{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:35:29Z","timestamp":1793043329926,"version":"4.5.0"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"23","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anal Bioanal Chem"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s00216-025-06054-0","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T11:19:38Z","timestamp":1756207178000},"page":"5171-5186","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Medium-entropy nanoenzyme with high oxidase-like activity for sensitive detection of interleukin-6 based on ELISA"],"prefix":"10.1007","volume":"417","author":[{"given":"Lifang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangshan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"6054_CR1","doi-asserted-by":"publisher","first-page":"12049","DOI":"10.1021\/acsnano.4c02265","volume":"18","author":"QR Fu","year":"2024","unstructured":"Fu QR, Wei C, Wang MZ. Transition-metal-based nanozymes: synthesis, mechanisms of therapeutic action, and applications in cancer treatment. ACS Nano. 2024;18:12049\u201395. https:\/\/doi.org\/10.1021\/acsnano.4c02265.","journal-title":"ACS Nano"},{"key":"6054_CR2","doi-asserted-by":"publisher","unstructured":"Liu JS, Ma DC, Li YB, Li JD. Revealing mechanism of transition metals doping in chlorapatite as single-atom nanozymes for high electrocatalytic activity of Fenton\/ Fenton-like reaction. Sep Purif Technol. 2024;336. https:\/\/doi.org\/10.1016\/j.seppur.2023.126238.","DOI":"10.1016\/j.seppur.2023.126238"},{"key":"6054_CR3","doi-asserted-by":"publisher","first-page":"9817","DOI":"10.1039\/D1CS00330E","volume":"50","author":"A Zhang","year":"2021","unstructured":"Zhang A, Liang YX, Zhang H, Geng ZG, Zeng J. Doping regulation in transition metal compounds for electrocatalysis. Chem Soc Rev. 2021;50:9817\u201344. https:\/\/doi.org\/10.1039\/D1CS00330E.","journal-title":"Chem Soc Rev"},{"key":"6054_CR4","doi-asserted-by":"publisher","unstructured":"Xiao ML, Han DW, Yang XQ, Tchinda NT, Du L, Guo YC, Wei YC, Yu XL, Ge MF. Ni-doping-induced oxygen vacancy in Pt-CeO2 catalyst for toluene oxidation: enhanced catalytic activity, water-resistance, and SO2-tolerance. Appl Catal B-Environ. 2023;323. https:\/\/doi.org\/10.1016\/j.apcatb.2022.122173.","DOI":"10.1016\/j.apcatb.2022.122173"},{"key":"6054_CR5","doi-asserted-by":"publisher","unstructured":"Niu X, Pei WY, Ma JF. Medium entropy FeCoNi nanoalloy supported on reduced graphene oxide for efficient electrochemical detection of roxarsone in food samples. Food Chem. 2024;455. https:\/\/doi.org\/10.1016\/j.foodchem.2024.139918.","DOI":"10.1016\/j.foodchem.2024.139918"},{"key":"6054_CR6","doi-asserted-by":"publisher","first-page":"343566","DOI":"10.1016\/j.aca.2024.343566","volume":"1337","author":"W Li","year":"2025","unstructured":"Li W, Cai T, Tian J, Dong Y, Hu F, Peng H. Medium entropy-derived flower-like FeCeCu nanozyme with excellent oxidase-like activity for on-site and visual detection of carbosulfan. Anal Chim Acta. 2025;1337:343566. https:\/\/doi.org\/10.1016\/j.aca.2024.343566.","journal-title":"Anal Chim Acta"},{"key":"6054_CR7","doi-asserted-by":"publisher","unstructured":"Wu H, Wang ZC, Li ZX, Ma YJ, Ding F, Li FQ, Bian HF, Zhai QX, Ren YL, Shi YX, Yang YR, Deng Y, Tang SC, Meng XK. Medium-entropy metal selenides nanoparticles with optimized electronic structure as high-performance bifunctional electrocatalysts for overall water splitting. Adv Energy Mater. 2023;13. https:\/\/doi.org\/10.1002\/aenm.202300837.","DOI":"10.1002\/aenm.202300837"},{"key":"6054_CR8","doi-asserted-by":"publisher","unstructured":"Yang YY, Tan XL, Wang YR, Shen BX, Yang YQ, Huang H. Heteroatom-doped nanozyme progress and perspectives: from synthesis strategies to biomedical applications. Chem Eng J. 2023;468. https:\/\/doi.org\/10.1016\/j.cej.2023.143703.","DOI":"10.1016\/j.cej.2023.143703"},{"key":"6054_CR9","doi-asserted-by":"publisher","unstructured":"Chang L, Jing HC, Liu C, Qiu CT, Ling X. High-entropy materials for prospective biomedical applications: challenges and opportunities. Adv Sci. 2024;11. https:\/\/doi.org\/10.1002\/advs.202406521.","DOI":"10.1002\/advs.202406521"},{"key":"6054_CR10","doi-asserted-by":"publisher","first-page":"165206","DOI":"10.1016\/j.jallcom.2022.165206","volume":"914","author":"N An","year":"2022","unstructured":"An N, Sun YN, Gao L, Wu YD, Xue JN, Li ZR, Hui XD. Long-term structural stability and excellent mechanical properties of CoCrNi system medium entropy alloys. J Alloy Compd. 