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Reference materials (RMs) with metrologically traceable values for these specific properties are ideal analytical tools to ensure requisite chemical measurements are reliable. However, identifying and comparing appropriate RMs for studying dietary ingredients and their metabolites is challenging, creating a barrier to reproducible regulatory testing and research. To address this challenge, the Office of Dietary Supplements at the National Institutes of Health coordinated the development of a new publicly available Reference Materials Search Tool (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/odsrmst.od.nih.gov\/\" ext-link-type=\"uri\">https:\/\/odsrmst.od.nih.gov\/<\/jats:ext-link>) database featuring comprehensive data records and search and comparison functionality. The RMST significantly expands research capacities to discover and select fit for purpose reference materials for dietary supplement and related food and natural product chemical analysis.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1007\/s00216-024-05664-4","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T05:07:38Z","timestamp":1736917658000},"page":"2379-2386","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A new database to guide reference material selection for dietary supplement and nutrition science"],"prefix":"10.1007","volume":"417","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8719-145X","authenticated-orcid":false,"given":"Adam J.","family":"Kuszak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0413-8934","authenticated-orcid":false,"given":"Sanem","family":"Hosbas Coskun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0021-1970","authenticated-orcid":false,"given":"Stephen A.","family":"Wise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"5664_CR1","unstructured":"Dietary Supplement Health and Education Act of 1994, Pub. L. No. 103\u2013417(1994). https:\/\/www.congress.gov\/103\/statute\/STATUTE-108\/STATUTE-108-Pg4325.pdf. Access date: 29\/09\/2024."},{"key":"5664_CR2","unstructured":"Current good manufacturing practice in manufacturing, packaging, labeling, or holding operations for dietary supplements. 21 CFR Ch 1, Part 111. Sect. Subpart A. 2007. https:\/\/www.ecfr.gov\/current\/title-21\/chapter-I\/subchapter-B\/part-111. Access date: 29\/09\/2024."},{"issue":"1","key":"5664_CR3","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1096\/fj.201902143R","volume":"34","author":"BC Sorkin","year":"2020","unstructured":"Sorkin BC, Kuszak AJ, Bloss G, Fukagawa NK, Hoffman FA, Jafari M, et al. Improving natural product research translation: from source to clinical trial. 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SAW is an Editor of the journal Analytical and Bioanalytical Chemistry and was not involved in peer reviewing this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The opinions expressed in this article are the authors\u2019 own and do not reflect the view of the National Institutes of Health or the US government. Any citations of commercial organizations or trade names in this report do not constitute an official NIH or US government endorsement or approval of the products or services of these organizations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}