"key":"5591_CR50","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/BF03160353","volume":"49","author":"W Paschen","year":"1987","unstructured":"Paschen W, Schmidt-Kastner R, Djuricic B, Meese C, Linn F, Hossmann KA. Polyamine changes in reversible cerebral ischemia. J Neurochem. 1987;49:35\u20137. https:\/\/doi.org\/10.1007\/BF03160353.","journal-title":"J Neurochem"},{"key":"5591_CR51","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.brainres.2006.04.038","volume":"1095","author":"PL Wood","year":"2006","unstructured":"Wood PL, Khan MA, Kulow SR, Mahmood SA, Moskal JR. Neurotoxicity of reactive aldehydes: the concept of \u201caldehyde load\u201d as demonstrated by neuroprotection with hydroxylamines. Brain Res. 2006;1095:190\u20139. https:\/\/doi.org\/10.1016\/j.brainres.2006.04.038.","journal-title":"Brain Res"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-024-05591-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00216-024-05591-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-024-05591-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T08:31:04Z","timestamp":1732091464000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00216-024-05591-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":51,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["5591"],"URL":"https:\/\/doi.org\/10.1007\/s00216-024-05591-4","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"21 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The use of laboratory animals and all study protocols were approved by the Animal Protection Committee and Use Committee of Anhui University of Chinese Medicine.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Male Sprague\u2013Dawley rats (250\u2009\u2212\u2009290\u00a0g) were provided by Liaoning Changsheng Biotechnology Co., Ltd.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Source of biological material"}},{"value":"The management and use of animals during the experiment comply with the relevant regulations of \u201cGuide for the Care and Use of Laboratory Animals issued by the National Research Council of the United States (2010),\u201d \u201cRegulations for the administration of affairs concerning laboratory animals (2017)\u201d issued by the Science and Technology Commission of China, and the relevant regulations provided by the Animal Protection Committee and Use Committee of Anhui University of Chinese Medicine.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement on animal welfare"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}