2022;914:165206. https:\/\/doi.org\/10.1016\/j.jallcom.2022.165206.","journal-title":"J Alloy Compd"},{"issue":"9","key":"6054_CR11","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.7150\/ijbs.4989","volume":"8","author":"S Rose-John","year":"2012","unstructured":"Rose-John S. IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int J Biol Sci. 2012;8(9):1237.","journal-title":"Int J Biol Sci"},{"key":"6054_CR12","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1038\/s41423-021-00652-5","volume":"18","author":"PH Yang","year":"2021","unstructured":"Yang PH, Zhao YZ, Li J, Liu CY, Zhu LN, Zhang J, Yu YY, Wang WJ, Lei GL, Yan J, Sun F, Bian CR, Meng FP, Xu Z, Bai CQ, Ye BW, Guo YY, Shu LM, Yuan XJ, Zhang N, Bi YH, Shi Y, Wu GZ, Zhang SG, Gao GRF, Liu LQ, Liu WJ, Sun HX. Downregulated miR-451a as a feature of the plasma cfRNA landscape reveals regulatory networks of IL-6\/IL-6R-associated cytokine storms in COVID-19 patients. Cell Mol Immunol. 2021;18:1064\u20136. https:\/\/doi.org\/10.1038\/s41423-021-00652-5.","journal-title":"Cell Mol Immunol"},{"key":"6054_CR13","doi-asserted-by":"publisher","first-page":"868348","DOI":"10.3389\/fimmu.2022.868348","volume":"13","author":"A Picod","year":"2022","unstructured":"Picod A, Morisson L, de Roquetaillade C, Sadoune M, Mebazaa A, Gayat E, Davison BA, Cotter G, Chousterman BG. Systemic inflammation evaluated by interleukin-6 or C-reactive protein in critically ill patients: results from the FROG-ICU study. Front Immunol. 2022;13:868348. https:\/\/doi.org\/10.3389\/fimmu.2022.868348.","journal-title":"Front Immunol"},{"issue":"5","key":"6054_CR14","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1002\/hep4.1883","volume":"6","author":"SJ Gairing","year":"2022","unstructured":"Gairing SJ, Anders J, Kaps L, Nagel M, Michel M, Kremer WM, Hilscher M, Galle PR, Schattenberg JM, W\u00f6rns MA, Labenz C. Evaluation of IL-6 for stepwise diagnosis of minimal hepatic encephalopathy in patients with liver cirrhosis. Hepatol Commun. 2022;6(5):1113\u201322. https:\/\/doi.org\/10.1002\/hep4.1883.","journal-title":"Hepatology communications"},{"key":"6054_CR15","doi-asserted-by":"publisher","unstructured":"Li J, Rong L, Cui R, Feng J, Jin Y, Yu Y, Chen X, Xu R. Dynamic changes in serum IL-6, IL-8, and IL-10 predict the outcome of ICU patients with severe COVID-19. Ann Palliat Med. 2021;10(4):3706\u20133714.  https:\/\/doi.org\/10.21037\/apm-20-2134","DOI":"10.21037\/apm-20-2134"},{"issue":"6","key":"6054_CR16","doi-asserted-by":"publisher","first-page":"e72","DOI":"10.1161\/CIRCULATIONAHA.105.595520","volume":"113","author":"EJ Armstrong","year":"2006","unstructured":"Armstrong EJ, Morrow DA, Sabatine MS. Inflammatory biomarkers in acute coronary syndromes: Part I: Introduction and cytokines. Circulation. 2006;113(6):e72\u20135. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.105.595520.","journal-title":"Circulation"},{"issue":"5","key":"6054_CR17","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.freeradbiomed.2010.05.019","volume":"49","author":"D de Gonzalo-Calvo","year":"2010","unstructured":"de Gonzalo-Calvo D, Neitzert K, Fern\u00e1ndez M, Vega-Naredo I, Caballero B, Garc\u00eda-Mac\u00eda M, Su\u00e1rez MF, Rodr\u00edguez-Colunga MJ, Solano JJ, Coto-Montes A. Differential inflammatory responses in aging and disease: TNF-\u03b1 and IL-6 as possible biomarkers. Free Radical Bio Med. 2010;49(5):733\u20137. