{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:49:43Z","timestamp":1784958583564,"version":"3.55.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Joint R&D Projects of the Yangtze River Delta Innovation Community for Science and Technology","award":["2023CSJGG1800"],"award-info":[{"award-number":["2023CSJGG1800"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1007\/s00216-025-05750-1","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T04:16:36Z","timestamp":1738728996000},"page":"1607-1617","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Quantification of mycophenolic acid in plasma by isotope dilution liquid chromatography-tandem mass spectrometry candidate reference method"],"prefix":"10.1007","volume":"417","author":[{"given":"Jing","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjue","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaipeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanle","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"issue":"8","key":"5750_CR1","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.2165\/00003495-200565080-00001","volume":"65","author":"M Behrend","year":"2005","unstructured":"Behrend M, Braun F. Enteric-coated mycophenolate sodium: tolerability profile compared with mycophenolate mofetil. Drugs. 2005;65(8):1037\u201350. https:\/\/doi.org\/10.2165\/00003495-200565080-00001.","journal-title":"Drugs"},{"issue":"3","key":"5750_CR2","doi-asserted-by":"publisher","first-page":"187","DOI":"10.14712\/23362936.2024.18","volume":"125","author":"S Merdita","year":"2024","unstructured":"Merdita S, Ry\u0161\u00e1nek P, Hartinger JM, Slana\u0159 O, \u0160\u00edma M. Pharmacokinetic-based dosing individualization of mycophenolate mofetil in solid organ transplanted patients. Prague Med Rep. 2024;125(3):187\u201394. https:\/\/doi.org\/10.14712\/23362936.2024.18.","journal-title":"Prague Med Rep."},{"issue":"6","key":"5750_CR3","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1097\/FTD.0000000000000658","volume":"41","author":"D Ranganathan","year":"2019","unstructured":"Ranganathan D, Abdul-Aziz MH, John GT, McWhinney BC, Fassett RG, Healy H, et al. Pharmacokinetics of enteric-coated mycophenolate sodium in lupus nephritis (POEMSLUN). Ther Drug Monit. 2019;41(6):703\u201313. https:\/\/doi.org\/10.1097\/FTD.0000000000000658.","journal-title":"Ther Drug Monit"},{"issue":"1","key":"5750_CR4","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/ajd.12259","volume":"56","author":"SJ Strathie Page","year":"2015","unstructured":"Strathie Page SJ, Tait CP. Mycophenolic acid in dermatology a century after its discovery. Australas J Dermatol. 2015;56(1):77\u201383. https:\/\/doi.org\/10.1111\/ajd.12259.","journal-title":"Australas J Dermatol"},{"issue":"3","key":"5750_CR5","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1093\/clinchem\/45.3.419","volume":"45","author":"E Sch\u00fctz","year":"1999","unstructured":"Sch\u00fctz E, Shipkova M, Armstrong VW, Wieland E, Oellerich M. Identification of a pharmacologically active metabolite of mycophenolic acid in plasma of transplant recipients treated with mycophenolate mofetil. Clin Chem. 1999;45(3):419\u201322.","journal-title":"Clin Chem"},{"issue":"3","key":"5750_CR6","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/clinchem\/46.3.365","volume":"46","author":"M Shipkova","year":"2000","unstructured":"Shipkova M, Sch\u00fctz E, Armstrong VW, Niedmann PD, Oellerich M, Wieland E. Determination of the acyl glucuronide metabolite of mycophenolic acid in human plasma by HPLC and Emit. Clin Chem. 2000;46(3):365\u201372.","journal-title":"Clin Chem"},{"issue":"2","key":"5750_CR7","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/j.1399-0012.2010.01226.x","volume":"25","author":"P Hiwarkar","year":"2011","unstructured":"Hiwarkar P, Shaw BE, Tredger JM, Brown NW, Kulkarni S, Saso R, et al. Mycophenolic acid trough level monitoring: relevance in acute and chronic graft versus host disease and its relation with albumin. Clin Transplant. 