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MH-5 displayed a rapid and highly selective colorimetric response to both Li<jats:sup>+<\/jats:sup> and CN<jats:sup>\u2212<\/jats:sup>, indicated by a distinct color change from pink to pale pink in the presence of Li<jats:sup>+<\/jats:sup> and to colorless upon CN<jats:sup>\u2212<\/jats:sup> detection, without interference from other cations or anions. The interaction mechanisms of MH-5 with Li<jats:sup>+<\/jats:sup> and CN<jats:sup>\u2212<\/jats:sup> ions were investigated using various analytical techniques, including <jats:sup>1<\/jats:sup>H NMR, ESI\u2013MS, FT-IR spectroscopy, and Job\u2019s plot analysis. These studies suggest that CN<jats:sup>\u2212<\/jats:sup> is detected through nucleophilic addition to the indolium moiety of MH-5, while Li<jats:sup>+<\/jats:sup> detection occurs via coordination with oxygen atoms in the crown ether structure. The fluorescence-based detection limits for Li<jats:sup>+<\/jats:sup> and CN<jats:sup>\u2212<\/jats:sup> were determined to be 0.150\u00a0\u00b5M and 0.154\u00a0\u00b5M, respectively. Additionally, MH-5 was evaluated in living cells, demonstrating effective cell penetration and reliable detection of Li<jats:sup>+<\/jats:sup> and CN<jats:sup>\u2212<\/jats:sup> ions for potential bio-imaging applications.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1007\/s00216-025-05852-w","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T09:54:47Z","timestamp":1743846887000},"page":"3127-3139","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A hemicyanine-based dual-responsive fluorescent sensor for the detection of lithium and cyanide ions: application in living cells"],"prefix":"10.1007","volume":"417","author":[{"given":"Ziya","family":"Aydin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukaddes","family":"Keskinates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Armagan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahar Yilmaz","family":"Altinok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mevlut","family":"Bayrakci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"5852_CR1","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.snb.2017.12.006","volume":"259","author":"D Udhayakumari","year":"2018","unstructured":"Udhayakumari D. 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