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2010.05.019.","journal-title":"Free Radical Bio Med"},{"key":"6054_CR18","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1038\/s41423-020-00522-6","volume":"17","author":"L Huang","year":"2020","unstructured":"Huang L, Zhao X, Qi Y, Li H, Ye GC, Liu YF, Zhang Y, Gou JJ. Sepsis-associated severe interleukin-6 storm in critical coronavirus disease 2019. Cell Mol Immunol. 2020;17:1092\u20134. https:\/\/doi.org\/10.1038\/s41423-020-00522-6.","journal-title":"Cell Mol Immunol"},{"key":"6054_CR19","doi-asserted-by":"publisher","first-page":"613422","DOI":"10.3389\/fimmu.2021.613422","volume":"12","author":"A Santa Cruz","year":"2021","unstructured":"Santa Cruz A, Mendes-Frias A, Oliveira AI, Dias L, Matos AR, Carvalho A, Capela C, Pedrosa J, Castro AG, Silvestre R. Interleukin-6 is a biomarker for the development of fatal severe acute respiratory syndrome coronavirus 2 pneumonia. Front Immunol. 2021;12:613422. https:\/\/doi.org\/10.3389\/fimmu.2021.613422.","journal-title":"Front Immunol"},{"issue":"2","key":"6054_CR20","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1053\/gast.1996.v110.agast960639","volume":"110","author":"AM Kusske","year":"1996","unstructured":"Kusske AM, Rongione AJ, Reber HA. Cytokines and acute pancreatitis. Gastroenterology. 1996;110(2):639\u201342. https:\/\/doi.org\/10.1053\/gast.1996.v110.agast960639.","journal-title":"Gastroenterology"},{"issue":"3","key":"6054_CR21","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1164\/ajrccm.154.3.8810592","volume":"154","author":"S Chollet-Martin","year":"1996","unstructured":"Chollet-Martin S, Jourdain B, Gibert C, Elbim C, Chastre J, Gougerot-Pocidalo MA. Interactions between neutrophils and cytokines in blood and alveolar spaces during ARDS. Am J Resp Crit Care. 1996;154(3):594\u2013601. https:\/\/doi.org\/10.1164\/ajrccm.154.3.8810592.","journal-title":"Am J Resp Crit Care"},{"issue":"11","key":"6054_CR22","doi-asserted-by":"publisher","first-page":"2743","DOI":"10.1016\/j.bios.2007.01.022","volume":"22","author":"X Hun","year":"2007","unstructured":"Hun X, Zhang Z. Functionalized fluorescent core-shell nanoparticles used as a fluorescent labels in fluoroimmunoassay for IL-6. Biosens Bioelectron. 2007;22(11):2743\u20138. https:\/\/doi.org\/10.1016\/j.bios.2007.01.022.","journal-title":"Biosens Bioelectron"},{"issue":"11","key":"6054_CR23","doi-asserted-by":"publisher","first-page":"2201910","DOI":"10.1002\/admt.202201910","volume":"8","author":"C Scandurra","year":"2023","unstructured":"Scandurra C, Bj\u00f6rkstr\u00f6m K, Sarcina L, Imbriano A, Di Franco C, \u00d6sterbacka R, Bollella P, Scamarcio G, Torsi L, Macchia E. Single molecule with a large transistor-SiMoT cytokine IL-6 detection benchmarked against a chemiluminescent ultrasensitive immunoassay array. Adv Mater Technol. 2023;8(11):2201910. https:\/\/doi.org\/10.1002\/admt.202201910.","journal-title":"Adv Mater Technol"},{"issue":"5","key":"6054_CR24","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1172\/JCI117206","volume":"93","author":"F De Benedetti","year":"1994","unstructured":"De Benedetti F, Massa M, Pignatti P, Albani S, Novick D, Martini A. Serum soluble interleukin 6 (IL-6) receptor and IL-6\/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis. J Clin Invest. 1994;93(5):2114\u20139. https:\/\/doi.org\/10.1172\/JCI117206.","journal-title":"J Clin Invest"},{"key":"6054_CR25","doi-asserted-by":"publisher","first-page":"116605","DOI":"10.1016\/j.trac.2022.116605","volume":"152","author":"P Peng","year":"2022","unstructured":"Peng P, Liu C, Li Z, Xue Z, Mao P, Hu J, Xu F, Yao C, You M. Emerging ELISA-derived technologies for in vitro diagnostics. Trac Trend Anal Chem. 2022;152:116605. https:\/\/doi.org\/10.1016\/j.trac.2022.116605.","journal-title":"Trac Trend Anal Chem"},{"issue":"9","key":"6054_CR26","doi-asserted-by":"publisher","first-page":"898","DOI":"10.3390\/bios13090898","volume":"13","author":"M Majdinasab","year":"2023","unstructured":"Majdinasab M, Lamy de la Chapelle M, Marty JL. Recent progresses in optical biosensors for interleukin 6 detection. Biosensors. 