2011;25(2):222\u20137. https:\/\/doi.org\/10.1111\/j.1399-0012.2010.01226.x.","journal-title":"Clin Transplant"},{"issue":"1","key":"5750_CR8","doi-asserted-by":"publisher","first-page":"33","DOI":"10.7182\/pit2014521","volume":"24","author":"S Rostas","year":"2014","unstructured":"Rostas S, Kim M, Gabardi S. Risk evaluation and mitigation strategies: a focus on the mycophenolic acid preparations. Prog Transplant. 2014;24(1):33\u20136. https:\/\/doi.org\/10.7182\/pit2014521.","journal-title":"Prog Transplant"},{"issue":"3","key":"5750_CR9","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1097\/FTD.0000000000000151","volume":"37","author":"PK Kunicki","year":"2015","unstructured":"Kunicki PK, Pawi\u0144ski T, Boczek A, Wa\u015b J, Bodnar-Broniarczyk M. A comparison of the immunochemical methods, PETINIA and EMIT, with that of HPLC-UV for the routine monitoring of mycophenolic acid in heart transplant patients. Ther Drug Monit. 2015;37(3):311\u20138. https:\/\/doi.org\/10.1097\/FTD.0000000000000151.","journal-title":"Ther Drug Monit"},{"issue":"5","key":"5750_CR10","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1097\/FTD.0b013e3181f01397","volume":"32","author":"B Chen","year":"2010","unstructured":"Chen B, Gu Z, Chen H, Zhang W, Fen X, Cai W, et al. Establishment of high-performance liquid chromatography and enzyme multiplied immunoassay technology methods for determination of free mycophenolic acid and its application in Chinese liver transplant recipients. Ther Drug Monit. 2010;32(5):653\u201360. https:\/\/doi.org\/10.1097\/FTD.0b013e3181f01397.","journal-title":"Ther Drug Monit"},{"key":"5750_CR11","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40780-018-0101-7","volume":"4","author":"M Kikuchi","year":"2018","unstructured":"Kikuchi M, Tanaka M, Takasaki S, Takahashi A, Akiba M, Matsuda Y, et al. Comparison of PETINIA and LC-MS\/MS for determining plasma mycophenolic acid concentrations in Japanese lung transplant recipients. J Pharm Health Care Sci. 2018;4:7. https:\/\/doi.org\/10.1186\/s40780-018-0101-7.","journal-title":"J Pharm Health Care Sci"},{"issue":"2","key":"5750_CR12","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.jpba.2006.08.012","volume":"43","author":"FA Elbarbry","year":"2007","unstructured":"Elbarbry FA, Shoker A. Simple high performance liquid chromatographic assay for mycophenolic acid in renal transplant patients. J Pharm Biomed Anal. 2007;43(2):788\u201392. https:\/\/doi.org\/10.1016\/j.jpba.2006.08.012.","journal-title":"J Pharm Biomed Anal"},{"issue":"6","key":"5750_CR13","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.3390\/pharmaceutics14061304","volume":"14","author":"F Lo Re","year":"2022","unstructured":"Lo Re F, Angelini J, Sponga S, Nalli C, Zucchetto A, Biasizzo J, et al. Therapeutic drug monitoring of mycophenolic acid as a precision medicine tool for heart transplant patients: results of an observational pharmacokinetic pilot study. Pharmaceutics. 2022;14(6):1304. https:\/\/doi.org\/10.3390\/pharmaceutics14061304.","journal-title":"Pharmaceutics"},{"key":"5750_CR14","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jmsacl.2024.06.001","volume":"33","author":"JK Wolken","year":"2024","unstructured":"Wolken JK, Cao W, Cui M, Jin Z. Therapeutic drug monitoring of mycophenolic acid and azole antifungals on two distinct LC-MS\/MS instruments. J Mass Spectrom Adv Clin Lab. 2024;33:7\u201313. https:\/\/doi.org\/10.1016\/j.jmsacl.2024.06.001.","journal-title":"J Mass Spectrom Adv Clin Lab"},{"key":"5750_CR15","doi-asserted-by":"publisher","first-page":"115504","DOI":"10.1016\/j.jpba.2023.115504","volume":"234","author":"I Etim","year":"2023","unstructured":"Etim I, Abasifreke B, Sun R, Kuddabujja D, Liang D, Du T, et al. Development of a novel UPLC-MS\/MS method for the simultaneous quantification of mycophenolic mofetil, mycophenolic acid, and its major metabolites: Application to pharmacokinetic and tissue distribution study in rats. J Pharm Biomed Anal. 2023;234:115504. https:\/\/doi.org\/10.1016\/j.jpba.2023.115504.","journal-title":"J Pharm Biomed Anal"},{"key":"5750_CR16","unstructured":"ISO 15193. In vitro diagnostic medical devices\u2014Measurement of quantities in samples of biological origin\u2014Requirements for content and presentation of reference measurement procedures (ISO 15193:2009). Geneva, Switzerland: International Organization Standardization; 2009."