2023;13(9):898. https:\/\/doi.org\/10.3390\/bios13090898.","journal-title":"Biosensors"},{"issue":"1","key":"6054_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1021\/acsanm.9b02003","volume":"3","author":"Y Gao","year":"2019","unstructured":"Gao Y, Zhou Y, Chandrawati R. Metal and metal oxide nanoparticles to enhance the performance of enzyme-linked immunosorbent assay (ELISA). ACS Appl Nano Mater. 2019;3(1):1\u201321. https:\/\/doi.org\/10.1021\/acsanm.9b02003.","journal-title":"ACS Appl Nano Mater"},{"key":"6054_CR28","doi-asserted-by":"publisher","first-page":"111556","DOI":"10.1016\/j.bios.2019.111556","volume":"142","author":"Z Tan","year":"2019","unstructured":"Tan Z, Dong H, Liu Q, Liu H, Zhao P, Wang P, Li Y, Zhang D, Zhao Z, Dong Y. A label-free immunosensor based on PtPd NCs@ MoS2 nanoenzymes for hepatitis B surface antigen detection. Biosens Bioelectron. 2019;142:111556. https:\/\/doi.org\/10.1016\/j.bios.2019.111556.","journal-title":"Biosens Bioelectron"},{"issue":"10","key":"6054_CR29","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1373\/clinchem.2009.129940","volume":"55","author":"L Le Pottier","year":"2009","unstructured":"Le Pottier L, Bendaoud B, Renaudineau Y, Youinou P, Pers JO, Daridon C. New ELISA for B cell\u2013activating factor. Clin Chem. 2009;55(10):1843\u201351. https:\/\/doi.org\/10.1373\/clinchem.2009.129940.","journal-title":"Clin Chem"},{"key":"6054_CR30","unstructured":"Lu B, Liu Q, Wang C, Masood Z, Morris DJ, Nichols F, Mercado R, Zhang P, Ge Q, Xin HL, Chen S. Ultrafast preparation of non-equilibrium Fe-Ni spinels by magnetic induction. J Energy Chem. 2021;53:290\u2013302. https:\/\/spj.science.org\/doi\/10.34133\/2022\/9756983."},{"issue":"11","key":"6054_CR31","doi-asserted-by":"publisher","first-page":"7379","DOI":"10.1016\/j.ijhydene.2021.12.058","volume":"47","author":"H Liu","year":"2022","unstructured":"Liu H, Zhong Z. Realizing stable electrochemical performance using MnNi2O4 micro\/nano mesospheres prepared by self-template route. Int J Hydrogen Energy. 2022;47(11):7379\u201387. https:\/\/doi.org\/10.1016\/j.ijhydene.2021.12.058.","journal-title":"Int J Hydrogen Energy"},{"key":"6054_CR32","doi-asserted-by":"publisher","first-page":"129271","DOI":"10.1016\/j.snb.2020.129271","volume":"330","author":"X Jin","year":"2021","unstructured":"Jin X, Li Y, Zhang B, Xu X, Sun G, Wang Y. Temperature-dependent dual selectivity of hierarchical porous In2O3 nanospheres for sensing ethanol and TEA. Sensor Actuat B: Chem. 2021;330:129271. https:\/\/doi.org\/10.1016\/j.snb.2020.129271.","journal-title":"Sensor Actuat B: Chem"},{"key":"6054_CR33","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.apcatb.2013.11.030","volume":"148","author":"C Zhang","year":"2014","unstructured":"Zhang C, Guo Y, Guo Y, Lu G, Boreave A, Retailleau L, Baylet A, Giroir-Fendler A. LaMnO3 perovskite oxides prepared by different methods for catalytic oxidation of toluene. Appl Catal B: Environ. 2014;148:490\u20138. https:\/\/doi.org\/10.1016\/j.apcatb.2013.11.030.","journal-title":"Appl Catal B: Environ"},{"issue":"7","key":"6054_CR34","doi-asserted-by":"publisher","first-page":"2100225","DOI":"10.1002\/smtd.202100225","volume":"5","author":"H Zhang","year":"2021","unstructured":"Zhang H, Yang D, Ma T, Lin H, Jia B. Flash-induced ultrafast production of graphene\/MnO with extraordinary supercapacitance. Small Methods. 2021;5(7):2100225. https:\/\/doi.org\/10.1002\/smtd.202100225.","journal-title":"Small Methods"},{"issue":"47","key":"6054_CR35","doi-asserted-by":"publisher","first-page":"44601","DOI":"10.1021\/acsami.9b15841","volume":"11","author":"G Yan","year":"2019","unstructured":"Yan G, Wang Y, Zhang Z, Li J, Carlos C, German LN, Zhang C, Wang J, Voyles PM, Wang X. Enhanced ferromagnetism from organic\u2013cerium oxide hybrid ultrathin nanosheets. ACS Appl Mater Inter. 2019;11(47):44601\u20138. https:\/\/doi.org\/10.1021\/acsami.9b15841.","journal-title":"ACS Appl Mater Inter"},{"key":"6054_CR36","doi-asserted-by":"publisher","first-page":"100593","DOI":"10.1016\/j.mtchem.2021.100593","volume":"22","author":"HJ Gao","year":"2021","unstructured":"Gao HJ, Wang SF, Fang LM, Sun GA, Chen XP, Tang SN, Yang H, Sun GZ, Li DF. Nanostructured spinel-type M (M = Mg Co, Zn) Cr2O4 oxides: novel adsorbents for aqueous Congo red removal. Mater Today Chem. 2021;22:100593. https:\/\/doi.org\/10.1016\/j.mtchem.2021.100593.","journal-title":"Mater Today Chem"},{"key":"6054_CR37","doi-asserted-by":"publisher","first-page":"153444","DOI":"10.1016\/j.apsusc.2022.153444","volume":"596","author":"K Wang","year":"2022","unstructured":"Wang K, Shao X, Zhang K, Wang J, Wu X, Wang H. 0D\/3D Bi3TaO7\/ZnIn2S4 heterojunction photocatalyst towards degradation of antibiotics coupled with simultaneous H2 evolution: in situ irradiated XPS investigation and S-scheme mechanism insight. Appl Surf Sci. 2022;596:153444. https:\/\/doi.org\/10.1016\/j.apsusc.2022.153444.","journal-title":"Appl Surf Sci"},{"key":"6054_CR38","doi-asserted-by":"publisher","first-page":"146729","DOI":"10.1016\/j.apsusc.2020.146729","volume":"526","author":"K Sakamoto","year":"2020","unstructured":"Sakamoto K, Hayashi F, Sato K, Hirano M, Ohtsu N. XPS spectral analysis for a multiple oxide comprising NiO, TiO2, and NiTiO3. Appl Surf Sci. 2020;526:146729. https:\/\/doi.org\/10.1016\/j.apsusc.2020.146729.","journal-title":"Appl Surf Sci"},{"key":"6054_CR39","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.watres.2017.09.034","volume":"126","author":"B Wu","year":"2017","unstructured":"Wu B, Fang L, Fortner JD, Guan X, Lo IMC. Highly efficient and selective phosphate removal from wastewater by magnetically recoverable La(OH)3\/Fe3O4 nanocomposites. Water Res. 2017;126:179\u201388. https:\/\/doi.org\/10.1016\/j.watres.2017.09.034.","journal-title":"Water Res"},{"key":"6054_CR40","doi-asserted-by":"publisher","unstructured":"Liu CL, Xuan K, Guo YP, Jiang H, Ma WJ, Wang XG, Zhou ZK, Li J, Guo YD. Facilitated electron-hole separation and enhanced uranium(Vi) capture via La-doped WO3: insights into oxygen vacancies and superior recyclability. J Hazard Mater. 2025;491. https:\/\/doi.org\/10.1016\/j.jhazmat.2025.137878.","DOI":"10.1016\/j.jhazmat.2025.137878"},{"key":"6054_CR41","doi-asserted-by":"publisher","unstructured":"Yuan T, Li PZ, Sun YY, Che HY, Zheng QF, Zhang YX, Huang S, Qiu J, Pang YP, Yang JH, Ma ZF, Zheng SY. Refining O3-type Ni\/Mn-based sodium-ion battery cathodes via \u201catomic knife\u201d achieving high capacity and stability. Adv Funct Mater. 2025;35. https:\/\/doi.org\/10.1002\/adfm.202414627.","DOI":"10.1002\/adfm.202414627"},{"key":"6054_CR42","doi-asserted-by":"publisher","unstructured":"Zhang XY, Yin H, Dang CC, Nie H, Huang ZX, Zheng SH, Du M, Gu ZY, Cao JM, Wu XL. Unlocking enhanced catalysis stability in acidic oxygen evolution: structural insights for Pem applications under high-current density. Angew Chem Int Edit. 2025;64. https:\/\/doi.org\/10.1002\/anie.202425569.","DOI":"10.1002\/anie.202425569"},{"key":"6054_CR43","doi-asserted-by":"publisher","unstructured":"Duan ER, Wang YH, Wang SF, Bai JY, Li DS, Zhang L, Deng JG, Tang XL. Revealing La doping activation or inhibition of crystal facet effects in Co3O4 for catalytic combustion and water resistance improvement. Chem Eng J. 2024;496. https:\/\/doi.org\/10.1002\/anie.202103557.","DOI":"10.1002\/anie.202103557"},{"key":"6054_CR44","doi-asserted-by":"publisher","unstructured":"Kuang JL, Liu ZM, Fu L, Shi Y, Zhang MJ, Wang Y, Ding N, Sun D, Tang YG, Wang HY. Charge tuning and anchor effect achieving stable high-voltage layered metal oxides for sodium-ion battery. Angew Chem Int Edit. 2025;64. https:\/\/doi.org\/10.1002\/anie.202500715.","DOI":"10.1002\/anie.202500715"},{"key":"6054_CR45","doi-asserted-by":"publisher","first-page":"112707","DOI":"10.1016\/j.bios.2020.112707","volume":"171","author":"J Wu","year":"2021","unstructured":"Wu J, Lv W, Yang Q, Li H, Li F. Label-free homogeneous electrochemical detection of microRNA based on target-induced anti-shielding against the catalytic activity of two-dimension nanozyme. Biosens Bioelectron. 