},{"key":"5750_CR17","unstructured":"ISO 17511. In vitro diagnostic medical devices\u2014Requirements for establishing metrological traceability of values assigned to calibrators, trueness control materials and human samples. Geneva, Switzerland: International Organization Standardization; 2020."},{"key":"5750_CR18","unstructured":"CLSI. Liquid Chromatography-mass Spectrometry Methods; Approved Guideline. CLSI document C62-A. Wayne, PA: Clinical and Laboratory Standards Institute; 2014."},{"key":"5750_CR19","unstructured":"CLSI. Mass Spectrometry in the Clinical Laboratory: general principles and guidance; Approved Guideline. CLSI document C50-A. Wayne, PA: Clinical and Laboratory Standards Institute; 2007."},{"key":"5750_CR20","unstructured":"CLSI. Evaluation of Precision of Quantitative Measurement Procedures; Approved Guideline-Third Edition. CLSI document EP05-A3. Wayne, PA: Clinical and Laboratory Standards Institute; 2014."},{"key":"5750_CR21","unstructured":"CLSI. Evaluation of Linearity of Quantitative Measurement Procedures: a statistical approach; Approved Guideline. CLSI document EP06-A. Wayne, PA: Clinical and Laboratory Standards Institute; 2003."},{"key":"5750_CR22","unstructured":"CLSI. Measurement Procedure Comparison and Bias Estimation Using Patient Samples; Approved Guideline-Third Edition. CLSI document EP09-A3. Wayne, PA: Clinical and Laboratory Standards Institute; 2013."},{"key":"5750_CR23","unstructured":"ISO\/IEC Guide 98\u20133. Uncertainty of measurement-part 3: guide to the expression of uncertainty in measurement (GUM:1995). Geneva: International Organization for Standardization; 2008."},{"key":"5750_CR24","unstructured":"EURACHEM\/CITAC Guide CG 4. Quantifying Uncertainty in Analytical Measurement-Third Edition. London: Laboratory of the Government Chemist; 2012."},{"issue":"5","key":"5750_CR25","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1002\/bmc.3682","volume":"30","author":"M Syed","year":"2016","unstructured":"Syed M, Srinivas NR. A comprehensive review of the published assays for the quantitation of the immunosuppressant drug mycophenolic acid and its glucuronidated metabolites in biological fluids. Biomed Chromatogr. 2016;30(5):721\u201348. https:\/\/doi.org\/10.1002\/bmc.3682.","journal-title":"Biomed Chromatogr"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-025-05750-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00216-025-05750-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-025-05750-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T17:05:31Z","timestamp":1741021531000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00216-025-05750-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,5]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["5750"],"URL":"https:\/\/doi.org\/10.1007\/s00216-025-05750-1","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,5]]},"assertion":[{"value":"3 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The collection of leftover plasma samples was approved by the Ethics Committee of Medical System Diagnostics (202411001).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Blank human plasma samples were collected from the remaining patient samples in Medical System Diagnostics.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Source of biological material"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}