2021;171:112707. https:\/\/doi.org\/10.1016\/j.bios.2020.112707.","journal-title":"Biosens Bioelectron"},{"key":"6054_CR46","doi-asserted-by":"publisher","first-page":"135280","DOI":"10.1016\/j.snb.2024.135280","volume":"404","author":"Y Gao","year":"2024","unstructured":"Gao Y, Gao X, Hou H, Qu Z, Li H, Du B, Tang P. Stabilizer-free MnO2 nanozyme with singlet-oxygen conducted high oxidase-like activity and fast catalysis capability for improving alkaline phosphatase assay. Sensor Actuat B: Chem. 2024;404:135280. https:\/\/doi.org\/10.1016\/j.snb.2024.135280.","journal-title":"Sensor Actuat B: Chem"},{"issue":"6","key":"6054_CR47","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1007\/s00216-022-04503-8","volume":"415","author":"J Chen","year":"2023","unstructured":"Chen J, Wu H, Liu J, Su Y, Li H, Lin P, Chen Y, Xiao W, Cao D. Sb-doped FeOCl nanozyme-based biosensor for highly sensitive colorimetric detection of glutathione. Anal Bioanal Chem. 2023;415(6):1205\u201319. https:\/\/doi.org\/10.1007\/s00216-022-04503-8.","journal-title":"Anal Bioanal Chem"},{"key":"6054_CR48","doi-asserted-by":"publisher","first-page":"121157","DOI":"10.1016\/j.apcatb.2022.121157","volume":"307","author":"N Zheng","year":"2022","unstructured":"Zheng N, He X, Hu R, Wang R, Zhou Q, Lian Y, Hu Z. In-situ production of singlet oxygen by dioxygen activation on iron phosphide for advanced oxidation processes. Appl Catal B: Environ Energy. 2022;307:121157. https:\/\/doi.org\/10.1016\/j.apcatb.2022.121157.","journal-title":"Appl Catal B: Environ Energy"},{"issue":"4","key":"6054_CR49","doi-asserted-by":"publisher","first-page":"e202300125","DOI":"10.1002\/cplu.202300125","volume":"88","author":"N Kaushal","year":"2023","unstructured":"Kaushal N, Jain A, Kumar A, Sarraf S, Basu AK, Raje CI, Saha A. Solvent-free synthesis of S, N-doped carbon dots for extended visible-light-induced oxidase-mimicking activities and antimicrobial applications. ChemPlusChem. 2023;88(4):e202300125. https:\/\/doi.org\/10.1002\/cplu.202300125.","journal-title":"ChemPlusChem"},{"key":"6054_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.aca.2015.02.027","volume":"871","author":"GL Wang","year":"2015","unstructured":"Wang GL, Jin LY, Wu XM, Dong YM, Li ZJ. Label-free colorimetric sensor for mercury (II) and DNA on the basis of mercury (II) switched-on the oxidase-mimicking activity of silver nanoclusters. Anal Chim Acta. 2015;871:1\u20138. https:\/\/doi.org\/10.1016\/j.aca.2015.02.027.","journal-title":"Anal Chim Acta"},{"issue":"13","key":"6054_CR51","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1002\/ange.200805279","volume":"121","author":"A Asati","year":"2009","unstructured":"Asati A, Santra S, Kaittanis C, Nath S, Perez JM. Oxidase-like activity of polymer-coated cerium oxide nanoparticles. Angew Chem. 2009;121(13):2344\u20138. https:\/\/doi.org\/10.1002\/ange.200805279.","journal-title":"Angew Chem"},{"key":"6054_CR52","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.aca.2016.11.035","volume":"951","author":"L Su","year":"2017","unstructured":"Su L, Dong W, Wu C, Gong Y, Zhang Y, Li L, Mao G, Feng S. The peroxidase and oxidase-like activity of NiCo2O4 mesoporous spheres: mechanistic understanding and colorimetric biosensing. Anal Chim Acta. 2017;951:124\u201332. https:\/\/doi.org\/10.1016\/j.aca.2016.11.035.","journal-title":"Anal Chim Acta"},{"issue":"6","key":"6054_CR53","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1002\/adma.201405105","volume":"27","author":"Y Tao","year":"2014","unstructured":"Tao Y, Ju E, Ren J, Qu X. Bifunctionalized mesoporous silica-supported gold nanoparticles: intrinsic oxidase and peroxidase catalytic activities for antibacterial applications. Adv Mater (Deerfield Beach, Fla). 2014;27(6):1097\u2013104. https:\/\/doi.org\/10.1002\/adma.201405105.","journal-title":"Adv Mater (Deerfield Beach, Fla.)"},{"issue":"16","key":"6054_CR54","doi-asserted-by":"publisher","first-page":"9618","DOI":"10.1039\/C3NR06896J","volume":"6","author":"CJ Yu","year":"2014","unstructured":"Yu CJ, Chen TH, Jiang JY, Tseng WL. Lysozyme-directed synthesis of platinum nanoclusters as a mimic oxidase. Nanoscale. 2014;6(16):9618\u201324. https:\/\/doi.org\/10.1039\/C3NR06896J.","journal-title":"Nanoscale"},{"key":"6054_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11051-016-3357-6","volume":"18","author":"L Guo","year":"2016","unstructured":"Guo L, Huang K, Liu H. Biocompatibility selenium nanoparticles with an intrinsic oxidase-like activity. J Nanopart Res. 2016;18:1\u201310. https:\/\/doi.org\/10.1007\/s11051-016-3357-6.","journal-title":"J Nanopart Res"},{"issue":"9","key":"6054_CR56","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1039\/C2TB00389A","volume":"1","author":"J Zhao","year":"2013","unstructured":"Zhao J, Xie Y, Yuan W, Li D, Liu S, Zheng B, Hou W. A hierarchical Co-Fe LDH rope-like nanostructure: facile preparation from hexagonal lyotropic liquid crystals and intrinsic oxidase-like catalytic activity. J Mater Chem B. 2013;1(9):1263\u20139. https:\/\/doi.org\/10.1039\/C2TB00389A.","journal-title":"J Mater Chem B"},{"issue":"15","key":"6054_CR57","doi-asserted-by":"publisher","first-page":"e202300119","DOI":"10.1002\/ange.202300119","volume":"135","author":"Y Wang","year":"2023","unstructured":"Wang Y, Cho A, Jia G, Cui X, Shin J, Nam I, Noh KJ, Park BJ, Huang R, Han JW. Tuning local coordination environments of manganese single-atom nanozymes with multi-enzyme properties for selective colorimetric biosensing. Angew Chem. 2023;135(15):e202300119. https:\/\/doi.org\/10.1002\/ange.202300119.","journal-title":"Angew Chem"},{"issue":"17","key":"6054_CR58","doi-asserted-by":"publisher","first-page":"9566","DOI":"10.1002\/ange.202017152","volume":"133","author":"Y Zhu","year":"2021","unstructured":"Zhu Y, Wang W, Cheng J, Qu Y, Dai Y, Liu M, Yu J, Wang C, Wang H, Wang S, Zhao C, Wu Y, Liu Y. Stimuli-Responsive Manganese Single-Atom Nanozyme for Tumor Therapy via Integrated Cascade Reactions. Angew Chem. 2021;133(17):9566\u201374. https:\/\/doi.org\/10.1002\/ange.202017152.","journal-title":"Angew Chem"},{"issue":"3","key":"6054_CR59","doi-asserted-by":"publisher","first-page":"112455","DOI":"10.1016\/j.jece.2024.112455","volume":"12","author":"S Pragalathan","year":"2024","unstructured":"Pragalathan S, Ruspika S, Chen SM, Dhanasekaran A, Velmurugan V, Balaji R, Mohan J, Chandrasekar N. Fabricating NiCoFe2O4 decorated PANI nanostructures for high-performance electrochemical detection of 3-nitro-L-tyrosine biomarkers for rapid diagnosis. J Environ Chem Eng. 2024;12(3):112455. https:\/\/doi.org\/10.1016\/j.jece.2024.112455.","journal-title":"J Environ Chem Eng"},{"key":"6054_CR60","doi-asserted-by":"publisher","first-page":"114467","DOI":"10.1016\/j.bios.2022.114467","volume":"213","author":"R Cancelliere","year":"2022","unstructured":"Cancelliere R, Di Tinno A, Di Lellis AM, Contini G, Micheli L, Signori E. Cost-effective and disposable label-free voltammetric immunosensor for sensitive detection of interleukin-6. Biosens Bioelectron. 2022;213:114467. https:\/\/doi.org\/10.1016\/j.bios.2022.114467.","journal-title":"Biosens Bioelectron"},{"issue":"48","key":"6054_CR61","doi-asserted-by":"publisher","first-page":"41659","DOI":"10.1021\/acsami.7b10753","volume":"9","author":"M Qi","year":"2017","unstructured":"Qi M, Huang J, Wei H, Cao C, Feng S, Guo Q, Goldys EM, Li R, Liu G. Graphene oxide thin film with dual function integrated into a nanosandwich device for in vivo monitoring of interleukin-6. ACS Appl Mater Inter. 2017;9(48):41659\u201368. https:\/\/doi.org\/10.1021\/acsami.7b10753.","journal-title":"ACS Appl Mater Inter"},{"key":"6054_CR62","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.aca.2020.10.025","volume":"1140","author":"Z Wang","year":"2020","unstructured":"Wang Z, Yang S, Wang Y, Feng W, Li B, Jiao J, Han B, Chen Q. A novel oriented immunosensor based on AuNPs-thionine-CMWCNTs and staphylococcal protein A for interleukin-6 analysis in complicated biological samples. Anal Chim Acta. 2020;1140:145\u201352. https:\/\/doi.org\/10.1016\/j.aca.2020.10.025.","journal-title":"Anal Chim Acta"},{"issue":"16","key":"6054_CR63","doi-asserted-by":"publisher","first-page":"2954","DOI":"10.1039\/C7AN00779E","volume":"142","author":"B Yin","year":"2017","unstructured":"Yin B, Zheng W, Dong M, Yu W, Chen Y, Joo SW, Jiang X. An enzyme-mediated competitive colorimetric sensor based on Au@ Ag bimetallic nanoparticles for highly sensitive detection of disease biomarkers. Analyst. 2017;142(16):2954\u201360. https:\/\/doi.org\/10.1039\/C7AN00779E.","journal-title":"Analyst"},{"key":"6054_CR64","doi-asserted-by":"publisher","first-page":"778269","DOI":"10.3389\/fbioe.2021.778269","volume":"9","author":"M Rahbar","year":"2021","unstructured":"Rahbar M, Wu Y, Subramony JA, Liu G. Sensitive colorimetric detection of interleukin-6 via lateral flow assay incorporated silver amplification method. Front Bioeng Biotech. 2021;9:778269. https:\/\/doi.org\/10.3389\/fbioe.2021.778269.","journal-title":"Front Bioeng Biotech"},{"key":"6054_CR65","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ab.2015.09.018","volume":"492","author":"J Peng","year":"2016","unstructured":"Peng J, Guan J, Yao H, Jin X. Magnetic colorimetric immunoassay for human interleukin-6 based on the oxidase activity of ceria spheres. Anal Biochem. 2016;492:63\u20138. https:\/\/doi.org\/10.1016\/j.ab.2015.09.018.","journal-title":"Anal Biochem"},{"key":"6054_CR66","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.bios.2017.11.023","volume":"102","author":"K Zhang","year":"2018","unstructured":"Zhang K, Liu G, Goldys EM. Robust immunosensing system based on biotin-streptavidin coupling for spatially localized femtogram mL-1 level detection of interleukin-6. Biosens Bioelectron. 2018;102:80\u20136. https:\/\/doi.org\/10.1016\/j.bios.2017.11.023.","journal-title":"Biosens Bioelectron"},{"issue":"12","key":"6054_CR67","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1007\/s00604-022-05570-5","volume":"189","author":"M Mahani","year":"2022","unstructured":"Mahani M, Faghihi-Fard M, Divsar F, Torkzadeh-Mahani M, Khakbaz F. Ultrasensitive FRET-based aptasensor for interleukin-6 as a biomarker for COVID-19 progression using nitrogen-doped carbon quantum dots and gold nanoparticles. Microchim Acta. 2022;189(12):472. https:\/\/doi.org\/10.1007\/s00604-022-05570-5.","journal-title":"Microchim Acta"},{"key":"6054_CR68","doi-asserted-by":"publisher","first-page":"132897","DOI":"10.1016\/j.snb.2022.132897","volume":"375","author":"T Xie","year":"2023","unstructured":"Xie T, Xu D, Shang Y, Li Y, Gu Y, Yang G, Qu L. Highly sensitive SERS detection of IL-6 in serum by Au@ Fe3O4 nanoring-based sandwich immunoassay. Sensor Actuat B: Chem. 2023;375:132897. https:\/\/doi.org\/10.1016\/j.snb.2022.132897.","journal-title":"Sensor Actuat B: Chem"},{"issue":"15","key":"6054_CR69","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1039\/d0ay02304c","volume":"13","author":"X Wang","year":"2021","unstructured":"Wang X, Ma L, Sun S, Liu T, Zhou H, Liu X, Guan M. Rapid, highly sensitive and quantitative detection of interleukin 6 based on SERS magnetic immunoassay. Anal Methods. 2021;13(15):1823\u201331. https:\/\/doi.org\/10.1039\/d0ay02304c.","journal-title":"Anal Methods"}],"container-title":["Analytical and Bioanalytical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-025-06054-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00216-025-06054-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00216-025-06054-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:02:36Z","timestamp":1757700156000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00216-025-06054-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":69,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["6054"],"URL":"https:\/\/doi.org\/10.1007\/s00216-025-06054-0","relation":{},"ISSN":["1618-2642","1618-2650"],"issn-type":[{"value":"1618-2642","type":"print"},{"value":"1618-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]},"assertion":[{"value":"6 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study followed the principles of the Declaration of Helsinki and was approved by the Medical Ethics Committees of Guangdong Second Provincial General Hospital (ethical approval number: GD2H-KYIRB-AF-SC.07\u201301.2).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}